Regulon - side effects. Contraceptive pills regulon, effectiveness, contraindications, side effects

Name:

Regulon

Pharmacological
action:

Monophasic oral contraceptive. The main contraceptive action is to inhibit the synthesis of gonadotropins and suppress ovulation. In addition, by increasing the viscosity cervical mucus slows down the movement of sperm cervical canal, and a change in the state of the endometrium prevents the implantation of a fertilized egg.
Ethinylestradiol is synthetic analogue of endogenous estradiol.
Desogestrel has a pronounced gestagenic and antiestrogenic effect, similar to endogenous progesterone, weak androgenic and anabolic activity.
Regulon has a beneficial effect on lipid metabolism: increases the concentration of HDL in the blood plasma, without affecting the content of LDL.
When taking the drug significantly reduced losses menstrual blood (with initial menorrhagia), the menstrual cycle normalizes, there is a beneficial effect on skin especially in the presence of acne vulgaris.

Indications for
application:

Contraception;
- treatment of disorders menstrual cycle such as dysmenorrhea, PMS, dysfunctional uterine bleeding.

Mode of application:

The drug is administered orally: Reception of tablets is begun from the 1st day of a menstrual cycle. Assign 1 tablet / for 21 days, if possible at the same time of day. After taking last pill a 7-day break is taken from the package, during which menstrual-like bleeding occurs due to drug withdrawal. The next day after a 7-day break (4 weeks after taking the first tablet, on the same day of the week), the drug is resumed from the next package, also containing 21 tablets, even if the bleeding has not stopped. This scheme of taking pills is followed as long as there is a need for contraception. Subject to the rules of admission, the contraceptive effect persists for the duration of the 7-day break.
First dose of the drug: The first tablet should be taken from the first day of the menstrual cycle. In this case, you do not need to use additional methods contraception. You can start taking pills from the 2-5th day of menstruation, but in this case, in the first cycle of using the drug, additional methods of contraception should be used in the first 7 days of taking the pills.
If more than 5 days have passed since the start of menstruation, you should postpone the start of taking the drug until the next menstruation.
Taking the drug after childbirth: Women who are not breastfeeding can start taking pills no earlier than 21 days after giving birth, after consulting with their doctor. In this case, there is no need to use other methods of contraception. If after childbirth there was already sexual contact, then taking the pills should be postponed until the first menstruation. If a decision is made to take the drug later than 21 days after birth, then in the first 7 days it is necessary to use additional methods of contraception.
Taking the drug after an abortion: After an abortion, in the absence of contraindications, pills should be started from the first day after the operation, and in this case there is no need to use additional methods of contraception.
Switching from another oral contraceptive: When switching from another oral preparation (21- or 28-day): the first tablet of Regulon is recommended to be taken the day after the completion of the course of the 28-day package of the drug. After completing the 21-day course, you must take the usual 7-day break and then start taking Regulon. There is no need to use additional methods of contraception.
Switching to Regulon after using oral hormonal drugs containing only progestogen ("mini-pill")
The first tablet of Regulon should be taken on the 1st day of the cycle. There is no need to use additional methods of contraception.
If menstruation does not occur when taking the "mini-pill", then after the exclusion of pregnancy, you can start taking Regulon on any day of the cycle, but in this case, additional methods of contraception must be used in the first 7 days (use of a cervical cap with spermicidal gel, a condom, or abstinence from sexual intercourse). Application calendar method in these cases it is not recommended.
Postponement of the menstrual cycle: If there is a need to delay menstruation, it is necessary to continue taking tablets from new packaging, without a 7-day break, according to the usual scheme. With a delay in menstruation, breakthrough or spotting bleeding may occur, but this does not reduce the contraceptive effect of the drug. Regular intake of Regulon can be restored after the usual 7-day break.
Missed pills: If a woman forgot to take a pill in a timely manner, and no more than 12 hours have passed after the missed one, you need to take the forgotten pill, and then continue taking it at the usual time. If more than 12 hours have passed between taking the pills - this is considered a missed pill, the reliability of contraception in this cycle is not guaranteed and the use of additional methods of contraception is recommended.
If one tablet is missed in the first or second week of the cycle, it is necessary to take 2 tablets the next day and then continue regular intake using additional methods of contraception until the end of the cycle.
If you miss a pill in the third week of the cycle, you must take the forgotten pill, continue to take it regularly and do not take a 7-day break. It is important to remember that due to the minimum dose of estrogen, the risk of ovulation and / or bleeding increases when a pill is missed, and therefore the use of additional methods of contraception is recommended.
Vomiting/diarrhea: If vomiting or diarrhea occurs after taking the drug, then the absorption of the drug may be defective. If the symptoms have stopped within 12 hours, then you need to take another tablet in addition. After that, you should continue taking the tablets in the usual way. If vomiting or diarrhea continues for more than 12 hours, then additional methods of contraception should be used during vomiting or diarrhea and for the next 7 days.

Side effects:

From the side of cardio-vascular system : arterial hypertension; rarely - arterial and venous thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, thromboembolism pulmonary artery); very rarely - arterial or venous thromboembolism of the hepatic, mesenteric, renal, retinal arteries and veins.
From the sense organs: Hearing loss due to otosclerosis.
Other: hemolytic-uremic syndrome, porphyria; rarely - exacerbation of reactive systemic lupus erythematosus; very rarely - Sydenham's chorea (passing after discontinuation of the drug).
Other side effects which are more common but less severe. The expediency of continuing the use of the drug is decided individually after consultation with a doctor, based on the benefit / risk ratio.
From the reproductive system: acyclic bleeding/ bloody issues from the vagina, amenorrhea after discontinuation of the drug, changes in the state of vaginal mucus, development inflammatory processes vagina, candidiasis, tension, pain, breast enlargement, galactorrhea.
From the side digestive system : nausea, vomiting, Crohn's disease, ulcerative colitis, the occurrence or exacerbation of jaundice and / or itching associated with cholestasis, cholelithiasis.
Dermatological reactions: erythema nodosum, exudative erythema, rash, chloasma.
From the CNS: headache, migraine, mood lability, depression.
From the organ of vision: increased sensitivity of the cornea (when wearing contact lenses).
From the side of metabolism: fluid retention in the body, change (increase) in body weight, decreased tolerance to carbohydrates.
Other: allergic reactions.

Contraindications:

The presence of severe and / or multiple risk factors for venous or arterial thrombosis (including severe or medium degree severity with BP ≥ 160/100 mm Hg);
- the presence or indication in the anamnesis of the precursors of thrombosis (including transient ischemic attack, angina);
- migraine with focal neurological symptoms, incl. in history;
- venous or arterial thrombosis / thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower leg, pulmonary embolism) at present or in history;
- the presence of venous thromboembolism in history;
- diabetes(with angiopathy);
- pancreatitis (including history), accompanied by severe hypertriglyceridemia;
- dyslipidemia;
- severe liver disease, cholestatic jaundice (including during pregnancy), hepatitis, incl. in history (before the normalization of functional and laboratory parameters and within 3 months after their normalization);
- jaundice when taking GCS;
- cholelithiasis currently or in history;
- Gilbert's syndrome, Dubin-Johnson syndrome, Rotor's syndrome;
- liver tumors (including history);
- severe itching, otosclerosis or its progression during a previous pregnancy or taking corticosteroids;
- hormone-dependent malignant neoplasms genital organs and mammary glands (including if they are suspected);
- vaginal bleeding unclear etiology;
- smoking over the age of 35 (more than 15 cigarettes per day);
- pregnancy or suspicion of it;
- lactation period;
- hypersensitivity to the components of the drug.

Carefully the drug should be prescribed in conditions that increase the risk of developing venous or arterial thrombosis / thromboembolism: age over 35 years, smoking, family history, obesity (body mass index over 30 kg / m2), dyslipoproteinemia, arterial hypertension, migraine, epilepsy, valvular defects heart, atrial fibrillation, prolonged immobilization, extensive surgical intervention, surgery for lower limbs, severe injury, varicose veins veins and superficial thrombophlebitis, postpartum period, the presence of severe depression (including history), changes biochemical indicators(activated protein C resistance, hyperhomocysteinemia, antithrombin III deficiency, protein C or S deficiency, antiphospholipid antibodies, including antibodies to cardiolipin, including lupus anticoagulant), diabetes mellitus, uncomplicated vascular disorders, SLE, Crohn's disease, ulcerative colitis, sickle cell anemia, hypertriglyceridemia (including family history), acute and chronic diseases liver.

Interaction
other medicinal
by other means:

medicines, inducing liver enzymes such as hydantoin, barbiturates, primidone, carbamazepine, rifampicin, oxcarbazepine, topiramate, felbamate, griseofulvin, St. oral contraceptives and increase the risk of breakthrough bleeding. Max level induction is usually achieved no earlier than 2-3 weeks, but may last up to 4 weeks after discontinuation of the drug.
Ampicillin and tetracycline reduce the effectiveness of Regulon (the mechanism of interaction has not been established). If co-administration is necessary, it is recommended to use an additional barrier method of contraception throughout the course of treatment and for 7 days (for rifampicin - within 28 days) after discontinuation of the drug.
oral contraceptives

Storage conditions:

The drug should be stored out of the reach of children at a temperature of 15 ° to 30 ° C.
Shelf life- 3 years.
Terms of dispensing from pharmacies: The drug is dispensed on prescription.

Pills, film-coated, biconvex white or almost white color, disc shape marked "P8" on one side, "RG" on the other side.

1 tablet contains:
0.03 mg ethinylestradiol and 0.15 mg desogestrel;
Excipients: alpha-tocopherol, magnesium stearate, anhydrous colloidal silica, stearic acid, povidone, potato starch, lactose monohydrate;
shell: propylene glycol, macrogol 6000, hypromellose;
21 pcs in a blister, 1 or 3 blisters in a box.

How to take Regulon? These birth control pills need to learn how to use them correctly and consciously. They are often used by the fairer sex as a contraceptive, as this drug is considered effective protection from unwanted pregnancy.

However, it regulates some metabolic processes in the female body.

This is a modern contraceptive drug, medicinal substances in which desogestrel and ethinylestradiol act. They are in volumes that allow you to achieve a contraceptive effect.

Compared to others medications this kind Regulon has the following advantages that make it indispensable for women:

If a representative of the weaker sex before using the medicine heavy menstruation, then after using this remedy, blood loss will be significantly less.
If there is a rash in the form of acne (acne), then after using Regulon, the condition of the skin will improve dramatically.
The use of the drug regulates lipid metabolism in the blood in such a way that lipoproteins appear in it with high density that prevent the development of symptoms of atherosclerosis.

Regulon protects a woman from unwanted pregnancy. This happens for the following reasons:

Under the influence of the drug, the production of hormones responsible for reproduction (gonadotropins) is interrupted. This leads to blocking the ovulation process.
The mucus that is on the cervix, under the influence of the drug, changes its composition and becomes a serious barrier that prevents spermatozoa from entering the uterus.
In some cases (very rarely), ovulation does occur, but this does not lead to the fertilization of the egg, since it does not have the ability to firmly attach to the walls of the uterus due to the thinning of the endometrium under the influence of the drug.

How is this drug taken?

There are 21 tablets in a box of Regulon tablets, so you can start taking the medicine by taking any of them.

The drug is used according to this scheme: the woman should take the first pill on the 1st day of the cycle. AT next days(it is not recommended to skip, otherwise the contraceptive effect may not work) take the pills at the same time as on the first day.

After the woman has used all 21 tablets, then you need to take a break for 7 days. During this period, bleeding should begin. Reception should be continued on the eighth day, opening a new Regulon after a break. This is done in any case, regardless of the beginning and end of menstruation.

If everything is done according to the instructions given above, then the contraceptive effect of the drug will appear from the first day. If the use of tablets began from the 2nd to the 5th day of the menstrual cycle, then the woman will need to be protected additionally for a whole week. If the patient starts using Regulon after the fifth day, then this will not bring any effect.

How long can Regulon be taken? It can be used as long as there is a need for contraception. There are no other time limits.

If a doctor recommended that a woman use Regulon after an abortion (curettage), then she can start on the day of these manipulations.

If a woman has recently given birth, then she can use this contraceptive as early as 21 days after giving birth. But this can only be done in cases where the young mother cannot (or does not want to) breastfeed her baby.

If she starts using Regulon later than the specified period, then it will be necessary to take additional measures for protection.

What should I do if a woman misses a pill?

As mentioned above, the Regulon contraceptive must be taken without skipping days at the same time. Only then will it have the effect indicated in the instructions on the body. What to do if, for some reason, the patient was unable to take the next pill on time?

If no more than 12 hours have passed since the last use of this medicine, then the remedy is taken according to the main scheme, and there is no need to additionally protect yourself.

If more than 12 hours have passed, then you must act in accordance with such recommendations. The day after the pass, a woman should drink 2 tablets, and then a day later, switch to 1 tablet per day.

But at the same time, it will be necessary to additionally protect yourself for 7-14 days. After this period, the patient should take the tablet that she missed and continue taking it according to the instructions until the package is over. It is also recommended to take other contraceptive measures.

In this case, there is no need to take a break of a week between packages - they begin to use the next portion of the drug.

Many women ask if it is possible to switch to Regulon if another drug has been used before. To do this, they do this: if the previous medicine had 28 tablets in the pack, then immediately after they finish, you can use Regulon according to the instructions. If there were 21 tablets in the package of the previous medicine, then the use of Regulon begins exactly one week after the end of the course of the previous medication.

If a woman used drugs containing progesterone, then after them it is recommended to take Regulon on the first day of the menstrual cycle if there is menstruation.

But if it is not there, then a woman can use Regulon on any day, while pregnancy should be excluded.

In this medical article, you can get acquainted with the drug Regulon. The instructions for use will explain in which cases you can take injections or tablets, what the medicine helps with, what are the indications for use, contraindications and side effects. The annotation presents the form of release of the drug and its composition.

In the article, doctors and consumers can only leave real reviews about Regulon, from which you can find out whether the medicine helped in contraception in women, as well as during pregnancy and lactation, for which it is also prescribed. The instructions list the analogues of Regulon, the prices of the drug in pharmacies, as well as its use during pregnancy.

Monophasic contraceptive medicine is Regulon. Instructions for use prescribes taking birth control pills to protect against unwanted pregnancy and eliminate menstrual irregularities.

Release form and composition

The drug is produced in the following dosage forms:

Regulon tablets have round shape, biconvex surface, white or almost white. They contain 2 main active ingredients - ethinylestradiol (30 mcg in 1 tablet) and desogestrel (150 mcg in 1 tablet). Also, the composition of the drug includes auxiliary components.

Regulon tablets are packaged in blisters of 21 pieces. A cardboard pack contains 1 or 3 blisters with tablets and instructions for using the drug.

pharmachologic effect

The main action of Regulon is associated with the suppression of ovulation and inhibition of the synthesis of gonadotropins. By inhibiting the process of ovulation, the drug makes it difficult for sperm to enter the uterus, and also prevents the fertilized egg from entering the uterine wall.

The active substances of Regulon are the female sex hormones desogestrel and ethinyl estradiol. Ethinylestradiol is a synthetic analogue of endogenous estradiol. As for desogestrel, it has a pronounced antiestrogenic and progestogenic effect, and exhibits slight androgenic and anabolic activity.

When using Regulon, there is a significant reduction in blood loss during menstruation, the menstrual cycle normalizes and improves general state skin covers.

Indications for use

What helps Regulon? The instructions indicate that the main purpose of the drug is to prevent unwanted pregnancy.

However, studies confirm that in addition to the contraceptive effect, Regulon is also characterized by the presence of a therapeutic effect. So, to the question “pills - what are they from?” the instruction to the drug answers that the use of Regulon is advisable for dysfunctional uterine bleeding, premenstrual syndrome, dysmenorrhea, etc.

The drug effectively relieves periodically occurring aching pain in the lower abdomen, helps to reduce soreness and profusion menstrual bleeding, dysparenia, eliminates slight discharge of dark color from the genital tract in the perimenstrual period, as well as soreness of the mammary glands.

It is often prescribed to increase the effectiveness of therapy prescribed for endometriosis. With uterine myoma, the agent is prescribed to stop the growth of the tumor (this is advisable if the diameter of the latter does not exceed 2 cm). In addition, Regulon promotes the resorption of retention ovarian cysts.

After 40 years, when a woman, as a rule, has already decided on family planning and birth required amount children, Regulon allows you to prevent abortion and its adverse effects(according to statistics, most of pregnancies at this age ends in induced abortion).

Instructions for use

Regulon is prescribed inside. Reception of tablets is begun from the 1st day of a menstrual cycle. Assign 1 tablet per day for 21 days, if possible at the same time of day. After taking the last pill from the package, a 7-day break is taken, during which menstrual-like bleeding occurs due to drug withdrawal.

The next day after a 7-day break (4 weeks after taking the first tablet, on the same day of the week), the drug is resumed from the next package, also containing 21 tablets, even if the bleeding has not stopped. This scheme of taking pills is followed as long as there is a need for contraception.

Subject to the rules of admission, the contraceptive effect persists for the duration of the 7-day break. The first dose of the drug The first tablet should be taken from the first day of the menstrual cycle. In this case, you do not need to use additional methods of contraception.

You can start taking pills from the 2-5th day of menstruation, but in this case, in the first cycle of using the drug, additional methods of contraception should be used in the first 7 days of taking the pills. If more than 5 days have passed since the start of menstruation, you should postpone the start of taking the drug until the next menstruation.

Vomiting/diarrhea

If vomiting or diarrhea occurs after taking the drug, then the absorption of the drug may be defective. If the symptoms have stopped within 12 hours, then you need to take another tablet in addition. After that, you should continue taking the tablets in the usual way. If vomiting or diarrhea continues for more than 12 hours, then additional methods of contraception should be used during vomiting or diarrhea and for the next 7 days.

Taking the drug after childbirth

Women who are not breastfeeding can start taking pills no earlier than 21 days after giving birth, after consulting with their doctor. In this case, there is no need to use other methods of contraception. If after childbirth there was already sexual contact, then taking the pills should be postponed until the first menstruation. If a decision is made to take the drug later than 21 days after birth, then in the first 7 days it is necessary to use additional methods of contraception.

Missed pills

If a woman forgot to take a pill in a timely manner, and no more than 12 hours have passed after the missed one, you need to take the forgotten pill, and then continue taking it at the usual time. If more than 12 hours have passed between taking the pills, this is considered a missed pill, the reliability of contraception in this cycle is not guaranteed and the use of additional methods of contraception is recommended.

If one tablet is missed in the first or second week of the cycle, it is necessary to take 2 tablets the next day and then continue regular intake using additional methods of contraception until the end of the cycle. If you miss a pill in the third week of the cycle, you must take the forgotten pill, continue to take it regularly and do not take a 7-day break.

It is important to remember that due to the minimum dose of estrogen, the risk of ovulation and / or bleeding increases when a pill is missed, and therefore the use of additional methods of contraception is recommended.

Taking the drug after an abortion

After an abortion, in the absence of contraindications, pills should be started from the first day after the operation, and in this case there is no need to use additional methods of contraception.

Postponement of the menstrual cycle

If there is a need to delay menstruation, it is necessary to continue taking the tablets from the new package, without a 7-day break, according to the usual scheme. With a delay in menstruation, breakthrough or spotting bleeding may occur, but this does not reduce the contraceptive effect of the drug. Regular intake of Regulon can be restored after the usual 7-day break.

Switching from another oral contraceptive

When switching from another oral preparation (21- or 28-day): the first tablet of Regulon is recommended to be taken the day after the completion of the course of the 28-day package of the drug. After completing the 21-day course, you must take the usual 7-day break and then start taking Regulon. There is no need to use additional methods of contraception.

Switching to Regulon after using progestogen-only oral hormonal preparations (“mini-pills”)

The first tablet of Regulon should be taken on the 1st day of the cycle. There is no need to use additional methods of contraception. If menstruation does not occur when taking the "mini-pill", then after the exclusion of pregnancy, you can start taking Regulon on any day of the cycle, but in this case, additional methods of contraception must be used in the first 7 days (use of a cervical cap with spermicidal gel, a condom, or abstinence from sexual intercourse). The use of the calendar method in these cases is not recommended.

Contraindications

There are a number of pathological and physiological states the body of a woman who are contraindications to taking Regulon tablets, these include:

genetic congenital pathology liver.
Dyslipidemia - metabolic disorder with a change in the ratio of the main classes of lipids in the blood.
Itching of the skin, damage to the inner and middle ear (otosclerosis) during pregnancy or against the background of the use of glucocorticosteroids.
Gallstone disease at the time of the start of the drug or transferred in the past.
The development of jaundice (an increase in the level of bilirubin in the blood) against the background of the use of glucocorticosteroids.
The presence of pregnancy or suspicion of it.
Diabetes mellitus with the development of angiopathy (vascular damage against the background of impaired metabolism).
Severe liver pathology with a decrease in its functional activity, including cholestatic jaundice, hepatitis.
Hormone-dependent malignant neoplasms of the mammary glands or organs of the reproductive system.
Bleeding from the vagina, the nature of the origin of which could not be clarified.
Period breastfeeding(lactation).
The formation of blood clots in the veins or arteries with the development of complications in the form of a cerebral stroke, pulmonary embolism or myocardial infarction.
Inflammation of the pancreas (pancreatitis) with elevated triglyceride levels in the blood.
Malignant or benign neoplasms liver, including those transferred in the past.
The presence at the time of the start of taking the drug or in the past forerunners of the development of thrombosis is a transient ischemic attack.
Smoking by a woman over the age of 35, as this increases the risk of blood clots (more than 15 cigarettes).
Past venous thromboembolism in the past.
Individual intolerance to the active ingredients or excipients drug.
Migraine with the development of focal neurological symptoms, including those suffered in the past.
The presence of processes that significantly increase the risk of developing intravascular thrombosis, including arterial hypertension(high blood pressure).

Side effects

Side effects that require discontinuation of the drug:

Cardiovascular system: arterial hypertension; rarely - stroke, myocardial infarction, deep vein thrombosis of the lower extremities, pulmonary embolism and other thromboembolism of arteries and veins; very rarely - arterial or venous thromboembolism of the renal, hepatic, retinal, mesenteric arteries and veins.
Digestive system: cholelithiasis, jaundice and / or itching (development or exacerbation) against the background of cholestasis, nausea, vomiting, ulcerative colitis, Crohn's disease. Metabolism: weight gain, fluid retention in the body, decreased carbohydrate tolerance.
Reproductive system: spotting from the vagina or acyclic bleeding, amenorrhea against the background of drug withdrawal, violation of the state of vaginal mucus, candidiasis, inflammatory processes in the vagina, galactorrhea, enlargement of the mammary glands, their tension and pain.
Dermatological reactions: rash, erythema nodosum, chloasma, exudative erythema.
The development of allergic reactions.
Porphyria, hemolytic-uremic syndrome; rarely - a period of exacerbation of reactive systemic lupus erythematosus; very rarely - Sydenham's chorea (transient).
Sense organs: otosclerosis complicated by hearing loss.
Nervous system: depression, migraine, headache, mood lability.
Organ of vision: when wearing contact lenses - increased sensitivity of the cornea.

The decision on the advisability of continuing contraceptive therapy is made individually, after comparing the benefits of the use and the real risk.

Children, during pregnancy and lactation

Contraindicated during pregnancy and breastfeeding. The drug is not used in childhood.

special instructions

To exclude the development of various complications, as well as sufficient contraception, it is important to carefully read the instructions for the drug before you start taking Regulon tablets. There are a number special instructions that are important to pay attention to include:

Regulon tablets are a fairly reliable oral contraceptive, the Pearl index when used is about 0.05.

With a planned surgical intervention, the drug is stopped 4 weeks before it is performed, and then resumed no earlier than 2 weeks after the operation.

The drug does not affect the functional state of the cerebral cortex.

The active ingredients of the drug may interact with medicines others pharmacological groups. In case of their use, the doctor should be warned about this.

When you skip taking pills, diarrhea, vomiting, the contraceptive effect of the drug decreases.

Before you start taking Regulon tablets, you must go through general clinical, gynecological and laboratory research to exclude pregnancy and the presence of medical contraindications to the use of the drug.

There is evidence that against the background of the use of the drug, the risk of developing malignant neoplasms of the organs of the female reproductive system increases.

After childbirth, the risk of intravascular thrombosis increases.

Suspect chest pain, headache, shortness of breath possible development thromboembolic complications and seek immediate medical attention.

Taking Regulon tablets increases the risk of developing thromboembolic complications, especially against the background of hypertension, depression associated with a violation of the production of tryptophan, dyslipidoproteinemia, diabetes mellitus, atrial fibrillation, smoking, hereditary predisposition, obesity, at the age of a woman over 35 years old, as well as with prolonged immobilization of the woman's body (immobilization associated with trauma or major surgery) .

The possible contraceptive effect, as well as complications, are evaluated by the doctor individually before starting the use of the drug.

While taking the drug, you should carefully monitor the woman's health indicators. If there are signs of epilepsy, migraine, disorders of the blood coagulation system (hemostasis), a decrease in the functional activity of the kidneys, the development of hormone-dependent tumor neoplasms, diabetes mellitus, sickle cell anemia, Regulon tablets should be stopped.

After the postponed viral hepatitis you can take Regulon tablets only six months after the normalization of clinical and laboratory parameters functional state liver.

Oral contraception using the drug does not reduce the risk of contracting HIV and other infectious diseases with predominantly sexual transmission.

drug interaction

The effectiveness of oral contraceptives is reduced in combination with drugs that induce liver enzymes: rifampicin, hydantoin, carbamazepine, barbiturates, oxcarbazepine, felbamate, primidone, topiramate, St. John's wort, griseovulfin.

In addition, when used in combination with Regulon, these drugs increase the likelihood of breakthrough bleeding.

The level of induction reaches a maximum no earlier than 2-3 weeks later, however, it can persist up to 4 weeks after discontinuation of the drug.

Violation of the menstrual cycle and a decrease in the contraceptive effect may occur when used simultaneously with:

antidepressants;
some antispasmodics;
laxatives;
antibiotics (especially with Tetracycline and Ampicillin);
barbiturates.

In case the reception the above drugs necessary, it is recommended to protect yourself with barrier contraceptives (during the entire period of treatment, as well as for an additional 7-28 days, depending on which medication was prescribed).

If it is necessary to use anticoagulants during the period of taking Regulon, it is necessary to carry out additional monitoring of prothrombin time. In some situations, it may be necessary to correct the dosing regimen of the anticoagulant.

Due to the increased likelihood of complications, Regulon should not be combined with hepatotoxic agents.

Against the background of taking oral contraceptives can:

decrease in carbohydrate tolerance;
increased need for oral antidiabetic drugs and insulin.

Regulon's analogs

According to the structure, analogues are determined:

Mercilon.
Novinet.
Marvelon.
Tri Mercy.

Analogues have a similar effect:

Belara.
Janine.
Jess.
Bonade.
Cyclo-Proginova.
Egestrenol.
Femoden.
Lindinette.
Oralcon.
Silest.
Rigevidon.
Evra.
Dailla.
Genettin.
Dimia.

Which is better - Regulon or Novinet?

Regulon and Novinet are generic drugs. They have the same composition, indications for use and contraindications, but are produced by different companies.

Holiday conditions and price

The average cost of Regulon (tablets No. 21) in Moscow is 400 rubles. Released by prescription.

The drug must be stored at a temperature of 15-30 C. Shelf life - 3 years.

Monophasic oral contraceptive

Active ingredients

Ethinylestradiol (ethinylestradiol)
- desogestrel (desogestrel)

Release form, composition and packaging

Film-coated tablets white or almost white, round, biconvex, marked "P8" on one side and "RG" on the other.

Excipients: α-tocopherol, magnesium stearate, colloidal silicon dioxide, stearic acid, potato starch, lactose monohydrate.

The composition of the film shell: propylene glycol, macrogol 6000, hypromellose.

21 pcs. - blisters - PVC/PVDC/Aluminum (1) - packs of cardboard.
21 pcs. - blisters - PVC/PVDC/Aluminum (3) - packs of cardboard.

pharmachologic effect

Monophasic oral contraceptive. The main contraceptive action is to inhibit the synthesis of gonadotropins and suppress ovulation. In addition, by increasing the viscosity of cervical mucus, the movement of spermatozoa through the cervical canal slows down, and a change in the state of the endometrium prevents the implantation of a fertilized egg.

Ethinylestradiol is a synthetic analog of endogenous estradiol.

Desogestrel has a pronounced gestagenic and antiestrogenic effect, similar to endogenous, weak androgenic and anabolic activity.

Regulon has a beneficial effect on lipid metabolism: it increases the concentration of HDL in the blood plasma, without affecting the content of LDL.

Against the background of the use of the drug, the loss of menstrual blood is significantly reduced (with initial menorrhagia), the menstrual cycle is normalized, and a beneficial effect on the skin is noted, especially in the presence of acne vulgaris.

Pharmacokinetics

Desogestrel

Suction

Desogestrel is rapidly and almost completely absorbed from the gastrointestinal tract and is immediately metabolized to 3-keto-desogestrel, which is the biologically active metabolite of desogestrel.

C max is reached after 1.5 h and is 2 ng / ml. Bioavailability - 62-81%.

Distribution

3-keto-desogestrel binds to blood proteins, mainly albumin and sex hormone-binding globulin (SHBG). V d is 1.5 l / kg. C ss is established by the second half of the menstrual cycle. The level of 3-keto-desogestrel increases 2-3 times.

Metabolism

In addition to 3-keto-desogestrel (which is formed in the liver and in the intestinal wall), other metabolites are formed: 3α-OH-desogestrel, 3β-OH-desogestrel, 3α-OH-5α-H-desogestrel (metabolites of the first phase). These metabolites do not have pharmacological activity and are partially, by conjugation (the second phase of metabolism), converted into polar metabolites - sulfates and glucuronates. Clearance from blood plasma is about 2 ml / min / kg of body weight.

breeding

T 1/2 3-keto-desogestrel is 30 hours. Metabolites are excreted in the urine and feces (in a ratio of 4:6).

Ethinylestradiol

Suction

Ethinylestradiol is rapidly and completely absorbed from the gastrointestinal tract. C max is achieved 1-2 hours after taking the drug and is 80 pg / ml. The bioavailability of the drug due to presystemic conjugation and the effect of "first pass" through the liver is about 60%.

Distribution

Ethinylestradiol is completely bound to plasma proteins, mainly with. Vd is 5 l/kg. C ss is set to 3-4 days of admission, while the level of ethinylestradiol in serum is 30-40% higher than after a single dose.

Metabolism

Presystemic conjugation of ethinylestradiol is significant. Bypassing the intestinal wall (first phase of metabolism), it undergoes conjugation in the liver (second phase of metabolism). Ethinylestradiol and its conjugates of the first phase of metabolism (sulfates and glucuronides) are excreted into the bile and enter the enterohepatic circulation. Clearance from blood plasma is about 5 ml / min / kg of body weight.

breeding

T1 / 2 ethinylestradiol averages about 24 hours. About 40% is excreted by the kidneys and about 60% through the intestines.

Indications

- contraception.

Contraindications

- the presence of severe and / or multiple risk factors for venous or arterial thrombosis (including severe or moderate arterial hypertension with blood pressure ≥ 160/100 mm Hg);

- precursors of thrombosis (including transient ischemic attack, angina pectoris) at present or in history;

- migraine with focal neurological symptoms, incl. in history;

- venous or arterial thrombosis / thromboembolism (including deep vein thrombosis of the lower leg, pulmonary embolism, myocardial infarction, stroke) at present or in history;

- the presence of venous thromboembolism in history;

- diabetes mellitus (with angiopathy);

- pancreatitis (including history), accompanied by severe hypertriglyceridemia;

- dyslipidemia;

- severe liver disease, cholestatic jaundice (including during pregnancy), hepatitis, incl. in history (before the normalization of functional and laboratory parameters and within 3 months after their normalization);

- jaundice due to the use of corticosteroids;

- cholelithiasis at present or in history;

- Gilbert's syndrome, Dubin-Johnson syndrome, Rotor's syndrome;

- liver tumors (including history);

- severe itching, otosclerosis or its progression during a previous pregnancy or taking corticosteroids;

- hormone-dependent malignant neoplasms of the genital organs and mammary glands (including if they are suspected);

- vaginal bleeding of unknown etiology;

- smoking over the age of 35 (more than 15 cigarettes per day);

- pregnancy or suspicion of it;

- lactation period;

- Hypersensitivity to the components of the drug.

Carefully the drug should be prescribed in conditions that increase the risk of developing venous or arterial thrombosis / thromboembolism: age over 35 years, smoking, family history, obesity (body mass index more than 30 kg / m 2), dyslipoproteinemia, arterial hypertension, migraine, epilepsy, valvular defects heart, atrial fibrillation, prolonged immobilization, extensive surgery, surgery on the lower extremities, severe trauma, varicose veins and superficial thrombophlebitis, postpartum period, severe depression (including history), changes in biochemical parameters (resistance of activated protein C, hyperhomocysteinemia, antithrombin III deficiency, protein C or S deficiency, antiphospholipid antibodies, including antibodies to cardiolipin, including lupus), diabetes mellitus not complicated by vascular disorders, systemic lupus erythematosus (SLE), Crohn's disease, ulcerative colitis, sickle cell anemia, hypertriglyceridemia (including . family history), acute and chronic liver disease.

Dosage

The drug is prescribed inside.

Taking tablets begins on the 1st day of the menstrual cycle and take 1 tablet / day for 21 days, if possible at the same time of day. After taking the last pill from the package, a 7-day break is taken, during which menstrual-like bleeding occurs due to drug withdrawal. The next day after a 7-day break (4 weeks after taking the first tablet, on the same day of the week), the drug is resumed from the next package, also containing 21 tablets, even if the bleeding has not stopped. This scheme of taking pills is followed as long as there is a need for contraception. Subject to the rules of admission, the contraceptive effect persists for the duration of the 7-day break.

First dose of the drug

The first tablet should be taken from the first day of the menstrual cycle. In this case, you do not need to use additional methods of contraception. You can start taking pills from the 2-5th day of menstruation, but in this case, in the first cycle of using the drug, additional methods of contraception should be used in the first 7 days of taking the pills.

If more than 5 days have passed since the start of menstruation, you should postpone the start of taking the drug until the next menstruation.

Taking the drug after childbirth

Taking the drug after an abortion

After an abortion, in the absence of contraindications, pills should be started from the first day after the operation, and in this case there is no need to use additional methods of contraception.

Switching from another oral contraceptive

When switching from another oral preparation (21- or 28-day): the first tablet of the drug Regulon is recommended to be taken the next day after the completion of the course of the 28-day package of the drug. After completing the 21-day course, you must take the usual 7-day break and then start taking Regulon. There is no need to use additional methods of contraception.

Switching to Regulon after using progestogen-only oral hormonal preparations ("mini-pill")

The first tablet of Regulon should be taken on the 1st day of the cycle. There is no need to use additional methods of contraception.

If menstruation does not occur when taking the mini-pill, then after excluding pregnancy, you can start taking Regulon on any day of the cycle, but in this case, additional methods of contraception must be used in the first 7 days (use of a cervical cap with spermicidal gel, a condom, or abstaining from sexual intercourse). The use of the calendar method in these cases is not recommended.

Postponement of the menstrual cycle

Missed pills

If a woman forgot to take a pill in a timely manner, and after the missed no more than 12 hours, you need to take the forgotten pill, and then continue taking it at the usual time. If it has passed between taking the pills more than 12 hours - this is considered a missed pill, contraceptive reliability is not guaranteed in this cycle, and additional methods of contraception are recommended.

When one tablet is missed first or second week of the cycle, you need to take 2 tab. the next day and then continue regular intake using additional methods of contraception until the end of the cycle.

When you miss a tablet third week of the cycle you need to take a forgotten pill, continue regular intake and do not take a 7-day break. It is important to remember that due to the minimum dose of estrogen, the risk of ovulation and / or bleeding increases when a pill is missed, and therefore the use of additional methods of contraception is recommended.

Vomiting or diarrhea

Side effects

Side effects that require immediate discontinuation of the drug:

Arterial hypertension;

Hemolytic-uremic syndrome;

Porfiria;

Hearing loss due to otosclerosis.

Rarely: arterial and venous thromboembolism (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism); exacerbation of reactive systemic lupus erythematosus.

Rarely: arterial or venous thromboembolism of the hepatic, mesenteric, renal, retinal arteries and veins; Sydenham's chorea (passing after discontinuation of the drug).

Other side effects that are less severe but more common are listed below. The expediency of continuing the use of the drug is decided individually after consultation with a doctor, based on the benefit / risk ratio.

From the side reproductive system: acyclic bleeding / bloody discharge from the vagina, amenorrhea after discontinuation of the drug, changes in the state of vaginal mucus, the development of inflammatory processes in the vagina, candidiasis.

From the mammary glands: tension, pain, breast enlargement, galactorrhea.

From the digestive system: nausea, vomiting, diarrhea, epigastric pain, Crohn's disease, ulcerative colitis, hepatitis, occurrence or exacerbation of jaundice and / or itching associated with cholestasis, cholelithiasis.

From the side of the skin: erythema nodosum, exudative erythema, rash, chloasma.

From the side of the central nervous system: headache, migraine, mood changes, depression.

From the sense organs: increased sensitivity of the cornea (when wearing contact lenses).

From the side of metabolism: fluid retention in the body, a change (increase) in body weight, a decrease in carbohydrate tolerance.

Others: allergic reactions.

Overdose

Symptoms: nausea, vomiting, in girls - bloody discharge from the vagina.

Treatment: in the first 2-3 hours after taking the drug in a high dose, gastric lavage is recommended. There is no specific antidote, treatment is symptomatic.

drug interaction

Drugs that induce liver enzymes, such as hydantoin, barbiturates, primidone, rifampicin, oxcarbazepine, topiramate, felbamate, griseofulvin, St. John's wort, reduce the effectiveness of oral contraceptives and increase the risk of breakthrough bleeding. The maximum level of induction is usually reached no earlier than 2-3 weeks, but may last up to 4 weeks after discontinuation of the drug.

Ampicillin and tetracycline reduce the effectiveness of Regulon (the mechanism of interaction has not been established). If co-administration is necessary, it is recommended to use an additional barrier method of contraception throughout the course of treatment and for 7 days (for rifampicin - within 28 days) after discontinuation of the drug.

Oral contraceptives may decrease carbohydrate tolerance, increase the need for insulin or oral antidiabetic agents.

special instructions

Before starting the use of the drug, it is necessary to conduct a general medical (detailed family and personal history, measurement of blood pressure, laboratory tests) and gynecological examination(including examination of the mammary glands, pelvic organs, cytological analysis cervical smear). A similar examination during the period of taking the drug is carried out regularly, every 6 months (due to the need for timely identification of risk factors and emerging contraindications).

The drug is a reliable contraceptive: the Pearl index (an indicator of the number of pregnancies that occurred during the use of a contraceptive method in 100 women for 1 year) with correct application is about 0.05.

In each case, before prescribing hormonal contraceptives, the benefits or possible negative effects of their use are individually assessed. This issue must be discussed with the patient, who, after receiving the necessary information, will make the final decision on the preference for hormonal or any other method of contraception.

The state of health of women must be carefully monitored. If any of the following conditions / diseases appear or worsen while taking the drug, you must stop taking the drug and switch to another, non-hormonal method of contraception:

- diseases of the hemostasis system;

conditions/diseases predisposing to the development of cardiovascular, kidney failure;

- epilepsy;

- migraine;

- the risk of developing an estrogen-dependent tumor or estrogen-dependent gynecological diseases;

- diabetes mellitus, not complicated by vascular disorders;

- severe depression (if depression is associated with impaired tryptophan metabolism, then vitamin B 6 can be used to correct it);

- sickle cell anemia, tk. in some cases (for example, infections, hypoxia), estrogen-containing drugs in this pathology can provoke thromboembolism;

- the appearance of deviations in laboratory tests for assessing liver function.

Thromboembolic diseases

Epidemiological studies have shown that there is an association between the intake of oral hormonal contraceptives and an increased risk of developing arterial and venous thromboembolic diseases (including myocardial infarction, stroke, deep vein thrombosis of the lower extremities, pulmonary embolism). Proved increased risk venous thromboembolic diseases, but it is much less than during pregnancy (60 cases per 100 thousand pregnancies).

Some researchers suggest that the likelihood of developing venous thromboembolic disease is greater with the use of drugs containing desogestrel and gestodene (drugs of the third generation) than with drugs containing levonorgestrel (drugs of the second generation).

The frequency of spontaneous occurrence of new cases of venous thromboembolic disease in healthy non-pregnant women not taking oral contraceptives is about 5 cases per 100,000 women per year. When using second-generation drugs - 15 cases per 100 thousand women per year, and when using third-generation drugs - 25 cases per 100 thousand women per year.

When using oral contraceptives very rarely, arterial or venous thromboembolism of the hepatic, mesenteric, renal or retinal vessels is observed.

The risk of developing arterial or venous thromboembolic diseases increases:

- with age;

- when smoking (heavy smoking and age over 35 are risk factors);

- if there is a family history of thromboembolic diseases (for example, in parents, a brother or sister). If you suspect genetic predisposition, it is necessary to consult a specialist before using the drug;

- with obesity (body mass index more than 30 kg / m 2);

- with dyslipoproteinemia;

- with arterial hypertension;

- in diseases of the heart valves, complicated by hemodynamic disorders;

- with atrial fibrillation;

- with diabetes mellitus complicated by vascular lesions;

- with prolonged immobilization, after a large surgical intervention, after surgery on the lower extremities, after a severe injury.

In these cases, a temporary cessation of the use of the drug is expected (no later than 4 weeks before surgery, and resumed no earlier than 2 weeks after remobilization).

Women after childbirth have an increased risk of venous thromboembolic disease.

It should be borne in mind that diabetes mellitus, systemic lupus erythematosus, hemolytic uremic syndrome, Crohn's disease, ulcerative colitis, sickle cell anemia, increase the risk of developing venous thromboembolic diseases.

It should be borne in mind that resistance to activated protein C, hyperhomocysteinemia, deficiency of proteins C and S, deficiency of antithrombin III, the presence of antiphospholipid antibodies increase the risk of developing arterial or venous thromboembolic diseases.

When evaluating the benefit / risk ratio of taking the drug, it should be borne in mind that targeted treatment given state reduces the risk of thromboembolism. The symptoms of thromboembolism are:

- sudden chest pain that radiates to left hand;

- sudden shortness of breath;

- any unusually severe headache that lasts for a long time or appears for the first time, especially when combined with sudden complete or partial loss of vision or diplopia, aphasia, dizziness, collapse, focal epilepsy, weakness or severe numbness of one half of the body, movement disorders, severe unilateral pain in calf muscle, symptom complex "acute" abdomen.

Tumor diseases

Some studies have reported an increase in the occurrence of cervical cancer in women who have been taking hormonal contraceptives for a long time, but the results of the studies are conflicting. play a role in the development of cervical cancer significant role sexual behavior, human papillomavirus infection and other factors.

Meta-analysis 54 epidemiological studies showed that there is relative increase risk of breast cancer among women taking oral hormonal contraceptives, however, higher detection of breast cancer could be associated with more regular medical examination. Breast cancer is rare among women under 40, whether they are taking hormonal birth control or not, and increases with age. The use of oral contraceptives can be regarded as one of many risk factors. However, women should be advised of the potential risk of developing breast cancer based on a benefit-risk assessment (protection against ovarian and endometrial cancer).

There are few reports of the development of benign or malignant tumor liver in women taking long-term hormonal contraceptives. This should be kept in mind in the differential diagnostic evaluation of abdominal pain, which may be associated with an increase in the size of the liver or intraperitoneal bleeding.

Chloasma

Chloasma can develop in women who have a history of this disease during pregnancy. Those women who are at risk of developing chloasma should avoid contact with sunbeams or ultraviolet radiation while taking Regulon.

Efficiency

The effectiveness of the drug may decrease with the following cases: missed pills, vomiting and diarrhea, simultaneous application other drugs that reduce the effectiveness of oral contraceptives.

If the patient is simultaneously taking another drug that can reduce the effectiveness of birth control pills, additional methods of contraception should be used.

The effectiveness of the drug may be reduced if, after several months of their use, irregular, spotting or breakthrough bleeding, in such cases it is advisable to continue taking the tablets until they are finished in the next package. If, at the end of the second cycle, menstrual bleeding does not begin or acyclic spotting does not stop, stop taking the tablets and resume it only after pregnancy has been excluded.

Changes in laboratory parameters

Under the influence of an oral contraceptive drug - due to the estrogen component - the level of some laboratory parameters may change (functional parameters of the liver, kidneys, adrenal glands, thyroid gland, indicators of hemostasis, levels of lipoproteins and transport proteins).

Additional Information

After suffering acute viral hepatitis, the drug should be taken after normalization of liver function (not earlier than after 6 months).

For diarrhea or intestinal disorders, vomiting contraceptive effect may decrease. Without stopping the drug, it is necessary to use additional non-hormonal methods contraception.

Women who smoke have an increased risk of developing vascular diseases with serious consequences (myocardial infarction, stroke). The risk depends on age (especially in women over 35) and on the number of cigarettes smoked.

A woman should be warned that the drug does not protect against HIV infection (AIDS) and other sexually transmitted diseases.

Influence on the ability to drive vehicles and mechanisms

The drug does not affect the ability to drive a car and work with mechanisms.

Pregnancy and lactation

The use of the drug during pregnancy and lactation is contraindicated.

During lactation, it is necessary to resolve the issue of either discontinuing the drug or stopping breastfeeding.

For impaired renal function

With caution and only after a careful assessment of the benefits and risks of using the drug should be prescribed for renal failure (including history).

This drug can be taken for a long time. In some cases, this drug is allowed for up to eight years or more. But if you are finally “ripe” for the birth of an heir, what should you do? You must stop taking the drug at least three months before you plan to become pregnant. According to medical statistics, pregnancy after taking oral contraceptives occurs, on average, after six months. But sometimes you have to work on conception for ten to twelve months. This is not out of the norm.
Future mothers are always very worried about the condition of their unborn child. In the first weeks of pregnancy, when you are not even aware of it yet, you may accidentally allow yourself to drink alcohol or take medicine.

It turns out that in the fair sex, who use regulon, the same processes take place in the body as in a woman who is in the first weeks of pregnancy. And if this drug is taken long time a woman who already had children, then exactly the same processes take place in her reproductive system as in women who gave birth and nursed twelve children of their own. That is, this drug actually does what, in the end, nature itself would do if women dared such feats. Birth a large number children, by the way, is the most effective method prevention of oncological diseases of the mammary glands and genital organs.

Such data completely refute the talk that when taking Regulon and other hormonal contraceptives latest generation You need to take breaks for a few months. In fact, such breaks are completely unnecessary. Today, doctors believe that breaks in use this drug and other hormonal contraceptives can harm a woman's health.

How longer woman takes regulon without intervals, the stronger therapeutic effect drug. These drugs should be started as soon as sex life, and use as long as there is a need for contraception. It turns out that among patients who use hormonal contraceptives, the percentage of women with infertility is several times less than among those who have never used by similar means. When using this drug for a long time, the body creates best conditions for egg maturation. To maintain the reproductive system in good condition, you should take vitamin dietary supplements (biologically active supplements).

Pharmacies are full of various contraceptives. How not to get confused in this abundance, how to choose the right drug for yourself? It is better, of course, if the choice is made by your gynecologist. But extra knowledge never hurt anyone. In this article, you will learn about one of the birth control pills.
This drug is available in the form of tablets packed in a blister. Each blister contains twenty-one tablets. There are three blisters in a carton box. Thus, if you choose these pills, then one box will last you three months.

Side effects of regulon are extremely rare. Nausea, vomiting, migraines, breast tightness, weight gain or loss, changes in libido may be present, Bad mood, in rare cases, inconvenience when using contact lenses. But these effects usually do not last long and disappear without a trace after 2-3 months. regular use. With longer use, they rarely appear dark spots on the skin.

Rarely, there is an increase in blood pressure, local thrombosis and thromboembolism, gallbladder pathology, hepatitis, skin rashes, hair loss, inversion of vaginal secretions, vaginal mycosis, severe fatigue, diarrhea.

The risk of implementing the above adverse reactions increases with the use of hormonal drugs without a doctor's certificate. The likelihood of adverse reactions with the correct selection of funds tends to zero.

Stop using Regulon immediately:

If you feel a migraine-like, abnormally severe headache for the first time or growing headache, at plummet vision, with symptoms of thrombosis or cerebral infarction;

With a sudden increase in blood pressure, with the progression of jaundice or hepatitis without symptoms of jaundice, with the appearance of generalized itching, with the appearance or increase in cases of epileptic seizures;

If you have an operation (6 weeks before the operation), with prolonged immobility (for example, with fractures).

It is necessary to start using Regulon on the first day of menstruation. They drink 1 tablet at a certain constant time of day for only 21 days, after which a 7-day pause is necessary, during which menstrual bleeding occurs. On the 8th day, the use of tablets from the next pack should be resumed (even if the bleeding has not yet stopped). To avoid confusion in use, the number and arrow are shown on the packaging.

The periods of use of the remedy are carried out for a long time, for the amount of time until the absence of pregnancy is required. If the drug is used constantly, the contraceptive effect lasts about 7 days, until the next dose.

When changing any oral contraceptive to Regulon, the same method of administration is used.

After childbirth, for non-nursing women, the remedy can be prescribed after 21 days, breastfeeding women are allowed to take the remedy, starting from the 6th month. After an abortion, the use of the drug should be started immediately or on the second day.

If the interval between the use of the drug was more than 1.5 days, there is a possibility of conception.

If you do not take one tablet in the first or second week of the cycle, you need to use 2 tablets on the next day and then return to the main scheme.

If two tablets in a row are not taken at 1-2 weeks of the cycle, it is required to use 2 tablets in the next 2 days, after returning to the main scheme, practicing other methods of contraception until the end of the cycle.

Pharmacology

Oral monophasic contraceptive consisting of estrogen and progestogen. The product contains artificially created gestagenic and estrogenic components, which are more effective than natural sex hormones. The effect is achieved, first of all, by blocking the production of follicle-stimulating and luteinizing hormones, which stops ovulation. This is achieved due to the increased viscosity of the cervical mucus, which prevents the entry of spermatozoa into the uterus. Regulon is a new low-dose contraceptive that contains the progestogen lll generation. Regulon does not negatively affect carbohydrate and lipid metabolism, which minimizes the harmful effect, and ensures normal tolerability when used appropriately.

Pharmacokinetics

Ethinylestradiol and desogestrel quickly and practically without residue penetrate the body through upper divisions small intestine. Ethinyl estradiol corresponds to first pass metabolism and enterohepatic circulation. Desogestrel is metabolized with the production of 3-keto-desogestrel, the remaining metabolites have no pharmacological effect. Both components have a strong (more than 90%) connection with plasma proteins. Most content in the blood is observed after 1.0-1.5 hours. Successfully spread through organs and tissues, ethinylestradiol is deposited in adipose tissue. Approximately 10% of the intake falls into breast milk. The half-life is usually 24 hours for ethinylestradiol and an average of 31 hours for desogestrel. Ethinylestradiol is eliminated by 40% by the kidneys as metabolites, by 60% by the liver.