Corticotropin prescription in Latin. The meaning of the word corticotropin in the reference book of medicines

Name: Corticotropin (Corticotropinum)

Pharmacological effects:
A hormone produced in the basophilic cells of the anterior pituitary gland (gland internal secretion located in the brain). Corticotropin is considered a physiological stimulant of the adrenal cortex. It causes increased biosynthesis (formation in the body) and release into the bloodstream of cortacosteroid hormones (hormones produced by the adrenal cortex), mainly glucocorticoids, as well as androgens (male sex hormones). At the same time, the content in the adrenal glands decreases ascorbic acid, cholesterol.
There is a close relationship between the release of corticotropin from the anterior pituitary gland and the concentration of adrenal hormones in the blood. Increased release of corticotropin begins when the concentration (content) of corticosteroids in the blood drops and is inhibited if the content of corticosteroids increases to a certain level.
The therapeutic effect of corticotropin is similar to the effect of glucocorticosteroids (hormones of the adrenal cortex that act on carbohydrate and protein metabolism). It has antiallergic and anti-inflammatory effects, has immunosuppressive (suppressive) protective forces body) activity, causes atrophy (loss of weight with weakening of function as a result of malnutrition) connective tissue, affects carbohydrate, protein metabolism and other biochemical processes.

Corticotropin - indications for use:

Corticotropin - method of administration:

Corticotropin - side effects:

Corticotropin - contraindications:

Corticotropin - release form:

Corticotropin - storage conditions:

Corticotropin - synonyms:

Important!
Before using the medicine Corticotropin you should consult your doctor. This instruction is intended for informational purposes only.

Corticotropin is a hormone that is produced in the anterior lobe of the pituitary gland. For those who don’t know, the pituitary gland is an endocrine gland that is located in the brain. Corticotropin-releasing hormone is a kind of stimulator of the adrenal cortex, thanks to which biosynthesis is enhanced, and more male sex hormones are released into the blood.

It has been proven that this hormone can be synthesized in human body in completely different concentrations, it all depends on the conditions environment, health indicators and even mood. For example, in the morning the level of corticotropin remains at its highest. high point, when in the evening it drops to almost zero.

A sudden change in time zone negatively affects the production of corticotropin. It should be noted that corticotropin cannot adapt to new conditions for a very long time, and its production comes at a normal condition only after a few weeks. It would seem that a vacation spent abroad should only bring positive emotions And good vacation for the whole organism, however, even such minor changes can greatly disrupt the uniform functioning of this hormone.

In addition to jet lag, hormone production can also be affected by excessive physical exercise, stress, fears and strong anxiety. All stated reasons can significantly increase the level of corticotropin in the human body. For the fair sex, everything is a little different; pregnancy and the menstrual cycle affect the increase in hormone levels.

Corticotropin is available in dosage form and is a drug of adrenocorticotropic hormone, which is produced in the human body by basophilic cells of the anterior pituitary gland. Do not forget that the medicine should be used only in the presence of the following diseases:

• Acute, infectious and rheumatoid arthritis;
• Diseases associated with connective tissues;
• Skin diseases such as psoriasis, eczema, dermatitis and lichen planus;
• Allergic types of diseases;
• Ulcerative colitis;
• Inflammatory and allergic diseases eye;
• Adrenal insufficiency, which can be caused by long-term use of certain medications.

In addition to the indications for which it is necessary to use this drug, there are also certain rules– the doctor treating and observing you must warn you about them. Do not forget to also carefully study the instructions that can be found in each package. Remember that corticotropin has a destructive effect on the gastrointestinal tract due to the enzymes that it contains, so it should only be administered intramuscularly.

Dosages should be prescribed only by an experienced specialist, since the calculation necessarily includes both the nature and severity of the disease, otherwise the drug will not bring the desired result. It is also worth noting that if the result is visible, the doctor usually reduces the initial dosage of the drug.

The soluble form of corticotropin is eliminated from the body very quickly; it is for this reason that the drug is re-administered approximately four injections per day, and the interval between them should be about six hours. The duration of the treatment course ranges from ten days to several months - it all depends on the type of disease. But usually the entire course does not last more than six weeks.

In particularly rare cases, in which a quick effect is required, the drug can be administered intravenously as a dropper, but only in a hospital setting. Do not try to install IVs yourself at home, especially if you do not have medical education, such negligence can lead to irreversible consequences.

Any treatment that uses corticotropin should be done in a hospital setting under the supervision of an experienced team of doctors and nurses.

Contraindications and side effects

Like anyone else medicinal product, which is used to treat a particular type of disease, corticotropin has its own contraindications for use and, of course, side effects. So, the side effects include:

• Possible fluid retention in the body leads to edema and increased blood pressure;
• Decrease in overall muscle tone, patients may complain of weakness;
• Excitation of the nervous system, which is expressed in excessive irritability, insomnia, menstrual irregularities in women, as well as the appearance of acne;
• Noticeable increase in body weight;
• May change and mental condition As a rule, at this time patients experience increased excitability and nervousness;
• Very often there is a delay in scarring of wounds;
• In patients younger ages Possible growth retardation.

Usually, if at least one of the above effects occurs, you should immediately inform your doctor about it, who will immediately take all necessary measures. As a rule, immediate discontinuation of the drug and administration of necessary treatment emerging symptoms.

The main contraindications include the presence of diseases such as psychosis, severe diabetes mellitus, adrenal hyperfunction, hypertension, tuberculosis, herpes, smallpox, heart failure, and stomach ulcers. More full list In any case, it is worth checking with a specialist in order to avoid undesirable consequences.

It should be noted that corticotropin should be used with extreme caution in elderly people and those who suffer from insufficient renal function. Do not forget that the use of this drug is strictly prohibited during pregnancy and breastfeeding.

special instructions

There are several special instructions, which not only the doctor, but also the patient must adhere to. First, corticotropin should be administered intramuscularly to the patient only if functionality the cortex of his adrenal glands has not yet completely exhausted itself, because the patient will have a negative reaction to the drug.

Secondly, to avoid any allergic reactions to corticotropin, it is necessary to inject the patient about fifteen minutes before its administration. antihistamine. Third, remember that avoid all side effects It’s quite possible if you follow a certain diet that consists of vegetables, fruits and proteins. Please note what is dietary food implies limited consumption of salt and various liquids.

In addition, corticotropin is allowed to alternate with corticosteroids. For example, in extreme heat and falling temperatures, this drug is used in combination with antibiotics. In addition, not everyone knows, but the drug works according to the principle replacement therapy, therefore, after its administration is stopped, a relapse of one or another type of disease occurs.

The drug is available in powder form, which is packaged in bottles, each of them hermetically sealed. The medicine must be stored in a well-protected place. sunlight place, at a temperature not exceeding twenty degrees above zero. It is better to keep the drug in a place that a child cannot reach. At proper storage the drug retains its properties for up to three years; after this period, its use is prohibited.

pharmachologic effect

Indications for use

Mode of application

Side effects

Contraindications

Release form

Storage conditions

Corticotropin- a drug of adrenocorticotropic hormone (ACTH), produced by basophilic cells of the anterior pituitary gland.

INDICATIONS FOR USE

Corticotropin is used according to indications:

• Acute rheumatic arthritis, nonspecific infectious polyarthritis, gout, spondyloarthritis, rheumatoid arthritis, psoriatic arthritis.
• Connective tissue diseases (rheumatism, systemic lupus erythematosus, dermatomyositis, periarteritis nodosa, scleroderma, primary reticulosis, sarcoidosis, psoriatic arthritis).
• Skin diseases: psoriasis and psoriatic erythroderma, common eczema, contact dermatitis, true pemphigus, disseminated erythematous lupus, lichen planus, multiforme exudative erythema, toxicoderma. Corticotropin is effective for prurigo, neurodermatitis, and eczema.
• Bronchial asthma and various allergic diseases.
• Ulcerative colitis.
• Rheumatic, allergic and inflammatory diseases eye.
• Prevention of adrenal insufficiency caused by long-term use large doses of corticosteroids, stimulation of the adrenal cortex with a decrease and transition to maintenance doses of corticosteroid drugs, interstitial pituitary insufficiency.
• Corticotropin in combination with Cortisone is used in complex therapy acute leukemia, severe exacerbations chronic leukemia and mononucleosis.

RULES OF APPLICATION

Corticotropin is destroyed by enzymes of the gastrointestinal tract, so it is administered intramuscularly.

For intramuscular injections contents of the bottle ex tempore dissolves aseptically in sterile bidistilled water or sterile isotonic (0.9%) sodium chloride solution. For every 10 units of the drug, take 1 ml of 0.9% sodium chloride solution.

Doses of corticotropin depend on the nature and severity of the disease.

Initial daily dose for various indications in the first 5–8 days it is 40–60 units (sometimes 80 units), then 20–15–10 units. Average therapeutic dose of Corticotropin: single - 10-20 units, daily - 40-80 units. Total drug per course of treatment - 800–1200–1500, sometimes up to 2000 units.

When a pronounced clinical improvement occurs, daily or once every 3 days, the dose of the hormone is reduced by 5 units, switching to maintenance dosages (5–10 units per day).

Since soluble forms of ACTH are quickly eliminated from the body (the peak incretion of corticosteroids occurs 3 hours after administration and their elimination ends after 6-8 hours), it is recommended to re-administer corticotropin 3-4 injections per day with an interval of 6-8 hours. The duration of treatment is from 10–20 days to several months (usually the course of treatment is no more than 3–6 weeks.

In rare cases, to obtain a stronger and faster therapeutic effect, the solution (at a dose of 10–25 units/day) is administered intravenously, but only in a hospital setting.

Long-term administration of corticotropin can lead to depletion of the adrenal cortex, so it is necessary to take one to three day breaks between courses of treatment or alternate them with the administration of cortisone and other corticosteroids (you can also take breaks in treatment 1 or 2 times a week).

For acute rheumatism and other arthritis corticotropin is administered in a daily dose of 40–80 units, gradually reducing the dose to 20–30 units. 800–1200 units of the drug are prescribed for the course of treatment. Repeated courses of treatment are carried out several times with 2-3 week breaks.

For children, the drug is administered in daily doses: up to 1 year - 15–20 units; from 3 to 6 years - 20–40 units; from 7 to 14 years - 40–60 units.

Daily doses are administered in 3–4 doses. In the treatment of rheumatism, maintenance doses of corticotropin can be combined with the use of other antirheumatic drugs (sodium salicylate or acetylsalicylic acid- 3–4 g per day, Amidopyrine - 1.5–2 g or Butadione - 0.4–0.6 g per day).

For gout treatment is carried out for 15–25 days: initially - 40–60 units, then – 20–30 units per day.

Treatment of bronchial asthma carried out in daily doses of 10–15 units for 2–6 weeks. When treating bronchial asthma, the daily dose for children, depending on age, is 5-15-30 IU with a dose reduction towards the end of treatment. Alternating injections of corticotropin and corticosteroids is recommended.

Treatment with corticotropin should be carried out in a hospital setting.

SIDE EVENTS

Retention of water, sodium and chlorine ions in the body with the development of edema and increased blood pressure; tachycardia, negative nitrogen balance, general muscle weakness, central nervous system agitation/irritability, insomnia, moderate hirsutism, menstrual irregularities (amenorrhea), acne, eosinopenia, lymphocytopenia, weight gain, moon face, hyperglycemia and glycosuria, decreased glucose tolerance, exacerbation infectious processes in hidden areas.

The risk of thrombosis and embolism, ulceration of the gastrointestinal mucosa, perforation, and ulcerative bleeding increases.

Diabetes mellitus (in patients suffering from diabetes - increased hyperglycemia and ketosis), mental changes, nervousness, increased excitability of the nervous system, insomnia, “hormone withdrawal syndrome”, allergic reactions are possible.

There is a delay in scarring of wounds, and growth inhibition is possible in children.

Treatment of complications: Discontinue the drug. Treatment is symptomatic. For anaphylaxis - adrenaline, artificial respiration. Aminophylline 0.5 g intravenously slowly.

CONTRAINDICATIONS

Psychoses, Itsenko-Cushing's syndrome, exhaustion or hyperfunction of the adrenal glands, severe forms diabetes mellitus and hypertension, keratitis, active and latent forms of tuberculosis (if not carried out specific treatment), malaria, herpes simplex, cowpox, chicken pox, decompensation of cardiac activity, decompensated heart failure (except for failure caused by the rheumatic process), severe atherosclerosis, acute endocarditis, peptic ulcer stomach and duodenum, nephritis, active forms syphilis, recent surgery, pregnancy.

Corticotropin should be prescribed with caution for hirsutism, osteoporosis, thrombophlebitis, renal failure, and the elderly.

PREGNANCY AND LACTATION

The use of Corticotropin during pregnancy is contraindicated.

SPECIAL INSTRUCTIONS

Corticotropin should be administered to the patient only if the functionality of the adrenal cortex has not been exhausted, since otherwise it is possible that negative reactions for the drug.

To prevent the development of allergic reactions, it is advisable to administer an antihistamine 15 minutes before the Corticotropin injection.

The side effects of the drug are reduced if you strictly follow a diet rich in vegetables, fruits and proteins, and limit the intake of liquids and table salt.

When treating people with diabetes mellitus with corticotropin, Lipocaine should be administered and the dose of insulin should be increased.

The use of Corticotropin can be alternated with the use of corticosteroids. With a long-term temperature that does not decrease, focal pneumonia hormonal treatment combined with the use of antibiotics. In the presence of circulatory failure, Corticotropin is used in combination with cardiac or diuretic drugs.

The action of the drug is carried out on the principle of replacement therapy and therefore, after stopping the administration of Corticotropin, a relapse of the disease occurs.

ACTH is used much less frequently than corticosteroids due to the lower therapeutic activity of the drug, the possibility of severe allergic reactions and the danger of depletion of the adrenal cortex.

COMPOSITION AND FORM OF RELEASE

Issued:

Prescription for Corticotropin

• Aseptically prepared lyophilized sterile powder in hermetically sealed bottles of 10 UNITS, 20 UNITS, 30 UNITS, 40 UNITS ACTH.

SHELF LIFE AND STORAGE CONDITIONS

Store with precautions (list B) in a place protected from light at a temperature not exceeding 20° C.

The shelf life of Corticotropin is 3 years.

PROPERTIES

Corticotropin(Corticotropinum pro injectionibus) - white or slightly yellowish shiny plates or scales.

Corticotropin is a polypeptide hormone consisting of 39 amino acids, isolated from the brain appendages (pituitary glands) of pigs, sheep and cattle. cattle; the drug is a water-soluble protein. The effect on the body of corticotropin is similar to glucocorticoids.

As a physiological stimulator of the secretion of hormones of the adrenal cortex, corticotropin enhances the biosynthesis and release into the blood of corticosteroid hormones (mainly glucocorticoids - cortisone, cortisol, and androgens), which have an inherent effect on the diverse functions of the body, regulation of carbohydrate, protein and mineral metabolism, inhibition of the development of lymphoid tissue, a decrease in the reactivity of the mesenchyme (in particular connective tissue) to mechanical and chemical damage, weakening of immune reactions, inhibition of hyaluronidase activity (and, consequently, a decrease in capillary permeability), antihistamine and anti-inflammatory effects.

When corticotropin is administered, phenomena characteristic of increased function adrenal cortex: decreased number of eosinophils in the blood, hyperglycemia, increased secretion with urine potassium, uric acid, 17-ketosteroids, decreased excretion of sodium, chlorides, water and other phenomena.

There is a close relationship between the concentration of hormones of the adrenal cortex and the production of ACTH - the release of ACTH is inhibited if the content of corticosteroids increases to a certain level, and it begins to actively wither if the concentration of corticosteroids in the blood decreases.

The amount of hormones secreted by the adrenal cortex under the influence of corticotropin administration and their ratio depend on the functional state of the adrenal cortex and are characterized by significant individual fluctuations.

ANALOGUES

Adrenocorticotropic hormone. Adrenocorticotrophin. Aktar. ACTH. Acton. Actron is long-lasting. Actrop. Acetrophan. Aethon. Corticotrophin. Corticotrophin "Z" (long-acting). Solantil. Cibaten. Exactgin. Exactin.

HUMAN SOMATOTROPIN FOR INJECTION- This is the so-called growth hormone. Somatotropin increases body weight and height. Somatotropin also stimulates metabolism (primarily protein and mineral). The effect of somatotropin is noticeable after 6-9 months. taking the drug.

General course of treatment with somatotropin: from 3 months to 2 years.

Side effects when using somatotropin: allergic reactions.

Contraindications to the use of somatotropin: for malignant tumors.

Somatotropin release form: 5 ml bottles containing 4 units.

Example of a somatotropin recipe in Latin:

Rp.: Somatotropini humani pro injectionibus 4 ED

D.t. d. N. 6

S. Dilute the contents of the bottle in 2 ml of water for injection or 0.25-0.5% novocaine solution; administer 1-2 ml intramuscularly 2-3 times a week.

CORTICOTROPIN FOR INJECTION is the so-called adrenocorticotropic hormone (ACTH). Corticotropin significantly increases the secretion of corticosteroids by the adrenal cortex, hormones that have antiallergic and anti-inflammatory effects. Corticotropin is used to prevent atrophy of the adrenal cortex and the development of “withdrawal syndrome” during corticosteroid therapy. Corticotropin is also prescribed for polyarthritis, rheumatism, allergic diseases and other things.

Side effects when using corticotropin: increased blood pressure, increased excitability, insomnia, allergic reactions, edema, tachycardia, dysfunction of the gastrointestinal tract, menstrual irregularities, growth retardation in children, impaired carbohydrate metabolism (diabetes).

Contraindications to the use of corticotropin: pregnancy, diabetes mellitus, psychosis, serious illnesses of cardio-vascular system, kidney, liver, peptic ulcer, tuberculosis (active form).

Corticotropin release form: bottles of 40 units. List B.

Example of a corticotropin prescription in Latin:

Rp.: Corticotropini pro injectionibus 40 ED

D.t. d. N. 10

S. Administer 1-20 units intramuscularly 3-4 times a day (for 1-3 weeks).

ZINC-CORTICOPROPIN SUSPENSION- has the same indications for use and contraindications as corticotropin, but causes a more prolonged effect (the effect lasts 24 hours).

Release form of zinc-corticotropin suspension: bottles of 5 ml. List B.

Example of a recipe for zinc-corticotropin suspension in Latin :

Rp.: Susp. zinc-corticotropini 5 ml

D. S. Administer 1 ml (20 units) intramuscularly once a day.

CHORIONIC GONADOTROPIN (pharmacological analogues:choriogonin, prophasy, rotnyl, choragon) - has the activity of luteinizing hormone (LH). Chorionic gonadotropin is used for hypofunction of the gonads in women and men, which is associated with the activity of the pituitary gland. Chorionic gonadotropin is also used for infertility in women, menstrual irregularities, and pituitary dwarfism with symptoms of sexual infantilism.

Side effects when using human chorionic gonadotropin: excessive enlargement of the ovaries in women, testicles in men (which can prevent them from descending with cryptorchidism), various allergic reactions.

Contraindications to the use of human chorionic gonadotropin: inflammatory processes in the genital area, as well as malignant neoplasms.

Release form of human chorionic gonadotropin: bottles of 500, 1000, 1500 units (with solvent).

in Latin :

Rp.: Gonadotropini chorionici 1000 ED

D.t. d. N. 3

S. Dissolve the contents of the bottle and administer 500 - 3000 units intramuscularly 1-2 times a week.

GONADOTROPIN MENOPAUSE FOR INJECTION- has follicle-stimulating hormone (FSH) activity. Mainly menopausal gonadotropin is used for infertility in men and women.

Side effects and contraindications to the use of menopausal gonadotropin the same as for human chorionic gonadotropin.

Release form of menopausal gonadotropin: bottles of 75 units (with solvent). List B.

Example of a prescription for human chorionic gonadotropin in Latin :

Rp.: Gonadotropini menopaustici pro injectionibus 75 ED

D.t. d. N. 5

S. Dissolve the contents of the bottle, administer 75 units per day.

HUMEGON ( pharmacological analogues: pergonal)- contains an equal amount of follicle-stimulating and luteinizing hormones (75 units per 1 ml). Humegon is used to treat infertility in women at a dose of 1-2 ml per day intramuscularly (the higher the dose, the higher the initial level of estrogen in the woman’s blood). When the preovulatory concentration of estrogen is reached, the administration of humegone is stopped, and then human chorionic gonadotropin (pregnyl, etc.) is administered for 1-3 days with its re-administration after 7 days. For men to normalize spermatogenesis, the drug is prescribed 3 times a week, 1-2 ml, administered intramuscularly, the course of treatment is 10-12 weeks.

Side effects when using Humegon: when using the drug in high dosages in women, it mayOvarian hyperstimulation may occur, and skin rashes may also occur. In connection with the above-described actions of humegone during the treatment process, it is necessary to carry out repeated control ultrasound examinations. In case of a sharp increase in estrogen levels, you must stop taking the drug.

Contraindications to the use of humegon: tumor diseases of the ovaries.

Humegon release form: bottles of 75 units with solvent.

Other drugs containing FSH (follicle stimulating hormone) and LH (luteinizing hormone).

ANTROGEN (FSH:LH in a ratio of 10:1); FELISTIMAN (FSH:LH in the ratio 70:1), MITRODINEand etc.; side effects and the precautions are the same as for humegon.

LACTIN FOR INJECTION - hormonal drug, which is obtained from the anterior pituitary gland of cattle. Lactin for injection enhances lactation during breastfeeding.

Side effects when using lactin for injection : allergic reactions.

Release form of lactin for injection: bottles of 100 and 200 units.

Example of a prescription for human chorionic gonadotropin in Latin :

Rp.: Lactini pro injectionibus 200 ED

D.t. d. N. 5

S. Administer 70-100 units intramuscularly 1-2 times a day for 5-6 days to enhance lactation.

PREFISON- a complex hormonal preparation, a standardized extract of the anterior pituitary gland. Prefisone is used for pituitary obesity, Down's disease, for diseases associated with hypofunction of the anterior lobe of the pituitary gland, hypogenitalism, etc. Prefisone is administered subcutaneously, intramuscularly and intravenously at 1-2 ml per day.

Prefisone release form: ampoules of 1 ml (25 units).

PARLODEL ( pharmacological analogues: bromocriptine)- activates dopamine receptors. Parlodel suppresses secretory function hormone of the anterior pituitary gland - prolactin. Parlodel helps reduce the level of growth hormone in the blood and also reduces the secretion of ACTH. Parlodel is prescribed for infertility and amenorrhea, for Itsenko-Cushing's disease, to suppress lactation, for parkinsonism. Doses (single) of the drug depend on the disease (usually 1/2-1 tablet is prescribed per dose). Daily dose parlodel and the duration of treatment with the drug are determined directly by the doctor.

Side effects when using Parlodel: dizziness, nausea, vomiting, in some rare cases - arterial hypotension.

Contraindications to the use of Parlodel: diseases of the gastrointestinal tract, arterial hypotension. Do not prescribe the drug simultaneously with MAO inhibitors and oral contraceptives.

Parlodel release form: tablets of 0.0025 g (2.5 mg).

DANAZOL ( pharmacological analogues: danol, danal) - suppresses the secretion of gonadotropins. Danazol also interacts with enzymes that regulate the metabolism and synthesis of sex hormones, as well as with intracellular hormonal receptors. Danazol causes a weak androgenic effect, but is neither a progestagon nor an estrogen. Danazol is used to treat benign diseases mammary gland,endometriosis and associated infertility, menorrhagia and other diseases that require regulation of pituitary secretion FSH hormones and LG. Danazol is prescribed orally: for adults 200 - 800 mg/day (in 2-4 doses), for premature puberty 100 - 400 mg/day (in 2-4 doses) for children in accordance with age, body weight, the body's response to the drug .

Side effects when using danazol: headache, emotional lability, fluid retention in the body, nausea, virilism, and hair loss may occur.

Contraindications to the use of danazol: dysfunction of the liver and kidneys, breastfeeding, pregnancy, diabetes.

Danazol release form : capsules 200 mg.