New pentalgin in white packaging. Pentalgin

Pentalgin, the composition of which is known and simple, - excellent remedy from inflammation. This antispasmodic is available in the form of tablets, which are coated with a greenish tint with pronounced white patches.

The composition of this drug allows you to localize many unhealthy processes in the body due to the successful combination of the following components:

1. Paracetamol. It is an analgesic-antipyretic, it has an antipyretic and analgesic effect.
2. Naproxen. Its impact is directly related to non-selective oppression. Relieves inflammation and fever, acts as an analgesic.
3. Drotaverin. Acts as a myotropic property with an antispasmodic effect, has a beneficial effect on blood vessels, muscles gastrointestinal tract and genitourinary system;
4. Pheniramine. Active blocker of histamine H1 receptors. It can be antispasmodic, sedative, helps to more effectively manifest the positive effects of paracetamol and naproxen.
5. Caffeine. Expands blood vessels, relieves feelings of fatigue, has a beneficial effect on the brain. An excellent stimulant. Caffeine can increase the permeability of the blood-tissue barrier.

Pentalgin plus and Pentalgin icn in their composition contain a large set of substances that can withstand many diseases, and has a general effect. The main ones are:

• analgesic;
• anti-inflammatory;
• antispasmodic;
• antipyretic.

The medicine eliminates nausea, any kind of cough, reduces inflammatory process. After taking the drug, pentalgin plus the components that make up its composition continue to work from 4 to 6 hours. A maximum of 6 hours after taking Pentalgin Plus, you may experience a feeling of fatigue and weakness.

Pentalgin plus is used to relieve pain in any part of the body and of any origin.

But as prescribed, pentalgin plus better reduces the pain associated with inflammation, and also helps with coughing.

In its composition pentalgin plus has codeine, so there is a risk of developing dependence on it. Because of this, depression, a decrease in intellectual and physical performance, and fatigue are possible.

With a certain period of use of pentalgin, urine may change to a yellow-red color.

The specific dosage of the drug is prescribed by the attending physician.

An overdose of the drug is dangerous. Signs of an overdose are as follows:

• malnutrition;
• stomach ache;
• nausea;
• intestinal bleeding;
• arrhythmia;
• headache;
• heat;
• epileptic seizures;
• tremor.

Signs of liver problems appear within 12-48 hours after a large dose has been taken. If there is some suspicion of an overdose, an urgent need to consult a doctor.

In case of overdose, activated charcoal should be used.

Side effects of the drug:

• rash;
• hives;
• angioedema.

Treatment with Pentalgin ICN

Pentalgin isn has a number of effects, such as:

• painkiller;
• antipyretic;
• anti-inflammatory.

The caffeine contained in this preparation can relieve a headache (or migraine). Pheobarbital improves the activity of metamizole sodium and paracetamol. Codeine suppresses the cough center, thereby reducing cough, works as a pain reliever, due to a change in the perception of pain.

The medicine can be used for joint pain, muscle pain, sciatica, menstrual pain, headache and toothache, as well as colds and fever.

Pentalgin icn is prohibited for use if with the following pathologies:

• greater susceptibility to any component of Pentalgin ICN;
• chronic diseases of the liver or kidneys;
• agranulocytosis;
• stomach disease;
• high pressure;
• pregnancy and feeding;
• bronchospasm;
• glaucoma.

Pentalgin icn must be taken as prescribed by the attending physician, who will prescribe the right dosage and duration of therapy. If used incorrectly, side effects may occur.

Side effects:

• allergy;
• violation in the circulatory system;
• cardiopalmus;
• dizziness;
• fatigue;
• nausea;
• constipation.

With prolonged use of the drug Pentalgin icn, tachycardia, disorders of the liver and kidneys, and a decrease in the rate of psychomotor reactions may occur.

With long-term use of the drug pentalgin icn, addiction occurs, the analgesic effect disappears.

Pentalgin tablets contain active ingredients: , caffeine, pheniramine maleate and .

Additional components: microcrystalline cellulose, croscarmellose sodium, potato starch, hyprolose, citric acid, butylhydroxytoluene, titanium dioxide, magnesium stearate, talc, indigo carmine, hypromellose, povidone, polysorbate 80, dyes.

Release form

Pentalgin is produced in the form of tablets, which are film-coated Green colour 2, 6, 10 and 12 pieces in a cell package, 1-2 in a pack.

Mn

Caffeine + Drotaverine + Naproxen + Paracetamol + Pheniramine maleate

pharmachologic effect

The medicine has analgesic, antipyretic and anti-inflammatory action.

Pharmacodynamics and pharmacokinetics

The combination drug shows analgesic, anti-inflammatory, antispasmodic and antipyretic Effect. Wherein therapeutic effect Pentalgin is determined by its constituent substances.

For example, as Wikipedia points out, paracetamol is -antipyretic providing antipyretic and anesthetic the effect that is provided by the blockade of COX in the nervous system and the effect on pain centers and thermoregulation.

Caffeine represents psychostimulant expanding agent blood vessels in skeletal muscle, heart and kidneys. In addition, mental and physical performance, eliminated fatigue and , increases the permeability of blood-tissue barriers, as well as the bioavailability of non-narcotic analgesics, helping to enhance the therapeutic effect. Marked tonic effect, reflected in the vessels of the brain.

Naproxen - this is NSAIDs , which shows anti-inflammatory, antipyretic and analgesic an action that is associated with non-selective suppression of the functions of COX that regulate the production of prostaglandins.

For drotaverine typical myotropic antispasmodic the effect, which is due to the inhibition of PDE 4, manifests an effect on the smooth muscles of the gastrointestinal tract, blood vessels, organs of the genitourinary system and biliary tract.

Histamine H1 receptor blocker substance - pheniramine – renders antispasmodic and light sedative effect, reduces the manifestations of exudation, enhances the analgesic effect of paracetamol and naproxen.

Indications for use

Main indications for use:

• various types of pain syndromes, for example, sciatica, articular, muscle pain, during menstruation, , algomenorrhea;
• spasm of smooth muscles caused by chronic cholecystitis, renal colic, postcholecystectomy syndrome ;
• post-traumatic and postoperative pain, including inflammation;
• colds with febrile syndrome.

It is also used as a medicine for toothache, .

Contraindications

Available various contraindications to the use of Pentalgin:

• erosive and ulcerative disorders of the gastrointestinal tract;
• gastrointestinal bleeding;
• intolerance to its components;
• , recurrent nasal polyposis and paranasal sinuses, intolerance acetylsalicylic acid and other NSAIDs;
• severe forms of hepatic and;
• processes that inhibit bone marrow hematopoiesis;
• transferred coronary artery bypass grafting ;
• hyperkalemia;
• diseases of the cardiovascular system;
• heavy arterial hypertension ;
• age under 18 years old.

Pentalgin is contraindicated in and . Therefore, if pain or other disorders occur during pregnancy, you need to get an appointment. suitable treatment at the doctor's.

A number of conditions have also been noted when the drug is prescribed with extreme caution, for example, with: cerebrovascular diseases, , peripheral arterial disease, benign hyperbilirubinemia, ulcerative lesions of the gastrointestinal tract, renal and liver failure middle and light form, viral hepatitis , defeat liver alcohol, and prone to seizures, old age, glucose-6-phosphate dehydrogenase deficiency, and so on.

Side effects

In the treatment of Pentalgin may develop unwanted effects, for example, disorders of the nervous, cardiovascular, digestive, genitourinary and hematopoietic systems, as well as sensory organs.

This may be accompanied by symptoms such as: , skin rash, thrombocytopenia, , leukopenia, anemia, methemoglobinemia , agitation, anxiety, sleep problems, heart failure, arrhythmia, increase, pain, erosive and ulcerative disorders of the gastrointestinal tract, nausea, vomiting, abnormal kidney function, hearing loss, and so on.

Tablets Pentalgin, instructions for use (Method and dosage)

Detailed instructions for the use of Pentalgin indicate that the tablets are administered orally one at a time 1-3 times a day. At the same time, the maximum daily dosage is no more than 4 tablets.

The duration of treatment is determined depending on the disorder. For example, as an antipyretic, Pentalgin green tablets are taken up to 3 days, as an anesthetic - up to 5 days. If it is necessary to increase the duration of therapy, you should consult with your doctor.

Overdose

When using tablets long time in high doses, an overdose may occur, which is accompanied by symptoms: pallor of the skin, anorexia, abdominal pain, nausea, vomiting, gastrointestinal bleeding, agitation, anxiety, confusion, arrhythmia, hyperthermia, increased urination, headaches, tremor, epileptic seizures and so on.

More severe forms of overdose are: the development of liver failure with increasing encephalopathy, arrhythmia, , coma, fatal outcome.

Typically, treatment includes: gastric lavage, intake, administration of a specific - or other drugs, depending on the symptoms.

Interaction

The use of Pentalgin with barbiturates, tricyclic antidepressants, increases the risk of hepatotoxicity. Also this drug can enhance the effect of indirect anticoagulants and reduce the effectiveness of uricosuric drugs.

Prolonged use of barbiturates reduces the effectiveness of paracetamol. While inhibitors of microsomal oxidation, for example, may reduce its hepatotoxic effect.

Simultaneous use with Diflunisal able to increase the concentration of paracetamol in plasma by 50%, increasing the development of hepatotoxicity.

Co-administration of caffeine with barbiturates, anticonvulsants often amplifies and increases the clearance of caffeine. Combination of caffeine with cimetidine, oral contraceptives, , - reduces the metabolism of caffeine.

With the simultaneous use of caffeinated drinks and other drugs that can stimulate the nervous system, it causes its excessive stimulation. Drotaverine significantly weakens the anti-Parkinsonian effect. . The use of Pheniramine and tranquilizers, hypnotics, MAO inhibitors, can increase the inhibitory effect on the nervous and other systems.

special instructions

It is contraindicated along with Pentalgin to take other medicines containing paracetamol and NSAIDs. Carefully prescribe funds intended to relieve cold symptoms, nasal congestion and flu.

If the patient takes this drug for more than 7 days, monitoring of peripheral blood and liver function is necessary.

The ability of paracetamol to distort the results is noted laboratory research associated with glucose levels and uric acid in the blood plasma.

When it is necessary to determine 17-ketosteroids, the drug is canceled 2 days before the study. It must be remembered that naproxen can increase bleeding time.

The effect of caffeine on the nervous system depends on its type and can manifest itself either by excitation or inhibition of nervous activity.

Terms of sale

Without recipe.

Storage conditions

To store these tablets, you need a dry and dark place inaccessible to children, at temperatures up to 25 ° C.

Best before date

Pentalgin's analogs

Coincidence in the ATX code of the 4th level:

Pentalgin and alcohol

During treatment it is forbidden to drink alcohol. The fact is that simultaneous reception paracetamol with ethanol increases the risk of developing acute pancreatitis.

Reviews about Pentalgin

As you know, various painkillers are very popular in society. A special need for them arises in people who are afraid or simply do not like to visit a doctor. Therefore, they manage with handy means, and in order to eliminate pain, they take Analgin, , Pentalgin and Pentalgin-N. According to reviews, these drugs are different people do not have the same effect.

In most cases, reviews of Pentalgin are associated with its use by women during menstruation, if they are concerned about strong pain. Also these green pills many help for a while to get rid of toothache and headaches. On medical forums, there are lengthy discussions on the topic: what does Pentalgin help best with? Often, patients compare the effect of this drug and its other types, for example, Pentalgin FS, which helps many people to eliminate muscle pain.

At the same time, experts do not get tired of specifying what Pentalgin tablets are, what they help with, when and for how long they can be taken. The fact is that any pain already indicates that a failure has occurred in the body, which means that it needs professional help. However, most people in such cases do not rush to the doctor, but begin to look for remedies to eliminate pain. You should be aware that this approach often complicates the course of the disease, the treatment of which over time will require more intervention and time.

Price of Pentalgin, where to buy

The price of Pentalgin tablets for 4-24 pcs. in a pack varies between 60-160 rubles. You can buy the drug in any Russian pharmacy without a prescription.

• Internet pharmacies in Russia Russia
• Internet pharmacies of Ukraine Ukraine

WER.RU

Pentalgin extra gel 5% 50 g Pharmstandard

Pentalgin extra gel 5% 30 g Lecco

Pentalgin tablets 4 pcs. Pharmstandard

Pentalgin tablets 12 pcs. Pharmstandard

Pentalgin tablets 24 pcs. Pharmstandard

Europharm * 4% discount with promo code medical11

Pentalgin 24 tab.Pharmstandard-Leksredstva JSC g.K

Introducing New Pentalgin®- an analgesic with analgesic, anti-inflammatory and antispasmodic action!

The combination of active ingredients in the new Pentalgin allows you to reduce their dose, which improves the safety profile of the drug.

The absolute novelty of the new Pentalgin is the introduction of drotaverine into the composition of the antispasmodic, which expands the range of use of the drug and enhances its effect in pain associated with smooth muscle spasm.

New Pentalgin produced in accordance with European quality standards.

The new Pentalgin does not contain codeine and is available without a prescription.

The new Pentalgin is available in several forms - 4, 12 and 24 tablets (the concept of "to go", "to work", "for home").

Indications for use

Pain syndrome various genesis, including pain in the joints, muscles, sciatica, menstrual pain, neuralgia, toothache and headache (including headache caused by spasm of cerebral vessels). Pain associated with spasm of smooth muscles, including chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, renal colic. Post-traumatic and postoperative pain syndrome, including accompanied by inflammation. Colds, accompanied by febrile syndrome (as a symptomatic therapy).

Video

Question answer

You produce several drugs with the name Pentalgin. Please explain how they differ and how to choose which drug is better to take?

The Pharmstandard company produces several drugs under the name Pentalgin, but differing in full name Pentalgin-N, Pentalgin-ICN, Pentalgin Plus and Pentalgin. Currently Full description formulations of drugs are presented on the company's website.

These drugs have a different composition of active ingredients, different shape and color of tablets. All drugs contain 5 components, and the main indication for their use is a pain syndrome of various origins.

Since the sensitivity to painkillers of different classes is individual for each person, the presence of several drugs in the Pentalgin line allows you to choose the most suitable analgesic for each consumer.

The table below contains a comparative description of the compositions of the preparations of the Pentalgin line.

Which of the Pentalgins is most effective for headaches?

All drugs of the Pentalgin line are designed to relieve pain of various origins, including headache. Because headaches can be caused by various reasons, it is impossible to determine it yourself and decide in advance which of the painkillers will be the most effective. The choice of a drug that affects different possible reasons occurrence of headache. Therefore, the preparations of the Pentalgin line contain various components that have different mechanism actions. The composition of the "new" Pentalgin includes drotaverine, which has an antispasmodic effect and therefore can be used for headaches caused by spasm of cerebral vessels. With a regularly occurring headache, you should consult a specialist - for an examination and determination exact reason headache.

Can Pentalgin be taken by children and adolescents?

Preparations Pentalgin-N, Pentalgin Plus and Pentalgin-ICN are approved for use in adults and children over 12 years old, Pentalgin is approved for use only in adults (over 18 years old), because. study of the efficacy and safety of the drug in childhood and adolescence has not been conducted.

Explain, please, Pentalgins are now dispensed with a prescription or without?

Currently, only Pentalgin, film-coated tablets, is subject to over-the-counter dispensing. It contains paracetamol, naproxen, caffeine, drotaverine and pheniramine. Preparations Pentalgin-N, Pentalgin-ICN, Pentalgin-plus are dispensed by prescription.

The composition of Pentalgin-N and Pentalgin-ICN includes phenobarbital and codeine - can this affect the results of blood and urine tests when determining the content of narcotic substances in the blood (for example, if you suspect driving while intoxicated)?

Pentalgin-N contains analgin (metamisole sodium), naproxen, caffeine, phenobarbital and codeine. The elimination period of half the dose of the Pentalgin N phenobarbital component, according to the literature, is 3-4 days, so trace amounts of barbiturates (phenobarbital) can sometimes remain in the body for up to 2-3 weeks, even after a single dose of any drug containing phenobarbital.

Therefore, the instructions for use of Pentalgin N and Pentalgin-ICN indicate that when taking the drug, it is recommended to refrain from potentially dangerous species activities requiring heightened attention and speed of psychomotor reactions, which include driving vehicles. The time period of abstinence from driving depends on the individual reaction and the rate of removal of components from the patient's body. It is possible to assess the possibility of driving and the presence of signs of intoxication only with a medical examination.

In which part of the gastrointestinal tract do Pentalgin tablets dissolve? And can they be used to relieve stomach pain?

Pentalgin tablets are film-coated, which dissolves no more than 30 minutes after ingestion - i.e. dissolution occurs in the stomach. However, the drug Pentalgin is not intended for stopping stomach pain.

Indications for taking Pentalgin include:

• Pain syndrome of various origins, including pain in the joints, muscles, sciatica, menstrual pain, neuralgia, toothache and headache (including headache caused by spasm of cerebral vessels).
• Pain associated with spasm of smooth muscles, including chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, renal colic.
• Post-traumatic and postoperative pain syndrome, including accompanied by inflammation.
• Colds, accompanied by febrile syndrome (as a symptomatic therapy).

To relieve pain in the stomach, special medications are used, the choice of which depends on accurate diagnosis.
We recommend that you contact a gastroenterologist for examination, diagnosis and decision on the need for a particular therapy.

How long can Pentalgin preparations containing codeine be taken continuously?

According to approved guidelines for medical use, Pentalgin-N, Pentalgin Plus and Pentalgin-ICN preparations should not be taken for more than 5 days as an anesthetic and for more than 3 days as an antipyretic without a doctor's prescription.

Can Pentalgin be taken while breastfeeding?

Taking the drug Pentalgin during lactation is contraindicated, the release of the components of the drug with breast milk and their effect on the child has not been studied. If necessary, the use of the drug during lactation should stop breastfeeding.

In this medical article you can see drug Pentalgin. The instructions for use will explain in which cases you can take pills, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Pentalgin, from which you can find out if the medicine helped in the treatment of headache, toothache and fever in adults and children, for which it is also prescribed. The instructions list analogues of Pentalgin, drug prices in pharmacies, as well as its use during pregnancy. The conditions of over-the-counter and prescription depending on the presence of components prohibited for general sale.

Anti-inflammatory and antispasmodic drug - Pentalgin. Instructions for use suggest taking tablets H, ICN, Plus, green without codeine for pain syndromes of various origins and colds accompanied by fever.

Release form and composition

The drug Pentalgin is available in the form of tablets (green over-the-counter) for oral use, covered with a green film-coated protective coating. On one side of the tablet there is an inscription in Latin letters (name of the drug). Tablets are packed in blister strips of 2, 6, 10 and 12 pieces in a carton box, instructions with a detailed description are attached to the preparation.

They also produce tablets (H, ICN, Plus).

The tablets contain:

• Paracetamol + Naproxen + Caffeine + Drotaverine hydrochloride + Pheniramine maleate + Excipients(tablets are green, do not contain codeine and are sold without a prescription).
• Paracetamol + Metamizole sodium + Caffeine + Phenobarbital + Codeine phosphate + excipients (Pentalgin ICN).
• Metamizole sodium + Naproxen + Caffeine + Phenobarbital + Codeine (in the form of phosphate) + excipients (Pentalgin N).
• Paracetamol + Propyphenazone + Caffeine + Codeine Phosphate + Phenobarbital + excipients (Pentalgin Plus).

pharmachologic effect

Pentalgin has analgesic, antispasmodic, anti-inflammatory, and antipyretic effects. The therapeutic effect of the drug is due to the properties of the active substances that are part of the drug:

Paracetamol has an antipyretic and analgesic effect, which is due to the blockade of COX in the central nervous system, as well as a depressant effect on the centers of pain and thermoregulation.

Caffeine, which is part of Pentalgin, causes the expansion of the blood vessels of the skeletal muscles, heart and kidneys, tones the vessels of the brain and eliminates the state of drowsiness. In addition, caffeine increases the permeability of histohematic barriers and increases the bioavailability of non-narcotic analgesics, which enhances the therapeutic effect of the drug.

Drotaverine has an effect on the smooth muscles of the gastrointestinal tract, genitourinary system, blood vessels and biliary tract.

Naproxen is pharmacological substance, which refers to non-steroidal anti-inflammatory drugs. This component has a pronounced antipyretic, anti-inflammatory and analgesic effect, which is associated with the normalization of prostaglandin synthesis.

Pheniramine has antispasmodic and mild sedative activity, and also enhances the analgesic effect of naproxen and paracetamol. Since some active substances penetrate the placental barrier, it is not advisable to use Pentalgin during pregnancy.

Indications for use

What helps Pentalgin? Tablets have the following indications for use:

• colds with febrile syndrome;
• various types of pain syndromes, for example, radiculitis, joint, muscle pain, during menstruation, neuralgia, algomenorrhea;
• post-traumatic and postoperative pain, including inflammation;
• pain with spasm of smooth muscles caused by chronic cholecystitis, cholelithiasis, renal colic, postcholecystectomy syndrome.

Also, the drug is used as a medicine for toothache, migraines.

Instructions for use

Pentalgin tablets are intended for oral use. Adult patients are prescribed 1 tablet 1 to 3 times a day, depending on the indications and the severity of the pain syndrome. An adult can take no more than 4 tablets per day, and the interval between doses should be at least 6 hours.

The duration of the course of therapy with the drug is determined by the doctor depending on the indications, however, it is not recommended to take pills for longer than 3 days, since in this case the risk of developing side effects and drug ulcers.

In some cases, treatment with the drug can be continued for up to 5 days with the permission of the doctor and under his supervision. In the absence of a therapeutic effect during treatment with Pentalgin tablets during the first day, the patient should consult a specialist to clarify the diagnosis and select another remedy.

Contraindications

• severe renal failure;
• severe arterial hypertension;
• children's and adolescence up to 18 years;
• lactation period (breastfeeding);
• complete or incomplete combination bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history);
• condition after coronary artery bypass grafting;
• frequent ventricular extrasystole;
• glaucoma;
• hyperkalemia;
• severe liver failure;
• erosive and ulcerative lesions Gastrointestinal tract (in the acute phase);
• anemia, leukopenia;
• heavy organic diseases of cardio-vascular system(incl. acute infarction myocardium);
• oppression of bone marrow hematopoiesis;
• hypersensitivity to the components of the drug;
• deficiency of glucose-6-phosphate dehydrogenase;
• pregnancy;
• alcohol intoxication;
• paroxysmal tachycardia;
• gastrointestinal bleeding.

Side effects

During treatment with Pentalgin, undesirable effects may develop, for example, allergic reactions, disorders of the nervous, cardiovascular, digestive, genitourinary and hematopoietic systems, as well as sensory organs.

This may be accompanied by symptoms such as:

• anxiety, tremor;
• pain, erosive and ulcerative disorders of the gastrointestinal tract;
• increase in blood pressure;
• deviations in the work of the kidneys;
• dizziness;
• methemoglobinemia, agitation;
• itching, skin rash;
• nausea, vomiting;
• constipation;
• heart failure, arrhythmia;
• thrombocytopenia, agranulocytosis;
• hearing loss;
• sleep problems;
• urticaria, angioedema;
• leukopenia, anemia;
• headache.

Children, during pregnancy and lactation

Contraindicated in pregnancy and lactation. Contraindicated in children under 18 years of age.

special instructions

Do not administer Pentalgin with other paracetamol-based or NSAID-containing drugs to relieve symptoms of colds, flu and nasal congestion. Taking the drug for more than 5-7 days requires monitoring of peripheral blood and liver function.

Paracetamol distorts the results of tests for the level of glucose and uric acid in blood plasma. If the determination of 17-ketosteroids is required, Pentalgin is canceled 48 hours before the test. It should be borne in mind that naproxen increases bleeding time.

The effect of caffeine in the composition of the drug can have both an excitatory and inhibitory effect on the central nervous system. During treatment, you should not drink alcohol. When driving vehicles care must be taken.

drug interaction

Barbiturates taken by the patient for a long time reduce the effectiveness of paracetamol. Diflunisal increases the plasma concentration of paracetamol by 50%, as a result of which the risk of developing its hepatotoxicity increases. Paracetamol reduces the effect of uricosuric drugs, enhances the effect indirect anticoagulants.

Oral contraceptives, disulfiram, cimetidine, norfloxacin and ciprofloxacin reduce the metabolism of caffeine in the liver, which slows down its excretion and increases the concentration in the blood.

Drotaverine, which is part of Pentalgin, can weaken the anti-Parkinsonian effect of levodopa.

Hydantoin-derived anticonvulsants (especially phenytoin), barbiturates, and primidone may increase metabolism and increase clearance of caffeine.

At simultaneous application other drugs that stimulate the central nervous system, or the use of caffeinated drinks, excessive stimulation of the central nervous system is possible.

Pheniramine - one of the active ingredients of Pentalgin - when interacting with ethanol, monoamine oxidase inhibitors, tranquilizers and sleeping pills enhances the inhibitory effect on the central nervous system.

With the simultaneous use of ethanol, tricyclic antidepressants, barbiturates or rifampicin, the risk of toxic effects on the liver increases, so such combinations should be avoided.

Another active substance Pentalgin - naproxen - can reduce the diuretic effect of furosemide, increase the effect of indirect anticoagulants, increase the toxicity of methotrexate and sulfonamides, reduce the excretion of lithium and increase its concentration in blood plasma.

Ethanol taken during treatment with Pentalgin increases the risk of developing acute pancreatitis. Inhibitors of microsomal oxidation (for example, cimetidine) reduce the likelihood of hepatotoxic effects of paracetamol.

Pentalgin's analogs

1. Paracetamol.
2. Ibuprofen.
3. Plivalgin.
4. Pentalgin Plus.
5. Pentalffen.
6. Pentamialgin.
7. Analgin.
8. Cardiomagnyl.
9. Sedalgin.
10. Amizon.
11. Pentalgin FS.

Holiday conditions and price

The average cost of Pentalgin (tablets No. 4) in Moscow is 90 rubles. Green tablets can be purchased at the pharmacy without a prescription. Other forms - according to the recipe.

Tablets should be kept in a cool, dark place out of the reach of children. The expiration date is indicated on the package, do not use the drug after the expiration of this period.

Name:

Pentalgin (Pentalgin)

Pharmacological
action:

Pentalgin - combined analgesic, antipyretic and anti-inflammatory drug.
The composition of the drug includes 5 active ingredients, pharmacological properties which determine the pharmacological properties of the drug Pentalgin:

- paracetamol and metamizole sodium- non-selective non-steroidal anti-inflammatory drugs with a pronounced antipyretic and analgesic effect, metamizole sodium also has a pronounced anti-inflammatory effect.
The mechanism of action of these substances based on their ability to inhibit the synthesis of prostaglandins by inhibiting the enzyme cyclooxygenase;

- phenobarbital- has a pronounced antispasmodic, muscle relaxant and sedative activity, enhances the therapeutic effects of non-steroidal anti-inflammatory drugs;

- codeine – medicine group of narcotic analgesics, reduces the excitability of the cough center, has an analgesic effect.
At therapeutic doses does not cause depression of the respiratory center and does not affect the secretory activity of the bronchi.
With frequent use of codeine, as well as taking large doses, the development of drug dependence is possible.
Helps enhance action sedative and non-steroidal anti-inflammatory drugs;

- caffeine- stimulates the central nervous system, prevents the development of collapse, enhances therapeutic effects paracetamol and metamizole sodium.
After oral administration, the active components of the drug are well absorbed in the gastrointestinal tract.

Metamizole sodium biotransformed in the walls of the intestine, unchanged substance in the bloodstream is not detected.
The degree of communication of the active metabolite of metamizole with plasma proteins reaches 50-60%. Metabolized in the liver, is excreted mainly by the kidneys in the form of pharmacologically active and inactive metabolites.

Paracetamol has a high degree association with plasma proteins.
Paracetamol and caffeine are metabolized in the liver are excreted primarily by the kidneys as metabolites. The elimination half-life of paracetamol is 1 to 4 hours.

Phenobarbital is metabolized in the liver, is an inducer of microsomal liver enzymes. It is excreted mainly by the kidneys in the form of metabolites, the half-life is about 3-4 days.

Codeine penetrates well through the blood-brain barrier, accumulates in the body, mainly the accumulation of codeine is observed in adipose tissue, lungs, liver and kidneys. hydrolysis of codeine under the action of tissue esterases, after which conjugation with glucuronic acid occurs in the liver.
Metabolites of codeine have analgesic activity.
It is excreted mainly by the kidneys in the form of metabolites, some part is excreted in the bile.

Indications for
application:

Pain syndrome of various origins, including pain in the joints, muscles, sciatica, algomenorrhea, neuralgia, toothache, headache (including due to spasm of cerebral vessels);
- pain syndrome associated with spasm of smooth muscles, incl. with chronic cholecystitis, cholelithiasis, postcholecystectomy syndrome, renal colic;
- post-traumatic and postoperative pain syndrome, incl. accompanied by inflammation;
- colds, accompanied by febrile syndrome (as a symptomatic therapy).

Mode of application:

A drug take orally, the tablet is recommended to be swallowed whole, without chewing or crushing, washing down necessary quantity water.
Should be respected interval of at least 4 hours between doses of the drug.
The duration of the course of treatment and the dose of the drug determined by the attending physician individually for each patient.

Adults and teenagers over the age of 12:
- with acute short-term pain syndrome usually prescribed 1 tablet of the drug once;
- with prolonged pain syndrome, which is accompanied by various diseases musculoskeletal system and nervous system, usually prescribed 1 tablet of the drug 1-3 times a day.
The maximum duration of the course of treatment is 5 days, unless otherwise prescribed by the attending physician;
- as an antipyretic agent, 1 tablet of the drug is usually prescribed 1-3 times a day. The maximum duration of the course of treatment is 3 days, unless otherwise prescribed by the attending physician.

Maximum daily dose the drug is 4 tablets.
At long-term use drug may develop drug dependence.

If it is necessary to use the drug for more than 7 days in a row, it is necessary to monitor liver function and the morphological composition of the blood.

Side effects:

allergic reactions:
- skin rash, itching;
- urticaria, angioedema.
From the hematopoietic system:
- thrombocytopenia, leukopenia;
- agranulocytosis, anemia, methemoglobinemia.

From the side of the central nervous system:
- agitation, anxiety, increased reflexes;
- tremor, headache, sleep disorders;
- dizziness, decreased concentration.

From the side of the cardiovascular system: palpitations, arrhythmias, increased blood pressure.
From the side digestive system :
- erosive and ulcerative lesions of the gastrointestinal tract, nausea, vomiting;
- epigastric discomfort, abdominal pain, constipation;
- impaired liver function.

From the urinary system: impaired renal function.
From the sense organs:
- hearing loss, tinnitus;
- promotion intraocular pressure in patients with angle-closure glaucoma.
Other: dermatitis, tachypnea (rapid breathing).

If any of the side effects indicated in the instructions are aggravated, or the patient notes any other side effects not indicated in the instructions, he should inform the doctor about this.

Contraindications:

Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);
- gastrointestinal bleeding;
- complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history);
- severe liver failure;
- severe renal failure;
- inhibition of bone marrow hematopoiesis;
- condition after coronary artery bypass grafting;
- severe organic diseases of the cardiovascular system (including acute myocardial infarction);
- paroxysmal tachycardia;
- frequent ventricular extrasystole;
- severe arterial hypertension;
- hyperkalemia;
- pregnancy;
- lactation period (breastfeeding);
- children and adolescents up to 18 years;
- Hypersensitivity to the components of the drug.

Should be used with caution drug in patients with:
- cerebrovascular diseases, diabetes mellitus;
- diseases of peripheral arteries;
- ulcerative lesions of the gastrointestinal tract in history;
- with renal and hepatic insufficiency of mild or moderate severity;
- viral hepatitis, alcoholic liver disease;
- benign hyperbilirubinemia (Gilbert, Dubin-Johnson and Rotor syndromes);
- epilepsy, with a tendency to convulsive seizures;
- deficiency of glucose-6-phosphate dehydrogenase;
- in elderly patients.
In the presence of any of the listed diseases and conditions the patient should consult a doctor before using the drug.

The use of the drug is contraindicated:
- during pregnancy and lactation (breastfeeding);
- with severe liver failure;
- with severe renal failure.
- children and adolescents under 18 years of age.

FROMshould be avoided simultaneous use of the drug Pentalgin with other drugs containing paracetamol and / or NSAIDs, as well as with drugs to relieve the symptoms of colds, flu and nasal congestion.

When applied drug Pentalgin more than 5-7 days peripheral blood parameters and the functional state of the liver should be monitored.
Paracetamol distorts the results of laboratory studies of glucose and uric acid in blood plasma.
If it is necessary to determine 17-ketosteroids, Pentalgin® should be canceled 48 hours before the study. Note that naproxen increases bleeding time.

The effect of caffeine on CN C depends on the type of nervous system and can be manifested by both excitation and inhibition of higher nervous activity.
During treatment, the patient should avoid drinking alcohol.

In some cases possible loss of concentration and the speed of psychomotor reactions, therefore, during the treatment period, the patient should be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Interaction
other medicinal
by other means:

While taking the drug Pentalgin with barbiturates, tricyclic antidepressants, rifampicin, ethanol increased risk of hepatotoxicity(These combinations should be avoided).

Paracetamol enhances the effect anticoagulants of indirect action and reduces the effectiveness of uricosuric drugs.
Prolonged use of barbiturates reduces the effectiveness of paracetamol.
With the simultaneous use of paracetamol with ethanol increases risk of acute pancreatitis.
Inhibitors of microsomal oxidation (including cimetidine) reduce the risk of hepatotoxic action of paracetamol.

Diflunisal increases the plasma concentration of paracetamol by 50%, which increases the risk of hepatotoxicity.

Naproxen is capable cause a decrease in the diuretic effect of furosemide, an increase in the effect of indirect anticoagulants, increases the toxicity of sulfonamides and methotrexate, reduces the excretion of lithium and increases its concentration in the blood plasma.

With the combined use of caffeine and barbiturates, primidone, anticonvulsants (hydantoin derivatives, especially phenytoin) possible increase in metabolism and increased clearance of caffeine.
With the simultaneous use of caffeine and cimetidine, oral contraceptives, disulfiram, ciprofloxacin, norfloxacin - decreased metabolism caffeine in the liver (slowing its excretion and increasing the concentration in the blood).

Simultaneous use of caffeinated drinks and other drugs that stimulate the central nervous system, can lead to overstimulation of the CNS.

With simultaneous use, drotaverine can weaken the anti-Parkinsonian effect of levodopa.
With the simultaneous use of pheniramine with tranquilizers, hypnotics, MAO inhibitors, ethanol may increase the inhibitory effect on the central nervous system.

Pregnancy:

A drug contraindicated for use during pregnancy.
If necessary, the use of the drug during lactation should decide on the interruption of breastfeeding.

Overdose:

Symptoms:
- pale skin, anorexia (lack of appetite);
- abdominal pain, nausea, vomiting, gastrointestinal bleeding;
- agitation, restlessness, confusion;
- tachycardia, arrhythmia, hyperthermia (increased body temperature);
- frequent urination, headache, tremors or muscle twitches;
- epileptic seizures, increased activity of hepatic transaminases;
- hepatonecrosis, increased prothrombin time.

Symptoms of liver dysfunction may appear 12-48 hours after an overdose.
For severe overdose develops liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis; arrhythmia, pancreatitis.
If you suspect an overdose, you should immediately seek medical help..

Treatment: gastric lavage followed by activated charcoal.
The specific antidote for paracetamol poisoning is acetylcysteine.
The introduction of acetylcysteine ​​is relevant for 8 hours after taking paracetamol.

For gastrointestinal bleeding it is necessary to introduce antacids and gastric lavage with an ice-cold 0.9% sodium chloride solution; maintenance of lung ventilation and oxygenation; with epileptic seizures - in / in the introduction of diazepam; maintaining fluid and salt balance.

Release form:

Tablets Pentalgin, film-coated, 2, 4, 6, 10, 12, 20 or 24 pcs.
Tablets Pentalgin-IC
Tablets Pentalgin-ICN 12 pieces in a blister, 1 blister in a carton.
Tablets Pentalgin-FS 10 pieces in a blister, 1 blister in a carton.
Tablets Pentalgin FS Extra in a blister pack 10 pcs., in a carton pack 1 or 2 packs or 12 pcs., in a carton pack 1 pack.
Tablets Pentalgin-N in a blister pack 10 pcs., in a box 1 or 2 packs.

Storage conditions:

The drug is recommended to be stored in a dry, protected from direct sunlight place at a temperature not exceeding 25 degrees Celsius.
Best before date regardless of the form of release - 3 years.
The drug is approved for use as non-prescription drugs.

1 tablet of the drug Pentalgin-IC contains:
- metamizole sodium - 300 mg;
- paracetamol - 200 mg;
- caffeine - 20 mg;
- phenobarbital - 10 mg;
- codeine phosphate - 9.5 mg (in terms of codeine - 7 mg);
Excipients: potato starch, calcium stearate, edible gelatin.

1 tablet of the drugPentalgin-ICN contains:
- metamizole sodium - 300 mg;
- paracetamol - 300 mg;
- caffeine - 50 mg;
- phenobarbital - 10 mg;
- codeine phosphate - 8 mg.
Excipients: potato starch, povidone (low molecular weight medical polyvinylpyrrolidone), stearic acid, calcium stearate.

1 tablet of the drug Pentalgin-FS contains:
- metamizole sodium - 300 mg;
- paracetamol - 300 mg;
- caffeine - 50 mg;
- phenobarbital - 10 mg;
- codeine phosphate - 8 mg.
Excipients: potato starch, polyvinylpyrrolidone, stearic acid, calcium stearate.

1 tablet Pentalgin FS Extra contains:
- metamizole sodium and paracetamol 0.3 g each;
- caffeine - 0.05 g;
- codeine phosphate - 0.008 g;
- phenobarbital - 0.01 g.
Excipients: starch, talc, calcium stearate.

1 tablet Pentalgin-N contains:
-naproxen - 100 mg;
- metamizole sodium - 300 mg;
- codeine - 8 mg;
- caffeine - 50 mg;
- phenobarbital - 10 mg.
Excipients: potato starch, low molecular weight polyvinylpyrrolidone (povidone), sodium citrate, magnesium stearate.