Diagnosis and treatment of acute and chronic drug-induced hepatitis. Hepatitis officinalis

- reactive inflammatory lesion liver caused by taking hepatotoxic drugs. Symptoms of drug-induced hepatitis may include nausea, vomiting, loss of appetite, constipation or diarrhea, jaundice, dark urine, and light-colored feces. Diagnosis of drug-induced hepatitis is made on the basis of anamnesis, determination of the level of liver tests, ultrasound of the liver. Treatment of drug-induced hepatitis requires the abolition of the pharmaceutical product that caused liver damage, detoxification therapy, and the appointment of hapatoprotectors.

General information

Drug (drug) hepatitis is a lesion of liver tissues as a result of toxic damage to hepatocytes by metabolites of medicinal substances, with the development of reactive inflammation and necrosis of liver cells. Drug-induced hepatitis complicates ongoing pharmacotherapy in 1-28% of cases and in 12-25% of cases leads to the development of liver cirrhosis and liver failure. Women suffer from drug-induced hepatitis 2-3 times more often than men. A special section of gastroenterology, hepatology, deals with the study and treatment of drug-induced hepatitis.

Causes

The most important function of the liver in the body is the neutralization and neutralization of toxic substances entering it with the bloodstream. Metabolism and utilization of chemical and biological toxins occurs under the action of the enzymatic neutralizing system of hepatocytes, followed by excretion harmful products from the body. The process of utilization of toxic substances takes place in the liver in several stages, during which metabolites are formed - intermediate products of biotransformation. The metabolites of some drugs are even more hepatotoxic than the drugs themselves. Long-term use of such drugs or their high dosage leads to the depletion of detoxifying enzyme systems and damage to hepatocytes, resulting in the development of drug-induced hepatitis.

To date, more than a thousand names of drugs are known that lead to the development of drug-induced hepatitis. The toxicity of the action of drugs increases with the combined use of 2-3 drugs, and with the simultaneous use of 6 or more drugs, the likelihood of toxic liver damage increases to 80%. The rate of development of drug-induced hepatitis against the background of taking medications varies from several days to several years.

Risk factors for the development of drug-induced hepatitis include genetically determined hypersensitivity to any drug; the presence at the time of taking the drug chronic hepatitis, viral hepatitis, autoimmune hepatitis, ascites; alcohol intake or toxic effects of solvents, toxic gases on the background drug therapy; pregnancy; protein deficiency in the diet; stress; kidney failure, heart failure, etc.

The main groups of drugs that cause drug-induced hepatitis include:

Tuberculosis drugs (rifampicin, isoniazid)
Antibiotics: tetracyclines (tetracycline, chlortetracycline, dixycycline), penicillins (benzylpenicillin, amoxicillin, etc.), macrolides (erythromycin)
Sulfonamides (sulfamethoxazole + trimethoprim, sulfadimethoxine, etc.)
Hormones (steroid hormones, oral contraceptives and etc.)
NSAIDs (diclofenac, ibuprofen)
Anticonvulsants and antiepileptics (phenytoin, carbamazepine, clonazepam, etc.)
Antifungals (amphotericin B, ketoconazole, fluorocytosine)
Diuretics (hydrochlorothiazide, furosemide, etc.)
Cytostatics (methotrexate)
Drugs for the treatment of arrhythmia, diabetes, peptic ulcer and many others. others

The list of drugs that have a hepatotoxic effect is far from being exhausted by the named drugs. Drug-induced hepatitis can be caused by almost any drug, and especially by a combination of several drugs.

Symptoms of drug-induced hepatitis

drug-induced hepatitis may occur in acute or chronic form. Acute drug-induced hepatitis, in turn, are divided into cholestatic, cytolytic (occurring with necrosis and fatty hepatosis) and mixed.

The symptoms of drug-induced hepatitis are similar to those of other types of hepatitis. Dominant in clinical picture are dyspeptic disorders: loss of appetite, nausea, belching bitterness, vomiting, diarrhea or constipation, weight loss. Main clinical manifestations may be preceded by a prodromal period that occurs with asthenic or allergic syndrome. With drug-induced hepatitis, moderate pain, heaviness, discomfort in the right hypochondrium are disturbing; palpation determines hepatomegaly, liver tenderness. Sometimes jaundice develops against the background of drug-induced hepatitis, pruritus, fever, lighter stools and darker urine.

In some cases, drug-induced hepatitis can be detected only on the basis of changes in biochemical parameters blood. Acute drug-induced hepatitis, which proceeds with the formation of submassive necrosis, quickly leads to cirrhosis of the liver. With massive necrosis of the liver, liver failure develops.

Diagnostics

In the process of diagnosing drug-induced hepatitis, it is important to exclude viral hepatitis, cholelithiasis, liver tumors, and pancreatic cancer. When taking anamnesis, it is important to find out the causal relationship of liver damage with the use of hepatotoxic drugs.

If drug-induced hepatitis is suspected, liver biochemical samples are examined, in which the activity of transaminases (AST, ALT) and alkaline phosphatase, bilirubin level, globulin fractions. A coagulogram study is carried out, general analysis urine and blood, coprograms.

Ultrasound of organs abdominal cavity reveals diffuse magnification liver, however, does not allow us to judge the cause of hepatitis.

Treatment of drug-induced hepatitis

The first step in treating drug-induced hepatitis is to stop the drug suspected of causing liver damage and replace it with a newer drug. safe analogue. It is strictly forbidden for the patient to change medications on his own. In order to remove toxic metabolites from the body, detoxification is carried out. infusion therapy, plasmapheresis, in severe cases - hemodialysis.

To restore damaged liver cells, hepatoprotective drugs (essential phospholipids, ademethionine, methionine) are prescribed. When prescribing drugs with a known hepatotoxic potential, it is recommended to take preventive hepatoprotectors, which helps prevent the development of drug-induced hepatitis.

Forecast and prevention

In severe cases, with lightning-fast development drug-induced hepatitis or massive necrosis of the hepatic parenchyma develops cirrhosis, liver failure, sometimes hepatic coma and death. With the timely cancellation of the hepatotoxic drug in most cases, complete recovery occurs.

Prevention of drug-induced hepatitis consists in the rational use of medicines, monitoring side effects, taking drugs only as prescribed by a doctor, excluding additional toxic effects. Against the backdrop of a long drug therapy the appointment of hepatoprotectors is recommended. Patients forced to long time take medication, it is necessary to periodically examine the level of transaminases in order to identify drug-induced hepatitis at an early stage.

When consuming any medication, whether hormone therapy or simple vitamins our liver suffers. This organ performs the function of a kind of body cleaner from toxic and other pathogenic effects. Sometimes too frequent use Some medications can lead to serious illness. One of the complications is drug-induced hepatitis. This disease is a rapid inflammation of the liver as a result of the use of hepatotoxic drugs. In many drug-induced hepatitis does not depend on the duration of the drug. According to statistics, women suffer from this disease more often than men.

Symptoms of drug-induced hepatitis

Drug-induced hepatitis occurs only in acute or chronic form. All the symptoms of this disease are very similar to the manifestations of other types of hepatitis. The acute form of drug-induced hepatitis can be divided into cholestatic and cytolytic. In the chronic form, the development of cirrhosis of the liver, liver failure, problems with the selection pharmacological preparations. The most common symptoms of drug-induced hepatitis are:

These signs may be accompanied by disorders of the central nervous system. The patient experiences general fatigue, fatigue. Sleep patterns are also disturbed. Sometimes among the symptoms you can observe itching of the skin. Any form of hepatitis is characterized by darkening of urine and lightening stool a slight increase in body temperature. A feature of such a disease as drug-induced hepatitis is an increase in the liver during palpation.

Drug-induced hepatitis and its causes

Once in the body, any medicine is processed by our liver. falling apart active ingredients drugs are sent to the necessary systems and organs to eliminate the symptoms of any disease, and the impurities contained in all drugs enter the liver. It is the liver, with the help of its enzymes, that neutralizes them and removes them from the body. And if the body does not cope with the task, the person runs the risk of getting drug-induced hepatitis.

Diseases such as:

The possible presence of an allergy or intolerance to the components of the drug used can also lead to violations of the liver. It is no secret that the huge pernicious influence use on the liver alcoholic beverages. Poisoning by various chemical and toxic substances disrupt the functioning of all organs and systems of the body. Also at risk are people who already have any form of hepatitis.

As for specific medications, then provoke given type virtually anyone can get hepatitis. The branch of the championship can be given especially dangerous means- antibiotics. Everyone knows about their effect on the liver. Among these, the following can be distinguished: Doxycycline, Tetracycline, Amoxiclav, Benzylpenicillin, Penicillins and Macrolides. Many anti-tuberculosis drugs are dangerous - Rifampicin, Isoniazid. Drug-induced hepatitis often develops against the background of the use hormonal drugs: oral contraceptives, estrogens, glucocorticosteroids.

Drugs such as Diclofenac, Aspirin and others, aimed at removing inflammatory processes in the body, can cause hepatitis. A wide range of diuretics also often act as provocateurs. Worth mentioning are the following:

Antiulcer drugs;
Cytostatics;
antidiabetic agents;
antifungal medicines;
Blood products.

Drug-induced hepatitis can manifest itself both on the first day of taking drugs, and after some incubation period. This period can last from a couple of months to several years. With this course of the disease, liver necrosis may occur, as the affected liver cells gradually die off. And if you don't start timely treatment, symptoms worsen, cirrhosis may occur.

Diagnosis of the disease

Before starting any treatment, it is worthwhile to conduct a qualitative diagnosis of the liver. If you suspect drug-induced hepatitis, contact a specialist for help. By conducting tests, this diagnosis will be confirmed or refuted. A gastroenterologist can help you with this. Diagnosis begins with clarifying the patient's symptoms, palpation of the abdominal cavity, determining the color of the skin and other mucous membranes. With help ultrasound the size of the liver and possible neoplasms on it are determined.

In the process of diagnosis, it is very important to exclude such possible complications like other types viral hepatitis, diseases of the biliary tract, tumor, pancreatic cancer. Appointed the following types analyses:

Treatment of drug-induced hepatitis

First of all, the treatment of hepatitis consists in the immediate abolition of the drugs that provoked this disease. If drug-induced hepatitis is at an initial degree of mild severity, this is quite enough. If the liver damage is serious, and the symptoms manifest themselves clearly and in their maximum number, it is necessary to carry out therapy aimed at detoxifying the body. This treatment is aimed at removing the remaining toxins in the body. To do this, use Ringer's solution, which is administered using a dropper. Also, therapy consists in such drugs:

10% glucose solution;
Reopoliglyukin;
Rheosorbilact;
Hemodez;
10% Albumin solution.

Hemodialysis is used to remove toxins from the blood. To restore normal work and all liver functions are prescribed hepatoprotectors: Essentiale, Heptral, Methionine. Such preparations can be administered either by injection or in the form of tablets. Minimum exchange rate treatment is one month. To achieve the maximum result from the treatment, you need to follow some rules in eating. To do this, you need to stop using:

It is worth paying attention to boiled and baked foods. The prerequisite is daily consumption fruits and vegetables. Favorably affect the liver carrots, celery, parsnips, strawberries, black currants. The patient needs to eat a large number of porridge The largest vitamin and mineral composition possesses buckwheat porridge. You should try to drink freshly squeezed juices as much as possible and dairy products such as kefir and curdled milk. The meal schedule should be fractional.

Prevention of drug-induced hepatitis

To avoid the occurrence of this disease and not cause its symptoms, you need to follow these recommendations:

Do not exceed the indicated dosage of the drug;
Treatment should take place only under the supervision of a doctor;
Take hepatoprotectors for prevention;
Eat more protein products;
Periodically undergo a medical examination.

Drug-induced (drug-induced) hepatitis is inflammatory disease liver caused by taking medications with hepatotoxic properties. The frequency of occurrence of this pathology varies in different years 1 to 25% of cases drug treatments in patients, while there is no dependence on the duration of treatment or the doses taken. Of these, up to 20% are complicated by cirrhosis and liver failure. Women suffer from this disease 2-3 times more often than men. Average age drug-induced hepatitis - 30-55 years.

Causes

Almost all medicinal substances pass through the human liver, where most of them break down into their constituent components. Active substances The drugs pass on with the blood flow to the necessary organs and tissues, and there they exert their effects. And impurities and other decay products of drugs go through the stages of neutralization and neutralization in the liver cells. There are drugs whose breakdown products are quite toxic to the liver. It is they who can cause, in the presence of a number of conditions and factors, drug-induced hepatitis in patients. However, one should also take into account the fact that without taking these medicines, the patient may be in great danger to his health, so these funds must be taken.

There are a number of predisposing factors that increase a patient's risk of drug-induced hepatitis:

Increased sensitivity of the patient to the drug taken;
The presence of hepatitis of any etiology (origin) at the time of treatment;
Frequent intake of alcoholic beverages;
Pregnancy;
Heart failure;
kidney failure;
Chronic kidney disease with impaired function;
Frequent stress;
Lack of protein foods in the diet;
Poisoning with solvents, gases, alcohol at the time of treatment with this drug;
Combination of two or more hepatotoxic drugs in one treatment.

There is a list of drugs that have high hepatotoxicity and can cause drug-induced hepatitis:

Cytostatics - Methotrexate
Antibiotics - a group of tetracyclines (Doxycycline, Tetracycline, etc.), much less often penicillins (Amoxiclav, Benzylpenicillin, etc.) and macrolides (Erythromycin, Azithromycin)
Anti-tuberculosis drugs - Isoniazid, Rifampicin
NSAIDs - Aspirin, Diclofenac, etc.
Hormonal agents - glucocorticosteroids (Prednisolone, etc.), oral contraceptives (Diana, Novinet, etc.)
Sulfanilamide preparations - Sulfadimetoksin, Biseptol, etc.
Diuretics (diuretics) - Furosemide, Hypothiazod, Veroshpiron, etc.
Antifungals (antimycotics) - Ketoconazole, Fluconazole
Antiepileptic (anticonvulsant) drugs - Clonazepam, Carbamazepine, etc.

Drug-induced hepatitis can develop both immediately after the start of treatment (during the first week of taking the drug), and after several months or years regular intake. In this case, the patient develops foci of inflammatory processes in hepatocytes. Soon, some of them begin to die off (necrosis of liver cells develops). Without appropriate treatment, foci of necrosis grow and merge into large areas, which leads to the development of cirrhosis of the liver and liver failure. Mortality from the development of such complications is up to 50-70% of all cases.

Classification

There is a division of drug-induced hepatitis into two groups, depending on the time of their occurrence and the duration of the pathology:

Acute drug-induced hepatitis - develops on average 7 days after the start of taking a toxic drug, disappears within 1 month from the onset adequate treatment and is most often associated with individual intolerance to the drug;
Chronic drug-induced hepatitis - can occur with prolonged therapy with a toxic drug (after months or even years), therapy can be delayed for several months.

Symptoms of drug-induced hepatitis

The main signs of drug-induced hepatitis:

The patient has a history of taking hepatotoxic drugs;
Severe weakness;
Sleepiness during the day;
Nausea;
Periodically vomiting;
Decreased or complete loss of appetite;
Bitterness in the mouth, belching bitter;
Violation of the stool (constipation, diarrhea or their alternation);
Slight weight loss
Pain in the right hypochondrium (discomfort, heaviness, aching, mild or moderate severity);
An increase in body temperature (ranges between 36.7-38 degrees);
Darkening of the color of urine;
Lightening of feces;
An increase in the size of the liver and pain in the right hypochondrium during palpation;
Increased activity of liver enzymes in blood tests (ALT and AST).

Diagnostics

First of all, for the diagnosis of drug-induced hepatitis, it is important to correctly collect an anamnesis and identify the cause of the development of the disease. This is due to the fact that Clinical signs diseases are no different from other hepatitis and liver damage.

After questioning the patient, his examination and palpation follow, where the doctor determines the color of the skin and visible mucous membranes (for jaundice), the presence of pain and the size of the liver (for its increase).

Among instrumental research an ultrasound of the hepatobiliary system is performed, where it is possible to determine the enlargement of the liver and the presence of signs of inflammation in it.

Treatment of drug-induced hepatitis

First of all, if a patient has drug-induced hepatitis, it is necessary to immediately stop taking the provoking drug. This is often enough to treat hepatitis mild degree gravity.

With more severe course drug-induced liver damage, detoxification therapy is used. It includes the introduction of an intravenous drip of Ringer's solution, 5-10% glucose solution, Reopoliglyukin, Reosorbilact, Hemodez, etc. The introduction of a 5-10% albumin solution also has a positive effect (completes the protein deficiency). These drugs are administered in an average of 200-400 ml 1-2 times a day, depending on the severity of the pathology and the weight of the patient.

Hemodialysis can also be used to remove toxins from the blood.

To restore the liver, hepatoprotectors are used - Essentiale, Heptral, Methionine, etc. They are prescribed both in the form of injections and tablet forms. The course of treatment takes at least 3-4 weeks.

If necessary, patients are prescribed as additional treatment symptomatic remedies depending on the manifestations of the disease.

Complications

Among the complications of drug-induced hepatitis most often develop:

Liver failure;
Hepatic coma;
Fatal outcome.

Prevention

To prevent the development of drug-induced hepatitis, a number of rules should be observed:

Do not self-medicate and strictly observe the recommended dosages of drugs;
At long-term treatment hepatotoxic agents, as well as their combination, hepatoprotectors should be taken for prevention;
Use in diet enough protein products (60-90 g pure protein per day);
With long-term treatment with hepatoprotective agents, periodically (1 time in 2-4 weeks) take tests for liver tests for early detection hepatitis A;
At the first sign of liver damage, immediately consult a doctor and begin treatment.

The prognosis of this disease with timely and proper treatment favorable - the patient recovers completely, liver cells are restored by 100%. However, if the doctor's recommendations are not followed or if you do not seek help in time, complications may develop, including death.

Drug-induced (drug) hepatitis is characterized by inflammation of the liver tissue due to the intake of hepatotoxic drugs. medications.

According to statistics, women are more susceptible to drug-induced hepatitis, they are twice as likely to suffer from this disease than men.

Diagnosis and therapeutic therapy of the disease is carried out by a specialist gastroenterologist-hepatologist.

Causes and symptoms

Long-term use of certain groups of drugs, overdose, the use of more than two drugs at the same time, can lead to depletion of the neutralizing enzymatic system liver and, as a result, to its damage by metabolites.

There is a high risk of getting this disease in people with a genetic hypersensitivity to any medicines; people with liver disease at the time of taking hepatotoxic drugs; people who take alcoholic beverages; in pregnant women; in people whose activities are associated with toxic solvents, toxic gases, stress; as well as in people with kidney or heart failure and protein deficiency in the diet.

Drug-induced hepatitis can lead to the use of such groups of drugs as:

These groups of drugs are divided into drugs with direct toxic effects, when the patient is aware of the hepatotoxic properties, and drugs of indirect effects, when the toxic effect on the patient's liver occurs due to individual sensitivity to the components of the drug.

There are two forms of drug-induced hepatitis: acute and chronic, which, in turn, is divided into cholestatic, cytolytic and mixed forms.

The chronic form of the disease can be a consequence acute form, if you do not limit the intake of toxic agents into the body.

Symptoms of drug-induced hepatitis may not appear at all, and the disease will reveal itself only in the results of tests for the biochemical composition of the blood.

But, in most cases, drug-induced hepatitis is manifested by the following symptoms:

Diagnosis and treatment

If the first signs of drug-induced hepatitis are detected, you should immediately contact the medical institution for diagnostic procedures and prescribing appropriate, timely and adequate treatment.

Types of studies of the disease:

A blood test for biochemical composition is the first thing a doctor will prescribe when symptoms appear to diagnose an illness.

Indicates liver damage increased content in the blood of liver enzymes, an indicator of ALT and AST transaminases.

Elevated levels of transaminases ALT and AST show abnormalities in the liver even before the onset of the first symptoms, it is for this reason that people who constantly take medications, it is recommended to periodically donate blood for analysis to monitor ALT and AST.

Important! Normal performance ALT and AST do not rule out liver disease. In alcoholic cirrhosis, in some cases, ALT and AST levels remain within the normal range. Therefore, these indicators are not always informative, and attention should be paid to related symptoms.

Indicators of ALT and AST in drug-induced hepatitis allow us to judge the activity and stage of development of the disease. So, rising levels of ALT and AST may indicate a chronic form of the disease. A rapid decrease in ALT and AST levels is a sure sign of the patient's recovery.

Also, the presence of the disease is indicated by an increase in such indicators in the blood as bilirubin, globulin fractions, alkaline phosphatase.

Ultrasound examination of the abdominal cavity will allow you to fix a total increase in the size of the liver.

An important condition for the diagnosis of the disease is the exclusion of hepatitis of viral, alcoholic, autoimmune and ischemic etiology, cholelithiasis, cancers, tumors. For this purpose, PCR and serological testing are used.

It is also important to ask the patient about possible tricks medicines. Discontinuation of drug-induced hepatitis medicinal product will give positive reaction, liver function will improve, the patient's condition will return to normal. Re-admission these drugs will lead to more severe forms organ damage.

Often, for the purpose of differential diagnosis of the disease, it is used needle biopsy. With drug-induced hepatitis, a significant amount of impurities of eosinophils, granulomas in the tissues will be observed. There is a clear boundary between areas of unaffected cells and areas of necrosis.

Basic principles of treatment and prevention

Drug-induced hepatitis is extremely dangerous disease, which, without proper treatment, leads to serious liver damage, cirrhosis and insufficiency. Any therapeutic effect in case of illness, it must be performed under the strict supervision of a specialist.

Therapeutic therapy of the disease is carried out according to the following basic principles:

The prognosis of the disease is different, depending on the form, timeliness of therapy, but with the development of jaundice, the percentage of deaths reaches 10 or more.

Adequate and relevant medical therapy in most cases leads to full recovery liver function and recovery of the patient.

There is no therapeutic prophylaxis for this disease.

Prevention of the disease consists in self-control of the medicines used, the study of their side effects. Reception necessary drugs carry out under constant monitoring of indicators of ALT and AST.

With forced long-term use of drugs, combine them with taking hepatoprotectors. And also find out if there is an individual intolerance to certain components of the drugs consumed.

The basis of Diet No. 5 according to Pevzner is the exclusion of any alcoholic beverages, the use of fruits, vegetables, fish and meat in the required proportions. It is necessary to eat food in small portions, at least five times a day. A prerequisite for a diet is daily intake clean drinking water, not less than 2.5 liters.

Food should have an optimal temperature for consumption; cold food is strongly discouraged. The method of cooking with this diet excludes frying. Just boil, bake and steam.

Be sure to exclude fatty, salty, spicy, spicy, smoked, canned, pickled foods, strong tea and coffee from the diet.

Drug-induced hepatitis is a disease in which a reactive inflammatory process occurs in the liver. It begins when a person takes hepatotoxic medical preparations. Hepatocytes are affected.

These are liver parenchyma cells that are involved in many processes:

protein synthesis and storage;
cholesterol synthesis;
detoxification;
synthesis of lipids and phospholipids;
removal of endogenous elements from the body;
bile initiation.

Metabolites of drugs contribute not only to the development of the inflammatory process, but also lead to cell necrosis, liver cirrhosis and liver failure. In men, drug-induced hepatitis is less common, mainly inflammatory process women are susceptible.

There is another type of disease, namely. It develops against the background of poisoning with pesticides, fungal toxins, industrial alcohol.

Toxic hepatitis occurs not only when a person has eaten or drunk something, infection can occur through Airways or pores skin. Contact with industrial poisons can provoke such a disease.

Very often, doctors are faced with mushroom poisoning. That's what it is toxic hepatitis. But in most cases it leads to death.

Causes of Hepatitis

The liver can be called the ideal filter in all of nature. It is responsible for neutralizing and removing toxic substances that enter it with the blood. When the blood contains a large amount of drug metabolites for a long time, liver cells begin to break down. Conclusion harmful substances from the body occurs in several stages. In the process of this, the formation of metabolites (intermediate products of biological transformation) occurs. Medicinal preparations contain too hepatotoxic elements that have a detrimental effect on cells and the liver as a whole.

If a person takes long time such drugs, there is a depletion of the neutralizing enzymatic system, damage to hepatocytes. As a result, drug-induced or drug-induced hepatitis begins to develop. Today, about 1000 drugs are known that can provoke hepatitis. The risk of inflammation of the liver cells increases tenfold if several drugs are taken at once. Simultaneous reception 8-9 medications increase hepatocyte damage by 93%. The process of development of the disease can take from 2 days to 1 year. Also, the reasons may be:

Drug-induced hepatitis occurs mainly if the dosage of medications is violated or the wrong combination of their intake is made.

Drug-induced hepatitis: symptoms and signs

With drug-induced hepatitis, the same symptoms occur as with all known varieties of the disease. These include:

fatigue;
weakness;
sleep disorders;
recurrent headache;
yellowing of the skin and whites of the eyes;
pain and heaviness in the liver (right hypochondrium);
bitter taste in the mouth;
loss of appetite;
diarrhea;
nausea, vomiting;
intense weight loss.

Since hepatitis has the same symptoms as hepatitis A, hepatitis B, hepatitis C, treatment can only be prescribed by a doctor after complete examination. In no case should you self-medicate or try to correct the situation with medicines, even those miraculous medicines that commercials talk about. This can only aggravate the situation and personally contribute to an even more intensive development of the disease.

Treatment of drug-induced (medicated) hepatitis

Treatment for drug-induced hepatitis begins with diagnostic examination and delivery of analyses. It is very important to understand that a person really has drug-induced hepatitis, because the course of treatment depends on it. Diagnosis is carried out by such methods as:

general analysis of blood and urine;
biochemical blood test (determination of the level of bilirubin in the blood, bilirubin and protein fractions);
study of the blood coagulation system (coagulogram);
palpation;
Ultrasound of the liver.

In the event that the disease is confirmed, doctors cancel the drug, which is toxic to liver cells. Subsequently, the complex curative measures, which will help to remove the poison and neutralize the body. In medicine, such procedures are called detoxification therapy. To cleanse the body, special preparations are used.

To restore the liver, there are substances that contribute to the rapid and effective regeneration of liver cells, their division.

When there are severe necrotic and cirrhotic lesions of the liver cells, organotherapy is used, which contributes to quick recovery hepatic tissues.

Diet for drug-induced hepatitis

The risk group is people who have already had cases in their family chronic diseases liver or hepatitis. Those who have problems with alcohol or who are constantly taking medication to restore one or another organ are at risk.

People who are at risk, and those who do not want to have liver problems, should take the most the best remedy for prevention. It's about about grass (thistle). It should be noted that all drugs that restore liver function are created on the basis of this natural medicine.

In order to prepare a decoction, you need 2 tbsp. l. crushed seeds pour 0.5 liters of boiling water and leave for 10-12 hours.

After that, strain the broth. Take 100 ml 5 times a day.

In addition, a person diagnosed with drug-induced (medicated) hepatitis must necessarily adhere to a certain diet. The liver is not "friendly" with:

alcohol and nicotine;
stress;
overweight;
sweets and pastries in large quantities;
spicy foods and spices;
lamb, fatty pork, lard;
smoked products, pickled vegetables and fruits;
canned food;
mushrooms.

The diet should be based on products with:

maximum reduced level cholesterol and fat;
plenty of fiber, vegetables and fruits.

In chronic (drug) hepatitis, doctors recommend:

avoid trans fats (margarine, fat, fast food, crackers, canned food);
reduce as much as possible the consumption of foods containing saturated fat (butter, ice cream, homemade milk, fried foods);
try to eat as many fresh fruits and vegetables as possible (but it is not recommended to replace them with juices or dried fruits);
eat whole grains, vegetable proteins, legumes;
eat chicken, pigeon, rabbit, veal, lean and unsalted fish;
consume less sugar, salt;
drink at least 2 liters of fluid per day;
not to starve;
eat boiled or baked foods.