How to take nystatin to a woman with thrush. Is it possible to use Nystatin tablets, suppositories, ointment for children? Nystatin tablets: what helps

Release form and mechanism of action

Nystatin is available in the form of tablets of 250,000 and 500,000 units. There are 2 strips of 10 tablets in a cardboard package. There are also 20 tablets in a glass jar.

Nystatin belongs to the group of polyene antibiotics. It acts selectively on certain types of fungi, especially yeast-like fungi of the genus Aspergilla and Candida.

The drug has low toxicity, is absorbed quite well orally after administration, and most of it is excreted in the feces. Nystatin activity is measured in action units (AU).

The drug is embedded in the cell membrane of the fungus and disrupts its permeability. This causes the main components to be output. Under the influence of Nystatin, fungal cells lose resistance to external forces.

The medicine does not act on protozoan microorganisms and viruses. The adaptation of mushrooms to the drug occurs very slowly. The drug is poorly absorbed and practically cannot be biotransformed. Nystatin is excreted from the human body along with feces, and in nursing women, also with milk.

Nystatin has established itself as a highly effective treatment for childhood laryngeal candidiasis. Pediatricians advise dissolving a powdered tablet of the drug at a dosage of 250,000 units in a 1 ml ampoule of vitamin B12 and lubricating the fungus-affected areas with the resulting mixture. oral cavity. As an alternative to vitamin B12, you can use regular boiled water.

10-12 months: 100-125000 units;

1-3 years: 250,000 units;

3-13 years: 250-400000 units;

over 13 years: 250-500000 units.

If you follow the dosage prescribed by your doctor, relief from the symptoms of candidiasis occurs on the 2-3rd day of using the medicinal solution.

Nystatin for thrush during pregnancy

Can the drug be used during pregnancy? Since Nystatin is not absorbed into the blood, there is no point in talking about its harm to the unborn fetus. Therefore, it can be used during pregnancy.

How to take and what form of the product to use? Many doctors recommend choosing ointment treatment if thrush appears during pregnancy. It is safer than suppositories and tablets. But does treatment with nystatin ointment help with thrush in pregnant women? The drug in this form of release is without complex treatment may have little effect on Candida fungus.

Despite all the positive properties of Nystatin, it should absolutely not be used during pregnancy. early stages. This is due to the effect of the drug on the mucous membrane, especially with vaginal candidiasis.

What is the best treatment for thrush in women?

This disease occurs more often in women. Causes:

• Hypothermia;
• Chronic infections of the genitourinary system;
• Reduced immunity;
• pregnancy, etc.

Vaginal candidiasis often becomes chronic, especially when a sexual partner is infected. Therefore, if the patient is in a relationship, a man should undergo simultaneous therapy. And while taking the drug, sexual intercourse should be stopped.

The main method of treatment for women is suppositories; in addition, the doctor prescribes pills.

If there is another infection, choose complex drug with Nystatin in the composition: Polygynax, Terzhinan.

During pregnancy, the immune system is under stress, so thrush occurs in every second woman. Usually Nystatin is not prescribed to pregnant women - only in rare cases, and only in the form of suppositories.

Men undergo treatment simultaneously with their sexual partner. They are prescribed tablets or ointment, often in combination.

For children, the drug is prescribed for mouth rinsing in the form of granules or tablets - a solution is prepared from them.

For girls under 18 years of age, suppositories are not prescribed for thrush - they are limited to ointments and tablets.

According to medical statistics, eight out of ten women of childbearing age regularly face the problem of excessive proliferation of the Candida fungus, which provokes discomfort in the genital area and heavy discharge grainy consistency with a pungent yeasty odor.

In the absence of proper treatment, thrush (vaginal candidiasis) can not only go from acute stage into a chronic one, but also provoke the development of complications, so if symptoms of the disease are detected, you should immediately consult a doctor. The article discusses in detail the main indications and contraindications for the use of the drug Nystatin for thrush (candidiasis), the instructions for using Nystatin for thrush are described in detail, possible side effects, the principle of action of Nystatin, release forms (Nystatin tablets, vaginal and rectal Nystatin suppositories).

Not everyone knows how to properly use Nystatin for thrush. The use of any drug for the treatment of thrush (candidiasis) requires knowledge of what form of development candidiasis is in. At the acute stage of thrush development, the doctor prescribes Nystatin vaginal suppositories along with ointment.

If you follow the specialist’s recommendations, recovery occurs on the 10th day of use. medicines. Thrush that has become chronic is difficult to cure. As a rule, to completely suppress the proliferation of harmful bacteria, it is necessary to undergo several courses of treatment with Nystatin with a break of 2-3 weeks.

1 consumption of alcoholic beverages;

2 uses of the drug rectally and vaginally during menstruation ( vaginal discharge interfere with the absorption of the active components of the drug);

3 sexual encounters;

4 doses of antacids containing magnesium, aluminum and calcium (Maalox, Almagel, etc.);

5 use of "Clotrimazole" (substances included in Nystatin reduce the effectiveness of the active components of the antifungal cream).

If the above rules are followed, relief of thrush symptoms occurs already on the 3-5th day of treatment. In order to reduce the risk of reinfection, it is recommended to undergo treatment with Nystatin together with a partner. There are a number of other drugs available to treat candidiasis if a particular drug is not suitable due to certain conditions.

1 candidiasis dysbacteriosis;

2 vaginal candidiasis;

3 candidiasis of the gastrointestinal tract;

4 candidiasis of the rectum.

The drug is widely used for the prevention postoperative complications, and also as a means of normalizing intestinal microflora before surgery.

1-3 years: 250,000 units;

One of the best and most proven drugs for thrush today is Nystatin. The principle of its action is binding to sterol molecules, after which the protective membrane of the fungal cell weakens and dies. It has a particularly destructive effect on fungi of the genus Candida, which provoke candidiasis.

1. Pills.
2. Candles.
3. Ointment.

Let's take a closer look at each of them. Let's study side effects, contraindications, precautions, interactions with other medications, user reviews on the forum and average prices. Well, instructions so that you understand how to take Nystatin.

Treatment of thrush with Nystatin can occur in two ways:

1. Systemic;
2. Local.

This largely depends on the type of candidiasis, as well as the gender of the patient. It is not recommended to use the drug without a doctor's prescription. Usually, when one partner is affected by candidiasis of the genital organs, the other is also prescribed a course of preventive treatment. During this period, it is recommended to refrain from unprotected sex.

The tablets can be taken by both men and women. They are prescribed for the treatment of all types of candidiasis. The protective layer of the tablet is yellowish in color. The full course of treatment is prescribed by the attending physician. It is usually necessary to take Nystatin tablets for 7-10 days to completely destroy the active fungus.

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It is important to note that you cannot stop taking the drug on your own. Even if there are no symptoms of thrush 2 days after the start of treatment, you need to drink the entire course. Tablets for candidiasis can be prescribed by a doctor as preventative measure. If fungal infection in the mouth or larynx, then you should put the tablet behind the cheek or under the tongue and wait for it to completely dissolve.

For rectal and vaginal candidiasis the drug is prescribed in the form of suppositories. Suppositories with nystatin are mainly prescribed to women for genital thrush. Before starting a course of treatment, a girl must consult a doctor and undergo a full examination.

The full course of drug administration is usually two weeks. But symptoms of thrush may go away within a few days after starting to use suppositories.

You should also remember that it is best to perform the procedure in the evening; before doing this, you need to take a shower. If you don't follow the rules intimate hygiene, then the colon and vagina are at risk of infection. The candle is inserted in a lying position. After this, it is not recommended to get up for 3 to 4 hours.

Nystatin ointment for thrush is prescribed quite often. It helps to cope with local foci of infection. In this case, it is recommended to use the ointment in conjunction with other forms of release of the drug. This way the treatment effect is enhanced by the medicine. The ointment for thrush is most often prescribed to men, but can also be used by women.

How to take Nystatin tablets for thrush

Frequency of administration: for adults – up to 8 times a day, for children – up to 4. There is no connection to food intake.

The dosage for adults is selected individually, taking into account the form, stage and characteristics of the disease. The instructions indicate: maximum 6,000,000 units (for generalized thrush). But doctors say that the fungicidal effect appears when consumed ≥ 10,000,000 units per day, which corresponds to 20 tablets. Simply put, 3-4 tablets at a time.

A single dose for children under 3 years of age is 25,000 units, a daily dose is 100,000 units.

The standard duration of therapy is 10-14 days.

Opinions about this medicine, as well as about any other, are different. Out of 10 respondents, 7 speak positively about the drug. Among the advantages, these people name:

• efficiency;
• affordability;
• no side effects (practically not absorbed, does not accumulate in the body).

Main disadvantages: long course of treatment, bitter taste.

One nuance cannot be ignored: 70% of respondents selected the drug on their own (without consulting a doctor or undergoing tests).

3 people complain about the absolute ineffectiveness of the tablet form of this antimycotic, but praise suppositories with nystatin.

It’s interesting: economically “savvy” comrades considered that full course They needed 14 packages of treatment No. 20, and the cost was 1,680 rubles. Agree, it's not that cheap.

99 out of 100 competent specialists consider this option obsolete and prescribe other systemic drugs. The reason is resistance. Simply put, the resistance of pathogenic microorganisms to therapeutic effects. In addition, there are a number of more powerful means, which are taken in a short course (1-3 pcs.) and in a lower dosage.

The tablet form of Nystatin for thrush according to the old scheme is recommended by doctors working in the outback far from the achievements of pharmaceuticals. And patients who are treating themselves buy it in accordance with previously received recommendations.

How to take Nystatin? Very simple. The tablets are taken orally. Swallow them whole. They need to be absorbed only in case of candidiasis of the mucous membrane. Exists daily norm doses of this medicine for an adult. It ranges from 1 to 3 million units. It is necessary to take the pills in such a way as to fit into this dose - this is the most important thing.

The average duration of treatment is from 10 to 14 days, however, in severe stages of the disease, such as generalized and recurrent candidiasis, a second course of treatment becomes necessary.

The drug does not cause any side effects. Nausea, chills and fever are possible, but only when the patient has increased sensitivity to the antibiotic. In such cases, you just need to reduce the dose.

You should not take the drug if you have pancreatitis, stomach ulcers, during lactation and, of course, if you are hypersensitive to the composition of this medicine. In all other respects there are no restrictions.

For the tablets to work properly, you must complete the full course of treatment. The drug must be taken after equal intervals time and never miss a dose. If you still missed a dose, you should take it immediately. But if it is time for the next dose, then you do not need to take a double dose.

• interaction with other drugs

The vast majority of reviews about the tablets are extremely positive. Users quickly get rid of their illness with the help of this drug and recommend it to others.

“How much does such a miracle cost? Expensive, perhaps?” - you ask. Relax, the price of the product will not hit anyone’s pocket - in very rare cases it exceeds 100 rubles. Basically, the cost in pharmacies varies from 50 to 90 rubles for 10 pieces.

Nystatin ointment

Nystatin ointment is intended for external use only. Under no circumstances should you use the drug to treat the mouth or nose. The ointment must be applied to the affected surface in a thin layer 1-2 times a day. For better effect and faster recovery, you can simultaneously use other nystatin drugs listed above orally. Nystatin cream for thrush goes quite organically with them.

The course of treatment is 10-14 days.

Allergic reactions such as itching and rashes may occur. In such cases it is necessary to symptomatic therapy, and cancel the medicine.

The ointment should not be used for pancreatitis, duodenal ulcers and various liver dysfunctions. And most importantly - with increased sensitivity to the substance nystatin.

During the course of treatment, refrain from sexual intercourse. If you have fungal diseases of the vagina, simultaneous treatment of your sexual partner is also recommended. For tuberculosis and viral lesions Skin use of the drug is strongly not recommended.

Do not use with Clotrimazole due to a decrease in last activity when used simultaneously. A similar effect is observed with Amphotericin B. In the presence of divalent ions and fatty acids the activity of the drug decreases.

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Reviews, as in the two previous cases, are mostly positive. People praise the ointment for the fact that it soothes the burning sensation very quickly and helps get rid of thrush. Occasionally there are reviews with an average rating, which users justify by saying that the tablets help them better. But here, in general, everything is individual.

The price of the product is not much different from its analogues - it also ranges from 40 to 100 rubles.

Use of Nystatin for the treatment of candidiasis (thrush) in children

Nystatin is prescribed:

• with skin fungus;
• damage to mucous membranes;
• intestines.

To prevent thrush, the medicine is prescribed during treatment with antibiotics, before operations on the intestines and genitals.

The treatment is not tied to food intake, the course lasts at least 10 days. Take twice a day with ½ glass of water.

For oral candidiasis, the tablets are not swallowed, but dissolved slowly after meals, 3-5 per day. After taking it, it is not advisable to eat or drink for an hour.

For children internal reception the drug is prescribed in the form of granules. A suspension is prepared from them by diluting with water. The granules are dissolved in water to create a rinse.

Vaginal ones are administered after hygiene procedures in the morning and at night in a lying position.

Anal ones are used after cleansing the intestines, also twice a day.

The ointment is applied to the external affected areas twice a day, often the ointment is combined with tablets.

The treatment regimen for acute thrush with Nystatin in women is as follows: vaginal suppositories are administered one suppository (0.5 million units) 2 times a day for at least 10 days (up to 14 days). For men, tablets of 0.25 million units - 0.5 million units are used 4 times a day for 14 days. The ointment is applied topically - applied to the affected areas 2 times a day for 10 days.

At chronic thrush It is mandatory to use the tablet form of Nystatin with local treatment ointment (for men) or suppositories (for women). The timing and regimen of treatment, doses of drugs, combination with other antifungal drugs are determined by the doctor.

1-3 years: 250,000 units;

Nystatin is used for diseases such as:

• Candidomycosis of the skin;
• Candidomycosis of the mucous membranes of the oral cavity, vagina, digestive system , kidneys, lungs;
• For the purpose of prevention, the drug is used in the treatment antibacterial drugs, especially when taking tetracycline antibiotics or Levomycetin orally, as well as in extremely depleted and weakened patients.

Nystatin is prescribed to both adults and children. Tablets must be taken orally, swallowed without chewing; for oral candidiasis, Nystatin tablets need to be dissolved:

• Children from 1 to 3 years old are prescribed 250,000 units 3-4 times a day;
• Children over 13 years of age are prescribed 250,000 to 500,000 units 3-4 times a day;
• Adults are prescribed 500,000 units 3-4 times a day or 250,000 units up to 8 times a day.

The course of treatment must be prescribed by a doctor. In most cases it lasts from 10 to 14 days.

The daily dose of Nystatin ranges from 1,500,000 to 3,000,000 units. In severe generalized form of the disease daily dose the drug can be increased to 6,000,000 units per day. In case of chronic, generalized or recurrent form of candidomycosis, repeated courses of treatment are carried out with breaks of 14-21 days.

• Causes of thrush
• Some medical facts about Nystatin
• Release forms
• The key to successful treatment
• Difficulties in treating thrush

Thrush is a disease caused by fungi of the genus Candida. In women, characteristic symptoms are usually yeast-like vaginal discharge, a specific odor and unpleasant itching in the outer part of the vagina. In men, such a disease will not have such clear signs.

Scientists have long proven that the pathogen that causes thrush is present in eighty percent of women as their own microflora. It helps maintain acid-base balance in the vagina, which is very important for the normal functioning of its epithelium.

There are quite a few reasons that can upset the delicate balance and create all the necessary conditions for the occurrence of thrush:

• Taking antibiotics. Such drugs cannot act selectively on only one microorganism, so the vaginal microflora also suffers;
• Immunity disorders. When immunity decreases, pathogenic flora begins to actively multiply, including fungi;
• Improper metabolism. One of the results of this is diabetes mellitus, which is often accompanied by thrush due to higher level carbohydrates;
• Unbalanced diet. At excessive consumption eating sweets, blood sugar rises, then in the vagina, which creates favorable conditions for fungal propagation;
• Pregnancy and taking contraceptives lead to changes in hormonal levels and increase the risk of developing thrush;
• Tight underwear and rare changes of sanitary pads.

Scroll medical supplies Large enough to treat thrush. It includes inexpensive, quite budget drugs, as well as quite expensive drugs. They come in different forms: ointments and creams, suppositories and tablets.

The selective effect of this drug lies in the fact that it affects only fungi of the genus Candida, without affecting other microorganisms. It is worth noting that in a small concentration, the proliferation of the fungus slows down, and in a large concentration, its death occurs.

Release forms

The drug is available in several dosage forms, which include:

1. Tablets in a special coating. They have a light yellow color with a greenish tint and a faint aroma of vanillin.
2. Rectal suppositories. They are yellow in color.
3. Nystatin suppositories for vaginal use, yellow color.
4. Ointment for external use. Produced in aluminum or polymer tubes

The activity of nystatin in one tablet or suppository is 250,000 or 500,000 units. (units of action) and 100,000 units. in one gram of ointment. The duration of use of all forms ranges from ten days to a couple of weeks. You can repeat the course of treatment after seven days if necessary.

There is always a possibility that resistant forms of fungi will arise, which will require stopping the ointment, taking pills or using suppositories. This is why there is no need to self-medicate. Put correct diagnosis and only a gynecologist can prescribe the correct treatment.

The most budget option Nystatin tablets will turn yellow. The Terzhinan and Polizhinaks candles are especially popular. They are more expensive, but easy to use, which makes everything worth it. Ointment also occupies not the last place in the price ranking. The disadvantage of drugs from the nystatin group is that they quickly become addictive and reduce their effectiveness with prolonged and frequent use.

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Like other drugs, Nystatin has its own characteristics, which must be taken into account in the correct management of the course of treatment.

Nystatin is not prescribed:

• pregnant women and nursing mothers;
• in the presence of individual intolerance;
• with hypersensitivity to the drug;
• for diseases of the gastrointestinal tract.

Possible side effects:

• slight vomiting and nausea, diarrhea;
• allergic reaction;
• irritation of the vaginal mucosa when using suppositories or ointments.

If possible, you should abstain from sex during the period of treatment, which should also be carried out on your regular sexual partner. It should not be combined with the drug Clotrimazole, so as not to reduce the activity of the latter. Also, you should not interrupt the course of treatment during your period.

Don’t forget that you should exclude sweet foods from your diet. There is no need to eat white bread or pasta, because the starch in their composition will also be processed into glucose during the digestion process. And any products containing yeast will increase the number of fungi. But various yogurts with increased content beneficial microorganisms will only come in handy.

Let us note the fact that today thrush is the leader not only in prevalence among all diseases in gynecology, but also in self-diagnosis and self-medication. According to statistics, errors in such cases amount to up to thirty-seven percent.

I would like to repeat once again: you cannot diagnose yourself on the basis of information obtained from the Internet, articles from magazines, or simply from television advertising. You cannot prescribe treatment for yourself based on all this.

Why errors occur and treatment with Nystatin does not help:

• This is not thrush. Often, during self-diagnosis, a woman may confuse thrush with diseases such as bacterial vaginosis, an atypical form of herpes and trichomoniasis. Therefore, confirming the diagnosis laboratory methods research is strictly necessary;
• Inaccurate dosage and duration of use. Only an experienced specialist should prescribe nystatin tablets, suppositories or ointment, as well as determine the dose and course of treatment. Otherwise, there will be no effect or resistance to the drug will develop;
• Incorrect treatment tactics in cases of chronic thrush. This requires combined and long-term therapy, which only a doctor can calculate, taking into account all the specific factors of this disease;
• The partner is not being treated. It is a common belief that if a partner does not have symptoms of thrush, then there is no need to be treated. This is a big mistake.

Contraindications and side effects

Nystatin contraindications are as follows:

• Intolerance (allergy) to the components of the drug (even in the past);
• Pregnancy;
• Breastfeeding (lactation period);
• Acute diseases of the gastrointestinal tract (cholecystitis, pancreatitis, peptic ulcer of the stomach and intestines, hepatitis).

• In case of hypersensitivity to its components;
• In case of severe impairment of liver and kidney function;
• For pancreatitis;
• For stomach and duodenal ulcers;
• During pregnancy;
• During lactation.

The use of the drug has its contraindications. It cannot be used to treat candidiasis of the esophagus, genital organs and other areas if the patient has diseases of the gastrointestinal tract, as well as disorders of the liver. Contraindication is also intolerance to the components.

Side effects may include the following symptoms, which will disappear immediately after stopping Nystatin:

• loss of appetite;
• nausea, vomiting;
• allergic reaction;
• diarrhea.

While taking nystatin-based medications, the following adverse reactions occur:

• reactions allergic type and skin manifestations - skin rashes with itching, fever;
• from the digestive system - nausea, discomfort in the stomach, vomiting, upset stool;
• from other body systems - unpleasant consequences are possible extremely rarely, because the drug is poorly absorbed.

Nystatin in any form of release is contraindicated during pregnancy and breastfeeding. The ban is due to the fact that the drug has been little studied, and there is still no exact data on how it can affect the course of pregnancy and the fetus.

Nystatin should not be taken in tablet form:

• for peptic ulcers of the stomach and duodenum
• inflammation of the pancreas
• And serious illnesses liver

It is also extremely rare that there is an individual intolerance to the components of the drug - then it cannot be treated either. Full review medications for the treatment of candidiasis in the article Treatment of thrush in women: drugs and recommendations.

Nystatin in any form of release is contraindicated during pregnancy and breastfeeding

Drug price

Manufacturer: OJSC Sintez (RF), RUE Belmedpreparaty (RB), OJSC Biosintez, etc.

The price of nystatin starts from 25-30 rubles per 15 g tube of ointment. Nystatin suppositories for thrush and tablets cost about 40-50 rubles. There are more expensive analogues this medicine - it makes sense to use them if the fungus has developed resistance to nystatin itself, or if you are intolerant to the drug.

In other cases, it is not worth overpaying for expensive substitutes - nystatin has the same properties as expensive drugs for candidiasis.

Nystatin is an inexpensive and effective remedy against candidiasis, which is available in the form of tablets, suppositories, as well as ointments and creams. The doctor will tell you which form of the drug to choose. Nystatin tablets should not be taken if you have diseases of the liver, pancreas or stomach problems.

It is unacceptable to use medications containing nystatin without a doctor's prescription. If the dosage is calculated incorrectly, a person may develop resistance to the main substance, and next time it will help worse or not help at all.

Suppositories and tablets for thrush Nystatin is perhaps one of the most well-known remedies in our country for the treatment of candidiasis, primarily vaginal and developing after long-term treatment antibiotics. Representatives of the older generation, whose youth was not marked by an abundance of drugs that could quickly cope with the annoying fungus of the genus Candida, remember this medicine especially well.

Nystatin is a first-generation antifungal antibiotic synthesized based on colonies of the microorganism Streptomyces noursei. Morphologically, it belongs to the species of actinomycetes, a unique form of life that has characteristics of bacteria and fungi. The most famous antibiotic that these creatures gave to humanity was Streptomycin, which saved millions of lives in various wars in the mid-20th century. At the end of the 40s, research also revealed the antifungal activity of substances secreted by actinomycetes. This is how a number of polyene antifungal drugs arose, used in the treatment of a variety of mycoses, including thrush, to this day. Antibiotics are used almost unchanged, since fungi practically do not develop resistance to them. The only thing that scientists have done is to develop a special lipophilic form of polyene drugs. In it, the antibiotic molecule is bound by a special component, which is separated from it only when it encounters a target fungal cell. This makes it possible to significantly reduce the toxicity of drugs, which, unfortunately, remains the main drawback of all antifungal and antimicrobial agents.

How does Nystatin work?

The biochemical mechanism of action of Nystatin and all other polyene antimycotics is based on the presence of double carbon-hydrogen bonds in the drug molecule, which determine the tropism of Nystatin to fungal membrane structures. As a result, the Nystatin molecule manages to integrate into the membrane, through which water and ions dissolved in it immediately begin to flow uncontrollably into the pathogen cell. Even if the fungus has enough strength to close the hole, its development slows down. But in most cases, polyenes exhibit fungicidal activity - the unfortunate fungal cell is simply torn into pieces, and its lysis occurs.

Nystatin has very selective activity; it is incorporated only into sterols and has almost no effect on bacteria and viruses. In high concentrations, it can cause damage to protozoa (Trichomonas) and amoebas. At the same time, there are some fungi that Nystatin has virtually no effect on, for example, dermatomycetes, which cause skin diseases. In total, about 400 species of pathogenic or opportunistic fungi are known today, so it is not surprising that Nystatin does not cope with all of them equally well.

Nystatin remains one of the most effective treatments for thrush. More recent antimycotics of the polyene series have been successfully used to treat systemic fungal diseases, including those affecting the brain and spinal cord.

Nystatin: dosage forms

Nystatin for candidiasis is used in the form of vaginal and rectal suppositories, ointments and creams, as well as tablets and suspensions for oral administration. It is important to remember: Nystatin, like all polyenes, is practically not absorbed in the gastrointestinal tract. Their oral administration is justified only in the case of dysbiosis and identified candidiasis of the large intestine, as well as in the prevention of candidiasis before and after surgical interventions, suppressive therapy, treatment with antibiotics. In all other cases, application is only local. If a gynecologist prescribes Nystatin tablets to a girl or woman for thrush, then most likely she misunderstood something, and the doctor meant nystatin suppositories. Taking Nystatin tablets for vaginal candidiasis is as useless as swallowing vaginal suppositories.

By the way, strong polyene drugs, for example, Amphotericin B, are administered intravenously. They are capable of treating severe visceral mycoses, for which there were no medical treatments half a century ago.

It should be noted that Nystatin in Russia is classified as a vital and essential drug (VED) as a means of treating and preventing candidiasis of the gastrointestinal tract.

Nystatin for vaginal thrush

Of course, in the vast majority of cases, the drug is used by girls and women suffering from vaginal thrush. If a woman has a regular sexual partner, then local prophylaxis is also indicated for him. Just in case, a man can take a scraping from the mucous membrane of the penis, which will show the presence increased amount Candida mushrooms with pseudomycelium - it is the latter that demonstrates that the mushrooms have taken the path of war.

Nystatin suppositories for thrush for vaginal and rectal use very similar to each other and interchangeable. Vaginal suppositories - 2.5 g, and rectal suppositories - 2.1 g. Suppositories should be inserted in a lying position as deeply as possible twice a day (morning and evening). During treatment, you must stop all sexual contact. During menstruation, treatment is not interrupted. The duration of the course is prescribed by the doctor, but usually it lasts 10–14 days. If unpleasant symptoms passed, you should still not interrupt therapy, since discontinuation of the drug will almost certainly lead to chronic infection and relapse in 1 - 2 months.

Candles are sold in blisters of 4 or 6 pieces. There are usually 2 blisters with candles in a cardboard pack.

Side effects with vaginal use are possible only if you are individually intolerant to the drug. Absorption of the drug through the mucous membrane of the vagina or rectum is even worse than through the intestinal mucosa, so the drug in the form of suppositories is effective for local application. However, doctors do not recommend treating thrush during pregnancy and breastfeeding. medications. No direct teratogenic effect of Nystatin on the fetus has been identified, but doctors prefer not to take risks.

Nystatin for dysbiosis and intestinal candidiasis

If, as a result of therapy with antibiotics or corticosteroids, dysbiosis has developed and, as a result, thrush has developed, Nystatin is used in the form of rectal suppositories and tablets. Suppositories are placed in the same way as vaginal suppositories. Before the procedure, you need to do a cleansing enema.

Nystatin tablets for thrush are taken 500 thousand units 3-4 times a day. For severe intestinal candidiasis maximum dose 6 million units per day (12 tablets) strictly under medical supervision. Despite the poor absorption of the drug into the blood, loading dose may cause toxic damage liver and negative phenomena from the gastrointestinal tract.

IN Lately Doctors are increasingly refusing to treat intestinal candidiasis with Nystatin in favor of using systemic drugs that act on Candida fungi through the blood.

Ointments for external use

The safest in terms of possible side effects. Intended for the treatment of candidiasis of the skin, external genitalia and candidal vaginitis by applying tampons inside. Nystatin ointment is applied in a thin layer to the affected surface 1 – 2 times a day. Before application, the skin, hand, and foot should be washed with warm water and soap or an antiseptic.

Interaction with other drugs

Nystatin for thrush is usually prescribed as monotherapy. There is evidence that when used in conjunction with antifungal drugs from the group of azoles (clotrimazole, ketoconazole), the effect of the latter is weakened. Like any antibiotic, Nystatin should not be combined with alcohol when taken orally. The latter enhances the absorption of the drug, which can have an extremely negative effect on the liver. In general, one should not expect a noticeable effect on the action of other drugs when taken orally due to poor absorption in the intestine, and when applied topically, little interaction is felt.

Pregnancy and lactation

As mentioned above, teratogenic, mutagenic and other harmful properties Nystatin was not detected, but doctors do not recommend drinking it during pregnancy and breastfeeding.

Childhood

special instructions

The shell of Nystatin tablets contains sugar, so they should be used with caution when diabetes mellitus, first reading the instructions for use and recalculating the milligrams of carbohydrates contained in the tablet.

Nystatin does not have any extraneous effect on orientation in space and the ability to control machines and mechanisms.

Nystatin cream increases skin sensitivity to ultraviolet rays. During treatment you should not sunbathe or visit a solarium.

Storage and shelf life

All dosage forms have a shelf life of 3 years, provided they are stored in a dry place, protected from light, at a temperature not exceeding +25°C. Like everyone medicinal product, tablets, suppositories and cream Nystatin is best all year round store in the refrigerator, avoid freezing.

Release from pharmacies

In accordance with the new rules that came into force on January 1, 2017, Nystatin, like any other antibiotic, must be available with a prescription.

Nystatin price

The price of Nystatin drugs is low and available to all categories of people. The cost of tablets is 100 pieces, 500 thousand units each. from 130 rubles.

Vaginal suppositories 10 pieces, 500 thousand units each. from 63 rubles.

Rectal suppositories 10 pieces, 500 thousand units each. from 82 rubles.

Ointment 100 thousand units. 15g from 39 rubles, 30g from 67 rubles.

Nystatin reviews

Olga Mukataeva

Nystatin is a polyene antifungal antibiotic. It is highly active against yeast-like fungi of the genus Candida. Previously, when using an antibiotic, patients were immediately prescribed this drug. This was done so that pathogenic fungal microflora did not arise in the body under the influence of the antibiotic. The release form of this drug is in the form of powder, tablets, suppositories and ointments. The cost of tablets (20 pieces) is 15.70 rubles - a penny. True, I heard that finding it in pharmacies is not so easy. But a week ago I calmly purchased it at the nearest pharmacy. As for the taste, it’s simply impossible disgusting. Against the background of complex treatment, the drug gives positive results (as confirmed by tests). Replace this drug with fluconazole. The cost of which is several times higher than nystatin.

Nadezhda N.

Weak

In the fight against thrush, all remedies are good, but not all have the same strength of interaction with the nasty yeast-like fungus of the genus Candida. Nystatin was one of the first drugs in my fairly extensive practice of killing fungus. Quite a convenient form of release (candles), reasonable price, but still there are more disadvantages. First of all, the duration of treatment (up to 10 days), secondly, candles have the unpleasant property of staining laundry, and in general they can only be used before bed in order to consolidate the effect of the treatment. Well, and the most important thing is that no matter how many times I used them, the thrush still came back. Therefore, Nystatin is on my black list of drugs for exterminating yeast-like fungi.

Olesya Zyuzina

I take it in combination with antibiotics, since taking antibiotics provokes thrush in me (I apologize for being blunt). But this is a very convenient and good, and most importantly not expensive drug. It used to be in children's form, but I recently found out that it was no longer produced for children because clinical trials have not been performed on children. For so many years they treated children, but here they didn’t conduct research on you... Well, at least they didn’t cancel the adult treatment and didn’t raise the price. I bought it for 125 rubles, there are 100 tablets in a package. Beauty, considering that lately I often get colds, it will come in handy. And if, against the background of inflammation, the first signs of thrush appear, then I immediately start taking Nystatin.

The drug Nystatin is an antifungal agent. Used to treat candidiasis (inflammation of the mucous membranes due to damage by yeast-like fungi). Nystatin is available in several forms for internal and external use - suppositories, tablets and ointment. Local forms of the drug are not toxic and are not absorbed into the general bloodstream, so it is allowed to be used even for the treatment of infants.

The active substance is nystatin. This drug is available in various forms:

1. Pills round shape light yellow in color with a greenish tint and the smell of vanillin. One tablet contains 250,000 or 500,000 units (units of action). Auxiliary components are Vaseline oil, magnesium carbonate, Tween-80, titanium dioxide, vanillin, starch. The tablets are packaged in contour cells of 10 pieces or 20 pieces in a bottle.
2. Ointment for external use has a brownish-yellow or yellow color. The product is packaged in 10, 15, 25 and 30 g tubes. 1 g of ointment contains the active substance in the amount of 100,000 units. Excipients are anhydrous lanolin, petroleum jelly.
3. Rectal and vaginal suppositories are yellow, torpedo-shaped. The active substance content is 250,000 or 500,000 units. Additional components - paraoxybenzoic acid ester, witepsol N-15 and W-35, citric acid. 5 and 10 pieces per package.

pharmachologic effect

Nystatin belongs to the group of polyenes. This substance disrupts the synthesis of sterol in the walls of the fungus, which disrupts its integrity. After this, cell death occurs. This manifests a fungistatic effect. Nystatin is effective against fungi of the genus Candida. The tablets are poorly absorbed from the intestine and are excreted mainly in the feces. The ointment is not absorbed from the surface of the epidermis and mucous membranes.

Resistance of pathogenic microorganisms to nystatin develops slowly.

Indications and contraindications

Various release forms allow you to effectively influence the fungus.

According to the instructions for use, this medicine is not recommended for use if:

• allergic reaction to incoming components;
• functional liver disorders;
• pancreatitis;
• ulcer of the stomach or duodenum, which is accompanied by a wall defect;
• disorders of the liver;
• pregnancy.

Before starting use, you should make sure there are no contraindications.

Method of administration and dosage of the drug

The method of application and dosage of Nystatin for thrush depend on the age of the patient and the form of the drug. The tablets are taken orally, regardless of food intake, without chewing.

Nystatin in childhood used against candidiasis. A 250,000 IU tablet should be ground into powder and combined with a 1 ml ampoule of vitamin B12. This composition is used to lubricate the oral cavity. Tablets for oral administration are prescribed in the following dosage:

• newborns and children under 1 year - 100-250 thousand units 3-4 times a day;
• 1-3 years - 250 thousand units 3-4 times a day;
• 3-13 years - 250-400 thousand units 3-4 times a day.

Duration of treatment is 10-14 days.

Dosage for adults:

• Candidiasis of internal organs - regardless of food intake, 500,000 units 3-4 times a day or 250,000 6-8 times a day. The course of treatment is 10-14 days. For recurring forms of fungal infection, it is recommended to undergo additional courses treatments with an interval of 2-3 weeks. In this case, the daily dosage increases to 6,000,000 units.
• Treatment of candidiasis of the oral mucosa - a tablet in a dosage of 500,000 units should be dissolved in the mouth. The procedure is performed 3-5 times a day after eating and brushing your teeth.
• Candidiasis of the digestive organs - 1-2 tablets at a dosage of 500,000 units 4 times a day. The duration of therapy is 14 days.
• For acute thrush in women, 1 vaginal suppository is prescribed at a dosage of 500,000 units 2 times a day for 10-14 days. Men are prescribed a tablet form of release - 1 tablet of 250,000 or 500,000 units 4 times a day for 14 days. The ointment is used topically - applied to the affected areas 2 times a day.
• For nipple thrush, use nystatin ointment 2-4 times a day after treating the nipple skin soda solution(1 tsp per 200 ml of water).
• Rectal suppositories are inserted deep into the rectum, 1 suppository 2 times a day (morning and evening). The course of treatment is 10-14 days. If necessary, repeat courses of treatment are carried out.

Side effects

During therapy, side effects from the digestive organs may develop - vomiting, diarrhea, nausea. Allergic reactions often occur - rash, itching, as well as chills and fever. If these symptoms occur, you should stop taking the drug and consult a doctor.

special instructions

Exist special instructions regarding taking Nystatin:

1. At misuse resistant forms of the fungus develop.
2. Children under one year of age are allowed to use Nystatin only after the recommendation of a doctor.
3. It is not necessary to interrupt treatment with suppositories during menstruation.
4. In case of fungal infection of the vagina, it is recommended to simultaneously treat the partner. During therapy, avoid sexual intercourse.
5. During pregnancy, it is prohibited to use Nystatin in the form of tablets and vaginal suppositories. It is possible to use rectal suppositories, but only if the benefit to the mother outweighs the possible threat to the fetus.
6. There is no data on the passage of the active substance into breast milk, so it is recommended to stop breast-feeding. During lactation, the use of ointments, rectal and vaginal suppositories is allowed, since the drug is not absorbed through the mucous membranes.
7. Nystatin in the form of vaginal and rectal suppositories is not recommended for use under 18 years of age.
8. For kidney disease, take the tablet form of the drug with caution.

Compatibility with alcohol and drugs

Nystatin interacts with big amount medicines, since it passes through the body in “transit”. Possible consequences when used together are indicated in the table.

When using ointments and suppositories, the active substance does not enter the general bloodstream and does not interact with ethanol. But drinking alcohol is not recommended because it affects the metabolism of carbohydrates. In addition, alcohol increases the concentration of sugar in the blood, which is a good environment for the proliferation of fungi. This negatively affects the effectiveness of therapy. The use of tablets affects the condition of the liver; in this case, drinking alcohol is prohibited.

Analogs

There are no analogues of Nystatin in tablet form.

In gynecology, drugs with similar effects are:

• McMiror;
• Polygynax.
• Natamycin;
• Ketoconazole;
• Miconazole;
• Fluconazole;
• Clotrimazole.

Nystatin is a drug that has a strong antifungal effect. This allows us to classify it as a remedy effective against yeast-like fungi, which, if excessively multiply, can cause a candidiasis infection.

The main component of the drug is the antibiotic component of the polyene group. A polyene antibiotic is characterized by the fact that it has a certain effect on fungal cells, without affecting bacterial cells.

The mechanism of action is that, as a result, it forms bonds with styrene molecules that are present in fungal cell membranes. This causes a significant weakening of the cellular protective membrane of the fungus, opening up access for the uncontrolled entry of free ions, which in turn leads to its death.

Based on this, it follows that, even in small quantities, Nystatin for thrush can significantly lead to a decrease in the speed and intensity of fungal reproduction processes, and at high concentrations it helps to completely get rid of it. It should also be noted that Nystatin for thrush has a selective effect, which is manifested in providing a targeted effect specifically against Candida fungi, without causing destruction among other microorganisms.

ATC

G01AA01 Nystatin

Active ingredients

Nystatin

Pharmacological group

Antifungal agents

pharmachologic effect

Antifungal topical drugs

Indications for use of Nystatin for thrush

The presence of candidal lesions of the female genital organs - thrush itself, in the acute phase or at the chronic stage.

It is advisable to use the medication for candidiasis dysbiosis, which can develop as a result surgical intervention or be provoked by prolonged courses of antibiotic therapy.

The scope of application of the drug also covers candidiasis of the mucous membranes of the oral cavity, the gastrointestinal tract in its lower parts, the vagina, and in addition in cases of damage to the skin.

Vaginal nystatin is used mainly for the treatment of the disease, it is also one of the main healing agents at bacterial vaginosis the type in which fungal flora predominates.

Indications for use suggest its use as prophylactic in order to prevent the occurrence of complications associated with the fungus after antimicrobial therapeutic measures.

It is advisable to use the ointment when the skin is affected by candidiasis, as well as to protect yourself and minimize the likelihood of infection with a fungus when visiting public places such as swimming pools, baths and saunas.

Release form

The release form can be varied; it can also differ in the concentration of the active substance in the medicine and in price. Most often for the treatment of disease medical specialists Prescribe rectal or vaginal suppositories, which contain 250 - 500 thousand units of active substance. A package often contains 10 candles.

The release form in the form of tablets has exactly the same amount of active substance in its composition (250 - 500 thousand units) and, accordingly, tablets containing 250 thousand units of active substance are sold in 20 pieces per package. Tablets containing 500 thousand units of the active substance are offered in 10 pieces per package. Tablets are less popular and are prescribed by doctors extremely rarely, as a complex therapy for the treatment of candidiasis.

The medicine is also available in the form of an ointment, the composition of which contains 100 thousand units of active substance and is produced in tubes of 15 g. The ointment has a smaller amount of active substance and, accordingly, has a more gentle effect on the body. The ointment is mainly prescribed by specialists for men as an aid in the complex treatment of both partners.

Pills

Tablets for thrush Nystatin is an antibiotic from the polyene group; this medication was first introduced back in 1950 in the now defunct USSR. The tablets have a yellowish tint and are covered with a protective coating on top. Medicine in tablets is usually prescribed by a doctor in case of intestinal candidiasis, for therapy vaginal candidiasis, infections of the mouth and skin. Tablets are used not only for the treatment of an existing disease, but also for its prevention.

It is not recommended to use Nystatin tablets for thrush as self-medication, due to the presence of a number of contraindications to their use. The medication in tablets is contraindicated during pregnancy or in patients suffering from duodenal or gastric ulcers. It is also undesirable to take the medication for pancreatitis, any type of allergy, during lactation and for liver diseases.

Medicine in tablets can cause side effects, for example, vomiting, nausea, intestinal upset and even allergic reactions. If any of the described side effects occur during use, you should stop taking the medication and be sure to contact your doctor.

Candles

Suppositories with Nystatin for thrush are effective means in the treatment of vaginal candidiasis. Suppositories act locally on the intestinal mucosa or vaginal mucosa.

Suppositories with Nystatin for thrush are prescribed by a medical specialist only after examining the patient and analyzing the discharge using bacteriological culture, which will help determine how sensitive the spores are to the effects of the Medication. For complex therapy of candidiasis, simultaneously with the use of suppositories, an ointment is used, which is applied to the skin of the inner thighs and external genitalia. Before starting to use suppositories for the first and all subsequent times, patients are advised to thoroughly wash the perineum, always using soap, and only after this procedure can the suppository be administered intravaginally. As a rule, suppositories are recommended for use in the treatment of candidiasis from 10 to 14 days. Therapy must be carried out simultaneously for both partners and while taking the medication it is necessary to abstain from sexual intercourse. After two weeks, smears of the discharge should be taken again for analysis. These suppositories can also be used for prophylactic purposes, in case of possible increase pathogenic microflora on the vaginal mucosa.

Rectal suppositories

Nystatin rectal suppositories for thrush are usually prescribed by a medical specialist for severe infection of the large intestine by Candida fungus.

Rectal suppositories containing drugs are usually prescribed by a doctor in combination with other medications for complex treatment.

Due to the very poor absorption of the active substance contained in rectal suppositories through the intestines, tablets are usually also prescribed as an adjuvant in the complex treatment of candidiasis.

The actual course of therapy for candidal infection of the large intestine lasts from 10 to 14 days, after which it is necessary to re-test for bacteriological culture. Due to the antibiotic Nystatin contained in rectal suppositories, they cause a side effect in the form of an allergic reaction to active substance and should be prescribed by a doctor only after receiving the results of thorough research.

There are also a number of contraindications. Nystatin rectal suppositories for thrush are not recommended for the treatment of candidiasis in pregnant women, during breastfeeding and in case of individual intolerance to the components of the medication.

Ointment

In most cases, Nystatin ointment for thrush can be prescribed by a doctor as an adjuvant in the complex treatment of candidiasis, along with tablets and suppositories. Often, Nystatin ointment for thrush is prescribed to men for the complex treatment of candidiasis in both partners, due to the fact that this medicine can be used equally well in both men and women. The use of the ointment does not require any complex skills; it is enough to apply it in a moderate layer to the skin, morning and evening. If the ointment is applied to the external genitalia and the inner thigh, before applying it, it is necessary to wash these areas of the skin and mucous membrane with warm water and soap and only then apply the ointment. Typically, the course of ointment therapy lasts from 7 and in severe cases up to 14 days. In cases where candidiasis infection is chronic, the course of treatment will need to be repeated after 21 days. The drug contained in the ointment can provoke allergic reactions in the form of hives, redness on the skin or burning and itching. If one of the listed side effects occurs, treatment with ointment should be stopped immediately and consult a doctor immediately.

Pharmacodynamics

Nystatin for thrush has an antimicrobial, antifungal effect. The medicine helps stop the growth and spread of fungi in the body, destroys their structure, and helps destroy them. Nystatin is an antibiotic that belongs to the polyene group. The structure of the active substance is saturated with molecules with a large number of double bonds, which contribute to the destruction of the structure of stearin formations in the fungal cell membrane.

At its core, the pharmacodynamics of Nystatin for thrush manifests itself as follows.

Thanks to double bonds, the molecule of the active substance Nystatin is able to integrate into the cell structure and forms a huge number of channels through which the uncontrolled entry of water, electrolytes, and non-electrolytes into the fungal cell begins. In this regard, the fungal cell stops its protective function against external influences and she gradually dies. The medicine is very effective in the fight against yeast-like fungi Candida and aspergillus. Protection and addiction to the active substance Nystatin in fungi develops rather mediocrely.

Pharmacokinetics

The drug has an extremely weakly expressed resistive effect. The pharmacokinetics of Nystatin for thrush is primarily manifested by insufficient absorption of the drug throughout the gastrointestinal tract.

In the case of topical use of the drug in the form of suppositories, rectal suppositories or ointments, there is a very small likelihood that the drug will enter the blood vessels through the skin or by penetration through the mucous membranes.

The pharmacokinetics of Nystatin for thrush can also be characterized as follows: positive thing medication, as in fact, the medicine does not tend to accumulate in large quantities in the body. That is, in essence, the medicine does not have cumulative properties, does not settle in the organs and cells of the body, and subsequently leaves it almost completely unnoticed.

The medicine is eliminated quite easily by the body. This medication is released as follows.

The main part of it, after ingestion, ultimately leaves the human body in the composition feces, and in addition to this, a small amount of the drug may be released from breast milk during lactation.

Use of Nystatin for thrush during pregnancy

The opinions of different medical specialists on whether the use of Nystatin for thrush during pregnancy is acceptable can differ significantly from each other.

If you carefully read the instructions for this medication, you will notice that, along with a categorical statement that it is contraindicated for pregnant women, there is also a clarification that if the benefit of such treatment for the mother is more important than the risk for the child, then the drug can be prescribed by a doctor.

But today, among medical specialists, drugs are considered to be not a particularly aggressive drug, due to its remarkable quality of minimal absorption gastrointestinal tract. It is this feature of the drug that makes it possible to prescribe it for the treatment of candidiasis to women during pregnancy.

And if the use of Nystatin for thrush during pregnancy is in question, then breastfeeding a child while the mother is taking the medicine is definitely prohibited. The use of this medicine by pregnant women in the first trimester of pregnancy is also categorically not recommended, since during this period any, even the most seemingly minimal, negative impact on the child’s body that is beginning to form can lead to irreparable and global consequences.

Contraindications

Contraindications for use are quite controversial. In particular, the instructions for the medicine contain a clear indication that the use of this medicine during pregnancy is prohibited, but the same instructions contain a statement that the medicine can be taken by pregnant women on the recommendation of a doctor and only if the benefits of the medicine exceed the harm caused to the fetus.

In any case, medical experts categorically do not recommend taking the drug to pregnant women in the first trimester of pregnancy. Antibiotics have a detrimental effect on the body of a pregnant woman and can threaten the health and even the life of the fetus. That is why you should refrain from taking such complex drugs during pregnancy.

Contraindications to the use of Nystatin for thrush also apply to children under the age of one year, although sometimes this drug is used to treat severe forms of mycosis in newborns only on the recommendation and under the supervision of the attending physician or local pediatrician.

Side effects of Nystatin for thrush

Often insignificant. However, if the person taking it has an individual sensitivity or intolerance to the drug, he may feel chills or nausea, the body temperature may often rise, and vomiting or diarrhea may occur. If any of the above symptoms appear, you should immediately consult your doctor, who can determine whether you should continue therapy with this drug.

Side effects of Nystatin for thrush also manifest themselves in the form of an allergy to the drug. Allergies to drugs may occur the following symptoms. This may include skin rashes, increased body temperature, red eyes, or swelling of the mucous membranes.

The drug is a fairly loyal and non-toxic antibiotic, and the patient often tolerates it excellently. However, in rare cases, when taking the drug orally in tablet form, a change in taste may occur.

When using suppositories or rectal suppositories, an allergic reaction may occur in the form of swelling or redness of the mucous membrane of the anus or vagina.

Also, a very dangerous side effect when taking the medicine is the occurrence and rapid proliferation of fungi that have zero sensitivity to the medicine. In this case, the doctor usually immediately cancels the therapy and prescribes another drug.

Directions for use and doses

Doses for adults are 500,000 units. 3-4 times a day or 250,000 units 6-8 times a day. If the disease develops into severe generalized candidiasis, the dose of the drug per day can be increased to 4,000,000-6,000,000 units. per day.

Doses for children are prescribed depending on the age of the child. For children under 1 year of age, the dose of the drug is 100,000 - 125,000 units. per day. Children from one to 3 years of age are prescribed 250,000 units 3-4 times a day; for children over 3 years of age, the drug is prescribed from 1,000,000 to 1,500,000 units. 4 times a day. On average, drug therapy continues for 10-14 days. The tablets must be swallowed without chewing.

In case of damage to the mucous membranes by candidiasis, for example, the mucous membrane of the mouth, nasopharynx or esophagus, therapy is carried out by placing a tablet of 500,000 units behind the cheek. for two weeks 3-4 times a day after meals. If candidiasis has taken a generalized form or a relapse has occurred, it is necessary to conduct a second course of treatment lasting two to three weeks.

To treat candidiasis that affects the mucous membranes or skin, ointment is often used. It must be applied in a thin layer to the affected areas after washing them with warm water and soap.

Candles and rectal suppositories containing drugs of 250,000 and 500,000 units. combined with both the use of tablets and the application of Nitatin ointment during the treatment of vaginal inflammation, genital candidiasis or candidiasis lower sections intestines. Suppositories and suppositories must be inserted twice a day into the vagina or rectum; on average, the course of treatment can last from ten days to two weeks.

Overdose

An overdose of drugs, no matter how strange it may seem, depends solely on the form of release of this drug. This is due to the fact that when it is used in the form of suspensions or tablets with drugs, this can be associated with the occurrence of all kinds of disorders of the digestive system, for example, such as diarrhea, heartburn or vomiting, and in addition, the body temperature may increase.

Overdose was not observed during the use of ointments, rectal suppositories or vaginal suppositories. However, patients who used the above during treatment dosage forms drug, complained of such side effects as the occurrence of all kinds of allergic reactions, manifested in the form of redness, rash or itching.

In fact, such abnormal reactions to drugs, for the most part, appear to be due to factors associated with individual characteristics each specific organism and depend on the strength of the reaction in each specific case. Often their occurrence occurs on early stages treatment. However, despite all these facts, cases of drug overdose did not occur and were not recorded.

Interactions with other drugs

Interactions of Nystatin for thrush with other drugs may be manifested in a number of factors that have not been comprehensively and sufficiently studied to date.

In this regard, first of all, it is necessary to consider the features of the combined action of medications containing drugs simultaneously with drugs, the use of which is also aimed at combating fungal infection.

As an example of the interaction of Nystatin against thrush with other drugs, let’s take its use together with Clotrimazole. This drug is one of the most common antifungal drugs. It is used for both external and local (which also includes intravaginal) applications.

Nystatin from thrush, interacting with Clotrimazole, is distinguished by the appearance of a pronounced tendency to reduce the activity of its therapeutic effect and reducing the effectiveness of its use.

Based on this, in order to ensure the possibility of a successful course of treatment for infection using medication in combination with other drugs, consultation with a specialist is required.

Storage conditions

Storage conditions are determined by a combination of environmental factors that may be decisive in ensuring that this medicinal product does not lose its properties due to their adverse effects. medicinal properties throughout the entire course of treatment with its use.

The ideal place for storing medicine in tablets is a place with a minimum level of humidity and excluding light. The temperature regime should correspond to the range from 18 to 20 degrees Celsius.

Storage conditions for nystatin against thrush, presented as an ointment, or in the form of vaginal or rectal suppositories, require a temperature optimum not exceeding 5°C. The place intended to store drugs in it must be dry and protected from the penetration of light rays.

The creation of these storage conditions, which results in the protection of the drug from adverse factors, prevents a possible premature decrease in effectiveness or complete loss of medicinal properties throughout the entire declared shelf life.

special instructions

Nystatin for thrush in children

Nystatin for thrush in children should only be used with close monitoring. family doctor, or from your local pediatrician.

The causes of damage to a child’s body by yeast fungi of the genus Candida may be reduced immunity, the consequences of aggressive or long-term treatment with antibiotics, wrong mode nutrition, stress factors of different origins sleep disturbances and even excessive exercise.

For girls adolescence candidiasis may occur as a result of a failure hormonal system or as a cause of prolonged hypothermia or a cold.

All this is a huge amount negative impacts creates an acidic environment in the child’s body, suitable to serve as an ideal springboard for the intensive proliferation of a fungal infection.

In any case, no matter what the cause of the disease, Nystatin should be used for thrush in children only as prescribed by a specialist, since self-therapy can pose considerable danger even for an adult, not to mention the fragile and not yet fully developed body of a child.

Nystatin for thrush in newborns

Nystatin for thrush in newborns is used in the treatment of oral candidiasis. The problem of candidomycosis stomatitis in infants occurs quite often. In many cases, the newborn has white coating in a language that is considered normal occurrence. But, however, if this plaque begins to look like cheesy masses, or looks like white round spots, this is candidiasis.

Infection in infants should not be taken lightly, despite the fact that the plaque is removed quite easily and quickly, underneath there are small, sometimes bleeding, ulcers through which germs and bacteria can freely penetrate the child’s body. This can be detrimental to the newborn's fragile immune system. If these types of symptoms occur, you should contact your pediatrician, who can prescribe you medications to treat the fungal infection.

Nystatin for thrush in newborns is used in the form of a suspension that can be easily prepared by any mother.

The suspension is prepared from a tablet, which must first be crushed and diluted with water in proportions of 250 thousand units per 5 ml of boiled (not hot) water. The procedure usually alternates with a 5% soda solution.

First, the mouth is wiped from plaque and washed with a cotton swab and soda solution, after which the affected areas are treated with a suspension. Procedures must be carried out every 6 hours. This should be done very carefully.

During lactation, the mother must wash her nipples and the skin around them before and after feeding. First, the breasts are washed with warm boiled water, and then 2% soda solution. Therapy for the disease in infants usually lasts for two weeks, or is determined by the attending physician.

Nystatin for thrush in men

Often, candidiasis infection is usually considered a disease of newborn children and women, and in the times of the former USSR, as a rule, only women were treated for candidiasis. It was believed that her partner did not need therapy.

However, today it is already known that this practice of treating candidiasis is ineffective, due to the fact that both partners suffer from candidiasis; only in men it can be asymptomatic. In the male body, candidiasis can be localized in the mouth or on the external genital organs, and in some rare and severe cases, a fungal infection can penetrate the blood and spread throughout the body.

Nystatin for thrush in men is used as an antifungal agent and is an antibiotic of the polyene group. The medication is very active against fungi of the genus Candida; it destroys the cell membrane of the fungal infection, which leads to the death of the fungus.

Nystatin for thrush in men is often used in the form of an ointment. This form of drug release is effective in the treatment of skin candidiasis, which manifests itself as redness, weeping sores, and swelling. In this case, the ointment is applied to the skin in a thin layer twice a day. The ointment is also used as a complex treatment when both partners are treated. In this case, the man is prescribed an ointment that must be applied in a thin layer twice a day to the penis and the skin around it. Before the procedure, a man must wash his genitals using warm water and soap.

If candidiasis in a man develops into severe or chronic form, the specialist also prescribes medicine in tablets.

Price

Nystatin is a polyene antibiotic that is used to treat fungal infections.

The active component was first isolated in 1950. At the beginning of the research, an injection was used in the development and creation of a therapeutic agent. But an elevated level of the substance was observed in the blood plasma, which is toxic to the body. Current forms of the drug are completely safe for humans.

Release forms and composition

Nystatin is available in tablets, suppositories and:

• the drug in tablets has a light yellow shell with a greenish tint and a slight vanilla odor;
• rectal and vaginal suppositories are yellowish in color, cylindrical-conical in shape;
• ointment yellow or brownish yellow.

The main active ingredient is nystatin, additional components:

• lactose;
• potato starch;
• talc;
• magnesium carbonate (MgCO3);
• vanillin;
• liquid paraffin (vaseline).

Chemical formula of Nystatin

Combination drug

The combination drug Nystatin with tetracycline is a broad-spectrum fungicidal antibiotic. Has a low price (70-75 rub.). This combination is used mainly for prophylactic purposes. It is used for treatment if the causative agent of the disease is sensitive to tetracycline. Prescribed for sore throats, bronchitis, intestinal infection, for eye diseases, sexually transmitted infections, skin lesions(eczema, acne).

For the purpose of prevention, it is prescribed in the period after surgery.

This medication should not be taken by pregnant, nursing mothers, or children under 8 years of age. It is not recommended to take tablets if you have liver dysfunction, leukopenia, or intolerance to the components of the drug. Tetracycline may cause side effects:

• disruption of the gastrointestinal tract;
• allergic reactions;
• The body's sensitivity to ultraviolet radiation increases.

Nystatin is part of vaginal suppositories - Polygynax. In addition to it, the composition contains neomycin and polymyxin B. Thanks to this composition, the suppositories have an antifungal, antibacterial, and bactericidal effect.

Pharmacological profile

Nystatin - penetrates the cells of the fungus and causes its death. The yeast-like fungus Candida and Aspergillus are especially susceptible to the medication.

The drug also suppresses vegetative forms of intestinal amoeba, which causes dysentery. The adaptation of the microorganism to this substance was actually not observed.

The drug has no effect on bacteria and viruses.

When applied topically, the main component does not pass through the mucous membranes. When Nystatin is administered orally, the tablets are poorly absorbed digestive tract. The active component is excreted unchanged in the feces. A high concentration of the drug in the stomach is enough for complete cure for candidiasis of the gastrointestinal mucosa.

The absorbed part of the drug is excreted from the body through the kidneys.

Purposes of use and contraindications

Nystatin is used to treat:

• mycoses of various localizations;
• fungal infection of the stomach, intestines, skin;
• suppositories with Nystatin effectively fight against genital thrush in women.

The drug is used to prevent the development of fungus:

• with prolonged use of an antibiotic (mainly tetracycline group, Levomycetin);
• with external use of antibacterial agents;
• before and after surgery on the intestines;
• in weakened patients.

The medication should not be taken if there is hypersensitivity to the components included in the composition.

During pregnancy, Nystatin is prescribed only when the expected positive result from treatment for the mother is higher than the danger to the development of the fetus. When taking the medicine, you must stop breastfeeding, since there is no information about whether the active substance passes into breast milk.

The following conditions are contraindications for prescribing the drug:

• inflammation of the pancreas;
• peptic ulcer of the stomach and duodenum;
• liver dysfunction.

Instructions for use

The timing of use and dosage is determined only by a specialist (dentist, infectious disease specialist), taking into account all existing diseases and the intensity of symptoms.

The tablets should be taken without chewing. The dosage used for an adult patient is 250,000 - 500,000 units, 3 - 4 times a day. The course of treatment is 1 – 2 weeks. If the disease has chronic course, repeat the course after 2 - 3 weeks.

During treatment, the tablet is placed under the cheek and kept there until it dissolves. Take the tablet after each meal, after rinsing your mouth with the decoction. pharmaceutical chamomile or baking soda.

Children are prepared for treatment special remedy: required amount grind the medications in tablets (the dosage is prescribed by the doctor) into powder and mix with an ampoule of Cyanocobalamin (vitamin B 12) or with plain water. Treat sore areas in the child’s mouth with this product.

The dose of the drug depends on the age of the child:

• up to 1 year – 100 – 125 thousand units;
• from one year to 3 years – 250,000 units;
• from 3 to 13 years – 250,000 - 400,000 units;
• over 13 years old – 250,000 – 500,000 units.

Nystatin suppositories are inserted as deep as possible into the vagina or anus. Before the procedure, the external organs are toileted, the vagina is washed with Furacilin solution.

Vaginal suppositories should not be used during pregnancy. A woman is recommended a cream that is applied to the affected areas.

Apply several times a day. Treatment is continued for 12–14 days.

When treating oral candidiasis, you need to remember that the topical medicine should be in the mouth for as long as possible. Therefore, it is recommended to chew Nystatin tablets and not swallow them immediately, but keep the resulting powder in your mouth.

You can prepare a solution or suspension. The taste will be slightly unpleasant, but it can be improved by adding sucrose. In this form, the active substance will remain in the mouth longer than if you make compresses.

When treating a sore throat, simply taking pills is not at all effective and useless. It is recommended to gargle with the suspension for as long as possible, then spit it out.

The prepared pulp from the tablet is used to treat the affected areas of the throat on the palate and tonsils. Before treating a sore throat, older people need to remove their dentures, since fungus may remain under them, and then rinse or lubricate the gums with medicine.

When using antifungal ointment Nystatin, a sandwich application is made. The product is applied between two cotton pads and placed behind the cheek.

The procedure is carried out up to 6 times a day. The condition improves on the 5th day, plaque disappears, and erosive wounds heal. The treatment course is carried out until all clinical manifestations diseases.

The medication does not affect the ability to drive or operate a car or any other equipment.

Precautionary measures

During the menstrual cycle, the treatment process is not interrupted. Both partners should carry out antifungal therapy, excluding sexual intimacy.

The ointment is used only externally. Do not apply it to the mucous membranes of the mouth and nose.

You cannot treat the affected areas if you have a skin disease of tuberculous, viral, or staphylococcal etiology.

Before you take a Nystatin capsule, you must definitely notify your doctor about what else you are being treated for. this moment. There are medications that, when interacting with each other, can cause side effects or mutually reduce the therapeutic effect.

You must be careful not to get the ointment into your eyes! If this happens, rinse your eyes with plenty of clean water.

Side effects and cases of overdose

The drug is non-toxic and is well tolerated. Rarely possible negative reactions:

In such cases, the use of the medicine is abandoned and, if necessary, symptomatic treatment is carried out.

There are no known cases of overdose when using vaginal suppositories, tablets and Nystatin ointment.

Interaction with other dosage forms

Nystatin is incompatible with the following chemicals:

• potassium permanganate;
• hydrogen peroxide;
• salicylic acid, lactic acid;
• sodium bicarbonate.

From practical application experience

The opinion of doctors and reviews of patients who used Nystatin to treat thrush.

The doctor diagnosed me with thrush. Was treated expensive drugs, But positive result I didn't receive it. The attending doctor prescribed Nystatin tablets. The course was long, but the result was positive. There is no addiction to the drug; you can take the course several times a year. And the price is affordable, which is very important!

Anonymous

The drug is inexpensive and has a narrow spectrum of action. On long period he was practically forgotten. But recently, tank cultures show that Candida fungi are sensitive to Nystatin.

Dermatologist

Purchase and storage

The drug belongs to list B. Tablets should be stored at temperature conditions 16 – 23 degrees. The storage location should be away from light and moisture. Shelf life: 24 months.

Ointment and suppositories are stored at a temperature of 4 - 7 degrees, shelf life is 36 months. After the specified period, it is better not to use the drug.

Nystatin tablets can be bought in pharmacies at prices ranging from 40 to 130 rubles, ointment costs 45 rubles - 75 rubles, vaginal suppositories about 50.

Similar medicines

Nystatin has many similar agents, similar in action and composition:

You can replace drugs with each other only after prior consultation with your doctor.