Ibuprofen 400 mg instructions for use. The drug is not prescribed

Nonsteroidal anti-inflammatory drugs are a group of drugs that are most often used to relieve inflammation and pain. In this article we will look at one of the most prominent representatives of the group. The drug "Ibuprofen" - what do these tablets help with, and what consequences of use should you be wary of?

The medicine against fever and pain is available in the form of round, white or slightly yellowish coated tablets, packaged in contour cells (10 pieces per blister). One cardboard box contains from one to five blisters and instructions for use.

The drug works due to active component– ibuprofen. One tablet contains 200 or 400 mg of active ingredient. In addition to the connection that stops inflammatory process, starch, dye, low molecular weight polymer, sorbate and stearic acid are added to the medicine.

Pharmacological action and pharmacokinetics

In the presence of the main active component of the tablets, the enzyme cyclooxygenase 1 and 2 suspends its action, as a result of which the conversion reaction stops arachidonic acid into prostaglandins. Prostaglandins are lipid compounds that transmit impulses from one cell to another. They trigger the process of inflammation, which results in pain syndrome.

The action of the drug is aimed at relieving swelling around the diseased joint, reducing pain and lowering temperature. The pain becomes less pronounced both at rest and with movement. Under the influence of the drug, motility, constrained by joint inflammation, increases. Improved mobility is noted not only during the day, but also in the morning.

The medicine is best absorbed when taken separately from food. After consumption before meals, it is found in the blood in the highest concentrations after 45 minutes. If the tablet was taken after a meal, then the highest concentration can be detected no earlier than 1.5 hours later.

The chemical compound actively penetrates joint tissues and fluids. After 24 hours it is completely eliminated from the body. The anti-inflammatory effect develops cumulatively. To achieve tangible results, you need to take the tablets regularly for one or two weeks.

Inactivation of the active component occurs in the liver. Less than one percent of the chemical compound is utilized by the kidneys and bile. In elderly people, pharmacokinetics proceed at the same pace.

What does Ibuprofen help with?

This drug is intended to relieve pain caused by inflammation. The drug can also temporarily lower body temperature.

Among the indications:

• Swelling and decreased mobility of the limbs against the background of inflammation and destruction of joints as a result of the development of psoriasis, gout, rheumatism, spinal diseases, and autoimmune diseases.
• Pain of various nature: muscle, dental, headache, menstrual, post-traumatic, postoperative, associated with inflammation of the pelvic organs, with the development of cancerous tumors.
• Fever and fever associated with colds and flu.

The medicine does not have therapeutic effect. It does not affect the course of the disease. Used only to relieve symptoms.

Instructions for use and dosage of Ibuprofen

To reduce the effect on the gastrointestinal tract, tablets are taken after meals. The recommended interval between doses is 6 hours. You can take the medicine again no earlier than four hours later.

For children

The dosage form of the tablet can be taken by children over six years of age. The child's weight must be at least 20 kg. Single dose for a representative junior group patients is 200 mg. Maximum amount There are four doses of Ibuprofen per day for children.

For adults

Adults and children over 12 years of age are prescribed the same single dose – 400 mg. It is acceptable to take tablets (400 mg) up to three times a day. After 18 years of age, no more than 1200 mg of the active substance is allowed per day. Patients under the age of majority can drink no more than 1000 mg of Ibuprofen per day.

Without examination by a specialist, the drug can be taken as an antipyretic or pain reliever for no longer than three days in a row.

Use during pregnancy and lactation

During pregnancy and lactation, the product can only be used as prescribed by a doctor. For pregnant women, Ibuprofen is considered less dangerous than other analgesics and acetylsalicylic acid. Probability of occurrence uterine bleeding against the background of his intake is insignificant.

It is worth mentioning that the drug is allowed to be used only in the first and second trimester of pregnancy. For more later it is strictly prohibited because it reduces the synthesis of hormones responsible for labor, and can also provoke intrauterine development pulmonary insufficiency in the fetus and infant.

During the period breastfeeding the drug is not discontinued.

Drug interactions with other drugs

• Concomitant use of the drug in question and other anti-inflammatory drugs non-steroidal group increases the risk of bleeding. The same effect is observed with the simultaneous administration of tablets and drugs that reduce the rate of blood clotting.
• Co-administration with drugs for the treatment of depression is not recommended. Due to combination therapy, there is a risk of gastric bleeding.
• These tablets increase the concentration of drugs that artificially suppress the effect of immunity (cyclosporine and drugs containing gold). As a result, the load on the kidneys increases and the threat of developing a nephrotoxic effect increases.
• Drugs that block calcium and increase heart rate increase the proportion medicinal substance in blood.
• Substances that accelerate microsomal oxidation, such as ethanol, three cyclic antidepressants and barbiturates, increase the danger of the drug in question for the liver. Their joint use is fraught with the development of toxic shock. Substances, on the contrary, suppress microsomal oxidation neutralize the hepatotoxic effect.
• The medicine is incompatible with vasodilators. It reduces their overall calming effect on the central nervous system.
• Simultaneous use with estrogens and corticosteroids provokes the appearance of hematomas and bleeding.
• To avoid increasing the load on the liver, it is not recommended to take tablets with medicines, predominantly decomposing in the hematopoietic organ.
• The drug enhances the action of insulin and increases the toxicity of antitumor drugs.

Ibuprofen: contraindications, side effects and overdose

Cases in which the use of the drug is contraindicated:

• tendency to be allergic to any of the constituent components;
• intolerance to acetylsalicylic acid and other non-steroidal analgesics;
• combination in any combination of aspirin intolerance with bronchial asthma, polyposis of the nasal and sinus mucosa.

The drug is not prescribed:

• patients suffering from inflammatory and peptic ulcers stomach and intestines in the acute or active stage;
• people with bleeding disorders, a tendency to hemorrhage, internal bleeding, including intracranial;
• patients with obvious insufficiency of liver function and renal pathologies in the active phase;
• pregnant women over 30 weeks and children under six years of age.

For elderly patients and patients with heart pathologies, this drug is prescribed only after a comprehensive examination. It should not be taken without a doctor's recommendation.

The drug tends to affect the gastrointestinal tract. As a result of its use, in some cases, diffuse abdominal pain and disruption of digestive processes are observed.

In addition, other negative reactions from various organs and systems are possible:

1. The active substance increases the risk of opening internal bleeding. In most cases, this symptom occurs suddenly. Among people with spontaneously opened hemorrhages, 60% are those who Lately took non-steroidal anti-inflammatory drugs.
2. When taking the drug, the moisture content of the oral mucosa deteriorates, and ulcerative lesions gums In some cases, erosive stomatitis is observed.
3. Non-CNS effects have been reported: headaches, nervousness, insomnia, and, in rare cases, loss of consciousness and hallucinations. In people prone to autoimmune diseases there is a slight risk of developing meningitis.
4. From the sensory organs, dry eye membranes, blurred vision, inflammation are observed. optic nerve.
5. Sometimes the pills cause shortness of breath and bronchospasm.
6. This drug can cause swelling, various rhinitis and dermatitis, rejection of skin membranes and all kinds of allergic reactions.
7. According to blood tests, anemia may be observed as a side effect when using the drug. Other effects include increased sweating.

In case of an overdose of the drug, the indicators drop sharply blood pressure. There is darkening of the eyes and noise in the ears. The patient may vomit. He loses consciousness and orientation in space.

The victim requires gastric lavage, activated carbon, alkaline drinks and symptomatic treatment medications.

Antipyretic analogues

The pharmaceutical drug is produced both under the original name and in the form of numerous analogues, among which there are such products as:

• Advil, tablets (ibuprofen 400 mg for adults and children over 12 years of age);
• "Ibufen", suspension ("Nurofen" for children) with 100 mg of active ingredient in every 5 ml of the drug;
• "MIG-400", film-coated tablets with a dosage of 400 mg;
• "Nurofen" in tablet form (200 mg);
• “Nurofen for children” (suspension 100 mg/5 ml);
• "Pedea", ampoules with a solution for intravenous injections(10 mg/2 ml);
• "Solpaflex" tablets and capsules 200 mg;
• "Faspik", dosage form - tablets, dosage - 400 mg.

All of the listed drugs are taken according to regimens similar to the original drug.

Since 2000, several mass observations have been carried out, resulting in a number of negative influences from non-steroidal painkillers. Among the risks provoked by them, there is a tendency to sudden stomach bleeding and development of heart attack. From which it follows that this category of drugs cannot be unreasonably prescribed to oneself, bypassing the doctor’s recommendations.

Ibuprofen.

Release form

Film-coated tablets Pink colour, biconvex; On a cross section, two layers are visible.

pharmachologic effect

Non-steroidal anti-inflammatory drug.

Indications for use

Symptomatic treatment:

• tension headaches and migraines;
• joint, muscle pain,
• back pain, lower back pain, radiculitis;
• pain when ligaments are damaged;
• toothache;
• painful menstruation;
• febrile conditions with colds, flu;
• rheumatoid arthritis, osteoarthritis.

NSAIDs are intended for symptomatic therapy, reducing pain and inflammation at the time of use, but do not affect the progression of the disease.

Directions for use and doses

Adults, elderly and children over 12 years of age: 200 mg tablets 3-4 times a day; in tablets of 400 mg 2-3 times a day. The daily dose is 1200 mg (do not take more than 6 tablets of 200 mg (or 3 tablets of 400 mg) within 24 hours. The tablets should be swallowed with water, preferably during or after meals. Do not take more often than after 4 hours. Do not exceed the indicated dose! The course of treatment without consulting a doctor should not exceed 5 days.

If symptoms persist, consult your doctor.

Do not use in children under 12 years of age without consulting a doctor. Children from 6 to 12 years of age (weighing more than 20 kg): 1 tablet of 200 mg no more than 4 times a day. The interval between taking tablets is at least 6 hours.

Contraindications

• erosive and ulcerative changes in the gastric mucosa or duodenum, active gastrointestinal bleeding;
• inflammatory diseases intestines in the acute phase, incl. ulcerative colitis;
• anamnestic data on an attack of bronchial obstruction, rhinitis, urticaria after taking acetylsalicylic acid or another non-steroidal anti-inflammatory drug (complete or incomplete acetylsalicylic acid intolerance syndrome - rhinosinusitis, urticaria, polyps of the nasal mucosa, bronchial asthma);
• liver failure or active disease liver;
• renal failure(creatinine clearance less than 30 ml/min), progressive kidney disease;
• confirmed hyperkalemia;
• hemophilia and other bleeding disorders (including hypocoagulation), hemorrhagic diathesis;
• in the period after coronary artery bypass surgery;
• pregnancy ( III trimester);
• childhood: up to 6 years and from 6 to 12 years (with body weight less than 20 kg) - for tablets 200 mg; up to 12 years - for tablets 400 mg;
• hypersensitivity to any of the ingredients included in the drug.

Carefully: elderly age, congestive heart failure, cerebrovascular diseases, arterial hypertension, ischemic disease heart, dyslipidemia/hyperlipidemia, diabetes, peripheral arterial diseases, nephrotic syndrome, CC less than 30-60 ml/min, hyperbilirubinemia, peptic ulcer stomach and duodenum (history), presence of infections Helicobacter pylori, gastritis, enteritis, colitis, long-term use of NSAIDs, blood diseases of unknown etiology (leukopenia and anemia), pregnancy (I-II) trimester, lactation period, smoking, frequent use alcohol (alcoholism), severe somatic diseases, concomitant therapy with the following drugs: anticoagulants (for example, warfarin), antiplatelet agents (for example, acetylsalicylic acid; clopidogrel), oral glucocorticosteroids (for example, prednisolone), selective serotonin reuptake inhibitors (for example, citalopram, fluoxetine, paroxetine, sertraline).

special instructions

At long-term use it is necessary to monitor the peripheral blood picture and functional state liver and kidneys. To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used. When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a blood test to determine hemoglobin and hematocrit, and a stool test for occult blood. If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the test. During the treatment period, you should refrain from drinking alcohol and activities that require increased concentration attention and speed of psychomotor reactions.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 30°C. Keep out of the reach of children.

Pain is defensive reaction body, a signal to a person that something has most likely gone wrong inside. But sometimes it is unbearable to endure it, and besides, it is often not necessary. There are many modern drugs, which allow you to quickly dock painful attacks. One of them is Ibuprofen (400 mg), the instructions for use of which recommend taking it to relieve discomfort in a wide variety of diseases.

general information

There is a big class medicines, which are non-steroidal anti-inflammatory drugs. They relieve pain and have an antipyretic effect. Also, these medications reduce the severity of the inflammatory process, and their effect is quite rapid. One of these drugs is Ibuprofen (400 mg). Instructions for use recommend taking it for pain of various natures and elevated temperature bodies.

The remedy is a fast-acting medicine that relieves symptoms, but, unfortunately, does not eliminate the causes of the disease. Therefore, most often "Ibuprofen" is included in complex therapy various diseases. It allows a person to undergo the recovery process much easier due to the fact that clinical picture while taking it, it becomes less pronounced. In parallel with it, etiotropic treatment is prescribed, that is, one that affects the real nature of the disease.

Release forms and composition

The first thing that catches your eye when opening the package of Ibuprofen (400 mg) is the instructions for use. The composition of the drug is as follows:

• active substance– ibuprofen;
• additional components (may vary depending on the manufacturer) - silicon dioxide, corn starch, magnesium stearate, titanium dioxide, talc, sodium carboxymethyl starch, povidone K30 macrogol 4000 hypromellose, microcrystalline cellulose.

Each tablet has a special feature that makes it possible to divide the medication into 2 equal halves. This is very convenient in cases where it is necessary to simultaneously take, say, 200 or 600 mg of ibuprofen.

Non-steroidal anti-inflammatory drugs with long-term use, unfortunately, negatively affect the mucous membrane of the digestive organs, this also applies to the drugs Ibuprofen. Instructions for use of the tablet (400 mg) recommend taking it after meals so that the stomach is not irritated by the drug.

Mechanism of action of drugs

During inflammation, prostaglandins are actively formed in tissues (physiologically active substances), increased level which brings to a person painful sensations. The reaction of their synthesis is accelerated by the enzymes cyclooxygenases type 1 and 2 (COX-1 and COX-2). Nonsteroidal anti-inflammatory drugs inhibit the formation of these catalysts, and the amount of prostaglandins rapidly decreases because the reaction is less intense. Ibuprofen (400 mg) also has this mechanism of action. Instructions for use and descriptions of the drug in pharmaceutical reference books indicate that the product effectively eliminates pain, relieves inflammation and reduces overall body temperature. The maximum concentration of the active substance is observed 1-2 hours after taking the tablet orally. The drug is excreted from the body mainly through urine, and accumulates in the body in the blood plasma and periarticular fluid.

The advantage of tablets over other dosage forms

Ibuprofen is available in different doses and dosage forms. It is available in syrups, tablets, suspensions and capsules. But if we consider Ibuprofen (400 mg), the instructions for use of which provide for oral administration, then in this dosage it is available only in tablets. This type of medicine has certain advantages:

• ease of reception;
• absence bad taste active substance due to the shell and additional components;
• lasting effect;
• precise dosing.

The use of tablets does not require participation medical personnel(as in the case of injections, for example) and compliance with sterility conditions. Ibuprofen tablets are medium in size and easy to swallow with a small amount of water.

Indications for use

The most comprehensive document that describes the indications for use of the drug Ibuprofen is the instructions for use. Tablets (400 mg) are usually prescribed to a patient with the following symptoms of the disease:

• migraine;
• painful menstruation;
• inflammation and pinched nerves;
• increased body temperature;
• toothache
• stiffness and discomfort in joints with arthritis, arthrosis and non-rheumatic inflammation;
• muscle pain;
• inflammation of the ligaments;
• rheumatoid processes;
• inflammation of the uterine appendages;
• Bekhterev's disease;
• manifestations of ARVI, sore throat, bronchitis.

The drug can be used as part of complex therapy in patients with nephrotic syndrome. It reduces the amount of protein in the urine and reduces the intensity of pain. The medicine helps reduce discomfort V postoperative period, although it cannot act as the only analgesic in this case.

"Ibuprofen" (400 mg): instructions for use, drug analogues

Tablets with this dosage are available under the following trade names:

• "MIG-400".
• "Nurofen Forte".
• "Faspic".
• "Brufen."
• "Burana".
• "Ibuprom Max".
• "Ibuprofen Nycomed"

There is also a high-quality domestically produced medicine, Ibuprofen Hemofarm (400 mg). Instructions for use suggest its use according to the following scheme:

• for moderate pain – 1 tablet 3 times a day;
• for rheumatoid inflammation of the joints - 2 tablets three times a day;
• at muscle pain and diseases - 15 tablets 2-3 times a day;
• for ankylosing spondylitis - 1-15 tablets up to 4 times a day.

These recommendations are standard for taking 400 mg ibuprofen tablets from any manufacturer. To reduce the temperature, the amount of the drug is calculated based on the patient’s weight. If the mark on the thermometer has reached 392, you need to drink a remedy in the ratio of 10 mg/kg of a person’s body weight (if the value is less, then 5 mg/kg of the patient’s body weight is enough).

Contraindications

Not all people can safely use Ibuprofen tablets (400 mg). Instructions for use indicate the following contraindications:

• peptic ulcers of the digestive system;
• gastritis and chronic inflammation intestines during periods of exacerbation;
• bronchial asthma;
• severe liver dysfunction (eg, cirrhosis or deep liver disease) blood vessels this body);
• age up to 12 years;
• last trimester of pregnancy;
• high blood pressure;
• swelling;
• diseases of the optic nerves;
• color perception disorders due to ophthalmic diseases;
• individual intolerance to the components of the drug;
• heart failure;
• poor blood clotting.

During lactation, ibuprofen penetrates into breast milk, but in very low doses. Cancel natural feeding for a newborn, when prescribing this drug to the mother, it is necessary only in cases where the woman will undergo long-term drug therapy.

What are the dangers of overdose?

Before treatment, it is advisable to find out the following information about the drug “Ibuprofen” (400 mg): instructions for use, release form and contraindications. But it is important to read about safe doses of the medicine, because exceeding them can lead to sad consequences. It is important to maintain a minimum interval of 6 hours between doses of the drug; you should not take these tablets more often because high risk side effects on the body. The daily dose of medication in any case should not exceed 24 g. Symptoms of taking an excessive amount of medication:

• nausea (sometimes vomiting is possible);
• headache;
• blurred vision;
• decreased blood pressure;
• abdominal pain;
• dizziness;
• labored breathing;
• blue skin.

There is no specific counteracting agent, therefore, if alarming symptoms the patient needs to rinse the stomach, provide access fresh air and immediately call an ambulance.

Compatibility with other drugs

Not all medicines are compatible with each other. They may enhance each other's side effects or reduce their effectiveness. The drug “Ibuprofen” (400 mg) is no exception in this regard. The instructions for use warn that the medicine should not be taken with the following medications:

• drugs for the treatment of hypertension (it reduces their activity and can cause an increase in blood pressure);
• Furosemide and similar diuretic drugs (ibuprofen worsens their effect);
• anticancer medications (as ibuprofen enhances them toxic effect on the body).

When treating with the drug, you should not drink alcohol, since this combination leads to undesirable side effects of Ibuprofen and increases harmful effects alcoholic drinks.

Reviews from doctors

Doctors say that ibuprofen is one of the safest representatives of non-steroidal anti-inflammatory drugs. Based on it, it is produced great amount over-the-counter medications high efficiency. Doctors noticed that those patients who took into account all contraindications and did not exceed the recommended dosages received only benefits from taking the medications. Reviews from experts indicate that the medicine can quickly relieve pain in neurological and orthopedic diseases. And although it does not eliminate the cause of their appearance, it still greatly alleviates the patient’s condition. When the pain subsides, a person’s mood improves and he calms down, and, according to doctors, the result of treatment half depends on psychological comfort.

Pain is a protective reaction of the body and a signal to a person that something has most likely gone wrong inside. But sometimes it is unbearable to endure it, and besides, it is often not necessary. There are many modern drugs that can quickly relieve pain attacks. One of them is “Ibuprofen” (400 mg), the instructions for use of which recommend taking it to relieve discomfort in a variety of diseases.

general information

There is a large class of drugs that belong to non-steroidal anti-inflammatory drugs. They relieve pain and have an antipyretic effect. Also, these medications reduce the severity of the inflammatory process, and their effect is quite rapid. One of these drugs is Ibuprofen (400 mg). The instructions for use recommend taking it for pain of various natures and elevated body temperature.

The remedy is a fast-acting medicine that relieves symptoms, but, unfortunately, does not eliminate the causes of the disease. Therefore, most often “Ibuprofen” is part of complex therapy various diseases. It allows a person to undergo the recovery process much easier due to the fact that the clinical picture becomes less pronounced when taking it. In parallel with it, etiotropic treatment is prescribed, that is, one that affects the true nature of the disease.

Release forms and composition

The first thing that catches your eye when opening the package of Ibuprofen (400 mg) is the instructions for use. The composition of the drug is as follows:

• active ingredient - ibuprofen;
• additional components (may vary depending on the manufacturer) - silicon dioxide, corn starch, magnesium stearate, titanium dioxide, talc, sodium carboxymethyl starch, povidone K30, macrogol 4000, hypromellose, microcrystalline cellulose.

Each tablet has a special feature that makes it possible to divide the medication into 2 equal halves. This is very convenient in cases where you need to take, say, 200 or 600 mg of ibuprofen at the same time.

Unfortunately, long-term use of the drugs negatively affects the mucous membrane of the digestive organs, this also applies to the drug Ibuprofen. Instructions for use of the tablet (400 mg) recommend taking it after meals so that the stomach does not succumb to the irritating influence of the drug.

Mechanism of action of the drug

During inflammation, prostaglandins (physiologically active substances) are actively formed in tissues, an increased level of which brings pain to a person. The reaction of their synthesis is accelerated by the enzymes cyclooxygenases type 1 and 2 (COX-1 and COX-2).

Non-steroidal anti-inflammatory drugs inhibit the formation of these catalysts, and the amount of prostaglandins rapidly decreases, since the reaction is not as intense. Ibuprofen (400 mg) also has this mechanism of action. Instructions for use and descriptions of the drug in pharmaceutical reference books indicate that the product effectively eliminates pain, relieves inflammation and lowers overall body temperature. The maximum concentration of the active substance is observed 1-2 hours after taking the tablet orally. The drug is excreted from the body mainly through urine, and accumulates in the body in plasma and periarticular fluid.

The advantage of tablets over other dosage forms

Ibuprofen is available in different doses and dosage forms. It is available in syrups, tablets, suspensions and capsules. But if we consider Ibuprofen (400 mg), the instructions for use of which suggest oral administration, then in this dosage it is available only in tablets. This type of medicine has certain advantages:

• ease of reception;
• absence of unpleasant aftertaste of the active substance due to the shell and additional components;
• lasting effect;
• exact dosage.

The use of tablets does not require the participation of medical personnel (as is the case with injections, for example) and compliance with sterile conditions. Ibuprofen tablets are medium in size and easy to swallow with a small amount of water.

Indications for use

The most comprehensive document that describes the indications for use of the drug "Ibuprofen" is the instructions for use. Tablets (400 mg) are usually prescribed to the patient for the following symptoms and illnesses:

• migraine;
• painful menstruation;
• inflammation and pinched nerves;
• increased body temperature;
• toothache;
• stiffness and discomfort in the joints due to arthritis, arthrosis and non-rheumatic inflammation;
• muscle pain;
• inflammation of the ligaments;
• rheumatoid processes;
• inflammation of the uterine appendages;
• Bekhterev's disease;
• manifestations of ARVI, sore throat, bronchitis.

The drug can be used as part of complex therapy in patients with It reduces the amount of protein in the urine and reduces the intensity of pain. The medicine helps reduce discomfort in the postoperative period, although it cannot act as the only analgesic in this case.

"Ibuprofen" (400 mg): instructions for use, drug analogues

Tablets with this dosage are available under the following trade names:

• "MIG-400".
• "Nurofen Forte".
• "Faspic".
• "Brufen."
• "Burana".
• "Ibuprom Max".
• "Ibuprofen Nycomed"

There is also a high-quality domestically produced medicine, Ibuprofen Hemofarm (400 mg). Instructions for use suggest its use according to the following scheme:

• for moderate pain - 1 tablet 3 times a day;
• for rheumatoid inflammation of the joints - 2 tablets three times a day;
• for muscle pain and ligament diseases - 1.5 tablets 2-3 times a day;
• for ankylosing spondylitis - 1-1.5 tablets up to 4 times a day.

These recommendations are standard for taking 400 mg ibuprofen tablets from any manufacturer. To reduce the temperature, the amount of the drug is calculated based on the patient’s weight. If the mark on the thermometer has reached 39.2, you need to drink a remedy in the ratio of 10 mg/kg of a person’s body weight (if the value is less, then 5 mg/kg of the patient’s body weight is enough).

Contraindications

Not all people can safely use Ibuprofen tablets (400 mg). Instructions for use indicate the following contraindications:

• peptic ulcers of the digestive system;
• gastritis and chronic intestinal inflammation during periods of exacerbation;
• bronchial asthma;
• severe liver dysfunction (for example, cirrhosis or deep damage to the blood vessels of this organ);
• age up to 12 years;
• last trimester of pregnancy;
• high blood pressure;
• swelling;
• diseases of the optic nerves;
• color perception disorders due to ophthalmological diseases;
• individual intolerance to the components of the drug;
• heart failure;
• poor blood clotting.

During lactation, ibuprofen passes into breast milk, but in very low doses. It is necessary to cancel breastfeeding of a newborn due to the prescription of this drug to the mother only in cases where the woman will undergo long-term drug therapy.

What are the dangers of overdose?

Before treatment, it is advisable to find out the following information about the drug “Ibuprofen” (400 mg): instructions for use, release form and contraindications. But it is important to read about safe doses of the medicine, because exceeding them can lead to dire consequences. It is important to maintain a minimum interval of 6 hours between doses of the drug; you should not take these tablets more often due to the high risk of side effects on the body. The daily dose of the drug in any case should not exceed 2.4 g.

Symptoms of Acceptance excess quantity medications:

• nausea (sometimes vomiting is possible);
• headache;
• blurred vision;
• decreased blood pressure;
• abdominal pain;
• dizziness;
• labored breathing;
• blue skin.

There is no specific counteracting agent, so if alarming symptoms occur, the patient needs to rinse the stomach, provide access to fresh air and immediately call an ambulance.

Compatibility with other drugs

Not all medicines are compatible with each other. They may enhance each other's side effects or reduce their effectiveness. The drug “Ibuprofen” (400 mg) is no exception in this regard. The instructions for use warn that the medicine should not be taken with the following medications:

• drugs for the treatment of hypertension (it reduces their activity and can cause an increase in blood pressure);
• Furosemide and similar diuretic drugs (ibuprofen makes their action difficult);
• antitumor drugs (since ibuprofen enhances their toxic effect on the body).

When treating with the drug, you should not drink alcohol, as this combination leads to undesirable side effects"Ibuprofen" and enhances bad influence alcoholic drinks.

Reviews from doctors

Doctors say that ibuprofen is one of the safest representatives of non-steroidal anti-inflammatory drugs. Based on it, a huge number of over-the-counter drugs with high efficiency are produced. Doctors noticed that those patients who took into account all contraindications and did not exceed the recommended dosages only benefited from taking the medicine.

10 tablets per blister 11ВХ/АЛ. 1, 2, 3 or 5 blisters with instructions for use in a cardboard pack. Composition: 1 film-coated tablet contains active ingredient: ibuprofen - 400 mg; Excipients: microcrystalline cellulose PH 101, sodium carboxymethyl starch, colloidal silicon dioxide, anhydrous, stearic acid; film shell: methacrylic acid and ethyl acrylate copolymer (1:1), talc, titanium dioxide E 171, polysorbate 80.

pharmachologic effect

Relieves pain, incl. joint pain at rest and with movement; reduces morning stiffness and swelling of joints, helps increase range of motion.

Indications for use

Pain syndrome: myalgia, arthralgia, ossalgia, arthritis, radiculitis, migraine, headache (including menstrual syndrome) and toothache, neuralgia, tendinitis, tendovaginitis, bursitis, post-traumatic and postoperative pain syndrome accompanied by inflammation, in cancer ,

Algodismenorrhea, inflammatory process in the pelvis, incl. adnexitis. Feverish syndrome with “colds” and infectious diseases.

Mode of application

Doses of ibu profen are selected individually so that the least amount of possible dose get what you want therapeutic effect. The effervescent tablet of the drug Ibuprofen-Hemofarm is completely dissolved in a glass (200 ml) of water, and the resulting solution is drunk immediately. Effervescent tablets should not be swallowed, chewed or sucked in the mouth.

Effervescent tablets are prescribed for children over 6 years of age and adults.

For adults, a single dose of ibuprofen is 1-2 effervescent tablets (200-400 mg); daily dose is 4-6 effervescent tablets (800-1200 mg), in divided doses with an interval of 4-6 hours.

Petit aged 6 to 12 years: a single dose is 1 effervescent tablet (200 mg); therapeutic dose - 1 effervescent tablet with an interval of 4-6 hours, 2-4 times a day. The maximum daily dose is 4 effervescent tablets (800 mg/day).

Leti over the age of 12 years: a single dose is 1-2 effervescent tablets (200-400 mg); therapeutic dose of 1-2 tablets with an interval of 4-6 hours. The maximum daily dose is 5 effervescent tablets(1000 mg).

Pills. film-coated tablets are prescribed for adults and children over 12 years of age, orally after meals, the tablets must be swallowed whole with a small amount of liquid.

Adults and children over 12 years old - 1 tablet (400 mg) orally. Repeated appointment no earlier than 4 hours later.

Adults should not take more than 3 tablets in 24 hours. The maximum daily dose is 1200 mg. The maximum daily dose for children aged 12-18 years is 1000 mg.

If symptoms persist after taking the drug for 2-3 days, you should stop treatment and consult a doctor.

Interaction

When administered simultaneously, ibuprofen reduces the anti-inflammatory and antiplatelet effects of ASA (possibly increasing the incidence of ospha coronary insufficiency in patients receiving small doses of ASA as an antiplatelet agent after starting ibuprofen).

When prescribed with anticoagulant and thrombolytic drugs (J1C) (alteplase, spheptokinase, urokinase), the risk of bleeding simultaneously increases.

Concomitant use with serotonin reuptake inhibitors (cyhalopram, fluoxetine, paroxetine, sertraline) increases the risk of developing serious gastrointestinal tract bleeding. Cefamandole, cefaperazone, cefotetan, valrosic acid, plicamycin increase the incidence of hyioprothrombinemia.

Cyclosporine and gold preparations enhance the effect of ibuprofen on the synthesis of prostatlandins in the kidneys, which is manifested by increased nephrotoxicity. Ibuprofen increases the plasma concentration of cyclosporine and the likelihood of developing its hepatotoxic effects.

Drugs that block tubular secretion reduce excretion and increase plasma concentrations of ibuprofen.

Inducers of microsomal oxidation (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants) increase the production of hydroxylated active metabolites, increasing the risk of developing severe gay toxicity.

Inhibitors of microsomal oxidation reduce the risk of hepatotoxicity.

Reduces the hypotensive activity of vasodilators (including blockers of “slow” calcium channels (SCBC), angiotensin-converting enzyme (ACE) inhibitors), sodium uretic and diuretic - furosemide and hydrochlorothiazide.

Reduces the effectiveness of uricosuric JICs, enhances the effect indirect anticoagulants. antiagents, fibripolitics (increased risk of hemorrhagic complications), enhances the ulcerogenic effect with bleeding of mineralocorticosteroids (MCS) and I lukocorticosteroids (GCS), colchicine, estrogens, ethanol.

Enhances the effect of oral hypoglycemic drugs (including sulfonylurea derivatives) and insulin.

Antacids and cholestyramine reduce the absorption of ibuprofen.

Increases the concentration of digoxin in the blood. lithium and methotrexate drugs.

Caffeine enhances the analgesic effect.

Myelotoxic drugs increase the manifestations of hematotoxicity of the drug.

Side effect

From the central and peripheral nervous system: headache, dizziness, insomnia, anxiety, nervousness and irritability, psychomotor agitation, drowsiness, depression, confusion, hallucinations, rarely - aseptic meningitis (more often in patients with autoimmune diseases).

From the senses: hearing loss, ringing or noise in the ears, reversible toxic optic neuritis, blurred vision or diplopia, dryness and irritation of the eyes, swelling of the conjunctiva and eyelids (allergic origin), scotoma.

From the outside respiratory system: shortness of breath, bronchospasm.

From the outside of cardio-vascular system(CVS): heart failure, tachycardia, increased blood pressure.

From the urinary system: acute renal failure, allergic nephritis, nephrotic syndrome (edema), polyuria, cystitis. Allergic reactions: skin rash(usually erythematous or urticaria), itchy skin, angioedema, anaphylactoid reactions, anaphylactic shock, bronchospasm, fever, multiforme exudative erythema(including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome), eosinophilia, allergic rhinitis.

From the hematopoietic organs: anemia (including hemolytic, aplastic), thrombocytopenia and thrombocytopenic purpura, agranulocytosis, leukopenia.

Other: increased sweating.

The risk of developing ulcerations of the gastrointestinal mucosa, bleeding ( gastrointestinal, gingival, uterine, hemorrhoidal), visual impairment (impaired color vision, scotomas, amblyopia) increases with long-term use in large doses.

Contraindications

Overdose

Treatment: gastric lavage (only within 1 hour after administration), Activated carbon, alkaline drink, forced diuresis, symptomatic therapy(correction of acid-base status, arterial pressure).

special instructions

When symptoms of gastropathy appear, careful monitoring is indicated, including esophagogastroduodenoscopy, a blood test to determine hemoglobin, hematocrit, and a stool test for occult blood.

To prevent the development of NSAID gastropathy, it is recommended to combine it with prostaglandin drugs (misoprostol).

If it is necessary to determine 17-ketosteroids, the drug should be discontinued 48 hours before the study.

Patients should refrain from all activities requiring increased attention, fast mental and motor reactions.

To reduce the risk of developing adverse events from the gastrointestinal tract, the minimum effective dose should be used for the shortest possible short course.