You can replace Klion D suppositories. All the most important things about the medicine “Klion-D”

Analogues of the drug Klion are presented, in accordance with medical terminology, called “synonyms” - drugs that are interchangeable in their effects on the body, containing one or more identical active ingredients. When selecting synonyms, consider not only their cost, but also the country of production and the reputation of the manufacturer.

Description of the drug

Klion- Antiprotozoal and antimicrobial drug, a 5-nitroimidazole derivative. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of microbial cells, inhibiting the synthesis of nucleic acids, which leads to the death of microorganisms.

Active regarding Trichomonas vaginalis, Entamoeba hystolitica, Gardnerella vaginalis, Giardia intestinalis, as well as obligate anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides distasonis, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some gram-positive microorganisms (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). The MIC for these strains is 0.125 μg/ml. In combination with amoxicillin, it is active against Helicobacter pylori(amoxicillin suppresses the development of resistance to metronidazole).

Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics effective against common aerobes.

Increases the sensitivity of tumors to radiation, causes disulfiram-like reactions, and stimulates reparative processes.

List of analogues

Note! The list contains synonyms of Klion, which have a similar composition, so you can choose a replacement yourself, taking into account the form and dose of the medicine prescribed by your doctor. Give preference to manufacturers from the USA, Japan, Western Europe, as well as well-known companies from of Eastern Europe: KRKA, Gedeon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Release form(by popularity)	price, rub.
Klion
Tab 250 mg N20 (Gedeon Richter - RUS ZAO (Russia)	82.70
Batsimex
V*Ergotex GMf8001 (Mannitol)
V*Ergotex FARM 004 (Metronidazole)
Deflamon
Metrovagin
Metrogil
Solution for infusion 5mg/ml 100ml (Unique Pharmaceutical Laboratories (India)	25.90
Vaginal gel 30g (Unique Pharmaceutical Laboratories (India)	175.40
Gel 30g (Unique Pharmaceutical Laboratories (India)	215.20
Dental gel 20g (Unique Pharmaceutical Laboratories (India)	260
Metroxan
Metrolacare
Metron
Metronidazole
250 mg No. 20 tab Ozone (Ozone LLC (Russia)	12
Tab 250 mg No. 20 Borisov (Borisov ZMP OJSC (Belarus)	14.40
250 mg No. 20 tab Biokhimik (Biokhimik OJSC (Russia)	16
5mg / ml 100ml r - r d / inf (Elfa Laboratories (India)	19.30
250 mg No. 20 tab Update (Update PFK ZAO (Russia)	28.60
Tab 250 mg N20 MS (Medisorb JSC (Russia)	31.60
500 mg No. 20 tab Ozone (Ozone LLC (Russia)	65.40
250 mg No. 24 tab Update (Update PFK ZAO (Russia)	75.40
Tab 500 mg N20 Nycomed (Nycomed Denmark ApS (Denmark)	77.40
250mg No. 40 tab FST - LS (Pharmstandard - Leksredstva OJSC (Russia)	136.90
Metronidazole IV Brown
Metronidazole MS
Metronidazole Nycomed
Tablets 500 mg, 20 pcs. (Takeda GmbH, Japan)	79
Metronidazole* (Metronidazolum)
Metronidazole-AKOS
5mg/ml 100ml solution for infusion (Sintez OJSC (Russia)	23.40
Metronidazole-Altpharm
Metronidazole-LekT
Metronidazole-Teva
Metronidazole-UBF
Metronidazole-F
Metronidazole-ESKOM
Metronidazole tablets 0.25 g
Metronidal
Metroseptol
Nirmet
Orvagil
Rozamet
Cream 1% 25g (JADRAN Croatia (Croatia)	223
Rosex
Cream 0.75% 30g (Galderma Laboratories (France)	674.20
Cyptrogyl
Tricho-PIN
Trichobrol
Trichopolum
Tab vag 500 mg No. 10 (Polpharma Pharmaceutical Plant (Poland)	311.30
Trichosept
500 mg vaginal sup. 10pcs Biosynthesis (Biosynthesis, Russia)	58
Flagyl
250 mg No. 20 tab p/pl.o (Famard Lyon (France)	120
Vaginal suppositories 500 mg N10 (Haupt Pharma Livron (France)	1437.20
Edgil
Efloran

Reviews

Below are the results of surveys of site visitors about the medicine Klion. They reflect the personal feelings of the respondents and cannot be used as an official recommendation for treatment with this drug. We strongly recommend that you contact a qualified medical specialist to select a personal course of treatment.

Visitor survey results

Two visitors reported effectiveness

One visitor reported an estimate of the cost

	Participants		%
Dear	1		100.0%

Four visitors reported frequency of intake per day

How often should you take Klion?
Most respondents most often take this drug 2 times a day. The report shows how often other survey participants take this drug.

	Participants		%
2 times a day	2		50.0%
1 per day	2		50.0%

Five visitors reported dosage

	Participants	%
51-100mg	1	20.0%
201-500mg	1	20.0%
6-10mg	1	20.0%
501mg-1g	1	20.0%
101-200mg	1	20.0%

Visitor start date report

Information has not yet been provided

Two visitors reported reception times

When is the best time to take Klion: on an empty stomach, before, after or during meals?
Site users most often report that they take this medication after meals. However, your doctor may recommend a different time for you. The report shows when the remaining patients surveyed take their medication.

24 visitors reported the patient's age

Visitor reviews

There are no reviews

Official instructions for use

There are contraindications! Read the instructions before use

Klion

Registration number:
P N015200/01
Tradename: Klion
International nonproprietary name:
Klion
Dosage form:
solution for infusion
COMPOUND
For a volume of solution for infusion of 100 ml:
Active substance: Klion - 500 mg;
Excipients: sodium dihydrogen phosphate dihydrate, sodium hydrogen phosphate dodecahydrate, sodium chloride, water for injection.
DESCRIPTION
Transparent, colorless or slightly greenish or greenish-yellow solution, without mechanical inclusions.
Pharmacotherapeutic group:
antimicrobial and antiprotozoal agent
CodeATX: J01XD01

Pharmacological properties

Antiprotozoal and antimicrobial drug, a derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of microbial cells, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria. Active against Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia intestinalis, as well as obligate anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella (Prevotella bivia, Prevotella buccae, Prevotella disiens) and some gram-positive microorganisms (Eubacterium, Clostridium spp ., Peptococcus spp., Peptostreptococcus spp.). The MIC for these strains is 0.125-6.25 µg/ml. In combination with amoxicillin, it is active against Helicobacter pylori (amoxicillin suppresses the development of resistance to metronidazole). Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), Klion acts synergistically with antibiotics effective against common aerobes. Increases the sensitivity of tumors to radiation, causes disulfiram-like reactions, and stimulates reparative processes.
Pharmacokinetics
Distribution: It has a high penetrating ability, reaching bactericidal concentrations in most tissues and body fluids, including lungs, kidneys, liver, skin, cerebrospinal fluid, brain, bile, saliva, amniotic fluid, abscess cavities, vaginal secretions, seminal fluid, breast milk, penetrates the blood-brain barrier (BBB) and the placental barrier.
Volume of distribution: adults - approximately 0.55 l/kg, newborns 0.54-0.81 l/kg. C max ranges from 6 to 40 mcg/ml depending on the dose. Communication with plasma proteins is 10-20%. With intravenous administration of 500 mg over 20 minutes, Cmax in blood serum after 1 hour is 35.2 μg/ml.
The concentration of metronidazole in the blood serum after 4 hours is 33.9 mcg/ml, after 8 hours - 25.7 mcg/ml; Cmin upon subsequent administration is 18 mcg/ml. TC max - 30-60 minutes, therapeutic concentration is maintained for 6-8 hours. With normal bile formation, the concentration of metronidazole in bile after intravenous administration can significantly exceed the concentration in plasma.
Biotransformation: About 30-60% of metronidazole is metabolized in the body by hydroxylation, oxidation and glucuronidation. The main metabolite (2-oxymetronidazole) also has antiprotozoal and antimicrobial effects.
Removal: Half-life (T 1/2) at normal function liver - 8 hours (from 6 to 12 hours), with alcoholic liver damage - 18 hours (from 10 to 29 hours), in newborns born during pregnancy - 28-30 weeks - approximately 75 hours, 32-35 weeks - 35 h, 36-40 weeks - 25 h. 60-80% is excreted by the kidneys (20% unchanged), through the intestines - 6-15%.
At pronounced violations renal function (creatinine clearance less than 10 ml/min.) in patients after repeated administration, accumulation of metronidazole in the blood serum may be observed, and therefore the dose of the drug should be halved.
Klion and its main metabolites are quickly removed from the blood during hemodialysis (T 1/2 is reduced to 2.6 hours). During peritoneal dialysis, it is excreted in small quantities.

Indications for use

Protozoal infections: extraintestinal amebiasis, including amoebic liver abscess, intestinal amebiasis (amoebic dysentery), trichomoniasis, balantidiasis, giardiasis, cutaneous leishmaniasis, Trichomonas vaginitis, Trichomonas urethritis.
Infections caused by Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus): infections of bones and joints, infections of the central nervous system, incl. meningitis, brain abscess, bacterial endocarditis, pneumonia, empyema and lung abscess, sepsis.
Infections caused by Clostridium spp., Peptococcus and Peptostreptococcus: infections abdominal cavity(peritonitis, liver abscess), pelvic infections (endometritis, abscess fallopian tubes and ovaries, infections of the vaginal vault), infections of the skin and soft tissues.
Pseudomembranous colitis (associated with antibiotic use).
Gastritis or peptic ulcer duodenum associated with Helicobacter pylori.
Prevention postoperative complications(especially interventions on colon, perirectal region, appendectomy, gynecological operations).

Contraindications

- increased individual sensitivity to metronidazole or other nitroimidazoles;
- pregnancy (first trimester), lactation period;
- leukopenia (including history);
- organic lesions of the central nervous system (including epilepsy);
- liver failure (in case of prescribing large doses).
CAREFULLY
Pregnancy ( II-III trimesters), kidney/liver failure.

Pregnancy and lactation

Pregnancy:
Klion is contraindicated for use in the first trimester of pregnancy. Use of the drug in II and III trimesters is possible only in cases where the expected benefit of therapy for the mother outweighs the potential risk to the fetus.
Lactation:
The drug passes into breast milk. If necessary, use of the drug should be discontinued breast-feeding. During breastfeeding, the use of the drug is contraindicated.

Directions for use and doses

Intravenously, drip. The injection rate is 5 ml/min.
If the patient's condition improves, the drug should be switched to oral administration.
Infections caused by anaerobic microorganisms

The initial dose is 15 mg/kg (3 ml).
The maintenance dose is 7.5 mg/kg (1.5 ml) every 6 hours for three days.
Then, at the same dose every 12 hours.
The maximum daily dose of metronidazole should not exceed 4 grams.
The average course of therapy is 7-10 days, but for more severe infections the course of therapy may last 2-3 weeks.
Children under 12 years old:
The initial dose is 7.5 mg/kg (1.5 ml), every 8 hours, for three days. Then, at the same dose, every 12 hours.
To prevent postoperative anaerobic complications Adults (body weight about 70 kg) and children over 12 years of age:
Intravenously, drip 15 mg/kg (3 ml), over 30-60 minutes.
Administration of the drug must be stopped 1 hour before the start of surgery. If necessary, 7.5 mg/kg (1.5 ml) of the drug can be administered 6-8 and even 12-16 hours after surgery.
Children under 12 years old:
The drug administration regimen is the same as above, but the single intravenous dose is 7.5 mg/kg (1.5 ml).
Use for renal impairment: Impaired renal function does not have a significant effect on the pharmacokinetic parameters of the drug, so the dose of Klion does not need to be changed. In patients with severely impaired renal function who are not on hemodialysis, with creatinine clearance below 10 ml/min. daily dose The drug should be reduced by 2 times.
In the case of simultaneous hemodialysis in a patient, it is necessary to remember to reduce the half-life of metronidazole. Therefore, after hemodialysis, additional administration of the drug may be required.
Hemodialysis: Klion and its metabolites are well excreted by hemodialysis. Since the elimination half-life decreases sharply during hemodialysis (to approximately 3 hours), in some cases it may be necessary to additional introduction drug.
For severe liver diseases Klion is metabolized more slowly.
As a result, Klion and its metabolites can accumulate in the blood plasma. In these cases, the dose and intervals between administration of the drug are set depending on the severity of liver damage.
Elderly patients: In elderly patients, the pharmacokinetics of metronidazole may change, so it may be necessary to monitor the concentration of metronidazole in the blood serum.

Side effects

From the gastrointestinal tract: nausea, vomiting, loss of appetite, cramping pain in the lower abdomen, diarrhea, constipation, coated tongue, bitter, metallic taste in the mouth, dry mouth, glossitis, pancreatitis.
From the hematopoietic system: reversible neutropenia (leukopenia).
From the side of the central nervous system: peripheral neuropathy (feeling of numbness in the extremities) is rare and only when long-term use headaches, convulsions, drowsiness, dizziness, impaired coordination of movements, ataxia, confusion, depression, increased excitability, weakness, insomnia, hallucinations occur.
Allergic reactions: skin rash, urticaria, itchy skin, multiforme exudative erythema, angioedema and anaphylactic reaction.
Local reactions: Thrombophlebitis is possible at the injection site.
From the hepatobiliary system: increased activity of liver enzymes, cholestasis, jaundice.
From the outside genitourinary system: dysuria, cystitis, polyuria, urinary incontinence, candidiasis, red-brown coloration of urine (causes a metabolite of metronidazole, does not have clinical significance).
Others: increased body temperature, flattening of the T wave on the electrocardiogram.

Overdose

If symptoms of overdose appear (nausea, vomiting, ataxia), symptomatic therapy, since Klion does not have a specific antidote.
Klion and its metabolites are easily eliminated by hemodialysis.

Interaction with other drugs

- The drug may enhance the effect of oral anticoagulant drugs. Prothrombin time may increase, so dose adjustment of oral anticoagulants is necessary;
- Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration in the blood serum and an increased risk of developing side effects.
- Inducers of microsomal oxidation enzymes in the liver (for example, phenytoin, phenobarbital) can accelerate the elimination of metronidazole, which will lead to a decrease in its concentration in the blood plasma.
- Concomitant use of alcohol causes reactions similar to disulfiram (cramping abdominal pain, nausea, vomiting, headache, skin hyperemia);
- Not acceptable joint use with disulfiram (additive effect, may cause confusion);
- The concentration of lithium in the blood may increase during the course of treatment with metronidazole, therefore, before starting to use Klion, it is necessary to reduce the dose of lithium or stop taking it for the duration of treatment;
- Simultaneous administration of cyclosporine with metronidazole may lead to an increase in the concentration of cyclosporine in plasma, which requires monitoring of the concentration of cyclosporine in the blood plasma;
- Klion reduces the clearance of fluorouracil, which increases its toxicity;
- At laboratory research while taking the drug, it may be difficult to determine the activity of ALT, AST, lactate dehydrogenase and triglyceride concentrations;
- Simultaneous administration of the drug with other solutions containing sodium salts may lead to sodium retention in the body.

special instructions

Intravenous administration of the solution for infusion is indicated for patients in whom oral administration of the drug is impossible. For mixed infections, infusion Klion can be used in combination with parenteral antibiotics, without mixing the drugs with each other.
When administered intravenously, it should not be mixed with other drugs.
When carrying out therapy for more than 10 days - only in justified cases, with strict monitoring of the patient and regular monitoring of laboratory blood parameters. If a longer course of therapy is necessary due to the presence of chronic diseases, the relationship between the expected effect and the potential risk of complications should be carefully weighed.
When using the drug, an exacerbation of candidiasis may occur.
The consumption of alcoholic beverages during the course of therapy is strictly prohibited.
When using the drug, slight leukopenia may occur, so it is advisable to monitor the blood picture (the number of leukocytes) at the beginning and at the end of therapy.
Impact on the ability to drive a car and engage in other activities that require concentration and speed of psychomotor reactions.
If side effects from the central nervous system occur, you should refrain from driving cars and working with potentially dangerous mechanisms.

Release form

Solution for infusion 5 mg/ml.
100 ml of solution in a colorless glass bottle for infusion (hydrolytic class I). 1 bottle in a cardboard box with instructions for use medical use.

Storage conditions

List B.
At a temperature of 15 to 30 ° C, in a place protected from light.
Keep out of the reach of children!

Best before date

3 years.
Do not use after expiration date.

Vacation conditions

On prescription.
Manufacturer's name and address
JSC "Gedeon Richter"
1103 Budapest, st. Demrei 19-21, Hungary
Consumer complaints should be sent to:
Moscow representative office of JSC Gedeon Richter
119049 Moscow, 4th Dobryninsky lane, building 8.

The information on the page was verified by physician-therapist E.I. Vasilyeva.

Klion D belongs to the antiprotozoal drugs that eliminate fungal infections and microorganisms.

Composition and release form of Klion D

In pharmacies, Klion D can be purchased in the form of tablets (20 pieces). 1 tablet of the drug contains 250 mg of metronidazole. Additional ingredients include sodium lauryl sulfate, colloidal anhydrous silica, povidone, magnesium stearate, sodium bicarbonate, tartaric acid, crospovidone and sodium carboxymethyl starch, lactose monohydrate and hydroxypropyl methylcellulose 2910.

They also produce vaginal tablets Klion D 100, 10 pieces per package, which consist of 100 mg of metronidazole and 100 mg of miconazole nitrate. Klion D candles have a white color and a special almond shape, as well as an uneven surface.

In addition, Klion D is produced in the form of an infusion solution (1 bottle of 100 ml).

Pharmacological action of Klion D

The main active ingredient of Klion D tablets and suppositories, metronidazole, restores the 5-nitro group at the biochemical level due to intracellular transport proteins of protozoa and anaerobic microorganisms. A completely reduced 5-nitro group entails the complete disappearance of bacteria.

In addition, the action of Klion D is aimed at destroying fungal cells.

Pharmacokinetics and pharmacodynamics

The instructions for Klion D note that when this drug is used intravaginally, metronidazole is completely absorbed into the blood.

Miconazole is not completely absorbed by tissues. After 8 hours, almost 90% of the miconazole nitrate is still in the vagina. This component of Klion D completely changes and dissolves, without manifesting itself either in the urine or in the blood.

The instructions for Klion D show that metronidazole, which is part of it, has an antiprotozoal effect and also fights various microbes and fungal formations. The drug cannot destroy only facultative anaerobes and aerobic microorganisms.

Miconazole is able to eliminate common dermatophytes, many fungi and yeasts in the body. Also in the instructions for Klion D it is indicated antibacterial effect miconazole against some gram-positive bacteria.

Reviews of Klion D show that this remedy is used to eliminate itching, which often leads to infections. Klion D suppositories are absolutely safe for the female body, because they do not change the pH of the vagina and certain composition microflora.

Indications for use of Klion D

Klion D is prescribed to eliminate infectious and inflammatory diseases, the cause of which is associated with the negative effects of a number of anaerobic bacteria. TO similar diseases may include osteomyelitis, sepsis, brain abscesses, peritonitis, lung and pelvic abscesses, meningitis, endometritis and gas gangrene.

Klion D 100 is also used for preventive purposes to get rid of infectious complications (caused by anaerobic streptococci and bacteroides) after surgery in the abdominal cavity and pelvic organs.

In some cases, Klion D suppositories are used to treat local vaginal infections.

Directions for use and dosage

Klion D tablets are prescribed in the following dosages:

If the patient has trichomoniasis, take 1 tablet (250 mg) orally, 2 times a day for 10 days. 1 is also assigned increased dosage in the evening – 8 tablets (2 g).
If an adult patient has giardiasis, take 2 tablets orally in the morning and evening for a week.
For amebiasis in adults - 2 tablets 3 times a day for 1-1.5 weeks.

The instructions for Klion D indicate that this drug is also used in the form of an infusion solution. In this case, children over 12 years of age and adults are administered Klion D by drip, 100 ml every 8 hours. The duration of treatment on average reaches a week. If there is urgency, intravenous administration funds can be continued. However, care must be taken to daily dosage did not exceed 4 g. After completing the course of treatment, the patient is prescribed Klion D tablets (400 mg 3 times a day).

For children under 12 years of age, Klion D 100 is administered at the rate of 1.5 ml of solution per 1 kg of body weight (the same dosage remains the same for preventive treatment this medicine).

For prevention, adults and children over 12 years of age are prescribed 100 ml of solution during, before and after surgery. This dosage is repeated every 8 hours. After this, Klion D tablets are prescribed (200-400 mg each).

If the patient has trichomoniasis, she needs to insert 1 Klion D suppository, pre-moistened with water, deep into the vagina. This should be done once before bedtime for 10 days. Additionally, take 1 tablet orally 2 times a day.

Side effects of Klion D

Reviews of Klion D show that in quality side effects most often there is burning, itching and irritation in the vagina (thick, white discharge, odorless), frequent urination, a burning sensation in the partner’s penis;
Nausea, dry mouth, change taste preferences, decreased appetite, vomiting, abdominal pain, diarrhea or constipation;
Reviews of Klion D indicate that rashes, hives, and itching may occur on the skin;
Dizziness and headache;
Leukocytosis and leukopenia. In reviews of Klion D, it is noted that quite rarely urine can turn red-brown.

Contraindications for use

Klion D should not be taken during following cases:

If the patient is hypersensitive to some components of this drug;
For blood diseases, leukopenia, problems with coordination of movement, liver failure, disorders of the central nervous system;
Klion D should not be used during pregnancy (in the first trimester) and lactation;
Patients with diabetes mellitus and problems with blood microcirculation require additional consultation.

Use during pregnancy and lactation

Klion D is contraindicated during pregnancy in the 1st trimester. In the 2nd and 3rd trimesters, the drug must be prescribed with caution. Use during breastfeeding is not recommended.

Drug interactions of Klion D

Klion D 100 should not be taken together with disulfiram, as the patient may experience mental disorders.

Klion D increases the active ingredient indirect anticoagulants, which slows down the formation of prothrombins.

In reviews of Klion D, it is noted that the drug cannot be combined with vecuronium bromide.

Concomitant use of barbiturates reduces the effect of metronidazole.

The use of cimetidine and Klion D 100 increases the concentration of metronidazole in the blood, which leads to the development of side effects.

The use of drugs containing lithium increases their content in the blood plasma.

Precautionary measures

During treatment with Klion D you should abstain from sexual intercourse.

The drug should be used with caution while driving a car or operating complex machinery.

Metronidazole may interfere with the Nelson test.

Storage conditions

Klion D should be stored in a dry place at a temperature of 15-25 degrees.

Photo of the drug

Latin name: Klion-D 100

ATX code: G01AF20

Active substance: Metronidazole, Miconazole

Manufacturer: JSC Gedeon Richter, Hungary

Description is valid on: 17.10.17

Klion-D 100 - synthetic combination drug, which has a wide spectrum of action. Used as an antibacterial, antifungal and antiprotozoal drug.

Active substance

Metronidazole, Miconazole.

Release form and composition

Available in the form of vaginal tablets white. It has an oval, biconvex shape with a pointed end and "100" engraved on one side. Aluminum strips are packaged in 10 pieces.

Indications for use

It is used for the treatment of infectious and inflammatory diseases that can be caused by numerous bacteroides and anaerobic cocci, clostridia, and fusobacteria. Such diseases include abscesses in the pelvic organs, osteomyelitis, sepsis, gas gangrene, peritonitis, and meningitis. It is proposed to use the drug as prophylactic after surgical interventions.

Helps prevent the occurrence of postoperative infectious complications caused by anaerobic streptococci, as well as bacteroides. Most often it is used after surgery on the pelvic organs. Klion-d 100 is usually used as a local medicine for vaginitis of mixed origin caused by simultaneous exposure to Candida spp. and Trichomonas spp.

Contraindications

Leukopenia;
liver failure;
epilepsy and other organic lesions of the central nervous system;
hypersensitivity to the components of the drug;
age up to 12 years;
I and II trimesters of pregnancy and lactation.

During pregnancy, the drug is not contraindicated only in the third trimester.

Particular caution is needed when prescribing the drug to people with blood microcirculation disorders and diabetes mellitus. During treatment you should not drink alcohol.

Instructions for use of Klion-D 100 (method and dosage)

Apply 1 vaginal tablet (pre-moistened with water) and insert it deep into the vagina in the evening before bed for 10 days in combination with taking Metronidazole orally.

Side effects

The use of the drug can cause the following side effects: irritation in the vaginal area with itching and even pain, as well as burning of the vaginal mucosa. These symptoms may appear on the partner's penis.

Overdose

There are no data regarding overdose with intravaginal use of metronidazole. However, when used concomitantly with metronidazole orally, systemic effects may develop.

Symptoms of metronidazole overdose: nausea, vomiting, abdominal pain, diarrhea, generalized itching, metallic taste in the mouth, movement disorders(ataxia), dizziness, paresthesia, convulsions, peripheral neuropathy, leukopenia, dark urine.

No symptoms of miconazole overdose have been identified.

Treatment: accidental ingestion large quantity vaginal tablets Klion-D 100, if necessary, gastric lavage can be performed, administration activated carbon, hemodialysis. Metronidazole does not have a specific antidote. Metronidazole and its metabolites are readily eliminated by hemodialysis. If any symptoms of overdose occur, symptomatic and supportive therapy is recommended.

Analogs

Analogs by ATX code: Vagisept, Vagiferon, Clomegel, Neo-Penotran.

Do not decide to change the drug on your own; consult your doctor.

pharmachologic effect

Klion-D100 is a broad-spectrum drug. The main active ingredient is metronidazole, which is a derivative of nitro-5-imidazole. The mechanism of action of this substance is to restore the 5-nitro group in anaerobic microorganisms and protozoa. This leads to the death of microorganisms due to the interaction of the reduced 5-nitro group of metronidazole with the DNA of the microorganism cell.

It is active against a large number of microorganisms, such as Entamoeba histolytica, Giardia lamblia, Trichomonas vaginalis, Gardnerella vaginalis, and it is also active against anaerobic bacteria - Bacteroides spp. Veillonella spp., Fusobacterium spp., Prevotella spp.
The use of this drug is also effective for the treatment of diseases caused by certain gram-positive microorganisms, such as Clostridium spp., Eubacterium spp., Peptococcus spp., Peptostreptococcus spp. Facultative anaerobes and aerobic microorganisms are insensitive to Klion-d 100, but its use is recommended for the treatment of mixed aerobic-anaerobic infections.
Very effective against fungi, including dermatophytes and yeast fungi. Suppositories for intravaginal use effectively combat Candida albicans. Miconazole is able to suppress the biosynthesis of ergosterol in fungal cells, which leads to their death. Wherein normal microflora and vaginal pH do not change during treatment with this drug.

special instructions

During the period of use of the drug, you should not drink alcohol (risk of developing disulfiram-like reactions).

Metronidazole can immobilize treponemes, resulting in a false-positive TPI test (Nelson test).

When using Klion-D 100, slight leukopenia may be observed, so it is advisable to monitor the blood picture (the number of leukocytes) at the beginning and at the end of therapy.

If side effects from the central nervous system occur, you should refrain from driving vehicles and working with potentially dangerous mechanisms.

During pregnancy and breastfeeding

Contraindicated for use in the first trimester of pregnancy. The use of the drug in the second and third trimesters is possible only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.

Metronidazole is excreted in breast milk. During breastfeeding, the use of Klion-D 100 is contraindicated. If it is necessary to use the drug during lactation, breastfeeding should be stopped.

In childhood

Information is absent.

In old age

Information is absent.

For liver dysfunction

Contraindicated in case of liver failure (when prescribing the drug in high doses).

Drug interactions

Since the systemic absorption of miconazole is low, interactions with other drugs are caused by metronidazole.
Metronidazole is compatible with sulfonamides and antibiotics.
When consumed simultaneously, alcohol causes reactions similar to disulfiram (cramping abdominal pain, nausea, vomiting, headache, skin flushing). Concomitant use with disulfiram is unacceptable (additive effects, may cause confusion).
The drug can enhance the effect of indirect anticoagulants. Prothrombin time may increase, so dose adjustment of indirect anticoagulants is necessary.
It is not recommended to combine the drug with non-depolarizing muscle relaxants (vecuronium bromide).
Inducers of microsomal oxidation enzymes in the liver (for example, phenytoin, phenobarbital) can accelerate the elimination of metronidazole, which leads to a decrease in its concentration in the blood plasma.
Cimetidine inhibits the metabolism of metronidazole, which may lead to an increase in its concentration in the blood serum and an increased risk of side effects.
It is possible that the concentration of lithium in the blood plasma may increase during the course of treatment with metronidazole, so before starting application of Klion-D 100 it is necessary to reduce the dose of lithium or stop taking it during treatment.

Klion D is a fairly high-quality and popular medicine, but you can always find a better medicine. Klion D 100 has a number of analogues, but there is no point in considering them all, due to the fact that not all of them have high quality and reasonable cost.

It is best to focus on the most successful analogues of this medicinal product. They have a number of features and therefore should be mandatory Familiarize yourself with the contraindications, otherwise you can easily harm your health.

Metromicon-Neo

Metromicon-Neo is widely used in gynecology, due to the fact that this drug contains two active substances that have an antibacterial effect: miconazole and metronidazole. The drug also has a detrimental effect on protozoan microorganisms (amoeba, lamblia, etc.) It is usually prescribed for various vaginal diseases, such as vaginitis and vaginal bacteriosis. In addition, Metromicon-Neo is very effective against infections caused by an aerobic bacteria.

Metromicon-Neo is prescribed for vaginal infections caused by fungus or bacteria. Most often it is prescribed for:

vaginitis;
vulvovaginitis;
vaginal bacteriosis;
vaginal trichomoniasis;
vaginal candidiasis.

This drug is not effective in treating diseases caused by aerobic bacteria. Although, it is a fairly successful analogue of Klion D.

Contraindications for use

Under no circumstances should the drug be used for: integrity of the hymen, lactation, allergies to active substances. The attending physician may discontinue the drug in the presence of kidney disease, diabetes mellitus and other diseases, if deemed necessary. The price of Metromicon-Neo varies from 300 to 400 rubles, but this drug is still cheaper than Klion D. The main thing is to strictly follow the advice of your doctor in order to avoid unpleasant consequences from taking medication.

Metronizadol

This drug is often prescribed for complex treatment various pathologies. It has been actively used in medicine since the 60s. The drug has antibacterial and antimicrobial effects. This medicine is also harmful to protozoan microorganisms. The active substance is a derivative of 5-nitroimidazole.

For what diseases is it prescribed?

Metronizadol is prescribed for:

infections caused by protozoan microorganisms;
infections caused by anaerobic bacteria;
gastritis;
ulcerative stomatitis;
alcoholism (although currently in this case it is rarely prescribed);
pseudomembranous colitis.

The drug comes in the form of tablets and suppositories. Candles can be used as additional drug at bacterial vaginitis. It would be worth saying that Metronizadol suppositories are no worse than Klion suppositories.

Contraindications for use

This drug is not recommended for use if you are allergic to any substance, during lactation, or for children under one year of age. If you have any doubts about taking the medicine or not, you should definitely consult your doctor. The price for this drug varies from 80 to 190 rubles.

Vagiferon

Vagiferon is a complex drug intended for intravaginal use. Its active ingredients interferon alpha-2b and fluconazole have antiviral and antifungal effects.

For what diseases is it prescribed?

Vagiferon is prescribed for similar diseases as Klion D, Metronizadol and Metromicon-Neo:

bacterial vaginosis;
bacterial vaginitis;
vaginitis caused by mixed infection (fungi, herpes simplex virus, mycoplasma).

Contraindications for use

The medicine should not be taken if you are hypersensitive to various components such as nitroimizadole, or during pregnancy. It is also better not to take Vagiferon for girls under eighteen, because the effectiveness and safety of the medicine for this group has not been established. Due to the fact that the medicine passes into breast milk, it is better to stop breastfeeding while you are taking the medicine. The price of Vagiferon is 300-350 rubles.

Metrovagin

The active ingredient of the drug is Metronizadol, which has an antimicrobial effect. When taking this drug, you should follow several recommendations, namely, both sexual partners should take Metrovagin at once; during treatment it is better to abstain from sexual intercourse. Headache and vomiting may occur while taking the medicine.

For what diseases is it prescribed?

urogenital trichomoniasis;
urethritis;
vaginitis;

The medicine is sold as gel, ointment and vaginal suppositories. This drug does not have suppositories.

Contraindications for use

It is better not to take the medicine when

allergies to certain of its components;
leukopenia (decrease in the number of leukocytes in the blood);
loss of coordination or presence of vestibulopathy;
epilepsy;
liver and kidney diseases;
lactation.

Also, the product should not be used during pregnancy. Metrovagin has a number of side effects such as allergic reactions, itching and burning of the penis in a partner, frequent urination, dryness in the oral cavity, constipation. The drug is not particularly different in cost from its analogues. Its price is 320 rubles.

Vagisent

Vagisent is a combination antiviral drug, which is very effective in treating various sexual diseases. The medicine is available in tablet form. The spectrum of action of Vagisent is the same as that of its analogues: various vaginitis and bacterial vaginosis.

This medicine is used intravaginally. This drug contains the following active ingredients: metronidazole (200 mg) and flucanozole (150 mg). Metrovagin and Vagiferon can be considered substitutes for Vagisent. Overall, Vagisent is quite effective remedy, but there are also contraindications.

Contraindications for use

It is better not to take the medicine if:

diseases of the nervous system (peripheral and central);
severe liver dysfunction;
pregnancy;
lactation;
allergies and sensitivity to components.

The price tag for Vagisent is 320 rubles.

Neo-Penotran Forte

A German-made drug that is used for various vaginal infections. There is a modification containing lidocaine to reduce painful sensations when taking medication. Neo-Penotran Forte is inserted into the vagina a few centimeters, but before the procedure you should thoroughly wash your hands with an antiseptic.

For what diseases is it prescribed?

Neo-Penotran Forte is prescribed for:

thrush;
vulvitis;
various vaginitis;
bacterial vaginosis;
urogenital trichomanades.

Klion D, analogues of which are Neo-Penotran Forte and Vagisent, can also be used to treat these diseases.

Contraindications for use

The drug should not be taken under any circumstances if:

epilepsy;
allergies;
pregnancy;
porphyria;
the presence of a hymen.

Efloran

A drug that has a strong antiviral and antibacterial effect, especially against anaerobic bacteria.

For what diseases is it prescribed?

The medicine is prescribed for:

vaginitis;
bacterial vaginosis;
various forms of amoebiasis.

Contraindications for use

The drug should not be prescribed to patients with hypersensitivity to its individual components. Efloran is also not prescribed for lactation, pregnancy and children under three years of age. Particular care should be taken when prescribing the medicine to persons suffering from diseases of the nervous system, alcoholism, and those with impaired liver and kidney function. The price for Efloran is 350 rubles.

Now it should become clear how to replace Klion D. this moment all its analogues are not limited to the listed medicines, you can find more of them, but why? The drugs listed above are very high quality and reliable. However, you should still not take them without the recommendation of your doctor. Self-medication can cost your health.

The same drug can be produced in the most different forms. Now I would like to talk about such a drug as “Klion-D” - suppositories. Instructions for use, dosage rules and all the most interesting things about this means you can find out right now.

All the most important things about the drug "Klion-D"

Initially, you need to understand in what cases this drug can be used. Thus, it is capable of providing antifungal, anti-inflammatory and antiprotozoal (that is, killing the simplest harmful microorganisms) effect.

The main active ingredient here is. It has wide range action, can fight a wide variety of microorganisms. It has an antifungal effect, that is, it can kill various dermatophytes, yeasts and gram-positive bacteria. It is also important to note that when using the drug in the form of suppositories, it does not affect the patient’s vaginal pH at all.

Another active ingredient is miconazole. This antifungal drug, which affects fungi on cellular level, killing them and preventing the process of reproduction and division.

What else can you say if we're talking about about the drug "Klion-D", suppositories? The instructions for use also include information that this drug is absorbed into the general bloodstream. 8 hours after using the medicine, its effect is still active by as much as 90%.

When should you take a medicine such as Klion-D or suppositories?

You definitely need to consider everything existing indications to the use of this medicinal product. So, it is used in the following cases:

To get rid of thrush (local treatment).
To combat vaginitis: nonspecific, candidiasis or trichomonas.

Candles "Klion-D": instructions for use

How to take this drug correctly? After all, it is available in different forms: tablets for internal reception, vaginal tablets(that is, candles), capsules. So, the drug "Klion-D": instructions for use of vaginal tablets:

Before insertion into the vagina, the tablet is generously moistened with water.
The drug should be injected into the vagina as deeply as possible. This should be done in a lying position.
After the procedure, you need to be in a horizontal position for a certain time.

The dosage of the drug is as follows: one tablet per day, inserted into the vagina immediately before bed (so as not to get up). The course of treatment is usually 10 days, but can be adjusted on the recommendation of the treating doctor.

The drug "Klion-D", suppositories: contraindications

It is also necessary to tell about who is contraindicated in using this drug. So, in the following cases, its use should be abandoned:

Disorders of the nervous system of organic nature.
Epilepsy.
Leukopenia.
Liver failure.

It is necessary to note who else should not take the drug “Klion-D” or suppositories. Contraindications – girls under 12 years of age, 1st trimester of pregnancy (first three months) or lactation period. The use of suppositories by those who have an allergic reaction or personal intolerance to the components of the medicine is also strictly prohibited.

Doctors note that with great caution and only under the supervision of the attending physician, this medicine is taken by those who have diabetes or blood microcirculation disorders.

Side effects that occur when using the drug "Klion-D"

As the others medicines, the medicine "Klion-D" may have side effects. They occur extremely rarely, but you still need to know about them.

It can be local symptoms: itching, burning, irritation of the mucous membranes of the vagina (the partner’s genital organ may also be irritated). Sometimes patients have thick mucous discharge from the vagina.
Symptoms may occur allergic reaction. In this case, we are talking about hives, skin rashes and itching.
From the digestive system, constipation or diarrhea is possible. Appetite may also disappear, sometimes change taste preferences or a metallic taste appears in the mouth. There may also be severe pain in the stomach, vomiting and nausea.
Sometimes patients complain of headaches and dizziness.
The drug contains a special water-soluble pigment, due to which urine can turn brownish-reddish.
If we talk about the hematopoietic system, then the patient’s production of leukocytes may decrease.

About overdose of Klion-D suppositories

It should be noted here that overdoses with correct use there can be no drug. However, sometimes it happens that a woman mistakenly takes this medicine inside. In this case, vomiting, nausea, and a severe headache may occur. The color of the urine may darken, seizures may occur, or motor function may be impaired.

Important points when using Klion-D candles

It must be said that the use of this drug is incompatible with the consumption of alcohol and low-alcohol drinks. We must also remember that treatment should be carried out not only in women, but also in the man who is the woman’s sexual partner.

It will also be important to know that the use of these suppositories can cause leukopenia, that is, a decrease in the level of leukocytes in the blood. That is why it is necessary to monitor their levels using tests.

It should also be noted that if, when using this drug, there are disturbances in the functioning of the central nervous system, in this case it is best to refuse to drive a car or perform serious responsible tasks.

Well, I would like to say a few words about the period of pregnancy and breastfeeding. As mentioned above, this remedy cannot be used during the first trimester of pregnancy. It can be used in the 2nd and 3rd trimester, but only under the strict supervision of a doctor, and only if the risk for the mother is too high. It should not be used during breastfeeding, because... the components of the drug are absorbed into breast milk. During the treatment period, breastfeeding should be completely stopped.