Trental analogues are cheap in tablets. Cheap analogues of trental: comparative characteristics and prices

When it is necessary to restore microcirculation, blood properties, one of the the best drugs- Trental, its analogues, by the way, are also quite accessible and well accepted by the body.

Main advantage this medicine is that it is very well absorbed and improves blood microcirculation in the body.

This drug saturates the blood with many useful elements, thereby improving rheological properties, lowers the level of viscosity and improves blood flow in those areas where blood circulation is disturbed.

Very often, this drug is prescribed for the formation of leg ulcers and gangrene. This medicine is very effective in the fight against atherosclerosis, ischemic stroke and post-stroke condition.

It can also be prescribed after frostbite and in cases where the process of functioning of the blood is disturbed in the patient's body or it changes its structure.

Often this drug is used in combination with other drugs that have the same functions and are used to normalize the properties and blood formula, as well as to expand coronary vessels person.

True, in such a situation, the attending physician especially carefully adjusts the dose. medicinal substance and regularly examines the level of hemoglobin and other substances in the patient's blood.

Trental is produced in the form of tablets and solution for injection.

For example, there is Trental 400 mg, and there are 100 mg tablets. Which drugs should be taken by a particular patient, the attending physician prescribes. How more difficult diagnosis, the more should be daily dose drug. Of course, the regularity of admission is determined individually depending on the indications of the patient.

In this case, the minimum dose is 400 mg per day, and the maximum dose is 1200 mg. The pills should be swallowed during or after a meal and washed down with plenty of water.

If the patient has impaired renal function or there is insufficiency in the functioning of the liver, then the dose should be adjusted taking into account the tolerability of the patient. this drug.

The same applies to patients who have reduced arterial pressure if the patient is at risk - people who may suffer from low blood pressure.

If a we are talking about injections, then in this case the drug must be administered intramuscularly.

When determining the dose of this drug, it is very important to consider the entire treatment regimen. For example, if the patient takes any other medications, then the total concentration of the constituent substance should not exceed the daily rate.

What are the analogues of the medical preparation?

Like any other drug, Trental has a number of analogues. The main analogues of Trental 400:

• Agapurin;
• Agapurin retard;
• Arbiflex;
• Vasonite;
• Pentamon;
• Pentilin;
• Pentilin forte;
• Pentohexal;
• Pentoxifylline;
• Pentomer;
• Radomin;
• Ralofect;
• Trenpental;
• Flexital.

These substitutes contain the same basic substance - pentoxifylline. Therefore, if Trental is taken together with drugs in which the concentration of this substance is higher than normal, then the dose must be adjusted.

The same applies to the use of analogue drugs; when prescribing, the doctor must adjust the daily dose depending on the composition of the drug.

• severe headaches;
• weakness and dizziness;
• state of anxiety;
• sleep disturbance;
• convulsions are noted;
• excessive rush of blood to the face and upper body;
• vomiting, diarrhea and many others.

Therefore, before you start taking the drug, the patient must always consult with his doctor and read the instructions for the drug. Especially carefully the treatment should be approached if the patient is a child. To date, the effect of the drug on children's body little studied by science.

What can replace the medical drug Trental?

But apart from medicines-analogues, this substance can be replaced and folk remedies. This question is often asked by people who suffer diabetes, tachycardia and other associated ailments. But it is worth saying right away that Trental is harmless for this category of patients and is allowed to be taken by patients with such an ailment.

Typically, Trental is prescribed in cases where patients have elevated level hemoglobin in the blood. Therefore, the main task of the patient is to reduce the level of hemoglobin in the blood by all accessible ways. For example, you can do this with special diet, which completely excludes the use of meat products, as well as bright red berries and fruits.

But in addition to the diet, the patient must strictly observe the daily routine. Should stop using sedatives and sleeping pills.

Hirudotherapy often helps with this diagnosis. But during treatment with leeches, it is necessary to strictly follow the schedule, you must not skip procedures, you must healthy lifestyle life and monitor the level of their nutrition.

It is necessary to check the level of hemoglobin in the blood. After all, as you know, self-treatment can both help and harm at the same time. It is worth remembering that in many cases, drugs that are taken without the supervision of a doctor can harm the patient's health. And if we are talking about traditional medicine, then this can happen even more so.

How to decide whether to take Trental or not?

Many patients do not always sensibly assess the situation with their health. Moreover, not everyone seeks help from a specialist in time. And even after this help is provided, the doctor's prescriptions are not always followed correctly.

If we talk about the effect of taking medications and using drugs traditional medicine, then it is a clear fact that drugs are much more effective than folk methods. Of course, no one argues that both treatments give positive result. But the recovery rate of a patient who takes medication prescribed by a doctor is much higher than that of a patient who is treated by his own methods.

It is known that in many cases the account goes on days and hours. Therefore, if the patient has sought the advice of a specialist, and the appropriate diagnosis has been established, then there is no need to delay the start of treatment. You should start taking the drugs immediately. You can additionally resort to traditional medicine, but it is better to be treated under the strict supervision of a doctor, otherwise you can only harm the state of your body. Treatment should also be in moderation. It is necessary to take any drug, like other methods of treatment, only under the strict supervision of a doctor.

What can replace Trental?

As you know, this drug costs a lot. Therefore, many patients are trying to find drugs that could replace this remedy. As mentioned above, the main constituent of this drug is pentoxifylline. Therefore, you can choose any other analogues, which include the same substance as in the above preparation. True, it is necessary to take into account the level of concentration of the latter in each individual drug. For example, there are more cheap analogue, which has the same name Pentoxifylline. They can replace Trantal. But only the attending physician can do this. If the patient himself tries to do this, then he can harm his health, and in some cases this harm will be incompatible with life.

It is worth remembering that in addition to the same components, all drugs have various additional components. And in some cases, they may be contraindicated for a particular patient.

Therefore, trying to save on your treatment, remember that life and health are at stake.

Another important advice, which is worth remembering: if the patient has any other illnesses internal organs, the intake of each drug must be specified in individually. And self-medication should be excluded.

This page contains a list of all Trental analogues by composition and indications for use. A list of cheap analogues, and you can also compare prices in pharmacies.

• The cheapest analogue of Trental:
• The most popular analogue of Trental:
• ATH classification: Pentoxifylline
• Active ingredients / composition: pentoxifylline

Cheap analogues of Trental

When calculating the cost cheap analogues Trental the minimum price was taken into account, which was found in the price lists provided by pharmacies

Popular analogues of Trental

The list of drug analogues based on the statistics of the most requested drugs

All analogues of Trental

Analogues in composition and indications for use

The above list of analogues of drugs, which indicates Trental substitutes, is the most suitable, since they have the same composition of active ingredients and match the indications for use

Different composition, may coincide in indication and method of application

To compile a list of cheap analogues of expensive drugs, we use the prices provided by more than 10,000 pharmacies throughout Russia. The database of drugs and their analogues is updated daily, so the information provided on our website is always up-to-date as of the current day. If you have not found the analogue you are interested in, please use the search above and select the medicine you are interested in from the list. On the page of each of them you will find everything possible options analogues of the desired medicine, as well as prices and addresses of pharmacies in which it is available.

How to find a cheap analogue of an expensive medicine?

Trental price

Trental instruction

Release form

Tablets, enteric film-coated.

Package

60 pcs per pack.

pharmachologic effect

Pharmacodynamics

A drug that improves microcirculation, an angioprotector, a xanthine derivative. Trental improves the rheological properties of blood (fluidity) by affecting the pathologically altered deformability of erythrocytes, inhibiting platelet aggregation and reducing increased viscosity blood. Improves microcirculation in areas of impaired circulation.

The mechanism of action of pentoxifylline is associated with the inhibition of phosphodiesterase and the accumulation of cAMP in vascular smooth muscle cells and blood cells.

Having a weak myotropic vasodilating effect, pentoxifylline somewhat reduces OPSS and slightly dilates the coronary vessels.

Treatment with Trental leads to an improvement in the symptoms of disorders cerebral circulation.

The success of treatment for occlusive lesions of peripheral arteries (for example, intermittent claudication) is manifested in lengthening the walking distance, eliminating nighttime cramps in calf muscles and the disappearance of pain at rest.

Pharmacokinetics

Suction

After oral administration, pentoxifylline is almost completely absorbed from the gastrointestinal tract.

Bioavailability averages 19%.

Metabolism

The main pharmacologically active metabolite 1-(5-hydroxyhexyl)-3,7-dimethylxanthine is determined in plasma at a concentration that is 2 times the concentration of the unchanged substance, and is in a state of reversible biochemical equilibrium with it. For this reason, pentoxifylline and its metabolite should be considered as an active whole, therefore, it can be considered that the bioavailability of the active substance is significantly higher. Pentoxifylline is completely biotransformed in the body.

breeding

T1 / 2 pentoxifylline is 1.6 hours.

More than 90% is excreted by the kidneys in the form of unconjugated water-soluble polar metabolites.

Pharmacokinetics in special clinical situations

In patients with severely impaired renal function, the excretion of metabolites is slowed down.

In patients with impaired liver function, an increase in T1 / 2 of pentoxifylline and an increase in its bioavailability were noted.

Indications

• Peripheral circulatory disorders of atherosclerotic origin (for example, intermittent claudication);
• diabetic angiopathy;
• trophic disorders (for example, leg ulcers, gangrene);
• disorders of cerebral circulation (consequences of cerebral atherosclerosis, such as impaired concentration, dizziness, memory impairment);
• ischemic and post-stroke conditions;
• circulatory disorders in the retina and choroid of the eye;
• otosclerosis;
• degenerative changes against the background of vascular pathology inner ear and hearing loss.

Contraindications

• Hypersensitivity to the components of the drug;
• massive bleeding;
• extensive hemorrhages in the retina;
• hemorrhage in the brain;
• acute infarction myocardium;
• age up to 18 years;
• pregnancy and lactation ( breast-feeding);
• hypersensitivity to other methylxanthines.

Caution should be used in patients with: serious violations heart rate(risk of worsening arrhythmia), arterial hypotension(risk of further decrease in blood pressure), chronic heart failure, with peptic ulcer stomach and duodenum, impaired renal function - CC less than 30 ml / min (risk of cumulation and increased risk development side effects), with severe liver dysfunction (risk of cumulation and increased risk of side effects), increased bleeding tendency, incl. as a result of the use of anticoagulants or in violation of the blood coagulation system (risk of more severe bleeding), after recent surgery.

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy.

If necessary, the use of the drug during lactation should stop breastfeeding.

special instructions

Application for violations of liver function

In patients with severely impaired liver function, T1 / 2 of pentoxifylline increases. Use the drug with caution in patients with severe hepatic impairment (risk of cumulation and increased risk of side effects).

Application for violations of kidney function

In severe renal impairment, the excretion of metabolites is slowed down. Use the drug with caution in patients with impaired renal function - CC less than 30 ml / min (risk of cumulation and increased risk of side effects).

special instructions

Treatment should be carried out under the control of blood pressure.

In diabetic patients taking hypoglycemic agents, the administration of the drug in high doses can cause severe hypoglycemia (dose adjustment is required).

When administered simultaneously with anticoagulants, it is necessary to carefully monitor the indicators of the blood coagulation system.

In patients who have recently had surgical intervention, requires systematic monitoring of hemoglobin and hematocrit levels.

In the elderly, dose reduction may be required (increase in bioavailability and decrease in excretion rate).

Smoking may reduce the therapeutic efficacy of the drug.

Pediatric use

The safety and efficacy of pentoxifylline in children have not been well studied.

Compound

1 tablet contains:

Active substances: pentoxifylline 100 mg.

Excipients: lactose, starch, talc, colloidal silicon dioxide, magnesium stearate.

Shell composition: methacrylic acid copolymer, sodium hydroxide, macrogol (polyethylene glycol) 8000, talc, titanium dioxide (E171).

Dosage and administration

The dose is set individually, in accordance with the characteristics of the patient.

The drug is administered orally at 100 mg (1 tab.) 3 times / day, followed by a gradual increase in dose to 200 mg 2-3 times / day. The maximum single dose is 400 mg. The maximum daily dose is 1200 mg. Tablets should be swallowed whole during or immediately after a meal with enough water.

In patients with impaired renal function (CC less than 30 ml / min), the dose should be reduced to 1-2 tablets / day.

In patients with severe hepatic impairment, a dose reduction is necessary, taking into account the individual tolerability of the drug.

In patients with low blood pressure, as well as in those at risk due to possible reduction AD (patients with severe coronary artery disease or with hemodynamically significant cerebral stenosis) treatment can be started in small doses, in these cases the dose should be increased gradually.

Side effects

From the side of the central nervous system: headache, dizziness, anxiety, sleep disturbances, convulsions; very rarely - aseptic meningitis.

Dermatological reactions: hyperemia of the skin of the face, flushes of blood to the skin of the face and upper part chest, swelling, increased fragility of nails.

From the side digestive system: xerostomia, anorexia, intestinal atony, feeling of pressure and fullness in the stomach, nausea, vomiting, diarrhea; in some cases - intrahepatic cholestasis and increased activity of hepatic transaminases (AST, ALT), alkaline phosphatase (alkaline phosphatase).

From the side of cardio-vascular system: tachycardia, arrhythmia, cardialgia, progression of angina pectoris, decrease in blood pressure.

From the hematopoietic system: leukopenia, thrombocytopenia, pancytopenia, bleeding from the vessels of the skin, mucous membranes, stomach, intestines, hypofibrinogenemia.

From the side of the organ of vision: visual impairment, scotoma.

Allergic reactions: itching, skin hyperemia, urticaria, angioedema, anaphylactic shock.

Side effects are possible when using Trental in high doses.

drug interaction

Pentoxifylline is able to enhance the effect of drugs that reduce blood pressure (ACE inhibitors, nitrates).

Pentoxifylline can enhance the effect of drugs that affect the blood coagulation system (indirect and direct anticoagulants, thrombolytics), antibiotics (including cephalosporins).

Cimetidine increases the plasma concentration of pentoxifylline (risk of side effects).

Co-administration with other xanthines can lead to excessive nervous excitement.

It is possible to increase the hypoglycemic effect of insulin or oral hypoglycemic agents when taking pentoxifylline (increased risk of hypoglycemia). If combination therapy is necessary, strict monitoring of the patient's condition is required.

In some patients, the simultaneous administration of pentoxifylline and theophylline may lead to an increase in the concentration of theophylline in the blood plasma. This may lead to an increase or increase in the side effects associated with theophylline.

Overdose

Symptoms: nausea, dizziness, tachycardia, decreased blood pressure, arrhythmia, hyperemia skin, chills, loss of consciousness, areflexia, tonic-clonic convulsions.

Treatment: if necessary, carry out symptomatic therapy. The patient should be given horizontal position with raised legs. The specific antidote is unknown. Conduct vital monitoring important functions body and general measures aimed at maintaining them, monitor the patency respiratory tract. With convulsions - diazepam.

Storage conditions

Store in a dry place below 25°C.

Keep out of reach of children.

Best before date

They have the same properties and mechanism of action. But they also have significant differences. To choose the right substitute, you need to evaluate all its qualities and shortcomings.

Briefly about Trental

This is a drug from the Indian company Sanofi. It reduces blood viscosity and prevents thrombosis. The medicine is produced in the form of tablets of 100 or 400 mg and a concentrate for solution.

The active substance is pentoxifylline. It normalizes microcirculation and eliminates symptoms venous insufficiency(convulsions, numbness,). Tablets and solution are used for, and angiopathy.

The dosage is 100 mg three times a day with meals. With a subsequent increase in dose up to 200 per dose. The highest daily dose is 1200 mg.

The medicine is contraindicated in:

• tendency to bleed;
• strokes;
• lactase deficiency;
• heart attacks;
• allergies to pentoxifylline and auxiliary components.

Trental is not prescribed during pregnancy, lactation and until the age of 18. The drug may cause side effects following systems body:

• nervous;
• cardio - vascular;
• immune;
• hematopoietic;
• digestive.

On a note!

The cost of medicine in ampoules is from 160 rubles for 5 pieces of 5 ml. The price of the drug in tablets of 0.1 g varies from 500 rubles. for 60 pieces. The same amount, but 400 mg each costs about 1500 rubles. The higher the dosage, the longer action active substance.

The best analogues

Trental's analogues are no less effective on. Thanks to a single active substance, the preparations cope well with local and common symptoms vascular insufficiency. Most analogues can be added to the list of the cheapest substitutes:

1. Flexital;
2. Pentoxifylline;
3. Agapurin;
4. Vasonite;
5. Trenpental;
6. Pentilin.

These are the most popular pentoxifylline-based products. They are prescribed for varicose veins and currents. Therapy is carried out by taking tablets orally, intramuscularly and intravenous injections. There are no external funds under such names.

Drugs that reduce blood viscosity and dilate blood vessels should be used under control clinical analysis blood and blood pressure.

Pentoxifylline

Under this name, analogues of the drug are produced mainly Russian production. But it is also produced in Belarus, India, China, Germany and Slovakia.

Unlike Trental, the drug has a ready-made solution for injection. The drug eliminates pain, heaviness in the legs and cramps. Pentoxifylline is prohibited during pregnancy and lactation. Treatment in pediatrics has not been studied. Dosing is individual depending on the stage of pathology. The treatment regimen is determined. Among the side effects:

• dizziness;
• nausea;
• vomit;
• sleep disturbance;
• anxiety;
• hypotension.

On a note!

The cost of an analogue is from 90 rubles for 60 pieces of 0.1 g each. The solution costs from 50 rubles 10 ampoules. This is the most cheap drug of all substitutes.

Flexital

This is an Indian drug from Sun Pharmaceutical Industries Ltd. It is used in chronic vascular insufficiency with circulatory disorders. The tool is shown with:

• violations of the trophism of the skin;
• venous ulcers;
• vascular thrombosis.

The drug has a high bioavailability (above 90%). Available in dosages of 400 and 100 mg, as well as in the form of a concentrate for infusion. Related to drugs long-acting. It has serious side effects and interacts with antibiotics, anticoagulants, and blood pressure medications.

Trental and its analogues are prescribed only by a specialist and according to strict indications for treatment. You should not independently purchase it from dubious companies.

pharmachologic effect

Vasodilating drug that improves microcirculation. Trental ® 400 improves the rheological properties of blood by affecting the pathologically altered deformability of erythrocytes, inhibiting platelet aggregation and reducing increased blood viscosity. Trental ® 400 improves microcirculation in areas of impaired circulation.

The active substance of the drug - pentoxifylline - is a derivative of xanthine. The mechanism of action of pentoxifylline is associated with the inhibition of phosphodiesterase and the accumulation of cAMP in vascular smooth muscle cells and blood cells.

It has a weak myotropic vasodilating effect, slightly reduces OPSS and slightly dilates the coronary vessels.

The use of Trental 400 leads to an improvement in symptoms in cases of cerebral circulation disorders.

With occlusive lesions of peripheral arteries (for example, with intermittent claudication), the effect of the drug is manifested in lengthening the walking distance, eliminating night cramps in the calf muscles and the disappearance of pain at rest.

Pharmacokinetics

Suction

After oral administration, pentoxifylline is almost completely absorbed from the gastrointestinal tract.

Bioavailability averages 19±13%.

Metabolism

The main pharmacologically active metabolite 1-(5-hydroxyhexyl)-3,7-dimethylxanthine is determined in plasma at a concentration that is 2 times the concentration of the unchanged substance (pentoxifylline).

Pentoxifylline is completely biotransformed in the body.

breeding

T 1/2 pentoxifylline is 1.6 hours.

More than 90% is excreted by the kidneys in the form of unconjugated water-soluble metabolites.

Pharmacokinetics in special clinical situations

In patients with severely impaired renal function, the excretion of metabolites is slowed down.

In patients with impaired liver function, an elongation of T 1/2 of pentoxifylline and an increase in its bioavailability were noted.

Indications

- disorders of the peripheral circulation of atherosclerotic origin (for example, intermittent claudication), diabetic angiopathy, trophic disorders (for example, leg ulcers, gangrene);

- disorders of cerebral circulation (consequences of cerebral atherosclerosis, such as impaired concentration, dizziness, memory impairment), ischemic and post-stroke conditions;

- circulatory disorders in the retina and choroid;

- otosclerosis, degenerative changes against the background of the pathology of the vessels of the inner ear and hearing loss.

Dosing regimen

Set individually.

The average dose of the drug for oral administration is 400 mg (1 tab.) 2-3 times / day. The maximum daily dose is 1200 mg (3 tablets).

Tablets are taken whole, without chewing, during or immediately after a meal, drinking plenty of water.

At patients with liver failure the dose of the drug is reduced taking into account individual tolerance.

In patients with arterial hypotension, as well as in those at risk due to a possible decrease in blood pressure (patients with severe coronary artery disease or with hemodynamically significant cerebral vascular stenosis), treatment can be started in small doses. In these cases, the dose increase should be carried out gradually.

Side effect

From the side of the central nervous system: headache, dizziness, anxiety, sleep disturbances, convulsions; very rarely - aseptic meningitis.

Dermatological reactions: flushing of the skin of the face, flushing of the skin of the face and upper chest, swelling, increased brittleness of the nails.

From the digestive system: xerostomia, anorexia, intestinal atony, feeling of pressure and fullness in the stomach, nausea, vomiting, diarrhea; very rarely - intrahepatic cholestasis, increased activity of hepatic transaminases, alkaline phosphatase.

From the side of the cardiovascular system: tachycardia, arrhythmia, cardialgia, progression of angina pectoris, decrease in blood pressure.

From the hematopoietic system: leukopenia, thrombocytopenia, pancytopenia.

From the blood coagulation system: bleeding from the vessels of the skin, mucous membranes, stomach, intestines, hypofibrinogenemia.

From the sense organs: visual impairment, scotoma.

Allergic reactions: itching, skin hyperemia, urticaria, angioedema, anaphylactic shock.

Side effects develop when using Trental 400 in high doses.

Contraindications for use

- acute myocardial infarction;

- massive bleeding;

- hemorrhage in the brain;

- massive retinal hemorrhage;

- pregnancy;

- lactation (breastfeeding);

- children's and adolescence up to 18 years;

- Hypersensitivity to the components of the drug.

- Hypersensitivity to other derivatives of methylxanthine.

FROM caution the drug should be used in patients with severe arrhythmias (risk of worsening arrhythmias); arterial hypotension (risk of further decrease in blood pressure); chronic heart failure; peptic ulcer of the stomach and duodenum; impaired renal function (CC less than 30 ml / min) (risk of cumulation and increased risk of side effects); severe hepatic impairment (risk of cumulation and increased risk of side effects); after recent surgery; with a tendency to bleeding, for example, as a result of the use of anticoagulants or in violation of the blood coagulation system (risk of more severe bleeding).

Use during pregnancy and lactation

The drug is contraindicated for use during pregnancy.

If necessary, the use of the drug during lactation should stop breastfeeding.

Use in children

Overdose

Symptoms: urge to vomit, dizziness, tachycardia, decreased blood pressure, arrhythmia, hyperemia of the skin, chills, loss of consciousness, areflexia, tonic-clonic convulsions.

Treatment: cancel the drug, give the patient a horizontal position with raised legs. Holding symptomatic therapy maintaining blood pressure and respiratory function. It is necessary to monitor the free patency of the airways. At seizures administer diazepam.

drug interaction

Pentoxifylline enhances the effect of drugs that reduce blood pressure (ACE inhibitors, nitrates).

Pentoxifylline can enhance the effect of drugs that affect the blood coagulation system (indirect and direct anticoagulants, thrombolytics), antibiotics (including cephalosporins).

Cimetidine increases the plasma concentration of pentoxifylline (risk of side effects).

Co-administration with other xanthines can lead to excessive nervous excitement.

The hypoglycemic effect of insulin or hypoglycemic drugs may be enhanced when taking pentoxifylline (increased risk of hypoglycemia). Such patients require strict clinical monitoring.

At simultaneous application Pentoxifylline and theophylline may increase the concentration of theophylline in the blood plasma and increase the side effects of theophylline.

Terms of dispensing from pharmacies

The drug is dispensed by prescription.

Terms and conditions of storage

List B. The drug should be stored out of the reach of children, in a dry place at a temperature not exceeding 25°C. Shelf life - 4 years.

Application for violations of liver function

Careful monitoring is required in patients with severe violations liver function (risk of cumulation and increased risk of side effects).

Application for violations of kidney function

At patients with severe renal dysfunction (CC less than 30 ml / min) the dose may be reduced to 400-800 mg/day.

Careful monitoring is necessary in patients with severe renal impairment with CC less than 30 ml / min (risk of cumulation and increased risk of side effects).

Use in elderly patients

special instructions

Treatment should be carried out under the control of blood pressure.

In diabetic patients taking hypoglycemic agents, the administration of the drug in high doses can cause severe hypoglycemia (dose adjustment is required).

When administered simultaneously with anticoagulants, it is necessary to carefully monitor the parameters of the blood coagulation system.

In patients who have recently undergone surgery, systematic monitoring of hemoglobin and hematocrit levels is necessary.

In patients with low and unstable blood pressure, the dose should be reduced.

In elderly patients, it may be necessary to reduce the dose of the drug (increase in bioavailability and decrease in the rate of excretion of pentoxifylline).

Smoking may reduce the therapeutic efficacy of the drug.

Pediatric use

The safety and efficacy of pentoxifylline in children have not been well studied.

Angioprotective medicine imported (Turkey), which has a beneficial effect on the microcirculation of the bloodstream in the human body, is called Trental. What are these pills, what are they from and how to take them correctly: instructions for using Trental, what analogues can be replaced, reviews about the drug and the price for it later in the article.

The drug, which is a xanthine derivative, reduces high blood viscosity and improves blood flow in areas with impaired blood circulation. It is good for encephalopathies of various origins (especially cerebral), problems with peripheral circulation and pathologies of blood vessels in the retina.

Indications for the use of Trental tablets are also:

• post-stroke conditions;
• post-thrombotic syndrome;
• otosclerosis (hearing impairment due to the pathology of the vessels of the inner ear);
• cerebral atherosclerosis of vessels (all types of dizziness, problems with memory and attention);
• occlusive pathology of peripheral arteries;
• angiopathy caused by diabetes;
• trophic ulcers;
• frostbite of any degree;
• paresthesia and a number of angioneuropathies;
• pulmonary obstructions (bronchitis, asthma, emphysema);
• problems with potency (vascular crises) and other intimate disorders.

Trental strengthens blood vessels, making them elastic. active ingredient means is, which thins the blood, improves its composition, has a vasodilating property, increases blood flow to the extremities, nourishes tissues with oxygen, and has a positive effect on the central nervous system.

In tablets for 100 mg, the price of Trental in pharmacies is 251-480 rubles, and 400 mg - 394-490.

Important! The drug can be taken only as directed by a therapist, neurologist, psychiatrist, surgeon.

The drug is presented in tablets of 100 and 400 mg. The dosage of the drug is selected by the doctor, taking into account the specific disease and concomitant diseases.

Patients are prescribed one tablet (100 mg) three times a day. Gradually increase the dose to 200 mg. Disposable maximum dose should not be more than 400 mg, and daily, respectively, 1200. Take the whole tablet with or after meals.

With functional pathologies of the kidneys, the patient takes up to two tablets of Trental per day.

With coronary artery disease or VSD of the hypotonic type, it is necessary to start the therapy regimen with small amounts, with gradual increase(so as not to cause collapse).

If a person has severe liver pathology, then the remedy is recommended in small doses, taking into account individual tolerance.

The drug lowers the number of clotted platelets, the level of fibrinogen; helps in the dissolution of blood clots and affects the viscosity of the blood, increasing the elasticity of red blood cells. The maximum concentration of the drug in the bloodstream is observed within 1 hour, from the moment of oral administration of the drug.

The active substance of Trental is well absorbed in the stomach and absorbed by the body (in the proportion it needs), removing residues through the urinary system. Only with renal and hepatic dysfunction, the drug is slightly delayed, but gradually excreted (therefore, such patients are prescribed small doses of the drug).

Trental increases the lumen of the vessels, due to its effect on adenic acid, acts on phosphodiesterase so that its excess does not reduce vascular elasticity. In addition, the drug promotes relaxation of vascular smooth muscles, electrical conductivity of impulses, positively affects the cellular respiration of the tissues of the central nervous system, and stimulates peripheral blood circulation in the extremities.

Trental categorically cannot be used when carrying a child and lactation, for the treatment of undergrowth under 18 years of age, individual intolerance to the drug. Other contraindications include:

• cerebral hemorrhage (intracerebral stroke);
• severe circulatory disorders of the retina of the eyes (with hemorrhages);
• bleeding that is considered massive.

Carefully, the drug is prescribed to patients with severe atherosclerosis, coronary artery disease, CHF, in postoperative period, arrhythmias, jumps in blood pressure, gastric and duodenal ulcers, diabetes mellitus.

Important! Therapy with Trental is always carried out with the control of blood pressure.

Reception more tablets than needed in the therapy regimen may lead to overdose. The patient will complain about severe nausea, palpitations, low blood pressure, fever, dizziness, convulsions, etc.

In such cases, urgent gastric lavage and taking several tablets is necessary. activated carbon(Enteroseptol or Atoxil). The patient remains under medical supervision until the condition improves.

Side effects of Trental include: headache, insomnia, aseptic meningitis, redness of the skin on the face, severe brittle nails, anorexia, skin allergies, a tendency to constipation due to intestinal atony, etc. All these manifestations are extremely rare.

If the patient begins to vomit "coffee grounds", then this symptom will indicate that he has started gastric or intestinal bleeding. Necessary emergency treatment in the surgical department.

With regard to interactions with other drugs, it is worth noting that with simultaneous reception Trental and Heparin, fibrinolytic drugs, ACE inhibitors, insulin, antidiabetic agents, the effect of all these drugs improves.

The main analogues of the drug include drugs, with active substance pentoxifylline. These are Pentin, Vasonite, Pentamon, Aguparin, Pentohexal, Arbiflex, Pentoxifylline. Some analogues of Trental tablets are much cheaper, but before replacing the drug with them, you should consult your doctor.

Structural analogues include a number of other drugs: Agapurin, Radomin, Pentilin forte, Flexital, Arbiflex, etc.

• Alekseev V.B., therapist, 10 years of experience:I often prescribe Trental to my patients for a number of diseases. I like the result of therapy, which I see at the end of the course. Side effects are extremely rare. I make sure that the concentration of the drug in the blood increases gradually. I tell patients in detail about the effect of the substance on the body. My recommendations to Trental!
• Olga A., 40 years old:After suffering the flu, some time later, she found herself with hearing problems. For several years I did nothing, until a young ENT doctor at prof. inspection. He prescribed me Trental and explained that my hearing loss was due to problems with the intra-ear vessels. Personally, the drug helped me. After the course, I began to hear better, my general well-being improved. Now I will take the medicine twice a year to support the body.