Statistics of successful eco protocols. How long does it take to repeat IVF under compulsory medical insurance?

Why is the first IVF often unsuccessful?

No implantation

IVF children

The first in vitro fertilization protocol is quite often unsuccessful. Pregnancy does not occur in approximately half of the cases. There is also a high probability of a frozen pregnancy or miscarriage early. After this, a reasonable question arises: when can you try again? We will talk about this in our article.

Why are attempts unsuccessful?

If an IVF attempt is unsuccessful, it is important to establish the true reason why the pregnancy did not take place. It depends on which factor or combination of reasons has an influence whether the chances of pregnancy will increase during the subsequent protocol. The reasons for failure can be very different.

Often, embryos obtained from the fertilization of maternal eggs with the sperm of a husband or donor do not meet strict quality requirements. They do not demonstrate high vitality; in fact, they are not strong and healthy. Such embryos have virtually no chance of successfully implanting.

Embryos may be injured during transfer, for example if the transfer is too fast. They also die, pregnancy does not occur. The reasons may lie in insufficient quality biological materials- oocytes and sperm.

Often the protocol ends unsuccessfully due to too aggressive hormonal stimulation ovaries in the first phase of the menstrual cycle in the first protocol. At the same time, an excess of estrogen and FSH occurs in the woman’s body, and ovarian hyperstimulation syndrome may develop, which significantly reduces the already far from one hundred percent probability of successful completion of the protocol.

A woman can get the flu or ARVI after the transfer of fertilized eggs into the uterine cavity. Her long-standing chronic diseases may worsen under the influence of aggressive hormone therapy. Sometimes the reason for the lack of pregnancy after an IVF attempt is autoimmune processes, as well as genetic incompatibility of partners. Sometimes doctors are unable to obtain sufficient quantity eggs, and sometimes a large number of fertilized eggs are not selected for suitability for transfer.

Quite often, implantation is hampered by the patient’s complicated obstetric history - endometriosis, pathologies of the uterus and cervix can be a significant obstacle to cherished motherhood.

Previous abortions and curettages (including diagnostic ones) can make the endometrium heterogeneous and too thin for a fertilized egg to successfully attach to it and begin to develop further.

Even if pregnancy has occurred, and this is confirmed by ultrasound and hCG tests, after IVF there is a fairly high probability of miscarriage or early miscarriage. This again can be a consequence of hormonal therapy, and is also caused by a variety of reasons.

Pregnancy after IVF is special; such expectant mothers require more careful monitoring. But even best doctors, alas, cannot always prevent the death and detachment of the fertilized egg.

Unsuccessful IVF, no matter how it ends, may be a consequence of the woman’s age. Optimal age When the success rate is highest, the age up to 35 years is considered, then every year the probability of a successful pregnancy decreases.

After an unsuccessful attempt, it is important to gather your willpower, and no matter how much you want to give up everything and cry, you must definitely go for an examination, which will help you understand what really happened and when you can start the next attempt.

What examinations need to be completed?

After the end of the next menstruation, which completed an unsuccessful protocol, the woman must do an ultrasound of the pelvic organs, as well as hysteroscopy, which will show all the features of the uterus and endometrium. It is necessary to donate blood for hormones, general and extended blood tests, and urine tests.

Couples over 35 years old, as well as couples who have had three or more unsuccessful transplants, need to visit a geneticist and get necessary tests on compatibility and karyotyping. An immunogram done in the clinic will help identify possible immune factors in which a woman’s body rejects pregnancy as something foreign.

If a miscarriage or miscarriage occurs, the woman will have to do all the same tests, and in addition to them, it is advisable to obtain a conclusion from a genetic laboratory that examined embryonic tissue after miscarriage or spontaneous miscarriage. With a high degree of probability, such a study will show whether the baby had genetic pathologies or whether his death was due to other reasons.

After passing the examination, you should immediately go to the doctor who did the IVF so that he can review the previous protocol and make adjustments to it. Sometimes it is simply enough to change the protocol from long to short, or replace one hormonal drug with another, or change the dosage so that the second attempt is more successful.

When can I try again?

The question of how many days later you can do repeated IVF is not entirely correct. In every specific case Individual deadlines are set, which depend on the woman’s well-being, health status and the reasons why the first protocol was unsuccessful.

The most common period a woman is given for recovery is three months. During this time, the woman usually has time to calm down after the previous defeat, gain hope and do all the necessary tests and examinations.

However, if the previous attempt was carried out without hormonal stimulation of the ovaries, natural cycle, you can try again in the next menstrual cycle, that is, in two weeks.

After a miscarriage or frozen pregnancy, a woman usually needs more time to recover, since in most cases such situations require curettage of the uterine cavity. She must first undergo treatment with antibiotics and anti-inflammatory drugs, then begin rehabilitation and, finally, preparation. The recommended pause in this case is six months.

Protocol success rate

A repeated protocol almost always has a better chance of success than the first one. This is because when trying again, there is often no need to stimulate the ovaries. If during the first stimulation a sufficient number of eggs are obtained and several oocytes are left frozen in the cryobank, then a cryoprotocol is prescribed. Transferring embryos into the uterus of a woman who has rested from aggressive hormonal influences significantly increases the likelihood of a successful pregnancy.

Even the stimulated second or third protocol is considered more successful than the first. So, with the first protocol, the probability of pregnancy after IVF is about 45%. In the second protocol, the probability of pregnancy reaches 60%. However, after the third attempt, the chances decrease significantly and amount to no more than 15-20%.

A woman's age influences the prediction - if she is under 35 years old, then the chances are high. At 38 years old they do not exceed 35%, at 40-42 years old the probability of pregnancy is 15-19%, and after 45 years old it is no more than 8%.

Any aggravating factors - ovarian hyperstimulation, tumors in the uterus, depleted endometrium, chronic diseases reduce the likelihood of success by approximately 5% for each factor. However, everyone always has a chance to get pregnant. Gynecologists know cases where IVF results in successful pregnancy in women 50 years of age and older, as well as in women with severe forms of infertility.

The following information will be useful as a “bonus”: the first or second IVF attempts, if they were carried out with hormonal support, significantly increase the likelihood that reproductive system women after a hormonal “shake-up” will begin to work more actively. Therefore, in 25% of couples, after an unsuccessful attempt or two, it is likely that pregnancy will occur from natural conception.

Usually this happens during the period of recovery and preparation for the next attempt at in vitro fertilization. Naturally, such an outcome is likely only in women who have preserved the ovulatory function of the ovaries and the ovaries themselves, and there is no obstruction of the fallopian tubes.

To all of the above, all that remains to be added is that there is no point in delaying the next attempt. A long break, as well as excessive haste, can have a bad effect on the outcome of the next attempt. Listen to your doctor, follow his recommendations and everything will definitely work out.

IVF statistics are an indicator of the quality and effectiveness of the procedure. Some couples mistakenly perceive the concept of “statistics”; they believe that it shows the probability of birth healthy child as a result of IVF. In fact, this term refers to the ratio of the number of protocols performed to the rate of successful pregnancy.

Before the doctor examines the woman’s health condition. The cause of infertility and associated factors that can reduce the success rate of the protocols are clarified. It is important to take into account all the nuances during the preparation process, since this will determine what chances an infertile couple has. The effectiveness of the procedure depends on external and internal factors, from the correct tactics of the doctor’s actions.

The age of the patient is important. In women under 30 years of age, the success rate reaches 60%. IVF at the age of 40 shows good results in only 6-10 patients out of 100 who decide to undergo the procedure.
Reason for lack of pregnancy. The statistics of successful IVF for tubal infertility is higher than for diseases caused by hormonal disorders: endometriosis, adenomyosis, polycystic disease, fibroids. If a woman has genetic diseases that cause infertility, then the chances of successful IVF are sharply reduced, since such cases are considered the most difficult.
State men's health. If the cause of infertility is the poor quality of the partner’s sperm, then the use of additional manipulations (ICSI) gives a high chance of pregnancy. It is important that the woman does not have any concomitant diseases.
Qualification of doctors. It is important to choose a clinic that professionally deals with in vitro fertilization. At the preparation stage, the reproductologist chooses hormonal drugs and the type of protocol; these decisions directly affect the result. When working with embryos, the responsibility and professionalism of the embryologist is important.
Patient's approach. Increase your chances of successful conception It is possible if you approach your preparation responsibly. Often women are in a hurry to join the program in order to quickly bring themselves closer to their cherished goal. However, there is no need to rush. The patient must be thoroughly examined and, if necessary, undergo treatment.

Reproduction statistics have been compiled relatively recently. However, each clinic using ART can provide its own data on the number successful protocols. Detailed study of techniques, innovations, and use modern drugs increases the frequency of protocols resulting in pregnancy.

On the first, second or third try?

A successful IVF protocol on the first try is quite possible. The likelihood of such a result is influenced by all the factors that we discussed above. If a woman and her partner are absolutely healthy, and the cause of infertility has not been established, then the probability of successful IVF the first time is on average 45-50% for all ages. The younger the patient, the greater the chance - up to 60%. Also, implantation on the first attempt often occurs in couples with tubal infertility, provided that there are no other problems. The success rate of IVF the first time is higher for those women who are implanted with not one, but several embryos at once.

Psychological condition patients affects the likelihood of pregnancy on the first try. In case of an unsuccessful protocol, a second IVF attempt is made, but not everyone decides to do it. It would be a mistake to refuse further procedures. After all, the second time the chance of pregnancy is higher. This is evidenced by generalized statistics from clinics specializing in ART.

The likelihood of success during repeated IVF depends on the condition of the woman’s ovaries. With each stimulation, the number of eggs decreases. If this is aggravated by the patient's age, then the chance of success will be lower.

In this case, the use of donor material increases the percentage of successful transfers. If pregnancy does not occur the first time, you need to be examined and find out the reason for the failure. In the next program, reproductive specialists will take this into account, and this will increase the chance of pregnancy.

In Vitro Fertilization Statistics

According to official data, average pregnancy rate in Russia with IVF is 38.5 percent.

But you cannot rely trustingly on the statistics of IVF protocols. Each patient’s body is individual, as are the diseases that cause infertility. The chances also depend on the type of protocol.

In a long protocol

Most of the clinics using ART are located in Moscow and St. Petersburg. And they are the ones who determine IVF statistics in Russia. Data from these institutions indicate a 30-60% chance of successful infertility treatment.

– the most difficult, both for the female body and for reproductive specialists. The duration of this scheme is variable and can range from 6 weeks to 6 months. The long protocol shows good results in women with hormonal diseases. With help medicines The functioning of the gonads is completely controlled. This approach regulates natural processes and minimizes unforeseen situations. The percentage of successful egg fertilization depends on the quality of the reproductive gametes of the man and woman.

In a natural cycle

The success rate with IVF in a natural cycle does not exceed 10. Plus - minimal impact on female body. The patient does not accept potent drugs, which facilitates the functioning of the reproductive system. However, in a natural cycle, only one (less often 2 or 3) egg is produced. It is impossible to say in advance what the quality of the gamete will be. Therefore, it often happens that when performing ART in a natural cycle, even the transfer of embryos is impossible due to their low quality.

With cryoprotocol

The chances of getting pregnant with IVF in a cryoprotocol are lower than in a long cycle, but higher than in a natural cycle. An important advantage is the absence hormonal correction. The embryos are transferred after thawing on a suitable day of the cycle. Optimal and natural conditions for implantation.

The pregnancy rate in the cryo protocol is no more than 25%. The decrease in results compared to the long protocol is due to the fact that the state of fertilized cells is affected by the process of vitrification and subsequent thawing.

With a donor egg

The success rate of in vitro fertilization with a donor egg is quite high - up to 46%. Most patients who decide to use material from another woman are in mature age. The number of their own gametes in the ovaries does not allow them to carry out stimulation. Therefore, they have almost no chance of successful IVF with their own egg.

Increases the success of the procedure significantly. It is important that after IVF all recommendations for taking maintenance medications are followed.

With ICSI

Intracytoplasmic injection is successful in IVF. Manipulation allows you to select the best and most mature sperm that will fertilize the egg. For primary IVF protocols, statistics (ICSI) is 32-33%. When repeated, success increases to 44%. The number of pregnancies occurring after the fifth attempt reaches 77 per 100 people.

It makes sense to study IVF statistics for couples just for fun. Only a reproductive specialist after an examination can say what the chance of conception is for certain partners who have their own health indicators.

When performing artificial insemination, it is not always possible to get pregnant the first time. If this does not work, a second IVF attempt is made. will be successful, with a scrupulous analysis of the previous failure and additional examination.

Reasons for failure

Despite careful preparation for the procedure, no one gives a complete guarantee of a positive outcome. The first embryo transfer is rarely successful, but the chances of a second IVF attempt increase significantly. Repeated fertilization does not harm the patient’s health and is absolutely safe.

Some parents-to-be are worried about availability possible deviations in children born after frozen embryo transfer. According to the research results, no pathologies in the child’s development were identified. The percentage of children born with any disorders using cryotransfer is no higher than that of children conceived naturally.

Deadlines

After how long can you do a repeat eco? The timing of a new attempt at artificial insemination mainly depends on the recommendations of the attending physician and the desire of the woman. By coordinating these indicators, after a certain time, you can do IVF, usually 2-3 months. But, taking into account the individual characteristics of the body, only the doctor will determine when a second IVF attempt can be made, after two months or after a longer time.

But no specialist guarantees that second IVF attempts will be successful. Therefore, it is important, after each failure, to correctly determine the reasons that prevent pregnancy. But the inability to get pregnant for the first or second time is not a reason for despair. Many factors can be eliminated, and in half of the cases the woman carries and gives birth to a healthy child.

Only in difficult situations, after three unsuccessful attempts, doctors suggest taking other options. For example, the use of donor embryos, sperm or eggs. Sometimes, only surrogacy is possible. But before making a decision, you should not refuse to make another attempt at fertilization.

Modern medicine uses the latest techniques, and now, almost every woman can become a mother. Everything should be considered as a new step towards a successful pregnancy. At the next transplant, they are minimized negative factors previous procedures.

When a married couple is unable to conceive a child naturally, but really wants to have a half-blooded heir, doctors advise using it reproductive technologies. The most commonly used technology in this case is IVF. But before you decide to take such a responsible step, it is useful to find out how effective this technique is and what the consequences may be.

Statistics of successful IVF protocols on the first try

The success of in vitro fertilization is influenced by the following factors:

age of the couple;
causes of infertility, severity and who has the problem (both partners or only the spouse);
quality and quantity of eggs taken during puncture;
quality and quantity of seed material;
number of “suitable” embryos;
duration of infertility;
the state of the uterine endometrium at the time of replantation;
number of unsuccessful attempts;
clinic level;
correct selection of the protocol;
reasonable choice and dosage of hormonal drugs;
genetic factors;
application of cryotechnology;
use of donor material;
use of ICSI;
the presence of bad habits among partners and their lifestyle;
chronic diseases and inflammatory processes in the female body.

For different age groups

The most important among the many factors on which the success of an IVF protocol depends is age. The older a woman’s body becomes, the lower her fertility and the likelihood of bearing a healthy child.

According to statistics, after the first procedure pregnancy occurs:

in 9% of patients over 40 years of age;
in 27% - at the age of 35–40 years;
38% are under 35 years of age.

In general, the relationship between a woman’s age and the successful birth of a child thanks to the IVF procedure looks like this:

For different countries of the world

The global average for IVF success the first time is 30–40 percent. But rates may vary depending on the clinic and country, ranging from 10–15% to 45–60%.

USA. According to 2013 data, 175,000 artificial insemination procedures were performed during this period. Pregnancy was recorded in 63,000 patients, which means the procedure was 36% successful.

Did you know? In Israel, the technique of in vitro fertilization has been carried out since 1980, so local specialists are considered the best in this industry.

Already in 2016, about 180,000 protocols were carried out (the first 120,000). 35% were successful and ended with the birth of healthy babies.

Israel. Now in this country the IVF success rate is 45–47%.
Spain. They are also famous here good results, 43% (in 20% pregnancy occurred on the first try). And in Barcelona this figure is 45%.

South Korea. The national average is 40%. If a foreign woman is seen by specialists, then the probability of a successful outcome for her will be 50%.

This jump is explained by the availability of high-quality diagnostic equipment, so when a woman diagnosed with infertility goes for examination, it may turn out that her problem is not so critical or does not exist at all.

Japan. In 2015, 424,200 protocols were carried out in the country, of which 51,000 resulted in successful delivery.

Poland. This country has the most successful IVF procedures in Europe (about 55%).
Türkiye and Cyprus. Here the most loyal laws are in relation to the patient’s status and age. Cryoprotocols are 43% successful here, and intrauterine insemination is 17.9%.

Ukraine. There are about 40 centers specializing in artificial insemination in the country. Their specialists are able to provide a positive result of 35–40% the first time.

Russia. The average statistics in the country is 55–60%. Of these, 35% of procedures are successful the first time, 40% are successful the second.

Probability of IVF on the second try

According to statistics, healthy woman no older than 30 years of age can become pregnant in 50% of cases after the second attempt of the IVF protocol. With age, this probability decreases.

Did you know? As of 1990« from a test tube» More than 20,000 children were born in the world. In 2010, this figure increased to 4 million.

In patients over the age of 40, the chance of a successful outcome is only 10–20%. But in general, when artificial insemination is attempted again, the chances of success increase and most women become mothers on the second attempt.
There are reasons for this:

This is facilitated by the use of a cryoprotocol if embryos have been preserved, since the best ones are always selected for freezing.
A repeated procedure, as a rule, is less exhausting for the female body, since it does not require additional stimulation - which means that the body has more strength to bear a child.
Doctors can more clearly develop an action plan based on unsuccessful result and for new tests.

Which IVF attempts are more likely to get pregnant?

The fact of pregnancy after IVF is a purely individual phenomenon for each woman, because, as mentioned above, this is influenced by a number of factors.

Therefore, it is impossible to say with certainty that your first attempt will be successful, or that after one failure you will definitely succeed.

Certainly, general indicators exist, we talked about them in the previous section - from them we can conclude that most often pregnancy occurs on the first or second attempt.
The more attempts, the lower the chance of success. But there are cases that pregnancy occurred only after 10–12 refills.

IVF in the natural cycle: statistics

When carrying out IVF in a natural cycle, ovarian stimulation is not performed, so one egg is obtained from the follicle, matured naturally.

For a woman’s body, this procedure is more acceptable, since hormonal drugs are not introduced, but at the same time it affects success. According to statistics, when performing IVF in a natural cycle, the probability of pregnancy is 7–10%.

What is the chance of successful IVF with a donor egg?

As a rule, a donor egg is used during artificial insemination if the patient has exhausted her own reserve of germ cells. This happens with age, so a narrow audience of older patients is used to obtain statistical data. In their case, a successful result is guaranteed at 45.8%.

IVF children are infertile: truth or myth

This issue has become a concern for many women who are planning to give birth to a test-tube baby after the appearance of a number of publications and television programs that speak negatively about the IVF procedure itself.

So far, scientists have not given a clear answer to this question, although American experts refute the truth of the statement about the infertility of IVF children.

All this is due to the fact that no one has specifically conducted research, since the method of artificial insemination has been widely used not so long ago, so there are no statistics. In addition, the audience for research has not yet been formed.

However, there is data on the fertility of the first two girls “from a test tube”: both of them successfully became mothers naturally. So it can be assumed that there is no risk with female babies. As for boys, there is no data to confirm or refute the myth about them, but there are fears that infertility is possible.
This is due to the fact that a male infant can inherit from the father the cause of infertility if he had it or was passed on through the generation through the male line.

That is: if the child’s father has reduced sperm motility, the baby may also have this disease. But the causes of infertility can also be inherited by those children who were conceived naturally.

IVF and cancer: statistics

Cancer is one of the possible complications after IVF. According to statistics, it occurs in 0.0001% of patients who have undergone IVF. According to other data borderline form Ovarian cancer occurred 4 times more often in such women compared to those whose pregnancy occurred naturally.

The invasive form arose with the same frequency. Such cancer development statistics do not indicate that IVF caused its appearance. There is also no consensus regarding breast cancer.

Video: Does IVF cause cancer? Australian scientists, after conducting a series of studies, determined that if in vitro fertilization was performed on women under 25 years of age, breast cancer occurred in them 55% more often than in women who became pregnant naturally. If the procedure was performed on women over 38 years of age, then the likelihood of breast cancer was the same for both categories.

Austrian scientists have found that a hormonally dependent form of cancer is 3% more common in women after IVF. At the same time, London experts claim that ovarian cancer after unsuccessful IVF is 35% more common than in those who did not undergo it. And usually young patients suffer from the disease.

Important! The main thing is to remember that if there are prerequisites for the development of a neoplasm, it can appear both after IVF and after pregnancy naturally. Any pregnancy- this is a hormonal surge that can support growth and developmentNot only embryo, but also a tumor, although with IVF this surge is more significant.

So, the relationship between oncology and IVF is a complicated issue. It remains open for the reason that no one has yet established the cause of the pathology, so it is difficult to predict how the body of a particular patient will behave after the protocol.

Possible complications

If after replanting the embryo takes root, then pregnancy occurs. However, it is necessary to consolidate the result, and also make sure that there are no complications that often arise during such a procedure, because there is a serious interference in the functioning of the entire female body.

Any violation of cyclicity can lead to negative consequences, That's why future mom should be under close medical supervision and be prepared for the following problems:

ovarian hyperstimulation (occurs due to stimulation of ovulation, occurs in 1.3% of cases, causes an increase in the organ’s size);
bleeding or injury to organs abdominal cavity(usually occurs during egg retrieval);
multiple pregnancy (occurs if more than one embryo was implanted, and 2 or more took root; the probability of this is 50%; often causes a miscarriage);
frozen pregnancy (occurs in 10–15% of patients over forty);
ectopic pregnancy (probability 2–3%);
spontaneous interruption.

Most often, complications occur in the first trimester of pregnancy. When analyzing statistical data on the success of IVF protocols, it should be remembered that they are all averages.

The final result will depend not only on the professionalism of the doctor and the level of the clinic, but also on the woman’s age, her medical history, as well as the medical history of her partner. Using static data, you can only choose a country and a clinic where your chance of success will be higher.

The IVF cycle includes several stages, and each of them must be successfully overcome to move to the next stage:

growth and development of at least one follicle must begin
follicles must mature
Premature ovulation should not occur before follicle puncture
During puncture, the eggs must be successfully retrieved from the follicles
sperm must fertilize at least one egg
the fertilized egg must begin to divide and develop
the embryo must be implanted in the uterus

In this chain, implantation still remains a mystery to scientists - why doesn't every embryo become a child?

Using modern technology, we are successfully able to obtain embryos in the laboratory, but we still cannot control the implantation process. We don't know what kind of embryo will become, and this brings a lot of disappointment to both the doctor and the patient.

Implantation is a very complex process. First of all, the embryo must continue to develop to the blastocyst stage and then emerge from its shell (zona pellucida). The hatched blastocyst must then implant into the endometrium of the uterus at short period time, called the implantation window. The three main phases of implantation are known as opposition, adhesion and invasion. Opposition, or orientation of the embryo in the uterine cavity, begins at the moment when the uterine cavity is maximally reduced due to the absorption of the fluid in it by pinopodia (small tuberculate structures that appear on the outer membrane of the cells lining the uterus).

Adhesion blastocyst is a chain of biochemical reactions leading to its attachment to the endometrium. Many molecules such as cytokines, growth factors and integrins play important role in that complex process, during which the blastocyst and the maternal endometrium enter into a subtle “dialogue”.

Invasion is a self-controlled process that allows the embryonic trophoblast (the cells of the blastocyst that will later become the cells of the placenta) to penetrate deep into the decidual maternal tissue (the cells of the endometrium that will later form the maternal part of the placenta) and invade the endometrial bloodstream. This occurs due to the development of special chemical substances called proteinase.

For successful implantation of the blastocyst, immune mechanisms are also very important, ensuring dialogue between the tissues of the mother and the embryo, which are genetically and immunologically different. Activated decidual tissue cells and trophoblast cells produce large amounts of immunological active substances, causing the necessary immune reactions.

How implantation is regulated and occurs remains a mystery, but it is worth noting that in humans the implantation process is surprisingly low in efficiency - Nature is not always competent! An absolutely healthy married couple has only a 20-25% chance of conceiving a child in each menstrual cycle. Responsibility for such low efficiency lies both with the embryo itself and with disturbances in the embryo-edometrial dialogue. Today we know that one of the main reasons for unsuccessful implantation is genetic pathologies of the embryo. Basic Research in the field of implantation are of great interest, since, apparently, implantation is the main factor limiting the effectiveness of ART. However, we have much more to learn before we can really control this process.

Analysis of a failed IVF cycle

If you don't get pregnant after your first IVF attempt, of course you will be very upset and disappointed. However, remember that this is not the end of the journey - it is just the beginning! After an unsuccessful IVF cycle, you will meet with your doctor and analyze what conclusions can be drawn. When analyzing an unsuccessful IVF attempt, the doctor pays special attention to the quality of the embryos and endometrium, as well as other important points:

Was your body optimally prepared for pregnancy? Of course, the presence of certain general and gynecological diseases does not always affect the onset of pregnancy, but on the other hand, a decrease in the ability to conceive in many diseases cannot be ruled out. Therefore, it is necessary to prepare the body for conception and conduct IVF during a period outside of the exacerbation of any chronic diseases.
Was the ovarian response to stimulation good enough?
Has fertilization occurred?
Were the embryos obtained good quality, did they develop normally in laboratory conditions?
Was the thickness and structure of the endometrium at the time of transfer optimal?
Were any abnormalities in the development of the endometrium identified during the IVF program?
Has implantation occurred, as determined by a blood test for the hCG hormone two weeks after embryo transfer?
Why didn’t pregnancy occur (although there is no answer to this question!).
Do I need to do any additional testing before my next IVF attempt?
Do I need to do any treatment before my next IVF cycle?
Can the same treatment regimen be repeated or does it need to be modified before trying again?
When can I start a repeat IVF cycle?

Even if you don't get pregnant, the very fact that you went through IVF will allow you to move on with your life knowing that you did the best you could using Newest technologies that modern medicine can offer.

Repeated IVF cycle

Most doctors advise waiting at least one month before starting the next treatment cycle. Although with medical point vision, it is possible to carry out a second IVF cycle as early as next month, most patients require a break to gather strength and recover peace of mind before starting all over again. As a general rule, we recommend a three-month break before attempting IVF again.

Depending on the results of the previous cycle, your doctor may need to change your treatment regimen. For example, if the ovarian response to stimulation was insufficient, the doctor may increase the dose of the drug to stimulate superovulation or change the stimulation protocol. If fertilization does not occur, you may need ICSI. If the quality of the eggs was poor, the doctor may recommend the use of donor eggs. However, if the results of the previous cycle were satisfactory, the doctor may recommend repeating the same treatment regimen: all that many patients need to succeed in an IVF cycle is time and one more try.

It is interesting to note that couples undergoing a repeat cycle of IVF tend to be much calmer and more in control of the situation. This may be due to the fact that they are already aware of all the necessary medical procedures, and better prepared for them; and also because they have already established personal contact with the doctor and staff IVF center.

We were working on the page.

You have already undergone more than one in vitro fertilization procedure, but the desired pregnancy has not occurred... Do not despair. Remember that this is not the end of the journey - this is just the beginning! Only 30-40% of IVF cases result in pregnancy. And if there is accompanying illnesses, then the percentage may be even lower. Most doctors advise waiting at least one month before starting the next treatment cycle. Although it is medically possible to repeat the IVF cycle as early as next month, most patients need a break to gather their strength and regain their peace of mind before starting all over again. As a rule, we recommend a two to three month break before trying IVF again.

Depending on the results of the previous cycle, your doctor may need to change your treatment regimen. For example, if the ovarian response to stimulation was insufficient, the doctor may increase the dose of the drug to stimulate superovulation or change the stimulation protocol. If fertilization does not occur, you may need ICSI or IMSI. If the quality of the eggs was poor, the doctor may recommend the use of donor eggs. However, if the results of the previous cycle were satisfactory, the doctor may recommend repeating the same treatment regimen: all that many patients need to succeed in an IVF cycle is time and one more try.

It is interesting to note that couples undergoing a repeat cycle of IVF tend to be much calmer and more in control of the situation. This may be due to the fact that they are already aware of all the necessary medical procedures and are better prepared for them; and also because they have already established personal contact with the doctor and center staff.

Our many years of experience show that there are no insoluble problems, and sooner or later pregnancy will still occur, the main thing is not to give up!

Let's look at the main reasons for unsuccessful IVF.
First of all, pregnancy after IVF may not occur if a woman is implanted with a low-quality embryo. An embryo is considered high quality if it consists of 6-8 cells, demonstrates high performance division, there is no fragmentation in it. If you suspect that your unsuccessful attempts to get pregnant are related to embryos, then think about changing the clinic. After all, highly qualified infertility specialists pay attention, first of all, to the quality of embryos and the environment in which they are cultured and frozen. Remember: little depends on you in the in vitro fertilization procedure. If you decide to take this step, then contact only those clinics that have a large number of positive reviews.
2. Successful implantation largely depends on the size and structure of the endometrium. The embryo takes root best in the mother's womb if the endometrium is 7-14 mm thick. If there are any endometrial diseases, then before the IVF procedure you must first address them. What are the types of endometrial diseases? First of all, it is chronic endometritis. It is diagnosed using an ultrasound examination of the pelvic organs. Chronic endometritis is a big obstacle for normal process invasion, development of the placenta and chorion. This disease very often provokes miscarriages. As a result of endometritis, scars form in the basal layer of the endometrium, which can develop into synechiae and cause infertility. What do we have to do?
First, undergo a diagnostic hysteroscopy procedure. The results determine which treatment method the doctor will choose. Then it is advisable to do a culture test, because it will determine what is the causative agent of this complex disease. You also cannot do without an endometrial biopsy. Treatment methods for chronic endometritis include laser and physiotherapeutic procedures, antibiotics, alternative medicine methods, as well as spa treatment.
3. Not less serious illness Pathologies of the fallopian tubes can also hinder a successful IVF program. In general, before starting the in vitro fertilization procedure, doctors always carry out diagnostics that check the patency of the fallopian tubes. This test allows you to determine whether the fallopian tubes have liquid formations. They negatively affect the embryo; pregnancy with a positive result of such diagnostics always ends in fetal death. What to do? One treatment option is to remove the “affected” tubes using laparoscopy. After this, as a rule, nothing interferes with the successful completion of artificial insemination.
4. An equally important aspect of unsuccessful IVF attempts are genetic problems. Studies have shown that couples suffering from infertility have an inversion of the 9th chromosome, which, at the time of maturation and fertilization of the egg, entails a number of pathologies in the cell division procedure. These pathologies, as a rule, prevent pregnancy. If it does occur, then the fetus most often has genetic diseases. Nature intended for such a pregnancy to end in miscarriage. Sometimes (very rarely) it happens that a normal pregnancy occurs.
If you or your relatives have ever experienced genetic diseases, then before planning IVF it is necessary to undergo a consultation with a geneticist. It will draw up your family tree and determine the risk of a number of diseases. It is advisable to do a cytogenetic analysis, which will determine specific genes or chromosomes, responsible for one disease or another. Perhaps, according to indications, you will also be recommended pre-implantation diagnostics.
5. Sometimes it happens that in vitro fertilization fails, although obvious reasons for this purpose no. In such cases, patients are recommended to undergo an immunological examination, including a complete immunogram and hemostasiogram with a lupus anticoagulant, testing for the presence of antisperm antibodies and a number of other studies. An important diagnostic method is HLA typing, which determines the similarity of spouses in a number of antigens. The higher the similarity, the less chance of getting pregnant, since the woman’s body will perceive the embryo as a foreign body and will reject it. In such cases, IVF will always fail.
6. There is a certain classification of the causes of fading pregnancy and miscarriages. Category 1 includes previously described cases of similarity of spouses in HLA antigens. The 2nd category is cases with antiphospholipid syndrome: if a woman has antibodies to such important elements for pregnancy as phosphatidylethanolamine and phosphatidylserine, then you should not count on the success of IVF. Category 3 includes cases with the presence of antihistone and antinuclear antibodies, which provoke inflammatory processes in the placenta, and, accordingly, miscarriage. Category 4 are cases with antisperm antibodies. Category 5 is the most difficult. It has several sections: cases associated with a natural killer cell (CD56) concentration of more than 12%; cases with activation of CD19+5+ cells; With high content CD19+5+ cells, which impair the blood circulation in the uterus and thereby contribute to infertility.
7. Medical errors also play an important role in unsuccessful IVF: incorrectly selected protocol, traumatic implantation of the embryo, incorrectly chosen time for embryo transfer, too rapid introduction of embryos, incorrect supportive therapy. If you have doubts about the competence of the doctor, do not hesitate and change the specialist.
8. Successful fertilization is closely related to the endocrine system. Diseases such as diabetes, hyperandrogenism, hyperprolactinemia negatively affect IVF. Before planning a pregnancy, you need to visit a fertility specialist who will advise you on how to properly prepare for the IVF procedure with such problems.
9. Unsuccessful fertilization may also be due to the fact that you do not give of great importance doctor’s prescriptions, as well as the fact that you are using low-quality drugs. 10. It is also important to know that a woman’s age affects the success of the IVF procedure. Women over 40 no longer have the same reproductive functions as before. And men after 39 years of age may suffer from severe sperm fragmentation.
11. If you are overweight, it is safe to say that you will have problems not only with conceiving, but also with successfully bearing a fetus. By losing excess weight, you will increase your chances of pregnancy. However, it’s worth thinking about whether your excess kilograms may be associated with some kind of disease...
12. Factors influencing the success of pregnancy and IVF in particular include the husband’s smoking. Components tobacco smoke directly affect the quality of sperm, and, accordingly, on normal development embryo. And if the husband is also old, then the chances of normal IVF are reduced hundreds of times.
Summing up the conclusions, it is worth noting that the reasons for unsuccessful IVF should be understood within 4 attempts. Starting from the 5th attempt, the chances of successfully getting pregnant decrease. For patients who have undergone more than five IVF attempts, it is recommended alternative ways, including surrogacy if a woman has a problem, and sperm donation if a man has problems. There are, of course, cases of successful IVF on the 9th or 10th attempt, but rarely. If alternative methods do not work for you, consider adoption. In conclusion, I would like to give some general recommendations that may help you properly prepare for the program.
Activities that help increase the chances of success in this treatment cycle
For women:
- Avoid, if possible, taking any medicines except for regular aspirin. If you are prescribed any medications by another doctor, you must inform your doctor before starting treatment.
- Avoid smoking and drinking alcohol.
- Limit your intake of coffee and caffeine-containing drinks as much as possible (no more than 2 cups per day).
- Avoid changes in diet and weight loss diets during an IVF cycle.
- Refrain from sexual intercourse for 3-4 days before follicle puncture, and subsequently after embryo transfer until the day of the pregnancy test (detailed recommendations will be given to you in the statement on the day of embryo transfer). Regular physical activity, like exercise physical exercise are not contraindicated until the ovaries enlarged as a result of treatment do not create some discomfort.
- Avoid hot baths, baths and saunas.
- Try to avoid contact with people with acute respiratory infections. viral infections(ARVI), avoid hypothermia. If your body temperature rises or cold symptoms appear, tell your doctor.
For men:
An increase in body temperature above 38° C 1-2 months before the IVF / ICSI procedure can negatively affect sperm quality; If you are sick, please measure your body temperature and report any increase (any illness or illness accompanied by an increase in body temperature).
Visiting baths and saunas is not recommended, as elevated temperature may adversely affect sperm quality; please refrain from visiting them, at least, within 3 months before the expected start of treatment.
Taking medications, drinking alcohol and smoking cigarettes should be avoided before starting IVF/ICSI treatment.
Do not start any new sports or strenuous activities. physical activity during the 3 months preceding the start of IVF/ICSI.
If you run, please try to switch to walking without overload.
Refrain from wearing tight underwear.
Avoid sexual intercourse for at least 3 days, but no more than 7 days before sperm collection (on the day of follicular puncture).
Good luck with your program and happy pregnancy!

When performing artificial insemination, it is not always possible to get pregnant the first time. If this does not work, a second IVF attempt is made. Repeated embryo transfer will be successful, subject to a scrupulous analysis of the previous failure and additional examination.

Reasons for failure

The main reasons for failure after IVF may be:

pathological condition of the endometrium - chronic endometritis, the presence of polyps, thinning;
negative changes in the fallopian tubes, promoting ectopic embryo transfer;
poor embryo viability;
genetic problems;
aggressive reaction of the mother's body to the embryo;
disturbances in the activity of the endocrine system and hormonal imbalance;
the age of the expectant mother, especially if the woman is over 40 years old;
poorly composed medical recommendations and unreliably conducted surveys.

Yours Negative influence, provide bad habits, chronic and infectious diseases, obesity and other factors.

In order to exclude a negative result, when carrying out repeated IVF, it is necessary to take the future protocol more seriously, choose a qualified specialist, and strictly follow all instructions.

Rehabilitation after failure

A failed first artificial insemination is not a death sentence. Each female body has individual characteristics, and health needs time to recover. The second IVF attempt is not made immediately after the first; rest for at least two months, or a break for rehabilitation, is required. During this period, a woman has the opportunity to gather strength and restore psychological balance.

The following are recommended as restorative measures for the second attempt:

the use of mud therapy, mineral baths;
acupressure, hirudotherapy;
taking vitamins as recommended by a doctor;
physical activity - swimming, dancing, walking, exercises that improve blood circulation in the pelvic organs are especially useful;
carrying out repeated full examination, taking tests to eliminate the risk of failure;
avoid stressful situations.

During the rehabilitation period and before undergoing IVF for the second time, a woman needs the support of her husband, close relatives and friends. In some situations, specialist help is required.

Repeated cryopreservation of embryos

If artificial insemination is unsuccessful, embryos frozen in liquid nitrogen are an additional chance in the desire to become a mother. The procedure is used as a 2nd IVF attempt in several special cases, for example, at the time of embryo transfer, the expectant mother fell ill with a viral infection.

The second transfer of frozen embryos is carried out after menstruation occurs, if the first attempt is unsuccessful. Further, in order to prepare the uterine lining for material transplantation, doctors prescribe various medications containing female hormones.

When preparing the uterus to receive embryos, a hormonal analysis is performed indicating its condition. If the parameters do not comply with the norm, the transfer is cancelled. Then, they wait for a new cycle, after which they can do repeated IVF.

Some future parents are worried about possible abnormalities in children born after a frozen embryo transfer. According to the research results, no pathologies in the child’s development were identified. The percentage of children born with any disorders using cryotransfer is no higher than that of children conceived naturally.

Deadlines

Only in difficult situations, after three unsuccessful attempts, do doctors suggest taking other options. For example, the use of donor embryos, sperm or eggs. Sometimes, only surrogacy is possible. But before making a decision, you should not refuse to make another attempt at fertilization.

Modern medicine uses the latest techniques, and now almost every woman can become a mother. All unsuccessful IVF attempts should be considered as a new step towards a successful pregnancy. During the next transplant, the negative factors of previous procedures are minimized.

ECO is an abbreviation for the in vitro fertilization procedure. After the first attempt, future parents, regardless of its results, are immediately interested in whether it is possible to do repeated IVF, how many times it can be done and when it should be done the second time. And also whether this increases the chance of success of the enterprise and how safe it is.

The answers to these questions largely depend on the couple themselves, since from a medical point of view, repeated IVF procedures are as safe as the first procedure. It happens that it is the second attempt that becomes decisive, therefore, if you have a great desire to have a child, you should decide on repeated in vitro fertilization.

Does repeat IVF have benefits and what are they?

Of course, repeated IVF has its advantages. It makes adjustments primary treatment, the failures of the first attempt are analyzed, so the chances of success increase. For repeat procedures married couples they walk more confidently, are less nervous, and the psychological state of future parents during IVF is an extremely important component of success not only for the treatment itself, but also for the gestation period itself.

When is the best time to try again?

Of course, there must be a time gap between two IVF programs. Treatment should begin a second time two months after the first in vitro fertilization procedure. This time interval is due to the fact that during these months doctors must have time to analyze the reasons for the unsuccessful previous attempt. And if the failure was caused by insufficiently high-quality eggs, then doctors may recommend using donor eggs.

In addition, during these two months you will need to undergo some more tests. Not to mention that the body itself requires a certain time to restore its strength. The psychological state that suffered from the failure of the first attempt must be stabilized.

How safe is a second attempt?

Unlike previous ideas, the current opinion of doctors is that the second time does not affect the woman’s health in any way and is absolutely safe. There are no oncological or gynecological problems.

How many times can IVF be performed?

In vitro fertilization can be done many times. A reproductive specialist who observes a woman and controls the process makes a decision on the number of attempts based on individual characteristics his patient, her psychological and physical health, as well as age, weight, medical history and other things.

So, after analyzing all the mistakes of primary IVF, do not give up on the second and third attempts, because this is a real chance to give birth to a child and make your dream come true.

The likelihood of pregnancy depends on many factors. During in vitro fertilization, the result of the procedure is directly influenced by the age of the couple, the duration and cause of infertility, the level of hormones and the type of germ cells. Indirect factors are the mother's body mass index and the bad habits of both parents. According to doctors, psychological disorders do not affect in vitro conception, only a positive attitude towards achieving results is important.

In general, studies show that the chance of pregnancy using artificial conception methods is about 40%. Female fertility declines markedly after age 35. In women over forty years of age, the ability to conceive is at the level of 30-35%; in men over 39 years of age, sperm fragmentation may be observed.

Often the first attempt is unsuccessful, when repeated procedures the chances increase significantly. This may be due to adjustments to the treatment program and taking into account previous mistakes. Analysis of statistical data shows that termination of pregnancy after artificial insemination occurs in 15-20% of patients, and this is only 5-10% higher than the rates of naturally occurring pregnancies.

The second and third attempts at in vitro fertilization are the most effective; all further efforts lead to a systematic decrease in their effectiveness. Physically, IVF can be carried out within a month after an unsuccessful attempt. Doctors recommend keeping a break between manipulations for at least 2-3 months to restore peace of mind and gather strength.

In the event that after three consecutive artificial insemination procedures long-awaited pregnancy did not occur, the reproductologist is reviewing the treatment plan. At insufficient production eggs from the ovaries, the doctor may increase the dose of the hormonal drug to stimulate them or review the procedure protocol.

If fertilization does not occur, ICSI or IMSI methods may be recommended to “force” conception under a microscope using a special needle to pierce the membrane of the egg. Modern technologies also include such possibilities as embryo transfer at the blastocyst stage, hatching, or laser exposure to the embryo membrane, the use of frozen embryos and the use of necessary supporting medications. Taken together, these measures increase the effectiveness of IVF to 75-80%.

An indicator of the success of the artificial insemination procedure is the level of anti-Müllerian hormone (AMH), which is produced by the ovaries. When its level is below 0.8 ng/ml, the probability of conception is quite low. In addition, the success of implantation depends on the structure of the endometrium of the uterus. The endometrial layer with a thickness of 7-14 mm provides Better conditions for embryo invasion. At chronic endometritis the uterus is not able to ensure the vital activity of the placenta and chorion, which becomes. Usually, before artificial insemination is carried out, detailed diagnostics to identify this disease.

Sometimes pregnancy does not occur without obvious reasons. In such cases, the woman is recommended to undergo an immunological examination. These tests detect antisperm antibodies and determine the similarity of the couple on a number of antigens. The more similarities between them, the higher the chances of pregnancy, since the female body will not perceive the embryo as a foreign body and reject it.

The condition of the germ cells is of decisive importance in complex manipulations. If the quality of the gametes is poor, IVF using donor material may be recommended. Long-term observations have proven that donor sperm and eggs have a higher chance of conception than their own.

Women's previous successful pregnancies play an important role in obtaining the desired result, especially high chances for those whose first pregnancy occurred naturally. Women who have not given birth have a lower chance of becoming pregnant through in vitro fertilization.

Medical errors are also not uncommon in such an innovative branch of medicine as reproductive medicine.

Incorrectly chosen procedure protocol and time for embryo transfer, traumatic implantation of the embryo and incorrect supportive therapy can cause a failed pregnancy. If you suspect unprofessionalism and lack of competence of the doctor, the best solution would be to change the clinic.

Couples who have been trying to conceive a child for several years should know that modern methods Infertility treatments involving donor programs and surrogacy can help all infertile couples without exception.