Cycloferon injections and tablets: instructions, reviews, analogues. How to take cycloferon to treat diseases of bacterial and viral etiology

Cycloferon is a representative of immunostimulating agents. The medicine contains meglumine and acridone acetate, which have a detrimental effect on immunodeficiency, encephalitis, hepatitis and herpes. Cycloferon tablets have wide range actions, they have excellent antiviral properties, are able to resist the development of tumors and relieve inflammation. Instructions for use of Cycloferon indicate the possibility of using the drug, including in the event of HIV infections. Cycloferon in the form of an ointment is used for nonspecific and bacterial inflammation of the female external genitalia and diseases of the urinary tract, infections caused by the herpes virus.

The price of Cycloferon depends on the form of release - Liniment 5%, tablets 150 mg or solution 250 mg/2 ml. The price of tablets depends on their number in the pack.

1. Pharmacological action

Cycloferon is able to penetrate all protective barriers of the body, including the barrier between the blood and the brain. The maximum concentration of the active substance is observed 3 hours after taking the drug orally and gradually decreases over 8 hours. In this case, the formation of Cycloferon clusters does not occur. The presence of the drug in trace concentrations is observed for 24 hours.

2. indications for use

• Treatment, groups B and C various shapes currents;

Cycloferon in tablet form (as part of a medicinal complex for adult patients):

• in early clinical stages;
• Acute respiratory viral diseases;
• Diseases caused by the herpes virus;
• Secondary immunodeficiency conditions caused by fungal and bacterial pathogens;
• B and C in various forms;
• Acute intestinal infectious diseases.

• on early stages;
• Viruses of all groups.

• All types of viral;
• in the early stages;
• Infectious diseases nervous system;
• Infectious diseases caused by cytomegalovirus or herpes virus;
• System inflammatory diseases connective tissue;
• Rheumatic diseases;
• Secondary immunodeficiency conditions caused by fungal or bacterial pathogens;
• Chlamydia;
• Degenerative.

• Infectious diseases caused by the herpes virus;
• Bacterial and nonspecific inflammatory diseases of the external genitalia in women;
• Bacterial and nonspecific inflammatory diseases of the urinary canal.

3. Method of application

When treating pediatric patients, the drug is taken once a day, half an hour before meals, and its dosage is calculated according to the following scheme:

• Age 4-6 years - 1 tablet;
• Ages from 6-11 years - 2 tablets;
• Ages from 12 years - 3 tablets.

• All types of viral hepatitis in acute form- 2 doses at an interval of 24 hours, 3 doses at an interval of 48 hours and 5 doses at an interval of 72 hours (general course - up to 30 tablets);
• All types of viral in chronic form - the interval between doses is 48 hours (general course up to 150 tablets);
• The initial stage is 2 doses at an interval of 24 hours, 3 doses at an interval of 48 hours and 4 doses at an interval of 72 hours at the recommended dosage. Then the frequency between doses is 3-5 days for 5 months;
• Infectious diseases caused by the herpes virus - 2 doses at an interval of 24 hours, 3 doses at an interval of 48 hours and 2 doses at an interval of 72 hours at the recommended dosage;
• Acute infectious bowel diseases - 2 doses at an interval of 24 hours, 3 doses at an interval of 48 hours and one dose at an interval of 72 hours in the recommended dosage (general course - up to 18 tablets);
• or acute respiratory viral diseases during epidemics - 4 doses at intervals of 24 hours at the recommended dosage. Next 5 doses every 72 hours. General course- up to 30 tablets;
• For the treatment of acute respiratory viral diseases - 5-9 doses within 24 hours.

• Infectious diseases caused by the herpes virus - 2-4 tablets: 2 doses at an interval of 24 hours, 3 doses at an interval of 48 hours and 5 doses at an interval of 72 hours (general course - up to 40 tablets);
• All types of viral - 4 tablets: 2 doses at an interval of 24 hours, 3 doses at an interval of 48 hours and 5 doses at an interval of 72 hours. Next - 4 tablets every 5 days for 3.5 months (general course - up to 150 tablets). It is possible to prescribe repeated courses of treatment a month after the end of the previous one. Prescribing more than 2 courses is contraindicated;
• Infectious diseases of the intestines - 2 tablets: 2 doses at an interval of 24 hours, 3 doses at an interval of 48 hours and 5 doses at an interval of 72 hours (general course - 20 tablets);
• Infectious diseases of the nervous system - 4 tablets: 2 doses at an interval of 24 hours, 3 doses at an interval of 48 hours and 5 doses at an interval of 72 hours. Next - 4 tablets every 5 days for 2.5 months (general course - 100 tablets);
• in the early stages - 4 tablets: 2 doses at an interval of 24 hours, 3 doses at an interval of 48 hours and 5 doses at an interval of 72 hours. Next - 4 tablets at intervals of 3-5 days (general course - up to 150 tablets). A repeat course is prescribed 3 weeks after the end of the previous one;
• Secondary immunodeficiencies - 2 tablets: 2 doses at an interval of 24 hours, 3 doses at an interval of 48 hours and 5 doses at an interval of 72 hours (general course - 20 tablets).

The drug is taken once a day in the form of intramuscular or intravenous injections.

The general regimen for using Cycloferon is: 2 doses every 24 hours, 3 doses every 48 hours and 7 doses every 72 hours at the recommended dosage. The dosage depends on the type of disease:

• All types of viral hepatitis – 250-500 mg of the drug: 10 injections;
• Infectious diseases caused by cytomegalovirus or herpes virus – 250 mg of the drug: 10 injections;
• Infectious diseases of the nervous system – 250-500 mg of the drug: 12 injections;
• Initial stages - 500 mg of the drug: 10 injections according to the general scheme, then 1 injection every 5 days for 2.5 months. The appointment of a second course occurs one month after the end of the previous one;
• Bacterial venereal diseases– 250 mg Cycloferon: 10 injections;
• Secondary immunodeficiency conditions – 250 mg of the drug: 10 injections;
• Systemic inflammatory diseases of connective tissue and joints – 250 mg of the drug: 5 injections. 4 courses are required with an interval of 2 weeks;
• Degenerative diseases of the musculoskeletal system – 250 mg of the drug: 5 injections. 2 courses are required with an interval of 2 weeks.

Cycloferon is used once a day. Daily dosage take at the rate of 6-10 mg per kg of body weight. The frequency of use depends on the type of disease:

• All types of viral hepatitis in acute form - 2 doses at an interval of 24 hours and 13 doses at an interval of 48 hours at the calculated dosage;
• All types of viral in chronic form - 2 doses at an interval of 24 hours and 8 doses at an interval of 48 hours at the calculated dosage. Next, the drug is used every 3 days for 3 months;
• in the early stages - 2 doses at an interval of 24 hours and 8 doses at an interval of 48 hours at the calculated dosage. Next, Cycloferon is used every 5 days for 3-6 months;
• Infectious diseases caused by the herpes virus - 2 doses at an interval of 24 hours, 3 doses at an interval of 48 hours and 5 doses at an interval of 72 hours at the calculated dosage. If necessary, treatment is continued at intervals of 5 days for 1 month.

During treatment skin lesions caused by the herpes virus:

A single application of a thin layer of the drug to the affected area for 5 days.

When treating genital herpes:

Daily single injections of the drug into the urethra or vagina, 5 ml for 15 days.

In the treatment of bacterial and fungal inflammations urethra:

A single injection of Cycloferon into the urethra every second day for 15 days.

In the treatment of bacterial inflammatory diseases of the genital organs in women:

Single daily administration of the drug into the vagina (or combined administration of the drug into the vagina and urethra - in case of a joint infectious process) in a dosage of 10 ml for 15 days.

4. Side effects

5. Contraindications

6. During pregnancy and lactation

7. Interaction with other drugs

8. Overdose

9. Release form

10. Storage conditions

Shelf life:

• Cycloferon in tablet form - no more than 2 years;
• Cycloferon in the form of an injection solution - no more than 3 years;
• Cycloferon in ointment form - no more than 2 years.

11. Composition

In 1 ml of Cycloferon liniment:

• meglumine acridone acetate* in terms of acridone acetic acid - 50 mg;
• Excipients: benzalkonium chloride, 1,2-propylene glycol.

1 tablet:

• meglumine acridone acetate* in terms of acridone acetic acid - 150 mg;
• Excipients: povidone, calcium stearate, hypromellose, polysorbate, copolymer of methacrylic acid and ethyl acrylate, propylene glycol.

1 ml solution:

• meglumine acridone acetate* in terms of acridone acetic acid - 125 mg;
• Excipients: water.

12. Conditions for dispensing from pharmacies

Instructions for use of Cycloferon tablets contain a list of symptoms and diseases for which the use of the drug is recommended, including:

• AIDS is a disease that can destroy any person. As a result of the virus damaging the body, our immune cells lose their ability to resist the harmful effects of even weak microorganisms. The price and demand for Cycloferon in this case is explained complete absence side effects and the possibility of long-term use without harm to internal organs.
• Nervous system infections.
• Rheumatic diseases.
• Bacterial infections of the genitourinary system.
• All types of viruses, etc.

In all cases, the medicine shows exceptional effectiveness provided it is used for a long time.

Presented on our website detailed instructions for use and current cost of Cycloferon.

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* Instructions for medical use to the drug Cycloferon has been published in free translation. THERE ARE CONTRAINDICATIONS. BEFORE USE, YOU MUST CONSULT WITH A SPECIALIST

Associate Professor of the Department of Pediatrics-1 at Osh State University. Neonatologist-reanimatologist
RS OMKB. Candidate of Medical Sciences.

The drug contains an interferon inducer – meglumine acridone acetate. The substance provokes the synthesis of protective proteins. Interferon suppresses the reproduction of influenza viruses, hepatitis B and C, ARVI, herpes, intestinal rotaviruses. Doctors prescribe Cycloferon tablets for the prevention of seasonal colds in children according to the instructions for use.

One yellow, biconvex, enteric-coated tablet contains 150 mg of interferon inducer. The peak activity of the tablet is 2-3 hours after administration. It is eliminated within a day and is not accumulated by the body.

Cycloferon tablets are used for prophylaxis in children if:

• in a child care facility or at home there is a patient or a contact of viral infections;
• there is a massive epidemic of influenza or ARVI;
• mucous discharge from the nose and sore throat are observed.

Attention! Children with gastritis, enteritis, colitis, duodenitis, endocrine disorders, with a tendency to allergies, the drug is given after consulting a doctor.

Instructions for use of Cycloferon tablets for children 3 years old

The appendix to the instructions for use of Cycloferon tablets states that studies confirming the safety of use of the drug for children under 4 years of age have not been conducted.
Only a doctor can prescribe the use of Cycloferon to a 3-year-old child after a detailed examination. As a rule, in this case the dosage is reduced by 2 times:

• 1/2 tablet for influenza and ARVI on the 1st, 2nd, 4th, 6th, 8th, 11th, 14th, 17th, 20th and 23rd day of treatment;
• 75 mg for disease prevention on days 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23.

Attention! Without consulting a pediatrician, Cycloferon should not be used in children under 3 years of age.
In such cases, the drug is replaced with an analogue or a drug similar in effect:

1. can be used in children from 1 month. Suitable for the treatment of influenza and ARVI, neuroinfections, herpesvirus and intestinal infections. In the first 2 hours, take 5 tablets every 30 minutes, then another 3 tablets at intervals of 3 hours. The next day, take 1 tablet 3 times a day at equal intervals.
2. Immunal solution is suitable for children over 1 year of age for prevention colds And . A child from 1 to 6 years old needs to dissolve 1 ml of solution in a small amount of water. Take 3 times a day. The therapeutic course is a minimum of 7 days and can be extended to 8 weeks of continuous use.
3. Interferon is intended for the treatment of viral diseases in children from birth. Available in the form of suppositories and lyophysiate for the preparation of a solution for instillation into the nose or inhalation. One suppository is administered 2 times a day. Before instillation into the nose, dilute the dry solution by filling the ampoule with water up to the mark. For prevention, instill 5 drops twice a day. IN acute period for treating diseases, instill 5 drops every 2 hours for three days. For inhalation, three ampoules of Interferon are diluted in 10 ml boiled water. Inhalations are carried out twice a day.

Instructions for use of Cycloferon tablets for children 4 years old

The official instructions for Cycloferon tablets allow their use for prevention in children over 4 years of age. The baby should be able to swallow the tablet without chewing or dissolving. Give one tablet once a day, half an hour before meals, with 100 ml of boiled warm water.

The prevention regimen depends on the contact virus:

• contacts of influenza, acute respiratory infections, acute respiratory viral infections take one tablet on days 1 and 2, then every other day - on days 4, 6, 8. Afterwards, take 2 days later - on the 11, 14, 17, 20, 23rd day from the moment of contact or the appearance of the initial clinic;
• contacts with herpes follow the regimen: one tablet in the first two days. We skip the third, fifth, seventh days and drink on days 4, 6, 8, continuing two days later on days 11, 14.

After 3 weeks the scheme can be repeated. The optimal frequency of prophylaxis is 2 times a year. If a pill is missed, continue taking it without changing the regimen or doubling the dose. At a temperature, skin rashes, vomiting, stool disorder, stop taking the drug and seek medical help.

The dosage and scheme of use of the drug for children 5 years of age corresponds to the instructions for 4 year old children.

Instructions for use of Cycloferon tablets for children 7 years old

Instructions for the use of Cycloferon tablets for prevention in children school age differs in the dosage of the drug. Children 7-12 years old are given 2-3 tablets per dose according to the scheme given in the instructions. On full course prevention of influenza and ARVI will require 20-30 tablets. To prevent the development herpetic infection You should stock up on 14–21 tablets.

Price of Cycloferon tablets 150 mg

Tablets with 150 mg of the active substance in contour cells of 10 pieces are produced by Polisan from St. Petersburg. Price of Cycloferon tablets with instructions included in the package for use in children:

• 10 tablets – 180 -200 rubles;
• 20 tablets – 330-360 rubles;
• 50 tablets – 750-850 rubles.

For children 4-6 years old, the cost of prophylaxis with Cycloferon tablets will be 200 rubles, for teenagers - 500-600 rubles.

Reviews on the use of Cycloferon 150 mg tablets for prevention in children

Reviews about Cycloferon tablets for the prevention of children are different.

Natalia
26 years

An excellent remedy for preventing colds in children

10.05.2018 11:47

Cycloferon tablets was taken for the first time, on the recommendation of a pediatrician. Without waiting for snot and fever, we took the tablets in the fall and spring. My daughter did not miss kindergarten even during the cold season. Yes, the price of the drug cannot be called budgetary, but it is certainly cheaper than being on sick leave

Advantages

The child was not sick

Strengthens immunity

Flaws

A bit expensive

Suitable for children over 4 years of age only

Konazakova I.A.
pediatrician

Good antiviral immunomodulator

17.06.2018 15:17

Cycloferon has been known to doctors for almost 20 years. The remedy is effective, but not easy. Its purpose requires experience and knowledge. I prescribe it for children only based on immunogram results. Prevents ARVI during the epidemic season, reduces the severity of symptoms in the existing disease. At correct appointment side effects No

Advantages

Effective in complex therapy

Stimulates protective functions body

Flaws

Difficult regimen for patients

Tatiana
38 years

No effect

22.10.2018 23:09

My boy gets sick often. I found out about Cycloferon on the forum. My son had a fever with a runny nose and cough. I decided to try these pills. We drank it for three days and didn’t notice any effect. At night the temperature jumped, a doctor was called. The doctor diagnosed bronchitis and prescribed it. The drug did not work for us.

Advantages

Flaws

No result

Negative reviews of the use of Cycloferon in children are associated with non-compliance with the instructions - violation of the dosage and dosage regimen.

It is convenient to give medications to babies in the form of syrup or suspension. The production of Cycloferon in syrup and suspension has not been established. For prophylaxis with syrup in children, Anaferon is used instead of Cycloferon. Give children from 1 month 10 drops three times a day for 5 days.

Cycloferon suppositories - instructions for use for prevention in children

Active substance from rectal suppositories enters the blood and has therapeutic effect, bypassing the gastrointestinal tract and liver barrier. Cycloferon is not produced in suppositories. Viferon suppositories can replace Cycloferon for prevention in children. Viferon suppositories for preventive purposes are prescribed to children from birth, 1 piece 3 times a day every 8 hours for 5 days.

For intravenous or intramuscular injection intended:

• dry dried (lyophilized) powder for preparing a solution with 250 mg of the main substance;
• ampoules of 2 ml of ready solution with 125 mg medicinal substance per 1 ml. The cardboard package contains 5 glass ampoules and instructions for using Cycloferon injections for children.

Indications for interferon inducer injections for children in complex treatment and prevention of exacerbations in chronic processes:

• acute and chronic viral hepatitis (A, B, C, D);
• carriage of the human immunodeficiency virus at stage 2A-2B;
• infection with the herpes virus.

The immunostimulant exhibits direct antiviral and anti-inflammatory activity. After injection, it reaches maximum concentration in blood plasma within an hour. The elimination period is 24 hours.

Note! Children with diseases thyroid gland, diabetes mellitus, liver pathologies, allergic reactions, the drug is not prescribed.

Instructions for use of Cycloferon for children over 3 years old

According to the instructions for use of Cycloferon ampoules, injections are not prescribed for children under 3 years of age due to the lack of data on safe use injection form medications at this age. If necessary, you can replace Cycloferon injections with drugs of similar action:

• Glutoxim has a pronounced immunomodulating effect. For children, the dosage is calculated at the rate of 2.5-5 mg per 1 kg of child weight per day. It is administered intramuscularly, intravenously and subcutaneously.
• Timalin Children under 1 year of age are administered intramuscularly at 1 mg, from 1 year to 3 3 years - at 1-2 mg. The therapeutic course lasts 3-10 days, a repeat course - after 1-6 months.
• Thymogen indicated for children intramuscularly at a dose of 50-75 mcg once a day for 3-10 days. A repeat course is carried out at least a month later. During the year you can conduct 4 courses. When using injections, it is possible to develop allergic reactions.

Instructions for use of Cycloferon for children 4 years old

The injection dose from an ampoule of Cycloferon for children is calculated according to the instructions for use as 6 mg per kg of body weight of the child. Children 4 years old use ampoules with ready-made solution. Inject 1 ml once a day. Scheme of injections by day:

• spicy viral hepatitis: injection on days 1, 2, then every other day on days 4, 6, 8, then on days 11, 14, 17, 20, 23. Repeat after 2 weeks;
• chronic viral hepatitis: on days 1, 2 an injection is given, the third, fifth and seventh days are skipped and injections are given on days 4, 6, 8, continuing on days 11, 14. Next 3 months maintenance injections three times a week;
• human immunodeficiency virus: 1, 2 days in a row, then every other day on days 4, 6, 8 and two days later on days 11, 14, 17, 20, 23. Then for 3 months they give one injection every three days. Repeated after 10 days;
• the herpes virus requires injections on days 1 and 2, then on days 4, 6, 8 and on days 11 and 14. Maintenance course – one injection every 3 days for a month.

The drug is combined with interferons and chemotherapy, enhancing their effect. Side effects include bluish urine. To avoid confusion, mark each injection given (or pill taken) on the calendar.

The daily dose is taken one time before meals (30-40 minutes). If a drug dose is missed, then next appointment Do not take a double dose.
For children 6 years of age, a single dosage is 150 mg (1 tablet) and is taken according to the following scheme:

• influenza and ARVI - on days 1, 2, 4, 6, 11, 14, 17, 20 and 23;
• prevention of influenza and ARVI - on days 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23;
• intestinal infections - 1, 2, 4, 6, 8 and 11 days;
• herpes - 1, 2, 4, 6, 8, 11 and 14 days;
• HIV - 1, 2, 4, 6, 8, 11, 14, 17, 20 and then after 3-5 days for 5 months;
• hepatitis - on 1, 2, 4, 6, 8, 10, 12, 14, 17, 20, 23, etc. up to 6 months.

The ready-made solution of the immunostimulant is indicated for children 6 years old in a dosage of 1-1.5 ml according to the scheme.

In addition, the injection solution can be used for diseases of the upper respiratory tract how to inhale:

1. Mix 2-4 ml of Cycloferon and 4 ml of saline solution.
2. For inhalation, use a nebulizer.
3. Treatment duration is 10 sessions.
4. After inhalation, do not eat or drink for 30-40 minutes. Don't go outside for an hour.

Children over 7 can make a solution from lyophilized powder or use a ready-made one. Administer 2 ml according to the disease regimen from the instructions. The dry powder is diluted with 2 ml of water for injection, shaking the bottle with the solution until smooth. Dry powder of Cycloferon is used in medical institutions, it is more convenient to use a ready-made solution at home.

Injection ampoules Cycloferon - instructions for use for children

Injections are given once a day according to the schedule in accordance with the age dosage:

• 4-6 years 1 ml;
• 6-7 years 1-1.5 ml;
• 7-12 years old, 2 ml.

Cycloferon is dispensed in ampoules according to a doctor's prescription. Stored in a dark, dry place, out of reach of children, at a temperature of 0-25 0 C. Shelf life - 5 years from the date of issue. Do not use expired medication. Normal solution transparent, yellow. If the color has changed or a sediment has appeared, the ampoule is unusable.

Tradename:

Dosage form:

Compound:

Description:

Pharmacotherapeutic group:

ATX code:

Pharmacological properties

Indications for use:

Contraindications:

Use during pregnancy and breastfeeding

Directions for use and doses

children 4-6 years old: 150 mg (1 tablet) per dose;
children 7-11 years old: 300-450 mg (2-3 tablets) per dose;
adults and children over 12 years old: 450-600 (3-4 tablets) per dose.

It is advisable to repeat the course 2-3 weeks after the end of the first course.

In adults:
1. When treating influenza and acute respiratory diseases, the drug is taken on days 1, 2, 4, 6, 8 (course of treatment - 20 tablets). Treatment should begin at the first symptoms of the disease.
At severe course For influenza, take six tablets on the first day.
If necessary, additional symptomatic therapy(antipyretic, analgesic, expectorant).
2. For herpes infection, the drug is taken on days 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23 (course of treatment: 40 tablets). Treatment is most effective when the first symptoms of the disease appear.

In children from four years of age:
1. For influenza and acute respiratory diseases, the drug is taken in age-specific doses on days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23. The course of treatment ranges from 5 to 10 doses, depending on the severity of the condition and severity clinical symptoms.
2. For herpes infection, the drug is taken on the 1st, 2nd, 4th, 6th, 8th, 11th, 14th day of treatment. The course of treatment may vary depending on the severity of the condition and the severity of clinical symptoms.
3. For emergency nonspecific prevention of influenza and acute respiratory diseases (in direct contact with patients with influenza or acute respiratory infections of another etiology, during an influenza epidemic): on the 1st, 2nd, 4th, 6th, 8th day. Next, take a break of 72 hours (three days) and continue the course on the 11th, 14th, 17th, 20th, 23rd day. The general course is from 5 to 10 doses.

Side effect

Overdose

Interaction with other drugs

special instructions

Release form:

Storage conditions

Best before date

Conditions for dispensing from pharmacies:

Company manufacturer:

There are contraindications. Consult your doctor.

Currently, analogues of the drug are NOT FOR SALE

Preparations containing Meglumine acridone acetate (ATC code not assigned):

Cycloferon - instructions for use. The drug is a prescription, the information is intended only for healthcare professionals!

Clinical and pharmacological group:

Antiviral and immunomodulatory drug. Interferon synthesis inducer

pharmachologic effect

Immunomodulator. Meglumine acridone acetate is a low-molecular-weight interferon inducer, which determines a wide range of its biological activity (antiviral, immunomodulatory, anti-inflammatory). Interferonogenic activity of the drug at oral administration stored for 3 days.

The main interferon-producing cells after administration of the drug are macrophages, T- and B-lymphocytes. The drug induces high titers of interferon in organs and tissues containing lymphoid elements (spleen, liver, lungs), activates stem cells bone marrow, stimulating the formation of granulocytes. Cycloferon® activates T-lymphocytes and natural killer cells, normalizes the balance between subpopulations of T-helpers and T-suppressors. Enhances the activity of?-interferons.

It has a direct antiviral effect, suppressing virus reproduction in the early stages (1-5 days) of the infectious process, reducing the infectivity of viral offspring, leading to the formation of defective viral particles. Increases the body's nonspecific resistance to viral and bacterial infections.

Cycloferon® is effective against tick-borne encephalitis, influenza, hepatitis, herpes, cytomegalovirus, human immunodeficiency virus, papilloma virus and other viruses. In acute viral hepatitis, Cycloferon® prevents the disease from becoming chronic. At the stage of primary manifestations of HIV infection, it helps to stabilize immunity levels.

The drug has been found to be highly effective in complex therapy of acute and chronic bacterial infections (neuroinfections, chlamydia, bronchitis, pneumonia, postoperative complications, urogenital infections, peptic ulcer) as a component of immunotherapy. Meglumine acridone acetate exhibits high efficiency for rheumatic and systemic diseases connective tissue, suppressing autoimmune reactions and providing anti-inflammatory and analgesic effects.

Pharmacokinetics

Pills

After taking the drug orally to the maximum permissible dose Cmax in blood plasma is reached after 2-3 hours, the concentration gradually decreases by 8 hours, after 24 hours the active substance is detected in trace quantities.

T1/2 is 4-5 hours. When Cycloferon is used in recommended doses, there are no conditions for its accumulation in the body.

Injection

When administered in the maximum permissible dose, Cmax in the blood plasma is achieved after 1-2 hours. After 24 hours, the active substance is detected in trace amounts.

Penetrates through the BBB.

T1/2 is 4-5 hours. At long-term use no accumulation is observed in the body.

Indications for use of the drug CYCLOFERON®:

For oral administration:

• herpetic infection;
• influenza and acute respiratory diseases;
• acute intestinal infections;
• neuroinfections, including serous meningitis, tick-borne borelliosis (Lyme disease);
• HIV infection (stages 2A-2B);
• secondary immunodeficiencies associated with chronic bacterial and fungal infections.

As part of complex therapy in children over 4 years of age:

• herpetic infection;
• prevention and treatment of influenza and acute respiratory diseases;
• chronic viral hepatitis B and C;
• acute intestinal infections;
• HIV infection (stage 2A-2B).

For parenteral use:

As part of complex therapy in adults:

• HIV infection (stages 2A-2B);
• neuroinfections: serous meningitis and encephalitis, tick-borne borelliosis (Lyme disease);
• viral hepatitis A, B, C, D;
• herpetic infection;
• cytomegalovirus infection;
• secondary immunodeficiencies associated with acute and chronic bacterial and fungal infections;
• chlamydial infections;
• rheumatic and systemic connective tissue diseases ( rheumatoid arthritis, systemic lupus erythematosus);
• degenerative-dystrophic diseases of the joints (including deforming osteoarthritis).

As part of complex therapy in children:

• viral hepatitis A, B, C, D;
• herpetic infection;
• HIV infection (stages 2A-2B).

For external use:

As part of complex therapy in adults:

• herpetic infection of the skin and mucous membranes;
• treatment of urethritis and balanoposthitis of nonspecific and specific (gonorrhea, candidiasis, chlamydia and trichomonas) etiology;
• treatment of nonspecific bacterial vaginitis and vaginosis;
• treatment of chronic periodontitis.

Dosage regimen:

Inside:

Cycloferon® in tablet form is taken 1 time per day 30 minutes before meals, without chewing.

For adults with herpes infection, the drug is prescribed 4 tablets per dose on days 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23. The course of treatment is 40 tablets. Treatment is most effective when the first symptoms of the disease appear.

When treating influenza and acute respiratory diseases, 4 tablets are prescribed per dose on days 1, 2, 4, 6, 8. The course of treatment is 20 tablets. Treatment should begin at the first symptoms of infection. In case of severe disease, take 6 tablets at the first dose. If necessary, additional symptomatic therapy is carried out (antipyretics, analgesics, expectorants).

For chronic viral hepatitis B and C, the drug is taken 4 tablets per dose on the 1st, 2, 4, 6, 8, 11, 14, 17, 20 and 23 days of treatment and then according to the maintenance regimen, 4 tablets per dose 1 time in 3 days for 6 months while maintaining replicative and cytolytic activity for up to 12 months. A combination with interferons and antiviral drugs is recommended.

In complex therapy of intestinal infections, 2 tablets are used per dose on days 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23. The course of treatment is 20 tablets.

For neuroinfections, 4 tablets per dose are prescribed on days 1, 2, 4, 6, 8, 11, 14, 17, 20 and 23 and then according to a maintenance regimen, 4 tablets per dose once every 3 days for 2.5 months. The course of treatment is 140 tablets.

For HIV infection (stages 2A-2B), the drug is prescribed on days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23, 4 tablets per dose, and then maintenance treatment is carried out, 4 tablets 1 time every 3 days for 2.5 months. The course of treatment is 140 tablets. A repeat course is carried out after 2-3 weeks. after finishing the previous one 2-3 times.

At immunodeficiency states associated with chronic bacterial and fungal infections, 4 tablets are prescribed in the first 5 doses on days 1, 2, 4, 6, 8 and 2 tablets in the next 5 doses on days 11, 14, 17, 20, 23. The course of treatment is 30 tablets.

Cycloferon® is prescribed to children according to the following basic regimen: at the age of 4-6 years - 150 mg (1 tablet), at the age of 7-11 years - 300 mg (2 tablets), over 12 years - 450 mg (3 tablets) per reception 1 time per day. It is advisable to repeat the course 2-3 weeks after the end of the first course.

For herpes infection, take on days 1, 2, 4, 6, 8, 11, 14 of treatment. The course of treatment may vary depending on the severity of the condition and the severity of clinical symptoms.

For influenza and acute respiratory infections viral infections the drug is prescribed in age-specific doses on days 1, 2, 4, 6, 8, 11, 14, 17, 20, 23 and then once every 3 days. The course of treatment ranges from 5 to 15 doses, depending on the severity of the condition and the severity of symptoms.

As a means of emergency nonspecific prevention of acute respiratory diseases and influenza during periods of increased incidence, the drug is prescribed in the indicated age-specific doses on days 1, 2, 4, 6, 8, then another 5 times with an interval of 72 hours (3 days).

At chronic forms hepatitis B and/or C, the drug is prescribed in the indicated doses on days 1, 2, 4, 6, 8, 11, 14 and then once every 3 days for 6 months while maintaining replicative and cytolytic activity for up to 12 months. A combination with interferons and antiviral drugs is recommended.

For acute intestinal infections the drug is prescribed on days 1, 2, 4, 6, 8, 11 of treatment once a day. The course of treatment is 6-18 tablets.

For HIV infection (stages 2A-2B), the drug is taken according to the basic regimen on days 1, 2, 4, 6, 8, 11, 14, 17, 20 of therapy, then once every 3 days for 5 months.

Parenteral use:

For adults, Cycloferon® is administered intramuscularly or intravenously once a day according to the basic regimen: every other day. The duration of treatment depends on the disease.

For herpetic and cytomegalovirus infections the drug is prescribed according to the basic regimen - 10 injections of 250 mg each. The total dose is 2.5 g. Treatment is most effective at the beginning of an exacerbation of the disease.

For neuroinfections, the drug is administered according to the basic regimen. The course of treatment is 12 injections of 250-500 mg in combination with etiotropic therapy. The total dose is 3-6 g. Repeated courses are carried out as needed.

At chlamydial infection treatment is carried out according to the basic scheme. The course of treatment is 10 injections of 250 mg. Total dose 2.5 g. Repeated course - after 10-14 days. It is advisable to combine Cycloferon with antibiotics.

For acute viral hepatitis A, B, C, D and mixed forms the drug is administered according to the basic scheme of 10 injections of 500 mg. The total dose is 5 g. In case of prolonged course, a repeat course is carried out after 10-14 days.

For chronic viral hepatitis B, C, D and mixed forms, the drug is administered according to the basic regimen of 10 injections of 500 mg, then according to the maintenance regimen 3 times a week. for 3 months as part of complex therapy. Recommended in combination with interferons and chemotherapy. The course is repeated after 10-14 days.

For HIV infection (stage 2A-2B), the drug is prescribed according to a basic regimen of 10 injections of 500 mg each and then according to a maintenance regimen once every three days for 2.5 months. The course is repeated after 10 days.

For immunodeficiency conditions, the course of treatment consists of 10 intramuscular injections according to the basic regimen in a single dose of 250 mg. The total dose is 2.5 g. A repeat course is carried out after 6-12 months.

For rheumatic and systemic connective tissue diseases, 4 courses of 5 injections are prescribed according to the basic regimen, 250 mg each with a break of 10-14 days. The doctor determines the need for a repeat course individually.

For degenerative-dystrophic diseases of the joints, 2 courses of 5 injections of 250 mg each are prescribed with a break of 10-14 days according to the basic regimen. The doctor determines the need for a repeat course individually.

For children, Cycloferon® is prescribed IM or IV 1 time per day. The daily therapeutic dose is 6-10 mg/kg body weight.

For acute viral hepatitis A, B, C, D and mixed forms, 15 injections of the drug are administered according to the basic regimen. In case of prolonged infection, the course is repeated after 10-14 days.

For chronic viral hepatitis B, C, D, the drug is administered according to a basic regimen of 10 injections and then according to a maintenance regimen 3 times a week for 3 months as part of complex therapy. Use in combination with interferons and chemotherapy is recommended.

For HIV infection (stages 2A-2B), a course of 10 injections is prescribed according to the basic regimen and then according to the maintenance regimen once every 3 days for 3 months. A repeat course is carried out after 10 days.

For herpes infection, a course of 10 injections is carried out according to the basic scheme. If the replicative activity of the virus is maintained, the course of treatment is continued according to a maintenance regimen with administration of the drug once every 3 days for 4 weeks.

External use:

For herpes infection, liniment is applied thin layer on the affected area 1-2 for 5 days. For genital herpes - intraurethral (intravaginal) instillations once a day, 5 ml for 10-15 days daily. It is possible to combine liniment with other antiherpetic agents (both systemic and local).

When treating nonspecific and candidal urethritis intraurethral instillations are performed in a volume of 5-10 ml, depending on the level of damage to the urethra. In case of defeat upper section urethra in men, the cannula of a syringe with liniment is inserted into the external opening of the urethra, then the opening is clamped for 1.5-3 minutes, after which the instillation solution is evacuated by gravity. After 30 minutes, the patient is advised to urinate. Longer exposure may lead to swelling of the urethral mucosa. The course of treatment is 10-14 days. For lesions of the posterior urethra, the area of ​​the seminal glands, intraurethral instillations through a catheter are used in a volume of 5-10 ml of the drug for 10-14 days every other day (5-7 instillations per course).

When treating urethritis of a specific etiology - the combined use of intraurethral instillations of Cycloferon with specific antimicrobial drugs according to traditional regimens.

For balanoposthitis, the glans penis should be treated and foreskin Cycloferon liniment 1 time per day (1/2 bottle or 5 ml) for 10-14 days.

In the treatment of candidal vaginitis, nonspecific vaginitis(endocervicitis) and bacterial vaginosis The drug can be used both as monotherapy and as part of complex treatment. Use intravaginal instillations of the drug, 5-10 ml, for 10-15 days, 1-2 times a day. In parallel, in the case of combined damage to the vaginal and urethral mucosa, it is advisable to use intravaginal and intraurethral instillations in volume (5 ml daily for 10-14 days). It is possible to use tampons impregnated with liniment.

For chronic forms of diseases, the drug combines well with the use of official medicines ( vaginal tablets, candles).

To use intravaginally, you should open the tube, pierce the membrane with a disposable needle and syringe (volume 5 ml), draw up liniment, remove and discard the needle. Insert the filled syringe into the vagina in a lying position and use a piston to squeeze out the liniment. If the package contains a vaginal applicator: pierce the membrane, screw the applicator until it stops on the hole. Squeeze the liniment into the applicator cavity until the entire piston is pushed out. Remove the filled applicator from the hole, insert it into the vagina and use a piston to squeeze out the liniment. To prevent free evacuation of the drug, the vaginal entrance is sealed with a small sterile cotton swab for 2-3 hours.

When treating chronic periodontitis, before using liniment, it is advisable to rinse the periodontal pockets with an antiseptic, then apply the liniment with a cotton swab in a volume of 1.5 ml (1/3) to the gum by application (do not rub in) 1-2 times with an interval of 10-12 hours. Duration of therapy 12-14 days.

For all indications, if necessary, you can repeat the course of treatment with Cycloferon after 14 days.

Side effect

Possible: allergic reactions.

Contraindications to the use of the drug CYCLOFERON®

• liver cirrhosis in the stage of decompensation;
• children under 4 years of age;
• pregnancy;
• lactation period (breastfeeding);
• increased sensitivity to the components of the drug.

Use of the drug CYCLOFERON® during pregnancy and breastfeeding

The drug is contraindicated for use during pregnancy and lactation (breastfeeding).

Use for liver dysfunction

Contraindicated in liver cirrhosis in the stage of decompensation.

special instructions

For diseases of the thyroid gland, the use of Cycloferon should be carried out under the supervision of an endocrinologist.

When treating influenza and ARVI, in addition to Cycloferon therapy, symptomatic therapy should be carried out.

Impact on the ability to drive vehicles and operate machinery

Cycloferon® does not affect the ability to drive vehicles.

Overdose

On currently no cases of drug overdose have been reported.

Drug interactions

Cycloferon® is compatible with all drugs used in the treatment of these diseases (including interferons and chemotherapy drugs).

Cycloferon® enhances the effect of interferons and nucleoside analogues.

At joint use Cycloferon® reduces the side effects of chemotherapy and interferon therapy.

Conditions for dispensing from pharmacies

The drug is available with a prescription.

Storage conditions and periods

List B. Enteric-coated tablets should be stored in a dry place, protected from light, at a temperature of 10° to 25°C. Shelf life - 2 years.

The solution for injection should be stored in a dry place, protected from light, at a temperature of 0° to 25°C. Freezing the injection solution during transportation (at negative temperatures) does not lead to a change in properties. Thawed at room temperature, the drug retains its biological and physicochemical characteristics. If the color of the solution changes and a precipitate forms, the use of the drug is unacceptable. Shelf life - 3 years.

Cycloferon is an effective antiviral, as well as an immunomodulatory drug that helps cope with various diseases infectious-inflammatory origin.

This drug has a pronounced antiviral effect against many strains of viral pathogens (influenza, herpes, viral hepatitis, tick-borne encephalitis and etc.).

Cycloferon, when used regularly, also exhibits good anti-inflammatory and analgesic (pain-relieving) effects quite quickly and effectively eliminating the inflammatory process.

Antiviral medicinal product may be prescribed for the prevention of various infectious diseases, and in the complex treatment of influenza, acute respiratory viral infections and other infectious and inflammatory processes.

Regular use of Cycloferon helps to significantly strengthen the body’s immunity, while preventing the risk of possible development viral diseases.

Main indications for the use of Cycloferon:

• herpes infection (herpes);
• flu or cold;
• viral hepatitis A, B, C, D;
• neuroinfection;
• rheumatic inflammatory diseases (rheumatoid arthritis, radiculitis, osteoarthritis);
• cytomegalovirus infection;
• HIV infection.

Attention: Before starting to use Cycloferon, it is recommended to consult with a qualified general practitioner!

The drug is available in the form of soluble tablets for internal reception, as well as a solution for intramuscular or intravenous injection.

How to take Cycloferon?

The daily dose of Cycloferon for adults is 1 t. 2-3 r. per day, preferably 20-30 minutes. before meals, drinking sufficient quantity water.

Children need daily dose is determined by the attending physician absolutely individually for each child, depending on the age and severity of the particular disease.

• 4-7 years: 1 t. (150 mg.) 1 r. for a day;
• 8-12 years: 1 t. 2 rubles/day;
• 13-16 years old: 1 t. 2-3 rubles/day.

The average duration of treatment with Cycloferon is 7-10 days, while a second course of taking this drug can be carried out. medicine, but not earlier than 2-3 weeks.

In case of sufficiently severe infectious and inflammatory diseases, the use of this drug in the form of injections may be prescribed.

Contraindications to the use of Cycloferon

• pregnancy and lactation (breastfeeding);
• hypersensitivity (increased sensitivity of the body to the main active substance medicinal product);
• severe liver disease (cirrhosis);
• child's age up to 4 years;
• stomach ulcer (may be used this drug with extreme caution).

Side effects of Cycloferon

As a rule, this antiviral drug is tolerated quite well by patients, but extremely rarely, local allergic reactions on the skin may develop (urticaria, increased itchy skin and etc.).

If any allergic reactions occur, it is recommended to consult your doctor!

In this article, we found out what Cycloferon helps with, as well as how to take it correctly.