How to inject Milgamma with nicotinic acid. Combilipen and nicotinic acid how to inject
This combination allows you to quickly obtain the desired results and provide long-term therapeutic effects.
Operating principle
Diclofenac is a non-steroidal anti-inflammatory drug. Its action is aimed at blocking the reactions of inflammatory processes at the tissue level, reducing the symptoms of fever, and eliminating severe pain. The chemical formula of Diclofenac is a product of the processing of phenylacetic acid, therefore therapeutic effect Diclofenac is much stronger than acetylsalicylic acid, which until recently was the most active anti-inflammatory drug.
Combilipen is a drug belonging to the group of combined vitamin preparations. It is actively used in the treatment of diseases that cause damage to nerve tissue. Combilipen increases the tone of the body, stimulates its resistance to external and internal negative attacks. Its formula consists of three vitamins (B1, B6 and B12). The effectiveness of such a combination in therapy and rehabilitation of diseases leading to damage to nerve tissue has been proven by many years of practice in using the drug.
Combilipen improves the conduction of nerve impulses, it helps improve the functioning of the central nervous system. One injection of vitamins can reduce pain caused by neuritis or osteochondrosis.
But if damage to the structures of the nervous system develops, accompanied by pronounced inflammatory processes (acute radiculitis, for example), one tablet of Combilipen will not help. In this case, the doctor may prescribe a course of injections and include Combilipen in the treatment regimen along with Diclofenac.
This choice allows you to simultaneously:
- relieve inflammatory swelling;
- provide the opportunity for vitamins to support the affected tissue.
Since both Diclofenac and Combilipen have an analgesic effect, the joint method of use relieves pain faster. On the fifth day of treatment, it completely disappears, which significantly improves the patient’s quality of life. Injections of Diclofenac and Combilipen are prescribed only if the disease is in acute phase. They are done from 5 days to two weeks (the course depends on the severity of the clinical picture). Then they switch to taking pills.
How to give injections correctly?
Is it possible to inject Diclofenac and Combilipen at the same time? Such treatment is possible, but you cannot immediately put both medications into one syringe. Each product has its own dosage regimen. A Diclofenac injection is given once a day (a double dose is administered only under the supervision of a doctor). It is recommended to inject every other day; more intense injections have a negative impact on work gastrointestinal tract. Injections are taken for no more than two days, then the patient is transferred to other forms of medication.
Kombilipen injections are made twice a day, for a week, 2 ml of the drug is taken in one syringe. At the end of the seven-day course, the patient can continue injections, but they will be given 2-3 times a week.
So how to inject the drugs described in the article? Each ampoule is collected separately and administered intramuscularly at time intervals. When it is necessary to use a more powerful painkiller, an analogue of Diclofenac is used - the drug Ketorol. It also goes well with Combilipen.
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Instructions for use of the drug Combilipen in ampoules - composition, indications, side effects, price and analogues
Combilipen - instructions for use
The drug belongs to the complex multivitamin preparations with neurotropic action, used for the treatment of neurological pathologies. Combilipen vitamins are intended for:
- increased blood circulation;
- improving metabolism;
- eliminating inflammation of nerve trunks;
- restoration of damaged tissues of nerve fibers;
- reducing pain caused by damage to the peripheral nervous system;
- normalization of nerve tissue conductivity;
- strengthening the immune system, increasing the resistance of the body's defenses to adverse factors: stress, smoking, drinking alcohol.
Compound
The complex effect of the injections is ensured by the active elements included in Combilipen in ampoules: benfotiamine (fat-soluble form of vitamin B1) - 100 mg, pyridoxine hydrochloride (vitamin B6) - 100 mg, cyanocobalamin (vitamin B12) - 1000 mcg, lidocaine hydrochloride - 20 mg. The injection solution contains excipients:
- sodium tripolyphosphate;
- sodium hydroxide;
- potassium hexacyanoferrate;
- benzyl alcohol;
- water for injections.
Release form
The drug Combilipen is produced in the form of tablets and solutions for injection in ampoules. The composition of the tablets is slightly different from the injections. Combilipen tabs does not contain lidocaine from the active ingredients, and the additional elements in the tablets include:
The injections are a pinkish-ruby colored liquid with a sharp, specific odor. Combilipen in ampoules contains two milliliters of solution for injection. The injections are packaged in cellular contours of 5 or 10 pieces. A scarifier is placed in the outer cardboard packaging if there are no notches or break points on the ampoules. The drug is dispensed in a pharmacy with a doctor's prescription. The ampoules must be stored at a temperature of 8 degrees in a room without sunlight. The shelf life of the drug is 2 years.
Pharmacodynamics and pharmacokinetics
The effect of the drug is ensured by an active mixture of B vitamins, which have a beneficial effect on the human nervous system, restorative ability in inflammatory and degenerative processes in nervous tissues and the musculoskeletal system. The main active substance is thiamine (vitamin B1), vitamins B6 and B12 enhance its effect and play important role in metabolic processes. Pharmacological effect Combilipena is achieved thanks to the following properties active substances:
- Vitamin B1. Previously, it was called Aneurin, because its discovery is associated with a disease of the nervous system - beriberi. This disease is characterized by fatigue, decreased mental abilities, pain in the location of nerve fibers, paralysis. The substance can restore function nerve tissue with the mentioned disease, with cerebral stroke and cerebrovascular disease. His role is normal provision glucose of nerve cells. If there is insufficient glucose, they become deformed, which leads to dysfunction - the conduction of impulses. Thiamine ensures contraction of the heart muscle.
- Vitamin B6. It is necessary for proper metabolism, normal hematopoiesis, with the help of the substance the processes of excitation and inhibition occur, the transmission of impulses at the points of contact of nerve fibers. Provides synthesis of the hormones norepinephrine and adrenaline, transportation of sphingosine, a substance that is part of the nerve sheath. With the help of the vitamin, serotonin is formed, which is responsible for sleep, appetite and human emotions.
- Vitamin B12. Enters the body with food products of animal origin. Participates in the biosynthesis of acetylcholine, which is responsible for the conduction of nerve impulses. Necessary for normal hematopoiesis; with the help of the substance, red blood cells resistant to hemolysis are formed. Responsible for the synthesis of myelin, a component of the nerve sheath. Necessary for metabolism folic acid. Participates in the synthesis of amino acids - building materials for cells of the epithelial layer, regulates the production of hormones by the genitals. Increases the regenerative abilities of tissues, slows down the aging of the body. Able to create an analgesic effect and increase the effect of anesthetics, normalize blood pressure.
- Lidocaine. Occupies an intermediate position between active and auxiliary elements. Does not belong to vitamins, is an anesthetic. Thanks to the substance, the injection becomes painless. Additionally, the element affects the dilation of blood vessels and promotes the absorption of vitamins by the body.
Combilipen injections - what are they prescribed for?
The ability of a vitamin preparation to have a beneficial effect on the nervous system, restore nerve tissue and their conductivity, reduce painful sensations in inflammatory and degenerative processes in nerve fibers and musculoskeletal system is used to treat:
- diseases of the musculoskeletal system;
- neuritis of the facial nerve;
- intercostal neuralgia and trigeminal nerve;
- polyneuropathy of alcoholic, diabetic etiology;
- lumboischialgia;
- pain syndrome, which is caused by degenerative changes in the cervical, cervicobrachial and lumbar regions spine (osteochondrosis).
How multivitamin preparation Kombilipen injections have a general strengthening effect. Positive results observed when administering injections to patients in postoperative period. The drug received good reviews from patients being treated. After completing the course of treatment, patients noted an improvement in their skin condition, a surge of energy, and a decrease in fatigue.
Vitamins Combilipen (injections or tablets) with diclofenac and other drugs: brief instructions
Diclofenac and Combilipen: method of application
- anti-inflammatory (block the development of the inflammatory reaction at the local tissue level);
- antipyretic (relieve fever by affecting the thermoregulation center in the brain);
- painkiller (relieves pain syndrome, affecting both peripheral and central mechanisms of its development).
Due to the presence of these effects, non-steroidal anti-inflammatory drugs are also called non-narcotic analgesics (painkillers) and antipyretic drugs.
How to administer drugs Ketorol and Combilipen?
What does the combination of Ketonal Duo and Combilipen treat?
Prescription of the drugs Combilipen, Mydocalm and Movalis (Artrosan, Meloxicam, Amelotex)
- decreases pathologically increased tone muscle tissue;
- relieves pain;
- increases the mobility of the muscles surrounding the damaged area of the spine;
- improves peripheral blood flow.
Movalis (international name meloxicam) is a non-steroidal anti-inflammatory drug that has a selective effect and for this reason rarely causes ulcerative complications in the gastrointestinal tract that are typical for this group of medications.
What does Combilipen and Mexidol help with?
Why are the drugs Combilipen and Alflutop prescribed?
- prevents the destruction of bone and cartilage tissue at the macromolecular level;
- stimulates regenerative processes;
- contains substances necessary for the restoration of damaged tissues.
The combination of the drugs Combilipen and Alflutop is especially effective for osteochondrosis. Alflutop stops degenerative processes in the spine, and Kombilipen restores damaged nerve tissue.
Injections Combilipen and nicotinic acid: instructions for use
- neuritis of the facial nerve;
- damage to nervous tissue due to osteochondrosis;
- acute and chronic disorders cerebral circulation;
- pathology of the central and peripheral nervous system associated with internal and external intoxication (diabetes mellitus, alcoholism, etc.).
In this combination a nicotinic acid performs a detoxification function, protecting nervous tissue from poisons of various origins - those entering the bloodstream, formed at the site of inflammation or in the damaged nerve tissue itself, and Kombilipen nourishes nerve cells, promoting their speedy recovery.
How to properly give an injection of nicotinic acid and combilipen, can they be given at the same time? The doctor prescribed 10 injections of each IM, after meals, but did not explain exactly how to do it - together at the same time or at different time do it with a pause (morning and evening for example), or do one first then the other. I know that they cannot be mixed in one syringe. I’m wondering if it’s possible to give both injections at once from different syringes; if so, what would be more correct - to inject both injections into one half or one into one and the other into the other?
The drugs "Kombilipen" and Nicotinic acid work well for various diseases of the peripheral nervous system: dorsopathies, radiculopathies, osteochondrosis, various neuralgia and neuropathies.
"Kombilipen" contains a combination of B vitamins (B1, B6, B12) and lidocaine, nicotinic acid or vitamin "PP". A good combination of these drugs according to the scheme:
daily x 1 time per day, inject these drugs in different syringes, you can in one buttock nearby, you can in different buttocks, then alternate. You cannot leave a needle in the gluteal muscle if you have injected one drug, then a syringe with another drug into the same needle.
Keep in mind that after injection of Nicotinic acid there may be redness of the face, hands, collar area, itchy skin. This side effect is usually due to a rapid vasodilator effect and quickly resolves within a few minutes. This is not an allergic reaction!
Every other day, i.e. it makes no sense to alternate drugs, since they are from different groups. And it is not advisable to “spread” the treatment for 20 days.
How to give injections of nicotinic acid and combilipen?
Doctors, developing treatment regimens to enhance therapeutic effect select drugs whose formulas enhance each other’s effects. Best result in the treatment of pain syndromes provoked by diseases of a neuralgic nature, demonstrates the compatibility of Combilipen with Diclofenac. This combination allows you to quickly obtain the desired results and provide long-term therapeutic effects.
Reviews of the drug Combilipen: pros and cons
Combilipen is a vitamin preparation. It contains B vitamins (B1, B6, B12) and lidocaine hydrochloride. Combilipen is successfully used for the treatment of neurological diseases (neuritis, neuralgia), as well as for various degenerative diseases of the spine - such as lumbar, thoracic, cervical osteochondrosis, etc. It is usually included in complex treatment, but is sometimes used as monotherapy.
Combilipen injections intramuscularly - instructions for use
Tell me, they prescribed injections: 1. Diclofenac 3.0 IM, No. 5 2. Nicotinic acid 2.0 IM, No. 10 3. Combillipen 2.0 IM, No. 10 How to administer injections, can be mixed into one syringe or not? Should I inject three at once or one at a time throughout the day? Specify who prescribed these drugs? The injection should be done in different syringes. Diclofenac, one ampoule intramuscularly for five days, and nicotine and combilipen injected for ten days. You can give three injections at the same time.
Nicotine injections instructions for use: features...
Injections of nicotinic acid (nicotine) are prescribed for various diseases. The thing is that it affects the body differently in case of certain ailments. This drug belongs to the vitamin group of medications. leads to normal blood circulation in certain areas and throughout the body as a whole;
What are Combilipen injections prescribed for and how to use them correctly?
A complex made up of a combination of B vitamins that ensures optimal functioning of the nervous system and improves energy metabolism is called Combilipen. When and why are Kombilipen injections prescribed: instructions for use, are there any analogues of the drug, its price, and patient reviews?
How to inject nicotine
If back pain takes us by surprise, we turn to a specialist for help. Included complex treatment B vitamins are often prescribed, in particular Combilipen. This combination drug has a relaxing, analgesic and anti-inflammatory effect, which usually occurs after the second injection.
Combilipen instructions for use price and analogues
Combilipen is a medicine that is a multivitamin. It is produced in Russia and is used mainly for the treatment of neurological diseases, as a component of combination therapy. Indications for use of the drug may be different, and it is important not only to rely on reviews of injections and tablets, but also mainly on the opinion of the doctor.
They prescribed injections - how to inject?
Nicotinic acid, or vitamin B3, is produced by both foreign and domestic pharmaceutical companies. The main active ingredient of the drug is nicotinic acid, and each milliliter of the drug contains 10 milligrams of this vitamin, and the tablet contains 0.05 grams of the main component.
Combilipen injections intramuscularly - dosage, treatment regimen...
The complex substance nicotinic acid is a stimulant drug. Its characteristics make it possible to effectively use the drug against osteochondrosis. It is enough to strictly follow the sequence of application and dosage to achieve sustainable results.
Combilipen injections intramuscularly - dosage, treatment regimen, contraindications and reviews
The nervous system plays an important role in regulating and coordinating the activities of all organs and systems of the body. There are medications that help support the central nervous system in good condition to ensure full human life. What mechanism is involved to prevent dysfunction of nerve cells, which parts of the spine have a beneficial effect on Combilipen injections for intramuscular injection, let's try to figure it out.
Combilipen instructions for use
Combilipen is a medicinal product that contains B vitamins, the action of the components is aimed at normalizing nervous activity, blood circulation and improvement of hematopoietic processes. The medication is widely used in neuralgia and orthopedics, increased dosage causes an analgesic effect. The drug also shows effectiveness in preventing damage to nerve tissue.
Nicotinic acid injections for osteochondrosis: instructions for use, indications, price and reviews
beef liver, buckwheat, peas, chicken eggs, walnuts, dairy products, fish. A healthy lifestyle and a properly composed diet will help create protection against diseases. And if violations have already occurred, early diagnosis and timely treatment will prevent the chronicity.
who received injections of nicotinic acid and combilipen?
I don’t understand if the reaction is normal 5 minutes after the injections, a tingling sensation all over the body, it’s hot, my ears turn burgundy) the taste in my mouth and the smell of this combilipen in my nose is just right.
It lasts about 5 minutes and it goes away...
This is a reaction to nicotine, the first time you need to inject 1 ml, the next day it’s already 2 as it should be, that’s what the doctor advised me. and combilipen is vitamins, there will be no reaction to it.
If it's not a secret, what are you treating?
The cervical nerve is pinched, the neurologist said..
Injections, physio tablets and massage now I have
wow! so everything is serious... come on, get treatment! Yes, this happened to me too. massage helped
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Milgamma injections with nicotinic acid – compatibility
Movalis - description
Movalis is a Spanish and Italian non-steroidal anti-inflammatory drug with the active ingredient meloxicam. Meloxicam is a modern painkiller that more selectively suppresses COX-1 compared to COX-2. This gives it an advantage in terms of safety - side effects on the digestive tract, due to the lesser effect on the gastric mucosa, occur much less frequently. The medication does not affect platelet aggregation, which makes it safe for patients with a tendency to poor blood clotting. It has pronounced antipyretic and anti-inflammatory properties in comparison with the analgesic effect, which makes it the drug of first choice for inflammatory processes in connective tissue.
Since osteochondrosis of the spine is the destruction of cartilage tissue with subsequent damage intervertebral discs, vertebrae. The danger of the disease is that cartilage tissue cannot be restored, degenerative processes can only be slowed down, but it is no longer possible to return the original healthy state of the connective tissue. In the presence of this disease, it develops inflammatory process and pain, which is why Movalis is prescribed to relieve acute inflammation and remove the unpleasant pain symptom. At acute conditions the injection is administered intramuscularly, once a day. One ampoule contains the maximum daily dosage of 15 mg. The duration of therapy should not exceed more than five days. Studying the interaction, there is another plus - the medication does not enter into replacement or negative reaction with B vitamins and lidocaine.
Nicotinic acid - description, for diseases of the spine
Nicotinic acid is a water-soluble B vitamin, also called nicotinamide, niacin, B3 or PP. The substance is known for being a cure for pellagra, which occurs in chronic alcoholics and people who eat mainly corn, that is, those who live in very poor countries and cannot afford meat. Also, when used for medicinal purposes, the vitamin causes a tingling sensation on the skin and redness of the face, because the substance is a strong vasodilator and dilates blood vessels, thereby improving blood circulation and flushes out cholesterol plaques.
The drug is indicated in the following cases:
- Poor circulation and obstruction blood vessels
- Cerebrovascular disorders
- For hemorrhoids and varicose veins
- Osteocondritis of the spine
- Hartnup disease
- Hypovitaminosis, diabetes mellitus
- Infectious diseases
- Poorly healing wounds
- Alcohol intoxication
- Gastritis with low acidity
- Violation fat metabolism and others.
The use of nicotinic acid for osteochondrosis is especially interesting. The drug is prescribed to improve metabolic processes, as well as in the presence of inflammation and pinching, because it can fight them and alleviate the patient’s condition. Positive effects from use:
- Replenishes the lack of substances in the body
- Nourishes damaged tissues by improving blood circulation
- Protects cells from free radical damage
- Improves metabolic processes in the body, due to which harmful substances are eliminated faster
- The most important property vitamin in this disease - restores the neural structure, due to which the nervous tissue is renewed and resists inflammatory processes.
In combination with niacin, milgamma is often prescribed - a mixture of lidocaine, thiamine, pyridoxine and B12 in one ampoule, but this drug is incompatible with nicotinamide, because these vitamins are destroyed among themselves. How then to combine everything together?
Milgamma - description and combinations
Milgamma is a mixture of three B vitamins and an analgesic so that the administration of substances does not cause pain. B1, B6 and B12 themselves are also incompatible, but a stabilizer, potassium hexacyanoferrate, is added as an auxiliary component, which makes it possible to introduce all three components. These three essential vitamins are needed for the treatment of diseases of the nervous tissue, nerve conduction disorders or degenerative-inflammatory processes that often occur with osteochondrosis.
Usually the attending physician explains how best to inject movalis, milgamma and niacin. If there were no recommendations, then you need to clearly know that milgamma is incompatible with nicotinic acid. It is best to inject niacin in the morning, movalis around lunchtime, and milgamma in the evening before bed. At such intervals, no conflict interactions will arise. In complex treatment, all three drugs give excellent results.
Nicotinic acid, also called vitamin B3 and vitamin PP, takes part in more than 50 enzymatic reactions occurring in the body, participates in the metabolism of lipids and carbohydrates, redox processes, and in the reaction of cellular respiration. It directly affects the state of the digestive organs: it helps normalize motor and secretory function stomach, increases production gastric juice. Vitamin B3 is also involved in protein metabolism. And a deficiency of the substance in the body is fraught with the development of such a dangerous disease as pellagra.
An interesting fact is that nicotinic acid is the only vitamin classified as a medicine, as it can actually treat diseases. Vitamin B3 is used to reduce cholesterol levels in the blood, dilate blood vessels, improve microcirculation in various organs and fabrics. It is often prescribed to people suffering from cardiovascular diseases, diabetes mellitus. Nicotinic acid increases joint mobility and relieves severe pain, therefore it is actively used in the treatment of osteoarthritis. It is also worth mentioning that this valuable vitamin, which has a sedative effect, increases the effectiveness of drugs used in the treatment of diseases of the nervous system. All of the above facts allow us to understand how important the issue of nicotinic acid compatibility with other medications and vitamins is. It is this topic that forms the basis of this article.
How does nicotinic acid interact with other vitamins?
The human body is, metaphorically speaking, a huge chemical enterprise, in the workshops of which various processes simultaneously take place. This continuous work involves many special elements - carbohydrates, fats, proteins, vitamins, minerals. In order for our body to easily absorb them all and use them effectively, we need to know which substances combine with each other and which do not. The interaction of nicotinic acid with other vitamins directly affects the process of its absorption. By the way, if vitamins combine well, their effect is noticeably enhanced. Nicotinic acid is perfectly compatible with vitamins B2, B6 and H. The presence of copper and vitamin B6 improves its absorption by the body.
Raising the question of how nicotinic acid is combined with other vitamins, it should be noted that this substance completely neutralizes the effect of thiamine. Vitamin B3 simply destroys vitamin B1. Vitamin B12 also shows poor compatibility with nicotinic acid. Under its influence, cyanocobalamin loses its activity. By understanding how nicotinic acid interacts with other vitamins, you can enhance the effectiveness of the product and avoid mistakes associated with an unsuccessful combination of substances.
Another topic that deserves our attention concerns whether vitamin B3 can be consumed together with complex fortified preparations. In particular, many are interested in the problem of compatibility between Combilipen and nicotinic acid. Doctors often prescribe these drugs to treat various neurological diseases. In this tandem, vitamin PP takes on the detoxification function, and Combilipen is responsible for nourishing nerve cells, which accelerates their recovery.
What other medications is nicotinic acid compatible with?
Before prescribing vitamin PP to a patient, the doctor must clarify what medications the patient is currently taking.
- When nicotinic acid interacts with neomycin, sulfonamides, barbiturates, and anti-tuberculosis drugs, an increase in toxic effect is observed.
- You should not take vitamin B3 at the same time as aspirin, anticoagulants, or antihypertensive drugs, so as not to increase the risk of side effects.
- Nicotinic acid is also poorly compatible with antidiabetic drugs, as it reduces their therapeutic effect.
- Taking vitamin B3 with lipid-lowering medications increases the risk of harm to liver health.
- In addition, you need to be careful when combining with cardiac glycosides, fibrinolytics, antispasmodics, as the effect of these drugs will be enhanced.
Is nicotinic acid compatible with alcohol?
Having clarified how to combine vitamins with nicotinic acid, we will also touch on the topic of its compatibility with alcohol. As the instructions say, vitamin B3 should not be taken simultaneously with alcohol or drugs containing ethanol. Mixing them can lead to a decrease in the absorption of bile acid sequestrants, as well as an increase in the toxic effect on the liver. At the same time, nicotinic acid itself has a powerful intoxicating effect. It promotes the active removal of toxic substances from the body and binds free radicals. That is why vitamin B3 is used to relieve severe hangover syndrome, used as part of treatment for alcohol and drug addiction. Contraindications For all the benefits of nicotinic acid, there are cases when its use is strictly contraindicated.
- Individual intolerance, allergic reactions to the substance;
- Exacerbation of stomach diseases and duodenum, including peptic ulcer;
- Liver disorders;
- Atherosclerosis (contraindicated intravenous use);
- Gout;
- Severe forms of hypertension;
- Increased levels of uric acid in the blood.
- Diabetes;
- Gastritis with increased acidity;
- Hemorrhage;
- Hepatitis;
- Glaucoma.
Women during pregnancy and lactation are under special supervision by doctors. It is known that expectant mothers are prescribed nicotinic acid in cases of multiple pregnancies, with identified liver pathologies and biliary tract, with drug dependence, with deviations in the functioning of the placenta. Nicotinic acid can improve blood circulation and reduce viscosity, which prevents the formation of blood clots and reduces the risk of blockage of blood vessels in the placenta. We can say that the remedy serves as a preventive measure premature birth and potential complications. During breastfeeding the vitamin can be prescribed to enhance lactation.
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The drug Milgamma is used to treat inflammation of the nervous tissue, inhibition degenerative changes and improving nerve conduction. Consists of several types of vitamin B. Usually prescribed for orthopedic and neurological diseases
. Milgamma vitamins help improve blood supply, have a positive effect on nerves, and have anesthetic properties.
About the drug
As the abstract says, Milgamma belongs to the group of vitamins(and not antibiotics, as some people believe). Basic active ingredients– thiamine (B1), pyridoxine (B6), cyanocobalamin ().
After injection into the muscle, thiamine is quickly and unevenly distributed throughout the body. It is not produced by the body, so it must be supplied externally every day in sufficient quantities. With its deficiency, hypovitaminosis appears. Excreted by the kidneys. Penetrates through the placental barrier.
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Irina Martynova. Graduated from Voronezh State University medical University them. N.N. Burdenko. Clinical resident and neurologist of the BUZ VO \"Moscow Polyclinic\".
Pyridoxine has properties similar to thiamine, but is distributed evenly throughout the body, after some time it is oxidized and excreted by the kidneys in an average of 3 hours. Passes through the placental barrier and is excreted in breast milk.
Cyanocobalamin enters the liver and bone marrow and accumulates. Can be reabsorbed from bile by the intestines.
Release form and prices
Milgamma is available in the form of injections, tablets and dragees.
The injection solution is supplied in ampoules, 2 ml each. Ampoules have Brown color Due to the coloring of the glass, a label is glued to each one. The package of ampoules can contain 5, 10 and 25 pieces. Price:
- for 5 ampoules – about 260 rubles;
- for 10 ampoules – about 470 rubles;
- for 25 ampoules – about 1050 rubles.
Film-coated tablets are supplied in packs of 30 and 60 pieces. Average price:
- for 30 tablets – 600 rubles;
- for 60 tablets – 1100 rubles.
The last form in which Milgamma can be found is a pill. Official tradename– Milgamma Compositum. Dragees are round balls white. Contained in cell packaging, 15 pieces per package. One box may contain 2 or 4 packages. Price:
- for 15x2 tablets – 700 rubles;
- for 15x4 dragees - 1200 rubles.
Composition of the drug
- lidocaine hydrochloride;
- cyanocobalamin;
- pyridoxine hydrochloride;
- thiamine hydrochloride;
- potassium hexacyanoferrate;
- sodium polyphosphate;
- benzyl alcohol;
- sodium hydroxide;
- water for injections.
The tablets contain:
- pyridoxine hydrochloride;
- benfotiamine;
- croscarmellose sodium;
- talc;
- long-chain partial glycerides;
- anhydrous colloidal silicon dioxide;
- microcrystalline cellulose;
- Povidone K30.
Indications for use
Milgamma is prescribed to relieve symptoms and treat diseases of the nervous system and spine, including:
- Plexopathy. Damage to the brachial, cervical, or lumbosacral nervous system due to tumor, radiation therapy, compression, or trauma. Alternative title– plexitis.
- Retrobulbar neuritis. Inflammation of the optic nerves.
- Polyneuropathy. Multiple lesions of peripheral nerves are usually accompanied by sensory disturbances and flaccid paralysis.
- Neuropathy. Non-inflammatory damage to a nerve or group of nerves.
- Neuritis. A disease of the peripheral nerves that is inflammatory in nature. Accompanied by paralysis, paresis and decreased sensitivity.
- Ganglionitis. Various lesions of nerve ganglia, having different symptoms depending on which of the nerve nodes was affected.
- Neuralgia. Inflammation of a nerve in which the only symptom is pain.
- Night muscle cramps. Sudden leg cramps, occurring mainly at night. They are not dangerous in themselves, but they interfere with normal sleep and can signal the presence of a more serious illness.
- Facial nerve paresis. A lightning-fast progressive disease of the facial nerves, leading to their asymmetry.
- Sciatica. Lower back pain radiating to one or both legs. As a rule, the cause of pain is damage to the sciatic nerve.
- Radiculopathy (radiculitis). Damage to the spinal roots as a result of inflammation, trauma or pinching.
- Muscular-tonic syndromes. Prolonged and painful muscle tension, which is usually caused by osteochondrosis.
Contraindications
Contraindications for use are as follows:
- Heart failure, anemia, cardiac muscle conduction disturbances.
- Childhood and adolescence.
- Pregnancy and breastfeeding.
- Hypersensitivity to B vitamins, up to complete intolerance.
Dosage and Application
The dosage must be prescribed by a doctor. The information provided below is for reference only.
The instructions for use of the drug Milgamma discuss injections, tablets and dragees.
Injections: when treating with Milgamma, injections are prescribed in the amount of one ampoule (2 mg) once a day. The course of treatment is from 5 to 10 days. For maintenance therapy, one ampoule should be injected every two days (every other day). To relieve an acute attack of pain, Milgamma is injected once. You need to insert the needle deep into the muscle, and then slowly press on the syringe plunger.
Tablets: Tablets are used for maintenance therapy and acute pain relief. For maintenance therapy, take 1 tablet once a day. To relieve pain – 1 tablet 3 times a day.
Dragees: used for maintenance therapy, up to 3 pills per day.
For any form of therapy, the course of treatment should not exceed one month.
Exceptions are possible only on doctor's orders.
Side effects and overdose
Side effects include tachycardia, increased sweating, urticaria, itching, acne, severe allergic reactions (anaphylactic shock, Quincke's edema).
In case of overdose symptoms from the list of side effects are observed y.
If symptoms of overdose appear, the drug is discontinued and prescribed symptomatic treatment under the supervision of a doctor.
Interaction with other drugs
Thiamine loses effectiveness or is destroyed under the influence of copper, high acidity (pH more than 3), sulfites. It is incompatible with all reducing or oxidizing compounds: phenobarbital, dextrose, acetates, ferric ammonium citrate, iodides, riboflavin, tannic acid, carbonates, disulfites, benzylpenicillin.
Cyanocobalamin has good compatibility with nicotinamide, but is incompatible with riboflavin, salts heavy metals and antioxidants.
Pyridoxine interacts with penicillamine, isoniazid, cycloserine, weakens the effect of levodopa.
Lidocaine, contained in ampoules, increases the load on the heart if used together with epinephrine and norepinephrine. Interaction with sulfonamides has been observed.
To enhance the positive effect, a complex of Mydocalm, Movalis and Milgamma products is often prescribed. When taken simultaneously, these drugs should not be mixed in the same syringe; it is also recommended to inject them into different buttocks.
Milgamma is compatible with Alflutop - this complex is often prescribed by a therapist to achieve maximum therapeutic effect.
Milgamma and vitamin B3(nicotinic acid) are highly compatible; the method of use should be checked with your doctor.
Milgamma is compatible with Voltaren.
Milgamma should not be used simultaneously with Compligam, since the drugs have a similar composition.
Their joint use may cause overdose.
Features of application
If the drug was accidentally administered intravenously, the patient should be immediately referred to a doctor or hospitalization, depending on the severity of symptoms.
Medicine cannot be given to children, pregnant and lactating women. There are no reports of harm in older people.
The drug does not affect attentiveness and concentration; when using it, you can drive a car.
Sometimes Milgamma is used to suppress withdrawal symptoms during treatment alcohol addiction. Despite this, simultaneous administration the drug and alcohol is undesirable, since the latter can deactivate the positive effect of the drug.
Storage
Milgamma should be stored at a temperature of 2-8 ° C, in a dark and out of reach of children.
Shelf life – 3 years.
Release from pharmacies
The drug is dispensed from pharmacies on prescription.
Analogues
The main analogues of Milgamma are: And.
The composition of Neuromultivit in ampoules is very similar to the composition of Milgamma, but it does not contain lidocaine. The Neuromultivit injection is painful, but it is safer for heart patients and children.
Combilipen is another vitamin complex. Similar in composition to Milgamma, but produced in Russia. It is cheaper, for 5 ampoules of Kombilipen you will have to pay 120-150 rubles, 10 ampoules will cost about 230 rubles. If financial position does not allow you to spend money on imported medicines, then you should give preference to Combilipen, since it is the only cheap Russian substitute Milgamma.
Reviews
Ivan Sergeevich, neurologist: “I often use Milgamma in my medical practice. It shows itself well in the complex treatment of pathologies of the nervous system, because it gives the body those vitamins that it lacks most. Of course, the drug is not ideal: approximately every twentieth patient has an allergy, and the injection is not the most painless. But the therapeutic and preventive effects are worth it.”
Anna Nikolaevna, rheumatologist: “The good thing about the drug is that it can be used in many areas - from withdrawal symptoms to brain diseases. The dosage of vitamins is quite serious, due to which seemingly ordinary vitamins begin to act in a therapeutic manner. There are allergic reactions to lidocaine, but you have to pay for a comfortable injection.”
Sergey, 42 years old, patient: “I developed right-sided hemiparesis after a stroke. We searched for a suitable medicine for a long time, until my wife came across Milgamma. We consulted a doctor and started injecting. After a week, I more or less began to come to my senses. The injection is quite painful, and the medicine itself smells unpleasant. But it's worth it. We will definitely repeat the course in a few months.”
Alla, 31 years old: “My mother was attacked by polyneuropathy. I had pain all over my body, especially in my legs. The doctor prescribed a bunch of medications, among them Milgamma. After 4 days the pain did not disappear, but weakened. The whole family breathed a sigh of relief. I don’t know if Milgamma helped or some other drug, but taking it definitely didn’t make things worse.”
Question answer
How do Milgamma and alcohol interact?
IN official instructions there is no mention of alcohol, but their compatibility is extremely doubtful, especially if Milgamma is administered by injection. Vitamins under the influence of alcohol are either destroyed or absorbed worse, and lidocaine, together with alcohol, loads the heart and central nervous system, which leads to dangerous side effects.
How effective is Milgamma for osteochondrosis, including the cervical and lumbar regions?
The most unpleasant manifestation of osteochondrosis is strong pain in one or another part of the spine. In order to relieve this symptom, the doctor prescribes potent drugs in injections, and Milgamma is one of them.
When is the drug prescribed with?
Diclofenac is a powerful pain reliever. Together with Milgamma they dock acute attacks. Diclofenac and Milgamma are often used together for osteochondrosis.
What is the difference between Milgamma and Mexidol?
– antioxidant. Its action is nonspecific, it is aimed at a wider group of diseases. Milgamma acts specifically on the nervous system.
How painful is it to inject it?
Milgamma's injection is sensitive, but it contains lidocaine, which reduces discomfort.
How often can it be injected?
Unless otherwise prescribed by your doctor, a course of Milgamma can be administered no more than once every 3 months.
Which company and in which country produces this drug?
Manufacturer: Solyufarm Pharmazoitische Erzoignisse GmbH. Country: Germany.
Which is better - Milgamma or Compligam?
They are similar in composition; the difference between them for a particular patient should be found out from the attending physician.
What to choose – Neurobion or Milgamma?
These drugs belong to the same group, but Neurobion does not contain an anesthetic. If you are not allergic to lidocaine, it is better to give preference to Milgamma.
How does the drug affect vertebral hernia?
It relieves pain symptoms and promotes the regeneration of nerve tissue. It is almost impossible to completely cure a hernia, but Milgamma will help muffle the symptoms and speed up the onset of the compensation reaction.
What vitamins are included in Milgamma?
B1 (thiamine), B6 (pyridoxine), B12 (cyanocobalamin).
How to treat acne after using the drug?
Acne, like itching, are side effects that will go away on their own after completing the course or stopping the drug.
What syringes are best to use for injections?
For comfortable administration of the drug, it is better to use syringes with a volume of 2-10 ml.
When is it better to inject - in the morning or in the evening?
Since this drug is a vitamin complex, it is better to inject it in the morning, when the metabolism is more active. A morning injection of vitamins can also cheer up the patient a little.
Watch a video about the drug
Milgamma is a complex of vitamins aimed at the prevention and treatment of diseases associated with the nervous system and musculoskeletal system. It can be used to relieve pain. It comes in the form of injections, tablets and pills.
Doctors often prescribe Milgamma along with other drugs for the complex treatment of diseases, as they are confident in its high effectiveness.
Reviews
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Sasha
4 months agoName: Milgamma
pharmachologic effect:
Milgamma contains neurotropic B vitamins. In a therapeutic dose, it is used for diseases of nerves and nervous tissue accompanied by inflammatory-degenerative processes and/or nerve conduction disorders. Also used for pathology musculoskeletal system. B vitamins in large dosages promote pain relief, improve microcirculation, stabilize the functioning of the nervous system, and improve hematopoietic processes.
Vitamin B1 (thiamine) is metabolized in the body into cocarboxylase (thiamine diphosphate) and thiamine triphosphate by phosphorylation. Cocarboxylase, as an enzyme coenzyme, participates in the chain carbohydrate metabolism what has important for the normal functioning of nerves and nervous tissue. Improves conductivity in nerves by influencing synaptic transmission. Vitamin B1 (thiamine) deficiency is accompanied by the accumulation of under-oxidized carbohydrate metabolic products in tissues: pyruvic acid, lactic acid. As a result, the functioning of the nervous tissue is disrupted with the formation of various pathological conditions.
In milgamma thiamine tablets, chloride is replaced with benfotiamine, which is a fat-soluble derivative of thiamine. Benfotiamine is metabolized by phosphorylation to thiamine pyruvate and thiamine triphosphate - biologically active substances. The role of thiamine triphosphate is to participate in carbohydrate metabolism (as a coenzyme for the enzymes pyruvate decarboxylase and transketolase). Thiamine pyruvate transfers aldehyde groups in the pentose phosphate cycle.
Vitamin B6 (pyridoxine) is phosphorylated in body tissues. Metabolic products are coenzymes of non-oxidative metabolism of almost all amino acids. Coenzymes are involved in the decarboxylation of amino acids with the formation of many physiologically active mediators - adrenaline, tyramine, dopamine, histamine, serotonin. Also involved in the anabolism and catabolism of amino acids through transamination processes. Vitamin B6 affects the metabolism of tryptophan; under its influence, α-amino-β-ketoadininic acid is catalyzed in the process of hemoglobin formation.
Vitamin B 12 (cyanocobalamin) has an antianemic effect, promotes the synthesis of creatinine, choline, nucleic acids, methionine. Participates in the processes of cellular metabolism. It is an analgesic.
Vitamin B1 (thiamine) is dephosphorylated in kidney tissue. The half-life is 35 minutes. It does not accumulate in body tissues due to its almost complete insolubility in fats. Metabolic products are excreted in the urine.
Pyridoxine (vitamin B 6) after phosphorylation is converted into pyridoxal-5-phosphate. After entering the blood plasma, the latter binds to albumin. Alkaline phosphatase hydrolyzes pyridoxal-5-phosphate, after which this metabolite can enter the cell.
Cyanocobalamin (vitamin B 12), when released into the blood plasma, binds to proteins to form a transport complex. In this form, it is absorbed by the liver tissue. Cyanocobalamin also accumulates in bone marrow, passes through the hematoplacental barrier. After excretion with bile, it can be absorbed again into the intestine (enterohepatic circulation).
Indications for use:
Neuritis, neuralgia;
the need for general strengthening action;
radicular syndrome;
polyneuropathy of various origins(alcoholic, diabetogenic);
myalgia;
retrobulbar neuritis;
herpes zoster and manifestations of other herpesvirus infections;
facial nerve paresis.
Mode of application:
Treatment begins with 2 ml of milgamma intramuscularly (very deep into the muscle) once a day. Maintenance therapy – 2 ml milgamma 2-3 times a week. Or further treatment with an oral form (1 tablet per day) is possible. To quickly relieve pain, use the parenteral form of milgamma or up to 3 tablets per day (1 tablet). For polyneuropathy, use a dosage of 1 tablet 3 times a day. The duration of treatment is 1 month.
Side effects:
Allergic reactions (rash, Quincke's edema, anaphylactic shock, skin itching, dyspnea).
Systemic reactions (sweating, decreased heart rate, arrhythmia, dizziness, nausea, convulsive syndrome). Systemic reactions develop during very rapid administration of the drug or if the dosage is exceeded.
Contraindications:
Heart failure (acute or severe forms chronic, decompensated heart failure);
disruption of cardiac muscle conduction;
hypersensitivity to milgamma components;
age up to 16 years.
Pregnancy:
Milgamma is not used during pregnancy and lactation, since studies on the effect on pregnancy and penetration into breast milk have not been conducted.
Interaction with other drugs:
When mixed with sulfate solutions, vitamin B1 disintegrates completely. In the presence of thiamine metabolic products, other vitamins are inactivated. Thiamine (benfotiamine) is inactivated in the presence of mercury chloride, acetates, carbonates, iodides, tannic acid, riboflavin, ferric ammonium citrate, penicillin (benzylpenicillin), metabisulfite and glucose. Thiamine activity decreases in the presence of copper (increased catalysis) and increasing pH.
Pyridoxine in a therapeutic dosage can reduce the effect of levodopa (antiparkinsonian effect) by enhancing peripheral decarboxylation, therefore vitamin B6 is not used with levodopa and drugs containing levodopa. Cyanocobalamin is inactivated in the presence of heavy metal salts.
Overdose:
An overdose of milgamma causes an increase in symptoms corresponding to the side effects. In case of overdose, syndromic and symptomatic therapy is necessary.
Release form:
Milgamma is available in parenteral form (solution for intramuscular administration in 2 ml ampoules) and in tablet form.
Storage conditions:
In a dry, dark place, away from children, at a temperature of about 15°C.
Compound:
Milgamma – solution for parenteral administration:
Active ingredients: thiamine hydrochloride 100 mg in a 2 ml ampoule, pyridoxine hydrochloride 100 mg in a 2 ml ampoule, cyanocobalamin - 1000 mcg in a 2 ml ampoule.
Auxiliary components: benzyl alcohol, lidocaine hydrochloride, sodium hydroxide, sodium polyphosphate, tertiary potassium hexacyanoferrate, water for injection.
Milgamma – tablets for internal use:
Active ingredients: benfotiamine – 100 mg, pyridoxine hydrochloride – 100 mg.
Auxiliary components: talc, anhydrous colloidal silicon dioxide, croscarmellose sodium, microcrystalline cellulose, partial long-chain glycerides, povidone.
Additionally:
Milgamma can be used by drivers and people working with complex mechanisms.
Attention!
Before using the drugMilgammayou should consult your doctor. These instructions for use are provided in free translation and are intended for informational purposes only. To get more complete information Please refer to the manufacturer's instructions.
Cerinath
Latin name: Cerinat
Pharmacological groups:
Composition and release form: 1 tablet contains brewer's yeast autolysate 390 mg; in bottles of 60 or 120 pcs. Brewer's yeast autolysate contains: vitamin B1 (thiamine), B5 (pantothenic acid), B6 (pangam acid), PP ( nicotine acid), H (biotin), D (calciferol), A (in the form of beta-carotene), C (ascorbic acid), E (alpha tocopherol), trace elements, easily digestible protein, essential amino acids.
Directions for use and dosage: Orally, without chewing, with a drink sufficient quantity liquids, 1 table. 2 times a day with an interval of 12 hours, to achieve maximum effect - 3 tablets.
- Cerinat
Milgamma
Latin name: Milgamma
Pharmacological groups: Vitamins and vitamin-like products
B02 Herpes zoster. G50.0 Trigeminal neuralgia. G51 Lesions of the facial nerve. G54.9 Damage to nerve roots and plexuses, unspecified. G58 Other mononeuropathies. G62 Other polyneuropathies. G62.1 Alcoholic polyneuropathy. G63.2 Diabetic polyneuropathy. H46 Neuritis optic nerve. M79.1 Myalgia. M79.2 Neuralgia and neuritis, unspecified. R52 Pain not elsewhere classified
Composition and release form:
15 pcs in blister; There are 2 or 4 blisters in a box.
in a box there are 5 ampoules of 2 ml each.
Pharmachologic effect:Painkiller, improves blood circulation, stimulates regeneration of nerve tissue. Neurotropic B vitamins have a beneficial effect in inflammatory and degenerative diseases of the nerves and musculoskeletal system; in high doses they have an analgesic effect, increase blood flow and normalize the functioning of the nervous system and the process of hematopoiesis.
Indications: Diseases of the nervous system of various origins: neuropathy (diabetic, alcoholic, etc.), neuritis and polyneuritis, incl. retrobulbar neuritis, peripheral paresis, incl. facial nerve, neuralgia, incl. trigeminal nerve and intercostal nerves, pain syndrome (radicular, myalgia, herpes zoster).
Contraindications: Hypersensitivity (including to individual components); severe and acute forms of decompensated heart failure, neonatal period (especially premature babies) (d/in solution).
With a daily dose of vitamins B6 up to 25 mg, there are no contraindications for use during pregnancy and breastfeeding. Dragees and solution contain 100 mg of the drug, and therefore are not recommended for use in these cases.
Side effects: Sweating, tachycardia, acne, other systemic reactions (d/in solution with very rapid administration), allergic reactions: skin rash, urticaria, itching, bronchospasm, Quincke's edema, anaphylactic shock.
Interaction: Thiamine completely decomposes in solutions containing sulfites. Dr. vitamins are inactivated in the presence of vitamin B1 breakdown products. Levodopa reverses the effect of therapeutic doses of vitamin B6.
Possible interaction with cycloserine, D-penicillamine, adrenaline, norepinephrine, sulfonamides.
Incompatible with redox substances, as well as phenobarbital, riboflavin, benzylpenicillin, glucose, metabisulfite, and heavy metal salts. Copper accelerates the breakdown of thiamine; in addition, thiamine loses its effect at a pH above 3.
Directions for use and dosage: Inside. 1 tablet up to 3 times a day with a sufficient amount of liquid for a month.
In severe cases and acute pain For rapid promotion the level of the drug in the blood requires one injection (2 ml) deep IM. After the exacerbation has passed and for mild forms of the disease, 1 injection 2-3 times a week is necessary. In the future, to continue treatment, take 1 tablet daily.
- Milgamma
Bullfight+
Latin name: Corrida+
Pharmacological groups: Biologically active food additives
Nosological classification (ICD-10): F17.2 Nicotine addiction
Composition and release form: 1 tablet weighing 0.5 g contains calamus rhizome powder, mint leaf powder and dietary fiber based on highly purified MCC; in bottles of 150 pcs. or in contour-free packaging of 10 pcs.
Characteristic: Biologically active additive to food containing essential oil calamus at least 1.5 mg per tablet.
Pharmachologic effect:Normalizing metabolic processes, tonic, anti-stress, anti-withdrawal.
Pharmacodynamics: Essential oils, phytoncides, alkaloids, glycosides, tannins suppress the desire to smoke, cause a reaction of aversion to tobacco smoke; vitamins, organic acids, macro- and microelements help restore normal metabolism; Insoluble dietary fiber (IDF), passing through the digestive system, binds waste and toxins and promotes their rapid removal from the smoker’s body.
Indications: Nicotine addiction (to reduce the craving for smoking and quit smoking), prevention of ARVI.
Directions for use and dosage: Inside, nicotine addiction: if you want to smoke - 1 tablet. (keep in mouth until completely absorbed). Depending on your craving for smoking, take from 5 tablets per day. and more. Maximum daily dose- up to 30 tablets Reception course - 5 weeks. When the desire to smoke decreases, the number of tablets taken decreases accordingly. In case of mild addiction, 10 tablets are enough. per day (for 7 weeks). It is recommended to always have the tablets with you for 7 weeks to timely suppress the desire to smoke until the body is completely freed from nicotine addiction.
As a preventative, health-improving agent: non-smokers - 1–2 tablets. 3-4 times a day for the prevention of colds (in spring and autumn or during periods of deterioration of health).
Precautionary measures: It should be borne in mind that when trying to smoke while taking the drug, unpleasant sensations may occur ( cold sweat, dizziness, palpitations, etc.), changes in taste, nausea. In this case, you should immediately stop smoking and take a few deep breaths and exhalations and take 1 more tablet.
- Corrida+
Mebicar
Latin name: Mebicarum
Pharmacological groups: Anxiolytics
Nosological classification (ICD-10):
pharmachologic effect
Application: nicotine
Contraindications:
Use during pregnancy and breastfeeding:
Side effects:
Interaction:
Directions for use and dosage:
Precautionary measures:
- Mebicarum
Mebix
Latin name: Mebix
Pharmacological groups: Anxiolytics
Nosological classification (ICD-10): F10.2 Alcohol dependence syndrome. F17.2 Nicotine addiction. F28 Other non-organic psychotic disorders. F40 Phobic anxiety disorders. F41 Other anxiety disorders. F43 Reaction to severe stress and adaptation disorders. F48 Others neurotic disorders. F48.0 Neurasthenia. R07.2 Pain in the heart area. R45.0 Nervousness. R45.4 Irritability and anger
pharmachologic effect
Active ingredient (INN) Mebicar (Mebicar)
Application: Neuroses and neurosis-like conditions, accompanied by irritability, emotional lability, anxiety, fear (including in patients with alcoholism in remission); mild hypomanic and anxious-delusional states without gross behavioral disturbances and psychomotor agitation (including anxiety-paranoid syndrome in schizophrenia, involutional and vascular psychoses); residual states after acute psychosis with symptoms of affective instability and residual productive symptoms; chronic verbal hallucinosis of organic origin; nicotine abstinence (as part of complex therapy).
Contraindications: Hypersensitivity, pregnancy (first trimester).
Use during pregnancy and breastfeeding: Contraindicated during pregnancy (first trimester).
Side effects: Hypotension, weakness, dizziness, hypothermia (by 1–1.5 °C), dyspeptic symptoms, allergic reactions (itching of the skin).
Interaction: Enhances the effect of sleeping pills.
Directions for use and dosage: Orally, regardless of food intake, 0.3–0.6–0.9 g 2–3 times a day. The maximum single dose is 3 g, the daily dose is 10 g. The course of treatment ranges from several days to 2–3 months, with mental illness- up to 6 months, with nicotine withdrawal - 5–6 weeks.
Precautionary measures: Should not be used by drivers while working Vehicle and people whose profession is associated with increased concentration.
- Mebix
Acid nicotine
Latin name: Nicotinic acid
Pharmacological groups:
Nosological classification (ICD-10):
pharmachologic effect
acid(Nicotinic acid)
Application:
Contraindications:
Restrictions on use:
Use during pregnancy and breastfeeding:
Side effects:
Interaction:
Directions for use and dosage: For prevention:
For pellagra:
For ischemic stroke: IV, 0.01–0.05 g.
For atherosclerosis:
For other diseases:
Precautionary measures:
- Nicotinic acid
Nicotine acid MS
Latin name: Acidum nicotinicum MC
Pharmacological groups: Angioprotectors and microcirculation correctors. Vitamins and vitamin-like products. Nicotinates
Nosological classification (ICD-10): E52 Nicotinic acid deficiency [pellagra]. E78.5 Hyperlipidemia, unspecified. G46 Vascular cerebrovascular syndromes in cerebrovascular diseases. G93.4 Encephalopathy, unspecified. I20 Angina pectoris [angina pectoris]. I25 Chronic ischemic disease hearts. I25.2 Previous myocardial infarction. I69 Consequences of cerebrovascular diseases. I70 Atherosclerosis. I70.2 Atherosclerosis of the arteries of the extremities. I73 Other peripheral vascular diseases. I73.0 Raynaud's syndrome. I73.1 Thromboangiitis obliterans [Buerger's disease]. I77.1 Narrowing of the arteries. I99 Other and unspecified disorders of the circulatory system. K29 Gastritis and duodenitis. K52 Other non-infectious gastroenteritis and colitis. R07.2 Pain in the heart area. T14.1 Open wound unspecified body area
pharmachologic effect
Active ingredient (INN) Nicotine acid(Nicotinic acid)
Application: Prevention and treatment of pellagra (vitaminosis PP); atherosclerosis, hyperlipidemia (including hypercholesterolemia, hypertriglyceridemia), peripheral vascular spasm, incl. obliterating endarteritis, Raynaud's disease, migraine, cerebrovascular accident, including ischemic stroke (complex therapy), angina pectoris, Hartnup disease, hypercoagulation, facial nerve neuritis, intoxication, long-term non-healing wounds, ulcers, infectious diseases, gastrointestinal diseases.
Contraindications: Hypersensitivity, peptic ulcer of the stomach and duodenum (in the acute stage), pronounced violations liver function, gout, hyperuricemia, severe forms of arterial hypertension and atherosclerosis (iv administration).
Restrictions on use: Pregnancy, breastfeeding.
Use during pregnancy and breastfeeding: Use caution during pregnancy and breastfeeding (high doses are contraindicated).
Side effects: Caused by the release of histamine: redness of the skin, incl. face and upper half of the body with a feeling of tingling and burning, a feeling of a rush of blood to the head, dizziness, hypotension, orthostatic hypotension (with rapid intravenous administration), increased secretion of gastric juice, itching, dyspepsia, urticaria.
At long-term use large doses: diarrhea, anorexia, vomiting, liver dysfunction, fatty degeneration liver, ulceration of the gastric mucosa, arrhythmia, paresthesia, hyperuricemia, decreased glucose tolerance, hyperglycemia, transient increase in the activity of AST, LDH, alkaline phosphatase, irritation of the gastrointestinal mucosa.
Interaction: Potentiates the effect of fibrinolytic agents, antispasmodics and cardiac glycosides, toxic effect alcohol on the liver. Reduces the absorption of bile acid sequestrants (an interval of 1.5–2 hours between doses is required) and the hypoglycemic effect of antidiabetic drugs. Possible interaction with antihypertensive drugs, acetylsalicylic acid, anticoagulants.
Directions for use and dosage: Orally (after meals), i.v. slowly, i.m., s.c. For prevention: orally, adults - 0.0125–0.025 g/day, children – 0.005–0.025 g/day.
For pellagra: adults - orally, 0.1 g 2–4 times a day for 15–20 days or IV 0.05 g or IM 0.1 g, 1–2 times a day for 10– 15 days; for children - orally, 0.0125–0.05 g 2–3 times a day.
For ischemic stroke: IV, 0.01–0.05 g.
For atherosclerosis: orally, 2–3 g/day in 2–4 divided doses.
For lipid metabolism disorders: orally, the dose is gradually increased (in the absence of side effects) from 0.05 g once a day to 2–3 g/day in several doses, the course of treatment is 1 month or more, breaks are necessary between repeated courses.
For other diseases: orally, adults - 0.02-0.05 g (up to 0.1 g) 2-3 times a day, children - 0.0125-0.025 g 2-3 times a day.
Precautionary measures: During treatment, liver function should be regularly monitored (especially when taking high doses). To prevent hepatotoxicity, it is necessary to include foods rich in methionine (cottage cheese) in the diet, or prescribe methionine or other lipotropic agents.
Use with caution for hyperacid gastritis, gastric and duodenal ulcers (in remission) due to the irritating effect on the mucous membrane (taking large doses in this case is contraindicated). Taking large doses is also contraindicated for liver diseases, incl. hepatitis, cirrhosis (possibility of hepatotoxicity), diabetes mellitus.
It is not advisable to use for the correction of dyslipidemia in patients with diabetes mellitus.
It should be borne in mind that subcutaneous and intramuscular injections are painful.
- Nicotinic acid MS (Acidum nicotinicum MC)
Acid nicotine-Darnitsa
Latin name: Nicotinic acid
Pharmacological groups: Angioprotectors and microcirculation correctors. Vitamins and vitamin-like products. Nicotinates
Nosological classification (ICD-10): E52 Nicotinic acid deficiency [pellagra]. E78.5 Hyperlipidemia, unspecified. G46 Vascular cerebrovascular syndromes in cerebrovascular diseases. G93.4 Encephalopathy, unspecified. I20 Angina pectoris [angina pectoris]. I25 Chronic ischemic heart disease. I25.2 Previous myocardial infarction. I69 Consequences of cerebrovascular diseases. I70 Atherosclerosis. I70.2 Atherosclerosis of the arteries of the extremities. I73 Other peripheral vascular diseases. I73.0 Raynaud's syndrome. I73.1 Thromboangiitis obliterans [Buerger's disease]. I77.1 Narrowing of the arteries. I99 Other and unspecified disorders of the circulatory system. K29 Gastritis and duodenitis. K52 Other non-infectious gastroenteritis and colitis. R07.2 Pain in the heart area. T14.1 Open wound of unspecified body area
pharmachologic effect
Active ingredient (INN) Nicotine acid(Nicotinic acid)
Application: Prevention and treatment of pellagra (vitaminosis PP); atherosclerosis, hyperlipidemia (including hypercholesterolemia, hypertriglyceridemia), peripheral vascular spasm, incl. obliterating endarteritis, Raynaud's disease, migraine, cerebrovascular accident, including ischemic stroke (complex therapy), angina pectoris, Hartnup disease, hypercoagulation, facial nerve neuritis, intoxication, long-term non-healing wounds, ulcers, infectious diseases, gastrointestinal diseases.
Contraindications: Hypersensitivity, peptic ulcer of the stomach and duodenum (in the acute stage), severe liver dysfunction, gout, hyperuricemia, severe forms of arterial hypertension and atherosclerosis (iv administration).
Restrictions on use: Pregnancy, breastfeeding.
Use during pregnancy and breastfeeding: Use caution during pregnancy and breastfeeding (high doses are contraindicated).
Side effects: Caused by the release of histamine: redness of the skin, incl. face and upper half of the body with a feeling of tingling and burning, a feeling of a rush of blood to the head, dizziness, hypotension, orthostatic hypotension (with rapid intravenous administration), increased secretion of gastric juice, itching, dyspepsia, urticaria.
With long-term use of large doses: diarrhea, anorexia, vomiting, impaired liver function, fatty liver, ulceration of the gastric mucosa, arrhythmia, paresthesia, hyperuricemia, decreased glucose tolerance, hyperglycemia, transient increase in the activity of AST, LDH, alkaline phosphatase, mucosal irritation shells of the gastrointestinal tract.
Interaction: Potentiates the effect of fibrinolytic agents, antispasmodics and cardiac glycosides, the toxic effect of alcohol on the liver. Reduces the absorption of bile acid sequestrants (an interval of 1.5–2 hours between doses is required) and the hypoglycemic effect of antidiabetic drugs. Possible interaction with antihypertensive drugs, acetylsalicylic acid, anticoagulants.
Directions for use and dosage: Orally (after meals), i.v. slowly, i.m., s.c. For prevention: orally, adults - 0.0125–0.025 g/day, children – 0.005–0.025 g/day.
For pellagra: adults - orally, 0.1 g 2–4 times a day for 15–20 days or IV 0.05 g or IM 0.1 g, 1–2 times a day for 10– 15 days; for children - orally, 0.0125–0.05 g 2–3 times a day.
For ischemic stroke: IV, 0.01–0.05 g.
For atherosclerosis: orally, 2–3 g/day in 2–4 divided doses.
For lipid metabolism disorders: orally, the dose is gradually increased (in the absence of side effects) from 0.05 g once a day to 2–3 g/day in several doses, the course of treatment is 1 month or more, breaks are necessary between repeated courses.
For other diseases: orally, adults - 0.02-0.05 g (up to 0.1 g) 2-3 times a day, children - 0.0125-0.025 g 2-3 times a day.
Precautionary measures: During treatment, liver function should be regularly monitored (especially when taking high doses). To prevent hepatotoxicity, it is necessary to include foods rich in methionine (cottage cheese) in the diet, or prescribe methionine or other lipotropic agents.
Use with caution for hyperacid gastritis, gastric and duodenal ulcers (in remission) due to the irritating effect on the mucous membrane (taking large doses in this case is contraindicated). Taking large doses is also contraindicated for liver diseases, incl. hepatitis, cirrhosis (possibility of hepatotoxicity), diabetes mellitus.
It is not advisable to use for the correction of dyslipidemia in patients with diabetes mellitus.
It should be borne in mind that subcutaneous and intramuscular injections are painful.
- Nicotinic acid-Darnitsa (Nicotinic acid)