Pentalgin green tablets instruction. Pentalgin

When pain occurs, a person is looking for a drug that can quickly stop discomfort and restore full functioning. "Pentalgin" is one of the common analgesics offered in pharmacies. It is important to consider what kind of pain the drug helps, what effect it has on the human body, and when its use is undesirable.

Form of release of the drug and its composition

The drug "Pentalgin" is a coated tablet. It is considered a combination drug, as it contains several ingredients.

Tablets "Pentalgin" consist of such active substances(in parentheses is the dosage in one tablet, mg):

paracetamol (325);
naproxen (100);
caffeine (50);
drotaverine hydrochloride (40);
pheniramine maleate (10).

In addition to the main active ingredients, the core of the tablets and the shell itself includes other ingredients. However, they do not provide any therapeutic effect. It is the 5 aforementioned medicinal compounds that are considered active substances.

The drug is packaged in cell membranes and cardboard boxes. In each, in addition to the drug itself, there is detailed instructions on the use of the remedy.

Pharmacological properties of the drug "Pentalgin"

The drug "Pentalgin" - combined remedy, which has an antispasmodic effect and has an anti-inflammatory and antipyretic effect. The effect of the drug is due to the reaction of the substances that make up the composition.

Important take a closer look at how each component works medicinal product.

Properties of the drug by active substances

Paracetamol. This active ingredient helps to improve well-being during viral infection. The medicine helps to eliminate pain, has an antipyretic effect. Paracetamol is used as part of complex therapy in the treatment of infectious diseases. Pain disappears by blocking the production of cyclooxygenase in the central nervous system, and by influencing the thermoregulation centers in the brain.

It is a non-steroidal anti-inflammatory drug that has antipyretic and analgesic effects. The drug also has an effect on the production of cyclooxygenase, due to which unpleasant symptoms and relief comes. It also suppresses the production of prostaglandins - stimulants inflammatory processes.

This component of the drug "Pentalgin" increases the effect of the use of other means. Slightly expand blood vessels. A person experiences a surge of strength, weakness and drowsiness disappear. Caffeine has a psychostimulating effect, so it tones and improves well-being.

Drotaverine hydrochloride. This component helps to eliminate spastic pain due to a relaxing effect. Under the action of the drug fall smooth muscle fibers. That is why the drug helps with pain in internal organs, namely - in the gallbladder and bladder, uterus.

This substance, contained in the Pentalgin tablet, has an antihistamine effect, has a mild sedative and relaxing effect. The component increases the activity of paracetamol and helps to eliminate swelling and spasm.

Indications for the use of the drug

The drug "Pentalgin" is prescribed to relieve pain of various etiologies. The drug is prescribed for such conditions or diseases:

pain in the teeth;
menstrual pain;
headache;
pain syndrome in the joints;
radiculitis;
neuralgia;
spastic pains;
attack cholelithiasis;
renal or hepatic colic;
migraine.

"Pentalgin" for pain is also used in postoperative periods. Often at this time the patient is haunted strong pain, inflammatory processes are possible. The drug greatly facilitates the healing process and improves the well-being of a person.

Pentalgin is also prescribed for fever and colds. These tablets perform auxiliary functions to the main therapy and eliminate fever and pain in the muscles, aches.

The drug is dispensed from a network of pharmacies without prescriptions. Independent single use of "Pentalgin" is allowed provided there are no contraindications. If the drug must be taken for a long time, in a course, it is not recommended to do this without the recommendation of the attending physician.

Rules for the use of the drug and dosage

The drug "Pentalgin" is taken entirely in the form of a tablet. It is not chewed, but swallowed whole. You should not crush the tablet into several doses - it is important to maintain the integrity of the shell. Medicine should be taken necessary quantity drinking water. The duration of treatment can be individual, as much depends on the patient's well-being, the indications for which the drug is used.

Medicinal medication "Pentalgin" is not recommended for the treatment of children. To reduce negative impact tablets, the drug is prescribed to patients over 12 years of age.

In the event of sudden pains that are not associated with any pathology requiring planned treatment, Pentalgin tablets are taken once, one at a time. If you want to re-admission, it is important to withstand at least 4 hours, and only then take the second pill.

Prolonged pain syndromes require systemic use medication. In the treatment of the musculoskeletal system, the drug is taken no more than 5 days on a tablet up to three times a day.

For elimination elevated temperature body and conditions associated with colds, Pentalgin is taken no more than 3 days. The medication can also be drunk 3 times a day, 1 tablet.

Specific dosages can be found by visiting a specialist. Do not exceed daily maximum dose medicinal product - 4 tablets. When therapy is carried out for a long time, medical supervision and periodic testing are important.

Contraindications

However, the drug "Pentalgin" can not always be taken. There are contraindications that must be taken into account.

Tablets "Pentalgin" can not be taken with such phenomena:

during periods of exacerbations of chronic diseases of the digestive system;
stomach and duodenal ulcer;
hypersensitivity to the components of the drug;
bronchospasm;
bronchial asthma;
nasal polyps;
damage to the kidneys and liver, accompanied by insufficiency;
arrhythmic manifestations;
tendency to bleed;
stable hypertension;
severe vascular disorders;
hyperkalemia;
surgical interventions on the aorta;
allergic reactions to aspirin or other drugs from the NSAID category.

It is forbidden to treat children under 12 years of age, since there is no data on how Pentalgin tablets act on young patients.

With caution, a medicinal pain reliever is prescribed to older patients, after 65 years. Negative effects may occur during the treatment of "Pentalgin" persons with epilepsy, diabetes and chronic pathologies liver and kidneys.

It is forbidden to use "Pentalgin" during pregnancy, as complex composition the drug may cause harm to the fetus. It is contraindicated to drink this medicine for women who are breastfeeding.

Possible adverse reactions

During treatment with Pentalgin tablets, the following side effects may develop:

skin itching and rash;
nausea and vomiting;
pain in the epigastric zone;
stool disorders;
changes in the composition of the blood;
loss of appetite;
hand tremor;
dizziness;
insomnia;
arrhythmic phenomena;
angioedema shock;
noise in ears.

If in the course of treatment there are any negative reactions It is important to inform the doctor about this. He will be able to choose a drug that has a similar effect and does not cause unpleasant symptoms.

Overdose reaction

An overdose of the drug can cause severe conditions requiring medical supervision. When using large doses with no assistance, it is possible fatal outcome. Signs of overdose occur 5 days after the use of increased doses.

Overdose symptoms are:

pain in the abdomen;
nausea and vomiting like "coffee grounds";
confusion;
lethargy and drowsiness;
increased excitability;
epileptic seizures;
heavy liver failure.

With an overdose of Pentalgin, the symptoms develop gradually. If a person mistakenly took a large number of tablets, it is necessary to provoke vomiting, wash the stomach, give enterosorbents and immediately contact a medical facility.

"Pentalgin" has an antidote. This is acetylcysteine. Apply it or not, decide after assessing the condition of the person. As a rule, therapy is symptomatic. The introduction of an antidote makes sense if no more than 8 hours have passed since the overdose.

Seizures are possible intestinal bleeding, respiratory disorders. Most of these conditions require careful medical supervision.

Analogues of the drug "Pentalgin"

The drug "Pentalgin" has many analogues, since analgesics and antipyretics are used very often. Instead of this drug, the following medicines are used:

"Pentamialgin";
"Plivalgin";
"Pentalffen".

Some of the above tablets contain narcotic components, so they are only available from pharmacies by prescription. If such a drug was prescribed by a doctor, there will be no problems with its acquisition.

By following the manufacturer's instructions and avoiding the uncontrolled use of drugs, a person can save his life and health.

To date, pharmacological companies produce several varieties of the Pentalgin drug - the composition of the medicines varies depending on the full name. The effectiveness of each of the drugs is evaluated in accordance with the causes that cause pain.

Composition of Pentalgin tablets

The type of pain reliever in question is the only one available without a prescription. Its formula has recently been improved in such a way as to eliminate pain not only due to inflammation and nervous tension but also due to vascular spasms.

The new or green Pentalgin has a composition without codeine and:

naproxen;
drotaverine;
paracetamol;
pheniramine maleate;
anhydrous caffeine.

The combination of these 5 components provides antispasmodic, anti-inflammatory, analgesic and mild antipyretic effect.

It is important to note that the possibility of over-the-counter purchase of such Pentalgin does not preclude the need to consult with your doctor. The fact is that the ingredients of the drug produce a lot of negative side effects especially for the digestive and of cardio-vascular system. Moreover, the content of caffeine in high concentration provokes an increase blood pressure, which is unacceptable for people suffering from hypertension.

Composition of Pentalgin Plus

This type of drug differs in the content of an additional analgesic - propyphenazone. This ingredient has a low anti-inflammatory activity, but has pronounced analgesic and antipyretic properties. The combination with the rest of the components of the drug allows you to achieve the fastest possible effect even with a very strong pain syndrome.

Full composition:

codeine phosphate;
phenobarbital;
caffeine;
propyphenazone.

As a rule, the described type of Pentalgin is prescribed for diseases and injuries of the joints, muscles, nerve infringement, toothache and headache. Sometimes it is used to relieve the symptoms of a febrile syndrome.

Composition of Pentalgin-ICN

The presented form of the line of analgesics refers to painkillers of high intensity. The combination of active chemical compounds provides stable and rapid relief of pain even in chronic diseases of the cardiovascular and nervous system. Pentalgin-ICN successfully eliminates clinical manifestations migraines, spasms of smooth muscles.

The drug consists of the following ingredients:

metamizole sodium;
codeine phosphate;
paracetamol;
caffeine;
phenobarbital.

Like the previous version of Pentalgin, the medicine in question is dispensed only with a prescription issued by a doctor.

Composition of Pentalgin N or Neo

Last form medication made without paracetamol. Such Pentalgin has excellent antispasmodic and analgesic properties, but has a less pronounced anti-inflammatory and antipyretic activity. This is due to the inclusion in the composition of naproxen, a non-steroidal substance with high pain relief indicators.

What Pentalgin is made of and can it help with pain different types, why the “ideal painkiller” is dangerous, how Pentalgin in the form of a gel is similar to Pentalgin in tablets (spoiler: nothing) and what side effects can await those taking this drug, we tell in the new issue of the “What they treat us” column.

Imagine that you took a whole handful of different painkillers (okay, not whole pills, but only their pieces, but three different types) along with half an allergy pill, and then washed it down with a cup of coffee. Sound dangerous? But you just took Pentalgin, which is traditionally in the top 20 best-selling drugs according to the DSM-Group. All drugs that overtook him this October have already become the heroes of our rubric, and Pentalgin has so far passed this cup. We're fixing it.

From what, from what

Let's start with the most interesting. Pentalgin contains paracetamol, drotaverine, naproxen, pheniramine and caffeine. The latter is in a 50 mg tablet, as in a small cup of brewed coffee (or in a teaspoon with a slide of instant coffee). The site of the drug indicates that the last two components “enhance” the action of the others, so there are fewer of them in Pentalgin. Let's check it out.

In one tablet of paracetamol from 200 to 500 mg of the active substance, in a tablet of Pentalgin paracetamol there will be 325 mg. Naproxen is available in the form of tablets of 200, 375 and 500 mg, in a Pentalgin tablet it is 100 mg. Drotaverine is known as the main active ingredient of the popular drug for pain and spasms No-shpa (you can read a separate one on the site), and in one tablet of this medicine there is the same active ingredient as in Pentalgin, 40 mg. Pheniramine in Pentalgin 10 mg, which is about 2.5 times less than a single dose for adults.

Structure of paracetamol

Naproxen structure

Ccroberts/Wikimedia Commons

The structure of drotaverine

Structure of pheniramine

Denwet/Wikimedia Commons

Structure of caffeine

Jynto/Wikimedia Commons

Structure of paracetamol

Benjah-bmm27/Wikimedia Commons

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Structure of paracetamol

Benjah-bmm27/Wikimedia Commons

Naproxen structure

Ccroberts/Wikimedia Commons

The structure of drotaverine

MarinaVladivostok/Wikimedia Commons

Structure of pheniramine

Denwet/Wikimedia Commons

Structure of caffeine

Jynto/Wikimedia Commons

Thus, Pentalgin combines two different anti-inflammatory and painkillers, an antispasmodic (a drug for pain associated with spasms), and two, as stated on the website of the drug "amplifier" of their action. Among them are the familiar caffeine and pheniramine. The second refers to blockers of H1-histamine receptors, which are involved in the development of many disease states: allergies and urticaria, blood stasis in capillaries and edema, burns and anaphylactic shock.

This allows you to prescribe it rather against the “congestion” of the nose during colds and against allergies, rather than to “strengthen” the same paracetamol. There is even a study (though only on 16 patients) that caffeine helps with pheniramine-induced drowsiness and sluggishness.

The compatibility of pheniramine and paracetamol was devoted to an entire Cochrane review. However, he proves the relief of cold symptoms with this combination of drugs. The manufacturers themselves do not recommend taking Pentalgin for colds, so we can only conclude that the combination of these two substances is relatively safe to use, although it causes more side effects than either of them separately.

Cochrane Library - database of international non-profit organization Cochrane Collaboration, which contributes to the development of World Health Organization guidelines. The name of the organization comes from the name of its founder, the 20th century Scottish medical scientist Archibald Cochrane, who advocated the need evidence-based medicine and holding competent clinical trials and wrote the book Efficiency and Efficiency: Random Reflections on Public Health. Medical scientists and pharmacists consider the Cochrane Database one of the most authoritative sources of such information: the publications included in it have been selected according to the standards of evidence-based medicine and report the results of randomized, double-blind, placebo-controlled clinical trials.

The same cannot be said about the entire set of Pentalgin components: in international base medical articles PubMed does not have a single clinical trial where all these substances are tested together.

In the lists (not) appeared

Paracetamol has not caused doubts among specialists about its effectiveness for a long time, although the mechanism of its action is still not fully known. Despite this, it is on the list of essential medicines of the World Health Organization. Numerous studies confirm its effectiveness against migraines and other types of pain, and it can also act as an antipyretic (although, according to a Cochrane review, it is a big question whether it is given to children against fever). According to a review in the journal Anestasia and Analgesia concerning pain after surgical operations, in combination with non-steroidal anti-inflammatory drugs, the analgesic effect of paracetamol is enhanced.

However, paracetamol has side effects. The most serious of them, according to the Food and Drug Administration food products drugs, or the FDA) is the harm that paracetamol can cause to the liver. Especially it increases with an overdose and the use of alcohol.

Another component of Pentalgin - naproxen - has also shown to be effective as an analgesic: for example, in a study published in The Journal of Headache and Pain, naproxen was about as effective as the combination of paracetamol with caffeine. According to one Cochrane review, naproxen is not very good for headaches, however, another review says that it can significantly reduce pain after surgery in about half of patients.

But, like all non-steroidal anti-inflammatory drugs to which it belongs, naproxen has two main lines of dangerous side effects. The first is associated with an increased risk of bleeding in the gastrointestinal tract, because the "target" of naproxen at the same time works to protect the mucous membrane of this organ. The second is with an increased risk of thrombosis, heart attacks and strokes. However, according to a meta-analysis published in The Lancet, naproxen has a lower risk of side effects on average than other non-steroidal anti-inflammatory drugs.

Drotaverine is known to be an antispasmodic. This means that it fights specific types of pain - namely, pain caused by smooth muscle spasms, such as muscle Bladder, bile ducts and intestines, and can also help relieve pain from renal colic cholecystitis and painful periods. However, there are not very many flawless studies of this drug in large samples of patients (we discussed them in detail in the article about with the same active ingredient).

Pentalgin and Fastum-gel: what is common

If for some drugs many forms and indications for one active substance are the norm (although not always laudable), the situation is different with Pentalgin. In addition to the usual tablets, it also exists in the form of a gel, but in this case there is only one main component - ketoprofen. It has nothing to do with the active ingredients of another form of release of this medicine. However, ketoprofen belongs to the same group of substances as naproxen - non-steroidal anti-inflammatory drugs. The main indications for the use of a gel with ketoprofen (which is also the main component, the properties of which we have already analyzed) are acute and chronic diseases musculoskeletal system, muscle pain(including rheumatism) and post-traumatic inflammation of soft tissues.

Ketoprofen

MarinaVladivostok/Wikimedia Commons

Gel Pentalgin is safer in terms of side effects, because its bioavailability is only 5%, that is, a very small amount of the active substance enters the bloodstream.

The topical efficacy of ketoprofen has been tested in multiple double-blind, randomized controlled trials.

Double-blind, randomized, placebo-controlled method - method clinical trial drugs, in which the subjects are not initiated into important details ongoing research. “Double-blind” means that neither the subjects nor the experimenters know who is being treated with what, “randomized” means that the distribution into groups is random, and placebo is used to show that the effect of the drug is not based on self-hypnosis and that this medicine helps better than a pill without active ingredient. This method prevents subjective distortion of the results. Sometimes the control group is given another drug with already proven efficacy, rather than a placebo, to show that the drug not only treats better than nothing, but also outperforms analogues.

In summary, the authors of the 2016 Cochrane Review, which included all such trials, concluded that the quality of evidence for the drug's efficacy against osteoarthritis was moderate. This means that it most likely works, although further research may change the opinion of the authors.

When taken orally, Ketoprofen is also effective against some types of pain, but we will not discuss this in detail in the hope that you will not eat the gel with it.

site warns: may help with pain, but there are also side effects

Five active components Pentalgin tablets are not a myth, but neither are substances uniquely invented specifically for this brand. One of them is, in fact, No-shpa, the other is paracetamol, the third is naproxen. In addition, Pentalgin has caffeine and pheniramine, a remedy for swelling of the mucous membranes and allergies, to “enhance” Pentalgin. And these substances are effective separately. However, it is difficult to create an ideal pill for all types of pain and forget about ailments forever. The interaction of these substances in such a combination has not been thoroughly studied, and there are no clinical trials on this topic in peer-reviewed English-language scientific journals.

But if you decide to still take Pentalgin, you need to pay attention to several important points. First, all its components have not been studied together, although individually (and sometimes in pairs) they have shown their effectiveness. Second, every drug on this list has side effects that can be quite serious. Whether they are enhanced by combining these substances, no one knows. Thirdly (and this applies to all painkillers), do not forget that, of course, you can drown out any pain with pills and return to comfort, but this approach will not help you recover, but only mask the symptoms, so if the pain is constant, you should find out the cause and try to defeat her, rather than risk the accumulation of dangerous concentrations of drugs in the body.

Therefore, Petalgin should not be taken by people with diseases of the cardiovascular system, problems with the liver and kidneys, ulcers gastrointestinal tract. Manufacturers prudently banned its use in children under 18 years of age, as well as pregnant and lactating women, since its safety has not been proven for them.

The good news is that in the case of Pentalgin brand gel, an overdose of non-steroidal anti-inflammatory drugs is unlikely to threaten you: after all, with topical application Ketoprofen does not enter the bloodstream as actively as a swallowed tablet, and manufacturers do not combine it in a gel with other drugs of the same group, which does not increase the risk of developing dangerous side effects. Other Excipients(for example, pepper tincture) in this gel can act as a warming agent. In terms of effectiveness, it can be concluded that the gel is likely to help.

"Pentalgin" is an anesthetic drug. Prescribed for all kinds of pain syndromes, colds, painful menstruation. It is also used for migraine, toothache, nervous conditions. Such extensive range The possibilities of the drug are explained by the fact that it includes 5 active ingredients at once. How and to whom you can use this drug, you can find out from the instructions for use.

Compound

Main medicinal substances are (mg):

Paracetamol (324.83);
Caffeine (40);
Naproxen (90);
Pheniramine (15);
Drotaverine (35).

Also included are:

Croscarmellose sodium (321);
Starch (55.40);
Hyprolose (32.65);
Yellow acid (2);
Povidone (3.65);
As well as minor inclusions of other components.

Release form

Sold in cell packs, 2-12 tablets per pack.

Producing countries:

Belmedpreparaty (Belarus);
Tomskhimfarm (Russia).

International name: Pentalgin.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 23°C.

Dosage

Take one tablet after meals. You can take no more than 4 pieces of the drug per day.

Doses cannot be increased. If there is no improvement, you should immediately consult a doctor.

Indications

Indications for use:

Pentalgin for cough

Suitable for treating cough, but only as aid. Take 2-3 tablets daily after meals. It is forbidden to use the drug for more than 3 days. Before use, you should consult with your doctor.

Pentalgin for migraine

Pentalgin will help with migraines, but this is too strong a drug. For headaches, it is better to use No-Shpu or Tamipul. It is advisable to consult a neurologist. It should also be understood that not everyone various reasons may be suitable for this drug.

Pentalgin for toothache

The duration of the course depends on the complexity of the situation. It is advisable not to consume more than 1 tablet per day. The duration of treatment is 3 days. Should only be used as directed by a dentist.

Pentalgin and alcohol

The use of alcohol is strictly prohibited. The effect of the substance phenobarbital is enhanced, which can cause nervous disorders, coma of the brain (extremely rare). Also, the combination of alcohol and 5 active substances at once (codeine, caffeine, naproxen, metamizole sodium and phenobarbital) negatively affects the functioning of the liver and kidneys.

Pentalgin during pregnancy

The use of Pentalgin is prohibited during pregnancy. You can not use the drug and when breastfeeding. Active substance codeine can get into the fetus, which will cause various defects and complications. It is also possible addiction to the drug.

Pentalgin during menstruation

With painful monthly periods, Pentalgin can be used. Most women and girls are advised to take this drug in critical days. However, if the pain is not very strong, it is better to take No-Shpu or any other painkiller, since Pentalgin is a fairly strong drug. This drug should only be used in extreme cases.

How does Pentalgin work?

Pentalgin consists of 5 active substances, which determine its effectiveness:

Naproxen. A substance of the propionic acid type. It acts antipyretic and analgesic. It is used in the treatment of arthritis and other rheumatic ailments, diseases of the musculoskeletal system, as well as dysmenorrhea and severe gout.
Drotaverine hydrochloride. Myotropic antispasmodic. By chemical structure and pharmacological properties similar to papaverine, but has a stronger and longer lasting effect.
Paracetamol. It is a common central non-narcotic analgesic, which has rather weak anti-inflammatory properties. Antipyretic and analgesic action.
Caffeine. It is a psychostimulant. Caffeine can be found in plants such as coffee tree, cocoa, mate, guarana, cola. Normalizes blood circulation, raises the tone.
Pheniramine maleate. Penetrating into the body, the substance goes along with the blood flow. Its highest concentration is fixed an hour after consumption. Soothes, has an analgesic effect.

Contraindications

Pentalgin, like others medicines has a lot of contraindications. It:

Pentalgin should be taken with extreme caution by those who have:

Diabetes;
epilepsy.

Side effects

Overdose

Symptoms:

If you notice one of these symptoms, you should immediately consult a doctor. This is especially true for the elderly.

Gastric lavage followed by activated carbon within 5 days (minimum);
The introduction of acetylcysteine;
Use antacids.

Treatment - only after examination and according to the doctor's recommendations.

Other instructions

It is necessary to avoid the use of Pentalgin together with drugs that contain:

Paracetamol;
Barbiturates (reduce the effect of paracetamol);
Ethanol (increases the risk of pancreatitis).

These compounds increase the risk of hepatotoxic effects.

You should also avoid combining with:

Antidepressants;
Cold medicines (drops, antipyretics).

During treatment, you should be careful when driving. Pentalgin helps to reduce concentration. That is why it is better to refrain from long trips.

Price

The price of Pentalgin varies from 75 to 195 rubles. for one package. The drug is released without a prescription. Available in all pharmacies.